JP2010524435A5 - - Google Patents
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- Publication number
- JP2010524435A5 JP2010524435A5 JP2010501433A JP2010501433A JP2010524435A5 JP 2010524435 A5 JP2010524435 A5 JP 2010524435A5 JP 2010501433 A JP2010501433 A JP 2010501433A JP 2010501433 A JP2010501433 A JP 2010501433A JP 2010524435 A5 JP2010524435 A5 JP 2010524435A5
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- JP
- Japan
- Prior art keywords
- seq
- cdr
- set forth
- region
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000282577 Pan troglodytes Species 0.000 claims 1
- 241000288959 Saguinus Species 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 230000009831 antigen interaction Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07006990 | 2007-04-03 | ||
| EP07006988 | 2007-04-03 | ||
| US91366807P | 2007-04-24 | 2007-04-24 | |
| EP07020640 | 2007-10-22 | ||
| EP07020641 | 2007-10-22 | ||
| EP07020646 | 2007-10-22 | ||
| EP08004741 | 2008-03-13 | ||
| PCT/EP2008/002663 WO2008119566A2 (en) | 2007-04-03 | 2008-04-03 | Cross-species-specific bispecific binders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013218769A Division JP6016747B2 (ja) | 2007-04-03 | 2013-10-22 | 種間特異的二重特異性バインダー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010524435A JP2010524435A (ja) | 2010-07-22 |
| JP2010524435A5 true JP2010524435A5 (enExample) | 2011-05-19 |
Family
ID=42582614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501433A Revoked JP2010524435A (ja) | 2007-04-03 | 2008-04-03 | 種間特異的二重特異性バインダー |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JP2010524435A (enExample) |
| DK (1) | DK2155788T3 (enExample) |
| ES (1) | ES2390243T3 (enExample) |
| NZ (1) | NZ580746A (enExample) |
| PT (1) | PT2155788E (enExample) |
| RS (1) | RS52492B (enExample) |
| RU (1) | RU2535992C2 (enExample) |
| SI (1) | SI2155788T1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100150918A1 (en) * | 2007-04-03 | 2010-06-17 | Micromet Ag | Cross-species-specific binding domain |
| WO2008119566A2 (en) * | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
| US20130273055A1 (en) * | 2010-11-16 | 2013-10-17 | Eric Borges | Agents and methods for treating diseases that correlate with bcma expression |
| US8846042B2 (en) * | 2011-05-16 | 2014-09-30 | Fabion Pharmaceuticals, Inc. | Multi-specific FAB fusion proteins and methods of use |
| UA115402C2 (uk) * | 2011-05-21 | 2017-10-25 | Макродженікс, Інк. | Cd3-зв'язувальна молекула, здатна до зв'язування з cd3 людини і cd3, що не є людським |
| JP6449295B2 (ja) | 2013-12-17 | 2019-01-09 | ジェネンテック， インコーポレイテッド | 抗ｃｄ３抗体および使用方法 |
| KR20170003591A (ko) * | 2014-05-28 | 2017-01-09 | 에프. 호프만-라 로슈 아게 | 인간 및 사이노몰구스 cd3 엡실론에 결합하는 항체 |
| CN107108738A (zh) * | 2014-07-25 | 2017-08-29 | 西托姆克斯治疗公司 | 抗cd3抗体、可活化抗cd3抗体、多特异性抗cd3抗体、多特异性可活化抗cd3抗体及其使用方法 |
| US20170275373A1 (en) * | 2014-07-31 | 2017-09-28 | Amgen Research (Munich) Gmbh | Bispecific single chain antibody construct with enhanced tissue distribution |
| HK1252158A1 (zh) * | 2015-05-01 | 2019-05-17 | Genentech, Inc. | 掩蔽抗cd3抗体和使用方法 |
| EP3430058A4 (en) | 2016-03-15 | 2019-10-23 | Generon (Shanghai) Corporation Ltd. | MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF |
| WO2018093821A1 (en) | 2016-11-15 | 2018-05-24 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| US10426424B2 (en) | 2017-11-21 | 2019-10-01 | General Electric Company | System and method for generating and performing imaging protocol simulations |
| MA51793A (fr) | 2018-02-08 | 2020-12-16 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène et procédés d'utilisation |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| US20230067182A1 (en) * | 2019-11-29 | 2023-03-02 | Boe Technology Group Co., Ltd. | Data Processing Device and Method, and Computer Readable Storage Medium |
| TWI897903B (zh) | 2019-12-13 | 2025-09-21 | 美商建南德克公司 | 抗ly6g6d抗體及其使用方法 |
| JP2022087602A (ja) * | 2020-12-01 | 2022-06-13 | 株式会社バイオピーク | 組換え大腸菌による有用タンパク質の生産性を向上するための培養方法 |
| KR20240007171A (ko) | 2021-05-14 | 2024-01-16 | 제넨테크, 인크. | 모수네투주맙 및 폴라투주맙 베도틴을 이용한 cd20 양성 증식성 장애의 치료 방법 |
| CN115932808B (zh) * | 2022-11-04 | 2025-05-27 | 四川九洲电器集团有限责任公司 | 一种基于多特征融合的被动声纳智能探测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2179862C1 (ru) * | 2000-12-26 | 2002-02-27 | Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" | Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки |
| CA2522894C (en) * | 2003-05-31 | 2013-06-25 | Micromet Ag | Pharmaceutical composition comprising a bispecific antibody specific for epcam |
| US7235641B2 (en) * | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| US7728114B2 (en) * | 2004-06-03 | 2010-06-01 | Novimmune S.A. | Anti-CD3 antibodies and methods of use thereof |
| US20070065437A1 (en) * | 2005-09-12 | 2007-03-22 | Greg Elson | Anti-CD3 antibody formulations |
| CA2625440C (en) * | 2005-10-11 | 2023-06-13 | Micromet Ag | Compositions comprising cross-species-specific antibodies and uses thereof |
-
2008
- 2008-04-03 RS RS20120412A patent/RS52492B/sr unknown
- 2008-04-03 PT PT08735000T patent/PT2155788E/pt unknown
- 2008-04-03 ES ES08735000T patent/ES2390243T3/es active Active
- 2008-04-03 NZ NZ580746A patent/NZ580746A/en unknown
- 2008-04-03 JP JP2010501433A patent/JP2010524435A/ja not_active Revoked
- 2008-04-03 DK DK08735000.5T patent/DK2155788T3/da active
- 2008-04-03 SI SI200830762T patent/SI2155788T1/sl unknown
- 2008-04-03 RU RU2009136913/10A patent/RU2535992C2/ru active