UY34453A - Moléculas de unión para bcma y cd3 - Google Patents
Moléculas de unión para bcma y cd3Info
- Publication number
- UY34453A UY34453A UY34453A UY34453A UY34453A UY 34453 A UY34453 A UY 34453A UY 34453 A UY34453 A UY 34453A UY 34453 A UY34453 A UY 34453A UY 34453 A UY34453 A UY 34453A
- Authority
- UY
- Uruguay
- Prior art keywords
- bcma
- union
- molecules
- union molecules
- escanear
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
Abstract
La presente invención se refiere a una molécula de unión que es al menos biespecífica, que comprende un primer y un segundo dominio de unión, en donde el primer dominio de unión es capaz de unirse al clúster de epítopes 3 de BCMA, y el segundo dominio de unión es capaz de unirse al complejo del receptor CD3 de células T. Más aún, la invención pro vee una secuencia de ácido nucleico que codifica la molécula de unión, un vector que comprende dicha secuencia de ácido nucleico y una célula hospedadora transformada o transfectada con dicho vector. Adicionalmente, la invención provee un proceso para la producción de la molécula de unión de la invención, un uso médico de dicha molécula de unión y un kit que comprende dicha molécula de unión.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161560178P | 2011-11-15 | 2011-11-15 | |
US201161560149P | 2011-11-15 | 2011-11-15 | |
US201161560144P | 2011-11-15 | 2011-11-15 | |
US201161560183P | 2011-11-15 | 2011-11-15 | |
US201161560162P | 2011-11-15 | 2011-11-15 | |
US201261651486P | 2012-05-24 | 2012-05-24 | |
US201261651474P | 2012-05-24 | 2012-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY34453A true UY34453A (es) | 2013-06-28 |
Family
ID=47388493
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY34453A UY34453A (es) | 2011-11-15 | 2012-11-15 | Moléculas de unión para bcma y cd3 |
UY34454A UY34454A (es) | 2011-11-15 | 2012-11-15 | Moléculas de unión para bcma y cd3 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY34454A UY34454A (es) | 2011-11-15 | 2012-11-15 | Moléculas de unión para bcma y cd3 |
Country Status (39)
Country | Link |
---|---|
US (7) | US9150664B2 (es) |
EP (4) | EP2780375B1 (es) |
JP (5) | JP6378087B2 (es) |
KR (4) | KR20140105758A (es) |
CN (3) | CN109485729A (es) |
AP (1) | AP2014007529A0 (es) |
AR (1) | AR088883A1 (es) |
AU (1) | AU2012327203A1 (es) |
BR (2) | BR112014010630B1 (es) |
CA (2) | CA2849196C (es) |
CL (1) | CL2014001254A1 (es) |
CY (1) | CY1122543T1 (es) |
DK (1) | DK2780375T3 (es) |
EA (2) | EA028162B1 (es) |
EC (2) | ECSP14004829A (es) |
ES (2) | ES2749451T3 (es) |
FR (1) | FR23C1013I1 (es) |
GE (1) | GEP20186928B (es) |
HR (1) | HRP20191697T1 (es) |
HU (1) | HUE046682T2 (es) |
IL (3) | IL232603B (es) |
LT (1) | LT2780375T (es) |
MA (2) | MA35450B1 (es) |
ME (1) | ME03521B (es) |
MX (2) | MX349396B (es) |
MY (1) | MY189544A (es) |
PE (1) | PE20141564A1 (es) |
PH (1) | PH12014501091A1 (es) |
PL (1) | PL2780375T3 (es) |
PT (1) | PT2780375T (es) |
RS (1) | RS59373B1 (es) |
SG (4) | SG10201704483RA (es) |
SI (1) | SI2780375T1 (es) |
TN (2) | TN2014000097A1 (es) |
TW (1) | TWI679212B (es) |
UA (1) | UA116766C2 (es) |
UY (2) | UY34453A (es) |
WO (2) | WO2013072415A1 (es) |
ZA (1) | ZA201401615B (es) |
Families Citing this family (155)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX338038B (es) * | 2008-10-01 | 2016-03-30 | Amgen Res Munich Gmbh | Anticuerpo de una sola cadena bis-especifico de pscaxcd3, cd19xcd3, c-metxcd3, endosialinaxcd3, epcamxcd3, igf-1rxcd3 o fapalfaxcd3 de especies cruzadas. |
TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對bcma之e3以及cd3的結合分子 |
BR112014020826A8 (pt) | 2012-02-24 | 2017-09-19 | Stem Centrx Inc | Anticorpo que se liga especificamente a um epítopo, ácido nucleico, vetor ou célula hospedeira, conjugado de fármaco anticorpo, composição farmacêutica compreendendo o referido anticorpo, uso do mesmo, kit e método de preparação do conjugado |
TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Bcma抗原結合蛋白質 |
US9243058B2 (en) | 2012-12-07 | 2016-01-26 | Amgen, Inc. | BCMA antigen binding proteins |
ES2829499T3 (es) * | 2013-02-05 | 2021-06-01 | Engmab Sarl | Método para la selección de anticuerpos contra BCMA |
EP2762496A1 (en) * | 2013-02-05 | 2014-08-06 | EngMab AG | Method for the selection of antibodies against BCMA |
RS58873B1 (sr) | 2013-02-22 | 2019-08-30 | Abbvie Stemcentrx Llc | Antidll3-antitelo-pbd konjugati i njihova upotreba |
AR095374A1 (es) * | 2013-03-15 | 2015-10-14 | Amgen Res (Munich) Gmbh | Moléculas de unión para bcma y cd3 |
ES2871418T3 (es) | 2013-08-28 | 2021-10-28 | Abbvie Stemcentrx Llc | Composiciones y métodos de conjugación de anticuerpos específicos de sitio |
DK3055327T3 (en) * | 2013-10-09 | 2019-03-11 | Res Found Dev | Monoclonal OLFML-3 Antibodies and Uses thereof |
GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
GB201317928D0 (en) | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
ES2959480T3 (es) | 2014-02-07 | 2024-02-26 | Univ Mcmaster | Acoplador de células T - antígeno trifuncional y métodos y usos del mismo |
AU2015218633A1 (en) | 2014-02-21 | 2016-09-01 | Abbvie Stemcentrx Llc | Anti-DLL3 antibodies and drug conjugates for use in melanoma |
CA2939411A1 (en) * | 2014-02-27 | 2015-09-03 | Ucl Business Plc | Ligand |
AU2015248956B2 (en) * | 2014-04-14 | 2020-06-25 | Cellectis | BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy |
JP2017520575A (ja) | 2014-07-01 | 2017-07-27 | ファイザー・インク | 二重特異的ヘテロ二量体ダイアボディおよびその使用 |
EP2982692A1 (en) * | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
JP2017536341A (ja) * | 2014-10-09 | 2017-12-07 | エンクマフ アーゲー | 卵巣がんの処置における使用のためのCD3εおよびROR1に対する二特異性抗体 |
EP3023437A1 (en) | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
WO2016079081A1 (en) * | 2014-11-20 | 2016-05-26 | F. Hoffmann-La Roche Ag | Common light chains and methods of use |
EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
PL3227432T3 (pl) * | 2014-12-05 | 2024-03-11 | Memorial Sloan Kettering Cancer Center | Chimeryczne receptory antygenowe ukierunkowane na antygen dojrzewania komórek b i ich zastosowania |
KR20170108944A (ko) * | 2014-12-05 | 2017-09-27 | 메모리얼 슬로안-케터링 캔서 센터 | B-세포 성숙화 항원을 표적화하는 항체 및 사용 방법 |
EP3262424A4 (en) * | 2015-02-24 | 2019-03-13 | The University of British Columbia | MICROFLUIDIC SYSTEM WITH CONTINUOUS FLOW |
EP3757128A1 (en) | 2015-04-13 | 2020-12-30 | Pfizer Inc | Chimeric antigen receptors targeting b-cell maturation antigen |
BR112017019785B1 (pt) * | 2015-04-13 | 2022-11-16 | Pfizer Inc | Anticorpo biespecífico, seu uso e composição farmacêutica |
US11046767B2 (en) * | 2015-05-13 | 2021-06-29 | Ablynx N.V. | T cell recruiting polypeptides based on CD3 reactivity |
CA2986254A1 (en) | 2015-05-18 | 2016-11-24 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
KR101997241B1 (ko) | 2015-05-21 | 2019-07-09 | 하푼 테라퓨틱스, 인크. | 삼중특이성 결합 단백질 및 사용 방법 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
TWI744242B (zh) * | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
US10683369B2 (en) * | 2015-08-03 | 2020-06-16 | Engmab Sàrl | Monoclonal antibodies against BCMA |
KR20180050321A (ko) | 2015-08-07 | 2018-05-14 | 이미지냅 인코포레이티드 | 분자를 표적화하기 위한 항원 결합 구조체 |
CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
DK3337824T3 (da) | 2015-08-17 | 2020-08-24 | Janssen Pharmaceutica Nv | Anti-bcma-antistoffer, bispecifikke antigen-bindende molekyler, som binder bcma og cd3, og anvendelse deraf |
AU2016325858B2 (en) | 2015-09-24 | 2022-05-26 | Daiichi Sankyo Company, Limited | Anti-GARP antibody |
WO2017091683A1 (en) | 2015-11-25 | 2017-06-01 | Visterra, Inc. | Antibody molecules to april and uses thereof |
TWI797073B (zh) | 2016-01-25 | 2023-04-01 | 德商安美基研究(慕尼黑)公司 | 包含雙特異性抗體建構物之醫藥組合物 |
EP3411404B1 (en) | 2016-02-03 | 2022-11-09 | Amgen Research (Munich) GmbH | Psma and cd3 bispecific t cell engaging antibody constructs |
BR112018015715A2 (pt) | 2016-02-03 | 2019-02-05 | Amgen Inc | construtos de anticorpo de engate de célula t biespecífica bcma e cd3 |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
ES2947230T3 (es) | 2016-03-22 | 2023-08-03 | Hoffmann La Roche | Moléculas biespecíficas para linfocitos T activadas por proteasa |
KR102591930B1 (ko) * | 2016-04-01 | 2023-10-24 | 카이트 파마 인코포레이티드 | Bcma 결합 분자 및 그의 사용 방법 |
JP7010491B2 (ja) | 2016-04-11 | 2022-01-26 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | ヒト化抗rage抗体 |
JP7042467B2 (ja) | 2016-05-20 | 2022-03-28 | ハープーン セラピューティクス,インク. | 単鎖可変フラグメントcd3結合タンパク質 |
BR112018073739A2 (pt) | 2016-05-20 | 2019-02-26 | Harpoon Therapeutics, Inc. | proteína de ligação de albumina sérica de domínio único |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
CN109641049B (zh) | 2016-06-21 | 2023-07-07 | 特尼奥生物股份有限公司 | Cd3结合抗体 |
WO2018014260A1 (en) * | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
JP7109789B2 (ja) | 2016-08-02 | 2022-08-01 | ティーシーアール2 セラピューティクス インク. | 融合タンパク質を使用したtcrの再プログラム化のための組成物及び方法 |
BR112019004873A2 (pt) * | 2016-09-14 | 2019-06-11 | Teneobio Inc | anticorpos de ligação a cd3 |
MX2019003899A (es) | 2016-10-07 | 2019-08-14 | Tcr2 Therapeutics Inc | Composiciones y metodos para reprogramacion de receptores de linfocitos t mediante el uso de proteinas de fusion. |
WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
CN110167964B (zh) | 2016-11-02 | 2023-12-01 | 百时美施贵宝公司 | 组合用于治疗多发性骨髓瘤的针对bcma和cd3的双特异性抗体和免疫药物 |
CN110114371A (zh) * | 2016-11-11 | 2019-08-09 | 奥托路斯有限公司 | 嵌合抗原受体 |
CN110177803A (zh) | 2016-11-22 | 2019-08-27 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重新编程的组合物和方法 |
MX2019006045A (es) | 2016-11-23 | 2019-11-11 | Harpoon Therapeutics Inc | Proteinas triespecificas dirigidas a psma y metodos de uso. |
KR102275008B1 (ko) | 2016-11-23 | 2021-07-13 | 하푼 테라퓨틱스, 인크. | 전립선 특이 막 항원 결합 단백질 |
AU2017382251A1 (en) | 2016-12-21 | 2019-07-11 | Teneobio, Inc. | Anti-BCMA heavy chain-only antibodies |
US20190375815A1 (en) | 2017-01-31 | 2019-12-12 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
KR20190115469A (ko) * | 2017-02-10 | 2019-10-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Bcma, nkg2d 및 cd16에 결합하는 단백질 |
ES2949364T3 (es) | 2017-02-17 | 2023-09-28 | Fred Hutchinson Cancer Center | Terapias de combinación para el tratamiento de cánceres y trastornos autoinmunitarios relacionados con BCMA |
WO2018158349A1 (en) | 2017-02-28 | 2018-09-07 | Affimed Gmbh | Tandem diabody for cd16a-directed nk-cell engagement |
EP3589662A4 (en) | 2017-02-28 | 2020-12-30 | Harpoon Therapeutics, Inc. | INDUCTIBLE MONOVALENT ANTIGBINDING PROTEIN |
US20200055948A1 (en) | 2017-04-28 | 2020-02-20 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
EP3621648A4 (en) | 2017-05-12 | 2021-01-20 | Harpoon Therapeutics, Inc. | TRISPECIFIC PROTEINS MSLN AND METHOD OF USE |
US10543271B2 (en) | 2017-05-12 | 2020-01-28 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
CN117567624A (zh) | 2017-06-20 | 2024-02-20 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
KR20200018498A (ko) | 2017-06-20 | 2020-02-19 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
WO2019000223A1 (en) * | 2017-06-27 | 2019-01-03 | Nanjing Legend Biotech Co., Ltd. | ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF |
HUE058233T2 (hu) | 2017-08-03 | 2022-07-28 | Amgen Inc | Interleukin-21-muteinek és kezelési eljárások |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
TWI783890B (zh) | 2017-08-24 | 2022-11-11 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
SG11202001499WA (en) | 2017-09-08 | 2020-03-30 | Amgen Inc | Inhibitors of kras g12c and methods of using the same |
JP2020533382A (ja) | 2017-09-14 | 2020-11-19 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 癌の組合せ治療 |
WO2019053612A1 (en) | 2017-09-14 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | POLY THERAPY FOR THE TREATMENT OF CANCER |
CN111094353A (zh) | 2017-09-14 | 2020-05-01 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于癌症的组合治疗 |
CA3078637A1 (en) | 2017-10-12 | 2019-04-18 | Mcmaster University | T cell-antigen coupler with y182t mutation and methods and uses thereof |
US11136403B2 (en) * | 2017-10-13 | 2021-10-05 | Harpoon Therapeutics, Inc. | Trispecific proteins and methods of use |
EP3694871A4 (en) | 2017-10-13 | 2021-11-10 | Harpoon Therapeutics, Inc. | B-CELL MATURATION ANTIG-BINDING PROTEINS |
CN111629749A (zh) | 2017-10-18 | 2020-09-04 | 诺华股份有限公司 | 用于选择性蛋白质降解的组合物和方法 |
EP3703688A2 (en) | 2017-11-01 | 2020-09-09 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for b-cell maturation antigen |
KR20200116077A (ko) | 2017-11-01 | 2020-10-08 | 주노 쎄러퓨티크스 인코퍼레이티드 | B 세포 성숙 항원에 특이적인 키메라 항원 수용체 및 암호화 폴리뉴클레오타이드 |
JP2021502979A (ja) | 2017-11-15 | 2021-02-04 | ノバルティス アーゲー | Bcmaターゲティングキメラ抗原受容体、cd19ターゲティングキメラ抗原受容体及び併用療法 |
US20200371091A1 (en) | 2017-11-30 | 2020-11-26 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
US11873336B2 (en) | 2017-12-22 | 2024-01-16 | Teneobio, Inc. | Heavy chain antibodies binding to CD22 |
KR20200104364A (ko) * | 2017-12-27 | 2020-09-03 | 테네오바이오, 인코포레이티드 | Cd3-델타/엡실론 이형이량체 특이적 항체 |
US11905327B2 (en) | 2017-12-28 | 2024-02-20 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against TIGIT |
WO2019136432A1 (en) | 2018-01-08 | 2019-07-11 | Novartis Ag | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
CR20200330A (es) | 2018-01-12 | 2020-12-23 | Amgen Inc | Anticuerpos anti-pd-1 y métodos de tratamiento |
US11713353B2 (en) | 2018-01-15 | 2023-08-01 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against PD-1 |
AU2019211326A1 (en) * | 2018-01-23 | 2020-09-10 | Nextcure, Inc. | B7-H4 antibodies and methods of use thereof |
AU2019215031A1 (en) | 2018-01-31 | 2020-08-20 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
EP3752203A1 (en) | 2018-02-13 | 2020-12-23 | Novartis AG | Chimeric antigen receptor therapy in combination with il-15r and il15 |
AU2019228128A1 (en) | 2018-03-02 | 2020-09-03 | Cdr-Life Ag | Trispecific antigen binding proteins |
CN116514995A (zh) * | 2018-04-12 | 2023-08-01 | 上海赛比曼生物科技有限公司 | 靶向bcma的嵌合抗原受体及其制法和应用 |
SG11202010064QA (en) * | 2018-04-13 | 2020-11-27 | Affimed Gmbh | Nk cell engaging antibody fusion constructs |
PE20210320A1 (es) | 2018-06-01 | 2021-02-16 | Novartis Ag | Moleculas de union contra bcma y usos de las mismas |
WO2019236684A1 (en) * | 2018-06-08 | 2019-12-12 | Imaginab, Inc. | Antigen binding constructs to cd4 |
DE202019005887U1 (de) | 2018-07-03 | 2023-06-14 | Marengo Therapeutics, Inc. | Anti-TCR-Antikörpermoleküle und Verwendungen davon |
US11110123B2 (en) | 2018-07-17 | 2021-09-07 | Triumvira Immunologics Usa, Inc. | T cell-antigen coupler with various construct optimizations |
AU2019307928A1 (en) | 2018-07-19 | 2021-02-11 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-BCMA x anti-CD3 antibodies and uses thereof |
JP2021532073A (ja) | 2018-07-31 | 2021-11-25 | アムジェン リサーチ (ミュニック) ゲゼルシャフト ミット ベシュレンクテル ハフツング | Bcma−cd3二重特異性抗体のための投与レジメン |
BR112021003305A2 (pt) | 2018-08-31 | 2021-05-25 | Novartis Ag | métodos para produzir células que expressam receptor de antígeno quimérico |
US20210171909A1 (en) | 2018-08-31 | 2021-06-10 | Novartis Ag | Methods of making chimeric antigen receptor?expressing cells |
MX2021002190A (es) | 2018-08-31 | 2021-05-14 | Regeneron Pharma | Estrategia de dosificacion que mitiga el sindrome de liberacion de citoquinas para los anticuerpos biespecificos cd3/cd20. |
JP7425049B2 (ja) | 2018-09-25 | 2024-01-30 | ハープーン セラピューティクス,インク. | Dll3結合タンパク質および使用方法 |
BR112021005669A2 (pt) | 2018-09-28 | 2021-06-22 | Amgen Inc. | anticorpos contra bcma solúvel |
CN109503716B (zh) * | 2018-10-08 | 2021-04-27 | 浙江生研生物科技有限公司 | 一种双特异性嵌合抗原受体分子及其在肿瘤治疗上的应用 |
EP3874272A1 (en) | 2018-10-31 | 2021-09-08 | GlaxoSmithKline Intellectual Property Development Limited | Methods of treating cancer |
US20230416385A1 (en) * | 2018-11-01 | 2023-12-28 | Shandong New Time Pharmaceutical Co., Ltd. | Bispecific antibody and use thereof |
EP3930763A1 (en) | 2019-02-25 | 2022-01-05 | Novartis AG | Mesoporous silica particles compositions for viral delivery |
CN113597328A (zh) | 2019-03-21 | 2021-11-02 | 瑞泽恩制药公司 | 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合 |
US20230074800A1 (en) | 2019-03-21 | 2023-03-09 | Novartis Ag | Car-t cell therapies with enhanced efficacy |
WO2020210678A1 (en) | 2019-04-12 | 2020-10-15 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
EP3959320A1 (en) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
CN114206927A (zh) | 2019-06-14 | 2022-03-18 | 特尼奥生物股份有限公司 | 与cd22和cd3结合的多特异性重链抗体 |
CA3144324A1 (en) * | 2019-06-24 | 2020-12-30 | Novartis Ag | Dosing regimen and combination therapies for multispecific antibodies targeting b-cell maturation antigen |
CN112204135A (zh) * | 2019-07-06 | 2021-01-08 | 苏州克睿基因生物科技有限公司 | 一种表达cd3抗体受体复合物的免疫细胞及其用途 |
WO2021004400A1 (zh) * | 2019-07-06 | 2021-01-14 | 苏州克睿基因生物科技有限公司 | 一种表达cd3抗体受体复合物的免疫细胞及其用途 |
BR112022002236A2 (pt) | 2019-08-06 | 2022-05-03 | Glaxosmithkline Ip Dev Ltd | Composições, composições farmacêuticas e uso das mesmas para tratar câncer, bem como formulações que compreendem as mesmas |
CA3149585A1 (en) * | 2019-09-25 | 2021-04-01 | Bahram VALMEHR | Multi-targeting effector cells and use thereof |
EP3819007A1 (en) | 2019-11-11 | 2021-05-12 | Amgen Research (Munich) GmbH | Dosing regimen for anti-bcma agents |
AU2020393912A1 (en) | 2019-11-26 | 2022-06-09 | Novartis Ag | Chimeric antigen receptors binding BCMA and CD19 and uses thereof |
KR20220143037A (ko) | 2020-02-18 | 2022-10-24 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 이의 용도 |
EP4106806A1 (en) | 2020-02-21 | 2022-12-28 | Harpoon Therapeutics, Inc. | Flt3 binding proteins and methods of use |
JP2023515211A (ja) | 2020-02-27 | 2023-04-12 | ノバルティス アーゲー | キメラ抗原受容体発現細胞を作製する方法 |
MX2022010604A (es) | 2020-02-27 | 2022-09-09 | Novartis Ag | Metodos de produccion de celulas que expresan receptores antigenicos quimericos. |
EP4121459A1 (en) | 2020-03-19 | 2023-01-25 | Amgen Inc. | Antibodies against mucin 17 and uses thereof |
WO2021222578A1 (en) | 2020-04-29 | 2021-11-04 | Teneobio, Inc. | Multispecific heavy chain antibodies with modified heavy chain constant regions |
JP2023526774A (ja) | 2020-04-29 | 2023-06-23 | テネオバイオ, インコーポレイテッド | 重鎖定常領域が修飾された多重特異性重鎖抗体 |
AU2021272291A1 (en) | 2020-05-11 | 2023-02-02 | Janssen Biotech, Inc. | Methods for treating multiple myeloma |
BR112022023392A2 (pt) | 2020-05-19 | 2022-12-20 | Janssen Biotech Inc | Composições que compreendem um agente terapêutico de redirecionamento de células t e um inibidor da via de adesão de vla-4 |
IL298473A (en) | 2020-06-11 | 2023-01-01 | Novartis Ag | zbtb32 inhibitors and uses thereof |
AU2021300179A1 (en) | 2020-06-30 | 2023-02-02 | Teneobio, Inc. | Multi-specific antibodies binding to BCMA |
EP4199960A2 (en) | 2020-08-21 | 2023-06-28 | Novartis AG | Compositions and methods for in vivo generation of car expressing cells |
AU2021345124A1 (en) | 2020-09-16 | 2023-03-30 | Amgen Inc. | Methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer |
EP4243936A1 (en) | 2020-11-10 | 2023-09-20 | Amgen Inc. | Methods for administering a bcma x cd3 binding molecule |
CN114573703A (zh) * | 2020-12-02 | 2022-06-03 | 康诺亚生物医药科技(成都)有限公司 | 一种t细胞衔接器治疗剂的开发和应用 |
WO2022135468A1 (zh) * | 2020-12-23 | 2022-06-30 | 信达生物制药(苏州)有限公司 | 抗bcma×cd3双特异性抗体及其用途 |
CN114763383A (zh) * | 2021-01-13 | 2022-07-19 | 博生吉医药科技(苏州)有限公司 | 靶向人bcma的单克隆抗体及其应用 |
JP2024506831A (ja) | 2021-01-28 | 2024-02-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | サイトカイン放出症候群を治療するための組成物及び方法 |
WO2022216993A2 (en) | 2021-04-08 | 2022-10-13 | Marengo Therapeutics, Inc. | Multifuntional molecules binding to tcr and uses thereof |
WO2022229853A1 (en) | 2021-04-27 | 2022-11-03 | Novartis Ag | Viral vector production system |
BR112023024804A2 (pt) | 2021-05-28 | 2024-02-15 | Glaxosmithkline Ip Dev Ltd | Terapias de combinação para tratar câncer |
US11453723B1 (en) | 2021-06-25 | 2022-09-27 | Mcmaster University | BCMA T cell-antigen couplers and uses thereof |
CA3227515A1 (en) | 2021-08-03 | 2023-02-09 | Glaxosmithkline Intellectual Property Development Limited | Biopharmaceutical compositions and stable isotope labeling peptide mapping method |
WO2023021477A1 (en) | 2021-08-20 | 2023-02-23 | Novartis Ag | Methods of making chimeric antigen receptor–expressing cells |
CA3233953A1 (en) | 2021-10-05 | 2023-04-13 | Matthew Bruce | Combination therapies for treating cancer |
WO2023144702A1 (en) | 2022-01-25 | 2023-08-03 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy for cancer |
US20230357446A1 (en) | 2022-04-11 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US567A (en) | 1838-01-09 | Machine for r-uibbii | ||
US1985A (en) | 1841-02-18 | Charles m | ||
US4816A (en) | 1846-10-17 | Bell machinery for hotels | ||
US556A (en) | 1838-01-09 | Machine foe | ||
US5013A (en) | 1847-03-13 | Improvement in apparatus for the manufacture of malleable iron | ||
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
DE122004000008I1 (de) | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
AU739331B2 (en) | 1997-10-01 | 2001-10-11 | Boston Scientific Limited | Dilation systems and related methods |
ES2203141T3 (es) | 1998-04-21 | 2004-04-01 | Micromet Ag | Polipeptidos cd19 x cd3 especificos y su utilizacion. |
ATE352559T1 (de) | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
IL144029A0 (en) | 1999-01-07 | 2002-04-21 | Zymogenetics Inc | Soluble receptor br43x2 and methods of using |
US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
RS51157B (sr) | 1999-08-17 | 2010-10-31 | Biogen Idec Ma Inc. | Baff receptor (bcma), imunoregulatorni agens |
UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
CA2408617A1 (en) | 2000-05-12 | 2001-11-22 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
CA2438682A1 (en) | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
RU2005137325A (ru) | 2003-05-31 | 2006-09-10 | Микромет Аг (De) | Фармацевтическая композиция, содержащая конструкт, специфичный к ерсам |
EP1673398B1 (en) | 2003-10-16 | 2010-12-29 | Micromet AG | Multispecific deimmunized cd3-binders |
US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
WO2005075511A1 (en) * | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants of the extracellular domain of bcma and uses thereof |
SI1716178T1 (sl) * | 2004-02-16 | 2010-11-30 | Micromet Ag | Manj imunogene vezne molekule |
CN101370830A (zh) * | 2005-09-26 | 2009-02-18 | 米德列斯公司 | 抗cd70的人单克隆抗体 |
ES2856451T3 (es) | 2005-10-11 | 2021-09-27 | Amgen Res Munich Gmbh | Composiciones que comprenden anticuerpos específicos para diferentes especies, y usos de las mismas |
JP6088723B2 (ja) | 2005-11-23 | 2017-03-01 | ジェネンテック, インコーポレイテッド | B細胞アッセイに関する組成物及び方法。 |
US20100183615A1 (en) * | 2007-04-03 | 2010-07-22 | Micromet Ag | Cross-species-specific bispecific binders |
JP2010524851A (ja) * | 2007-04-03 | 2010-07-22 | マイクロメット アーゲー | 種間特異的結合ドメイン |
EP4059964A1 (en) | 2007-04-03 | 2022-09-21 | Amgen Research (Munich) GmbH | Cross-species-specific binding domain |
CA2720682A1 (en) * | 2008-04-25 | 2009-10-29 | Zymogenetics, Inc. | Levels of bcma protein expression on b cells and use in diagnostic methods |
PL2352763T5 (pl) | 2008-10-01 | 2023-01-30 | Amgen Research (Munich) Gmbh | Bispecyficzne przeciwciała jednołańcuchowe o specyficzności wobec antygenów docelowych o dużej masie cząsteczkowej |
US10981998B2 (en) * | 2008-10-01 | 2021-04-20 | Amgen Research (Munich) Gmbh | Cross-species-specific single domain bispecific single chain antibody |
CA2738565C (en) | 2008-10-01 | 2023-10-10 | Micromet Ag | Cross-species-specific psmaxcd3 bispecific single chain antibody |
MX338038B (es) | 2008-10-01 | 2016-03-30 | Amgen Res Munich Gmbh | Anticuerpo de una sola cadena bis-especifico de pscaxcd3, cd19xcd3, c-metxcd3, endosialinaxcd3, epcamxcd3, igf-1rxcd3 o fapalfaxcd3 de especies cruzadas. |
NZ612647A (en) | 2009-03-10 | 2015-03-27 | Biogen Idec Inc | Anti-bcma antibodies |
CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
EP2640750A1 (en) | 2010-11-16 | 2013-09-25 | Boehringer Ingelheim International GmbH | Agents and methods for treating diseases that correlate with bcma expression |
EP4338754A2 (en) | 2011-05-27 | 2024-03-20 | Glaxo Group Limited | Antigen binding proteins |
TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對bcma之e3以及cd3的結合分子 |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
EP2731280B8 (en) | 2012-11-07 | 2019-03-20 | Telefonaktiebolaget LM Ericsson (publ) | Loopback-based built-in-self-test |
TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Bcma抗原結合蛋白質 |
EP2762497A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
AR095374A1 (es) * | 2013-03-15 | 2015-10-14 | Amgen Res (Munich) Gmbh | Moléculas de unión para bcma y cd3 |
BR112018015715A2 (pt) * | 2016-02-03 | 2019-02-05 | Amgen Inc | construtos de anticorpo de engate de célula t biespecífica bcma e cd3 |
-
2012
- 2012-11-14 TW TW101142376A patent/TWI679212B/zh active
- 2012-11-15 UY UY34453A patent/UY34453A/es active IP Right Grant
- 2012-11-15 CA CA2849196A patent/CA2849196C/en active Active
- 2012-11-15 LT LT12805432T patent/LT2780375T/lt unknown
- 2012-11-15 US US13/678,264 patent/US9150664B2/en active Active
- 2012-11-15 KR KR20147016300A patent/KR20140105758A/ko not_active Application Discontinuation
- 2012-11-15 CN CN201811036957.6A patent/CN109485729A/zh active Pending
- 2012-11-15 CN CN201280056357.0A patent/CN104114578B/zh active Active
- 2012-11-15 EP EP12805432.7A patent/EP2780375B1/en active Active
- 2012-11-15 PT PT128054327T patent/PT2780375T/pt unknown
- 2012-11-15 JP JP2014541658A patent/JP6378087B2/ja active Active
- 2012-11-15 AP AP2014007529A patent/AP2014007529A0/xx unknown
- 2012-11-15 MY MYPI2014001357A patent/MY189544A/en unknown
- 2012-11-15 WO PCT/EP2012/072730 patent/WO2013072415A1/en active Application Filing
- 2012-11-15 SG SG10201704483RA patent/SG10201704483RA/en unknown
- 2012-11-15 EP EP19192268.1A patent/EP3623385A1/en active Pending
- 2012-11-15 PE PE2014000669A patent/PE20141564A1/es active IP Right Grant
- 2012-11-15 AU AU2012327203A patent/AU2012327203A1/en not_active Abandoned
- 2012-11-15 EP EP12803509.4A patent/EP2780374B1/en not_active Revoked
- 2012-11-15 MX MX2014005852A patent/MX349396B/es active IP Right Grant
- 2012-11-15 US US14/358,511 patent/US10766969B2/en active Active
- 2012-11-15 UY UY34454A patent/UY34454A/es not_active Application Discontinuation
- 2012-11-15 BR BR112014010630-4A patent/BR112014010630B1/pt active IP Right Grant
- 2012-11-15 GE GEAP201213496A patent/GEP20186928B/en unknown
- 2012-11-15 PL PL12805432T patent/PL2780375T3/pl unknown
- 2012-11-15 AR ARP120104307 patent/AR088883A1/es active IP Right Grant
- 2012-11-15 SG SG10201606484SA patent/SG10201606484SA/en unknown
- 2012-11-15 ES ES12803509T patent/ES2749451T3/es active Active
- 2012-11-15 EA EA201490931A patent/EA028162B1/ru not_active IP Right Cessation
- 2012-11-15 ME MEP-2019-270A patent/ME03521B/me unknown
- 2012-11-15 SI SI201231673T patent/SI2780375T1/sl unknown
- 2012-11-15 BR BR112014010940A patent/BR112014010940A2/pt not_active Application Discontinuation
- 2012-11-15 US US14/358,520 patent/US9598500B2/en active Active
- 2012-11-15 SG SG11201401729PA patent/SG11201401729PA/en unknown
- 2012-11-15 WO PCT/EP2012/072699 patent/WO2013072406A1/en active Application Filing
- 2012-11-15 EA EA201490932A patent/EA201490932A1/ru unknown
- 2012-11-15 CN CN201280056358.5A patent/CN104169300A/zh active Pending
- 2012-11-15 SG SG11201400671YA patent/SG11201400671YA/en unknown
- 2012-11-15 EP EP19196304.0A patent/EP3611193A1/en active Pending
- 2012-11-15 MX MX2014005851A patent/MX2014005851A/es unknown
- 2012-11-15 DK DK12805432T patent/DK2780375T3/da active
- 2012-11-15 RS RSP20191279 patent/RS59373B1/sr unknown
- 2012-11-15 US US13/678,247 patent/US9340621B2/en active Active
- 2012-11-15 KR KR1020147016296A patent/KR102062231B1/ko active IP Right Grant
- 2012-11-15 HU HUE12805432A patent/HUE046682T2/hu unknown
- 2012-11-15 KR KR1020197038468A patent/KR102229469B1/ko active IP Right Grant
- 2012-11-15 KR KR1020217007556A patent/KR102346029B1/ko active IP Right Grant
- 2012-11-15 CA CA 2850591 patent/CA2850591A1/en not_active Abandoned
- 2012-11-15 ES ES12805432T patent/ES2751996T3/es active Active
- 2012-11-15 UA UAA201405451A patent/UA116766C2/uk unknown
- 2012-11-15 JP JP2014541660A patent/JP6231007B2/ja active Active
-
2014
- 2014-03-04 ZA ZA2014/01615A patent/ZA201401615B/en unknown
- 2014-03-06 TN TNP2014000097A patent/TN2014000097A1/en unknown
- 2014-03-21 TN TNP2014000121A patent/TN2014000121A1/en unknown
- 2014-03-21 MA MA36846A patent/MA35450B1/fr unknown
- 2014-03-21 MA MA36845A patent/MA35449B1/fr unknown
- 2014-05-13 IL IL232603A patent/IL232603B/en active IP Right Grant
- 2014-05-13 CL CL2014001254A patent/CL2014001254A1/es unknown
- 2014-05-14 PH PH12014501091A patent/PH12014501091A1/en unknown
- 2014-05-14 IL IL232636A patent/IL232636A0/en unknown
- 2014-06-12 EC ECIEPI20144829A patent/ECSP14004829A/es unknown
- 2014-06-13 EC ECIEPI20144893A patent/ECSP14004893A/es unknown
-
2017
- 2017-06-05 JP JP2017110658A patent/JP2017195889A/ja active Pending
- 2017-11-02 JP JP2017212359A patent/JP6738314B2/ja active Active
-
2018
- 2018-06-20 IL IL260189A patent/IL260189A/en unknown
-
2019
- 2019-09-19 HR HRP20191697 patent/HRP20191697T1/hr unknown
- 2019-11-13 CY CY20191101198T patent/CY1122543T1/el unknown
-
2020
- 2020-07-17 JP JP2020122548A patent/JP7250736B2/ja active Active
- 2020-09-03 US US17/011,849 patent/US20220064336A1/en active Pending
-
2021
- 2021-06-01 US US17/336,152 patent/US20220356268A1/en active Pending
-
2022
- 2022-02-15 US US17/672,546 patent/US20220251243A1/en not_active Abandoned
-
2023
- 2023-02-22 FR FR23C1013C patent/FR23C1013I1/fr active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY34454A (es) | Moléculas de unión para bcma y cd3 | |
CL2015002742A1 (es) | Moléculas de unión para bcma y cd3. | |
UY34836A (es) | Nuevo organismos | |
CO7350623A2 (es) | Agentes moduladores de autotaxina (atx) | |
UY34456A (es) | Anticuerpos anti-il-36r | |
UY34885A (es) | Proteínas de unión anti-mesotelina | |
UY34484A (es) | Benzotienilo-pirrolotriazinas disustituidas y sus usos | |
UY34587A (es) | Formulaciones estabilizadas que contienen anticuerpos antiang2 | |
UY34817A (es) | Tienopirimidinas | |
CO7091177A2 (es) | Inhibidores de la beta-secretasa | |
BR112014001219A2 (pt) | perfume | |
UY34582A (es) | Anticuerpos anti-cxcr3 | |
UY34027A (es) | Inhibidores sustituidos de acetil-coa carboxilasa. | |
UY34167A (es) | Pirrolotriazinas sustituidas con hidroximetilarilo y sus usos | |
UY4210Q (es) | Silla | |
BR112014026634A2 (pt) | direcionador | |
UY4153Q (es) | Batería | |
BR112013024363A2 (pt) | método, e aparelho | |
BR112014027219A2 (pt) | método | |
UY4152Q (es) | Batería | |
BR112013025764A2 (pt) | dispositivo impulsionador | |
UY4247Q (es) | Silla | |
UY4189Q (es) | Exhibidor para mostrador | |
TN2011000372A1 (fr) | جهاز مراقبة وتحكم في استهلاك المياه | |
TN2011000399A1 (fr) | دراجة كهربائية ذات شحن الي |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
110 | Patent granted |
Effective date: 20221101 |