MX2021002190A - Estrategia de dosificacion que mitiga el sindrome de liberacion de citoquinas para los anticuerpos biespecificos cd3/cd20. - Google Patents

Estrategia de dosificacion que mitiga el sindrome de liberacion de citoquinas para los anticuerpos biespecificos cd3/cd20.

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Publication number
MX2021002190A
MX2021002190A MX2021002190A MX2021002190A MX2021002190A MX 2021002190 A MX2021002190 A MX 2021002190A MX 2021002190 A MX2021002190 A MX 2021002190A MX 2021002190 A MX2021002190 A MX 2021002190A MX 2021002190 A MX2021002190 A MX 2021002190A
Authority
MX
Mexico
Prior art keywords
bispecific antibodies
cytokine release
release syndrome
mitigates
dosing
Prior art date
Application number
MX2021002190A
Other languages
English (en)
Inventor
Israel Lowy
Carrie Brownstein
Lieve Lucille Adriaens
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2021002190A publication Critical patent/MX2021002190A/es

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Abstract

Se describen los regímenes de administración para las proteínas terapéuticas (por ejemplo, anticuerpos biespecíficos que activan las células T) que mitigan el síndrome de liberación de citocinas y la reacción relacionada con la infusión. Los métodos emplean una dosificación fraccionada inicial con la administración opcional de agentes adicionales tales como esteroides o antagonistas de las citocinas que se interrumpen con la dosificación máxima semanal durante el transcurso del régimen de dosificación.
MX2021002190A 2018-08-31 2019-08-30 Estrategia de dosificacion que mitiga el sindrome de liberacion de citoquinas para los anticuerpos biespecificos cd3/cd20. MX2021002190A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862726137P 2018-08-31 2018-08-31
US201862774019P 2018-11-30 2018-11-30
US201962861100P 2019-06-13 2019-06-13
PCT/US2019/049027 WO2020047389A1 (en) 2018-08-31 2019-08-30 Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies

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MX2021002190A true MX2021002190A (es) 2021-05-14

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MX2021002190A MX2021002190A (es) 2018-08-31 2019-08-30 Estrategia de dosificacion que mitiga el sindrome de liberacion de citoquinas para los anticuerpos biespecificos cd3/cd20.

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US (2) US11590223B2 (es)
EP (1) EP3844189A1 (es)
JP (1) JP2021535142A (es)
KR (1) KR20210054528A (es)
CN (1) CN112771077A (es)
AU (1) AU2019331024A1 (es)
CA (1) CA3110513A1 (es)
IL (1) IL280875A (es)
MA (1) MA53495A (es)
MX (1) MX2021002190A (es)
WO (1) WO2020047389A1 (es)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
JP2023527926A (ja) 2020-06-04 2023-06-30 バイオインベント インターナショナル アーべー 静脈内投与と関連する抗体耐容性の改善
EP3919077A1 (en) 2020-06-04 2021-12-08 BioInvent International AB Model for prediction of tolerability issues in connection with intravenous administration of therapeutic antibodies
WO2022072762A1 (en) 2020-10-02 2022-04-07 Regeneron Pharmaceuticals, Inc. Combination of antibodies for treating cancer with reduced cytokine release syndrome
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