PL2344539T3 - Leczenie pediatrycznej ostrej białaczki limfoblastycznej - Google Patents

Leczenie pediatrycznej ostrej białaczki limfoblastycznej

Info

Publication number
PL2344539T3
PL2344539T3 PL09764710T PL09764710T PL2344539T3 PL 2344539 T3 PL2344539 T3 PL 2344539T3 PL 09764710 T PL09764710 T PL 09764710T PL 09764710 T PL09764710 T PL 09764710T PL 2344539 T3 PL2344539 T3 PL 2344539T3
Authority
PL
Poland
Prior art keywords
treatment
lymphoblastic leukemia
acute lymphoblastic
pediatric acute
pediatric
Prior art date
Application number
PL09764710T
Other languages
English (en)
Inventor
Gerhard Zugmaier
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of PL2344539T3 publication Critical patent/PL2344539T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PL09764710T 2008-11-07 2009-11-06 Leczenie pediatrycznej ostrej białaczki limfoblastycznej PL2344539T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11232308P 2008-11-07 2008-11-07
US18329109P 2009-06-02 2009-06-02
US22126909P 2009-06-29 2009-06-29
EP09764710.1A EP2344539B1 (en) 2008-11-07 2009-11-06 Treatment of pediatric acute lymphoblastic leukemia
PCT/EP2009/007969 WO2010052013A1 (en) 2008-11-07 2009-11-06 Treatment of pediatric acute lymphoblastic leukemia

Publications (1)

Publication Number Publication Date
PL2344539T3 true PL2344539T3 (pl) 2015-07-31

Family

ID=41796119

Family Applications (3)

Application Number Title Priority Date Filing Date
PL09764710T PL2344539T3 (pl) 2008-11-07 2009-11-06 Leczenie pediatrycznej ostrej białaczki limfoblastycznej
PL17206868T PL3330293T3 (pl) 2008-11-07 2009-11-06 Leczenie ostrej białaczki limfoblastycznej wieku dziecięcego za pomocą biswoistych przeciwciał przeciwko cd3xcd19
PL15154416T PL2918604T3 (pl) 2008-11-07 2009-11-06 Leczenie pediatrycznej ostrej białaczki limfoblastycznej

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL17206868T PL3330293T3 (pl) 2008-11-07 2009-11-06 Leczenie ostrej białaczki limfoblastycznej wieku dziecięcego za pomocą biswoistych przeciwciał przeciwko cd3xcd19
PL15154416T PL2918604T3 (pl) 2008-11-07 2009-11-06 Leczenie pediatrycznej ostrej białaczki limfoblastycznej

Country Status (27)

Country Link
US (2) US20110262440A1 (pl)
EP (4) EP2344539B1 (pl)
JP (2) JP5798036B2 (pl)
KR (1) KR101695329B1 (pl)
CN (2) CN102209729B (pl)
AU (1) AU2009313039B2 (pl)
BR (1) BRPI0921341A2 (pl)
CA (1) CA2742242C (pl)
CY (3) CY1116160T1 (pl)
DK (3) DK2344539T3 (pl)
ES (3) ES2662929T3 (pl)
HK (1) HK1255590B (pl)
HR (3) HRP20150400T1 (pl)
HU (3) HUE036922T2 (pl)
IL (1) IL212651A (pl)
LT (2) LT3330293T (pl)
MX (1) MX2011002931A (pl)
NO (1) NO2918604T3 (pl)
NZ (1) NZ591312A (pl)
PL (3) PL2344539T3 (pl)
PT (3) PT2344539E (pl)
RS (3) RS53980B1 (pl)
RU (3) RU2536933C2 (pl)
SG (1) SG195549A1 (pl)
SI (3) SI3330293T1 (pl)
SM (3) SMT201800149T1 (pl)
WO (1) WO2010052013A1 (pl)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6358588A (ja) * 1986-08-29 1988-03-14 Toshiba Corp バ−コ−ド読取装置
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
CN102209729B (zh) * 2008-11-07 2016-05-25 安进研发(慕尼黑)股份有限公司 小儿急性淋巴细胞白血病的治疗方法
ES2565439T3 (es) * 2009-01-09 2016-04-04 Oxford Biomedica (Uk) Ltd Factores
US20150231241A1 (en) * 2012-08-14 2015-08-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
NZ746691A (en) 2012-11-13 2020-08-28 Astellas Pharma Inc Agents for treatment of claudin expressing cancer diseases
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
CN103131777A (zh) * 2013-02-05 2013-06-05 南京艾迪康医学检验所有限公司 用于检测e2a-pbx融合基因相对表达量的试剂盒
DK3105252T3 (da) 2014-02-12 2019-10-14 Michael Uhlin Bispecifikke antistoffer til anvendelse ved stamcelletransplantation
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
LT3149480T (lt) 2014-05-30 2019-04-25 Amgen Research (Munich) Gmbh B ląstelių pirmtakų ūmia limfoblastine leukemija (all) sergančių pacientų rizikos stratifikacijos būdas
US20170252364A1 (en) 2014-07-30 2017-09-07 Mor Research Applications Ltd. Compositions for treatment of acute lymphoblastic leukemia and methods of use thereof
WO2016061368A1 (en) * 2014-10-15 2016-04-21 The Children's Hospital Of Philadelphia Compositions and methods for treating b-lymphoid malignancies
AU2015350075B2 (en) 2014-11-17 2021-06-03 Regeneron Pharmaceuticals, Inc. Methods for tumor treatment using CD3xCD20 bispecific antibody
EP3253408A4 (en) * 2015-02-05 2018-09-26 Stc.Unm Anti-pre-bcr antagonists and methods
US10556952B2 (en) 2015-03-30 2020-02-11 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to Fc gamma receptors
IL303972A (en) 2015-04-08 2023-08-01 Novartis Ag CD20 treatments, CD22 treatments and combined treatments with CD19 chimeric antigen receptor expressing cell
DK3298042T3 (da) 2015-05-20 2025-02-24 Amgen Res Munich Gmbh B-celledepletering som en diagnostisk markør
TWI784917B (zh) 2015-09-23 2022-11-21 美商再生元醫藥公司 最優化抗cd3雙特異性抗體及其用途
EA201891495A1 (ru) * 2015-12-22 2018-11-30 Ридженерон Фармасьютикалз, Инк. Биспецифические анти-cd20/анти-cd3 антитела для лечения острого лимфобластного лейкоза
GB201602974D0 (en) * 2016-02-19 2016-04-06 Clube Jasper R Engineered cells & methods (1)
CA3017743A1 (en) * 2016-03-14 2017-09-21 Millennium Pharmaceuticals, Inc. Method of preventing graft versus host disease
KR20240036704A (ko) * 2016-06-06 2024-03-20 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료법을 이용한 b 세포 악성종양의 치료 방법
EP3548046A2 (en) 2016-12-03 2019-10-09 Juno Therapeutics, Inc. Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors
AU2018261951B2 (en) * 2017-05-05 2025-05-22 Amgen Inc. Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
KR20200054160A (ko) 2017-06-02 2020-05-19 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 요법을 사용한 치료를 위한 물품 제조 및 방법
WO2019089858A2 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
KR102083481B1 (ko) 2018-03-22 2020-03-02 강원대학교산학협력단 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물
IL280875B2 (en) 2018-08-31 2024-12-01 Regeneron Pharma Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies
JP7680358B2 (ja) * 2019-01-30 2025-05-20 ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー 癌抗原を標的とするdnaコード化二重特異性t細胞エンゲージャーおよび癌治療薬における使用方法
IL288024B2 (en) 2019-05-14 2025-12-01 Provention Bio Inc Methods and compositions for preventing type
TWI905099B (zh) 2019-05-21 2025-11-21 瑞士商諾華公司 Cd19 結合分子及其用途
EP3998081A4 (en) 2019-07-05 2023-07-12 Ono Pharmaceutical Co., Ltd. TREATMENT OF BLOOD CANCER WITH PD-1/CD3 DUAL SPECIFICITY PROTEIN
US12006366B2 (en) 2020-06-11 2024-06-11 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
US12285494B2 (en) 2021-02-16 2025-04-29 Children's Health Care Methods for treating B-ALL by administering a pre-BCR complex antagonist
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.
PE20241619A1 (es) 2021-10-15 2024-08-07 Amgen Res Munich Gmbh Administracion subcutanea de anticuerpos acopladores a linfocitos t de union a cd19
WO2025101672A1 (en) 2023-11-06 2025-05-15 City Of Hope Methods comprising oncolytic viruses expressing cd19t and bispecific t cell engagers
US20250230251A1 (en) 2023-12-20 2025-07-17 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rb) and related methods

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4119397A (en) * 1996-08-28 1998-03-19 Viva Diagnostika Diagnostische Produkte Gmbh Novel combination preparations and their use in immunodiagnosis and immunotherapy
DK1071752T3 (da) * 1998-04-21 2003-10-20 Micromet Ag CD19xCD3-specifikke polypeptider og anvendelsen deraf
JP2008501621A (ja) * 2003-05-31 2008-01-24 マイクロメット アクツィエン ゲゼルシャフト B細胞関連疾患を処置するための二重特異性抗cd3、抗cd19抗体構築物を含む薬学的組成物
JP4948174B2 (ja) * 2003-10-16 2012-06-06 マイクロメット アクツィエン ゲゼルシャフト 多重特異的脱免疫cd3−結合物質
US8007796B2 (en) 2005-12-16 2011-08-30 Micromet Ag Means and methods for the treatment of tumorous diseases
JP5825756B2 (ja) * 2006-08-14 2015-12-02 ゼンコー・インコーポレイテッドXencor、 Inc. Cd19を標的とする最適化抗体
AU2009299793B2 (en) * 2008-10-01 2016-03-10 Amgen Research (Munich) Gmbh Bispecific single chain antibodies with specificity for high molecular weight target antigens
CN102209729B (zh) * 2008-11-07 2016-05-25 安进研发(慕尼黑)股份有限公司 小儿急性淋巴细胞白血病的治疗方法
CN102282128B (zh) * 2009-01-19 2015-06-17 Abbvie公司 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
HUE025527T2 (en) * 2009-01-19 2016-04-28 Abbvie Inc Apoptosis inducers for the treatment of cancer, immune and autoimmune diseases
JP2012528177A (ja) * 2009-05-27 2012-11-12 アボット・ラボラトリーズ キナーゼ活性のピリミジン阻害剤
CN105820138A (zh) * 2009-09-20 2016-08-03 Abbvie 公司 用于治疗bcl-2蛋白相关疾病的abt-263晶体形式和溶剂化物
NZ598732A (en) * 2009-10-27 2014-09-26 Amgen Res Munich Gmbh Dosage regimen for administering a cd19xcd3 bispecific antibody

Also Published As

Publication number Publication date
RU2736802C2 (ru) 2020-11-20
ES2662929T3 (es) 2018-04-10
JP5798036B2 (ja) 2015-10-21
RS53980B1 (sr) 2015-10-30
CY1120022T1 (el) 2018-12-12
EP2344539A1 (en) 2011-07-20
CY1122428T1 (el) 2021-01-27
HK1158667A1 (en) 2012-07-20
NZ591312A (en) 2012-09-28
IL212651A (en) 2015-03-31
PL2918604T3 (pl) 2018-05-30
PT2918604T (pt) 2018-03-02
CN106390114A (zh) 2017-02-15
PL3330293T3 (pl) 2020-02-28
HK1255590B (en) 2020-07-10
PT3330293T (pt) 2019-10-18
CA2742242A1 (en) 2010-05-14
ES2748126T3 (es) 2020-03-13
SI2344539T1 (sl) 2015-06-30
JP2015232023A (ja) 2015-12-24
DK2918604T3 (en) 2018-03-19
PT2344539E (pt) 2015-04-01
WO2010052013A1 (en) 2010-05-14
EP2918604A1 (en) 2015-09-16
HK1215258A1 (en) 2016-08-19
RU2014141180A3 (pl) 2018-06-09
HRP20191715T1 (hr) 2019-12-13
CA2742242C (en) 2023-01-10
HRP20150400T1 (hr) 2015-05-08
RS56989B1 (sr) 2018-05-31
LT2918604T (lt) 2018-03-26
EP3330293A1 (en) 2018-06-06
SI2918604T1 (en) 2018-04-30
RU2677324C2 (ru) 2019-01-16
RU2536933C2 (ru) 2014-12-27
JP6130451B2 (ja) 2017-05-17
AU2009313039A1 (en) 2010-05-14
CY1116160T1 (el) 2017-02-08
US20110262440A1 (en) 2011-10-27
BRPI0921341A2 (pt) 2016-04-26
KR101695329B1 (ko) 2017-01-23
US20230235053A1 (en) 2023-07-27
NO2918604T3 (pl) 2018-05-19
HUE036922T2 (hu) 2018-08-28
LT3330293T (lt) 2019-10-10
EP2918604B1 (en) 2017-12-20
SMT201500104B (it) 2015-07-09
HUE046222T2 (hu) 2020-02-28
MX2011002931A (es) 2011-04-11
RU2014141180A (ru) 2016-05-10
EP2344539B1 (en) 2015-02-11
AU2009313039B2 (en) 2015-06-18
KR20110091669A (ko) 2011-08-12
RU2011122827A (ru) 2012-12-20
SMT201800149T1 (it) 2018-05-02
HUE025452T2 (en) 2016-05-30
HRP20180426T1 (hr) 2018-04-20
CN102209729A (zh) 2011-10-05
DK2344539T3 (en) 2015-05-04
RU2018144313A3 (pl) 2020-06-15
SMT201900546T1 (it) 2019-11-13
JP2012508163A (ja) 2012-04-05
EP3594237A1 (en) 2020-01-15
SG195549A1 (en) 2013-12-30
CN102209729B (zh) 2016-05-25
ES2535257T3 (es) 2015-05-07
EP3330293B1 (en) 2019-07-24
SI3330293T1 (sl) 2019-10-30
DK3330293T3 (da) 2019-10-07
IL212651A0 (en) 2011-07-31
RU2018144313A (ru) 2020-06-15
RS59348B1 (sr) 2019-10-31

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