ATE290205T1 - Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen - Google Patents

Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen

Info

Publication number
ATE290205T1
ATE290205T1 AT97954785T AT97954785T ATE290205T1 AT E290205 T1 ATE290205 T1 AT E290205T1 AT 97954785 T AT97954785 T AT 97954785T AT 97954785 T AT97954785 T AT 97954785T AT E290205 T1 ATE290205 T1 AT E290205T1
Authority
AT
Austria
Prior art keywords
detecting
active substances
identifying infectious
bioluminescence
infectious active
Prior art date
Application number
AT97954785T
Other languages
English (en)
Inventor
Bruce J Bryan
Stephen Gaalema
Randall B Murphy
Original Assignee
Prolume Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolume Ltd filed Critical Prolume Ltd
Application granted granted Critical
Publication of ATE290205T1 publication Critical patent/ATE290205T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G01N21/763—Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/18—Sulfur containing
    • Y10T436/186—Sulfur dioxide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT97954785T 1996-12-12 1997-12-12 Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen ATE290205T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3374596P 1996-12-12 1996-12-12
US3767597P 1997-02-11 1997-02-11
PCT/US1997/023089 WO1998026277A2 (en) 1996-12-12 1997-12-12 Apparatus and method for detecting and identifying infectious agents

Publications (1)

Publication Number Publication Date
ATE290205T1 true ATE290205T1 (de) 2005-03-15

Family

ID=26710086

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97954785T ATE290205T1 (de) 1996-12-12 1997-12-12 Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen

Country Status (10)

Country Link
US (4) US6458547B1 (de)
EP (1) EP1015872B1 (de)
JP (2) JP3795533B2 (de)
AT (1) ATE290205T1 (de)
AU (1) AU741076B2 (de)
CA (1) CA2271717A1 (de)
DE (1) DE69732667T2 (de)
IL (1) IL129767A0 (de)
NZ (1) NZ335453A (de)
WO (1) WO1998026277A2 (de)

Families Citing this family (276)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251691B1 (en) 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6117643A (en) * 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
EP1040349B2 (de) * 1997-12-17 2012-12-19 Ecole Polytechnique Federale De Lausanne (Epfl) Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
EP1925320A3 (de) 1998-03-27 2008-09-03 Prolume, Ltd. Luciferasen, fluoreszierende Proteine, Nukleinsäuren zur Kodierung der Luciferasen und der fluoreszierenden Proteine sowie deren Verwendung zur Diagnose, zum Screening mit hohem Durchsatz und zur Behandlung neuartiger Probleme
WO2001007896A1 (en) * 1999-07-21 2001-02-01 Tropix, Inc. Luminescence detection workstation
KR20020048425A (ko) * 1999-09-30 2002-06-22 해리 제이. 레온 하르트 마이크로전자 어레이 상의 생체분자 부착 부위
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
ATE340025T1 (de) * 2000-01-06 2006-10-15 Caliper Life Sciences Inc Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse
EP1265990B1 (de) * 2000-03-15 2006-03-08 Prolume, Ltd. Luciferase, fluoreszenzproteine, für luciferase und fluoreszenzproteine kodierend nukleinsaüre und ihre verwendung in der diagnose, hoch-durchsatz screeningsverfahren
US7109315B2 (en) 2000-03-15 2006-09-19 Bruce J. Bryan Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US6927851B2 (en) * 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
AU7299301A (en) 2000-06-21 2002-01-02 Bioarray Solutions Ltd Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US7270730B2 (en) * 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
DE10054487A1 (de) * 2000-11-03 2002-05-23 Eppendorf Ag Verfahren und Vorrichtung zum Temperieren von Proben
GB2368903A (en) * 2000-11-08 2002-05-15 Proimmune Ltd Analysis of biological and biochemical assays
CA2328684A1 (en) * 2000-12-15 2002-06-15 Yahia Gawad Photon-triggered luminescent assay
WO2002066969A1 (fr) * 2001-02-19 2002-08-29 Kyowa Medex Co., Ltd. Detecteur de composant charge, son procede d'utilisation et un panneau de detection
JP3729251B2 (ja) * 2001-03-12 2005-12-21 オムロン株式会社 コントローラ及びシステム
US6828545B1 (en) * 2001-05-15 2004-12-07 Raytheon Company Hybrid microelectronic array structure having electrically isolated supported islands, and its fabrication
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
AU2012200643B2 (en) * 2001-06-29 2014-12-04 Meso Scale Technologies, Llc Assay plates reader systems and methods for luminescence test measurements
AU2016201009A1 (en) * 2001-06-29 2016-03-03 Meso Scale Technologies, Llc Assay plates reader systems and methods for luminescence test measurements
JP2004534226A (ja) 2001-06-29 2004-11-11 メソ スケイル テクノロジーズ,エルエルシー 発光試験測定用のアッセイプレート、リーダシステム及び方法
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US6710877B2 (en) * 2001-07-23 2004-03-23 Corning Incorporated Apparatus and methods for determining biomolecular interactions
EP1451348B1 (de) * 2001-09-10 2015-08-12 Meso Scale Technologies, LLC Verfahren, reagentien, kits und vorrichtungen zur proteinfunktionsanalyse
ES2712173T3 (es) 2001-10-15 2019-05-09 Bioarray Solutions Ltd Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
GB0127913D0 (en) * 2001-11-21 2002-01-16 Elan Vital Uk Ltd Fluid analyser systems
US6960298B2 (en) 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US6849910B2 (en) * 2002-04-01 2005-02-01 Bruce J Oberhardt Systems and methods for improving the performance of sensing devices using oscillatory devices
US6946286B2 (en) * 2002-05-09 2005-09-20 Matsushita Electric Industrial Co., Ltd. Method and apparatus for detecting DNA hybridization
US20040005572A1 (en) * 2002-07-05 2004-01-08 Rosner S. Jeffrey Electronically readable microarrays
JP4092990B2 (ja) * 2002-09-06 2008-05-28 株式会社日立製作所 生体および化学試料検査装置
US8524488B2 (en) * 2002-09-10 2013-09-03 The Regents Of The University Of California Methods and devices for determining a cell characteristic, and applications employing the same
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US7469076B2 (en) * 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US20060057625A1 (en) * 2002-09-16 2006-03-16 Carlson Robert E Scaffold-based artificial receptors and methods
US7595883B1 (en) * 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
JP4497874B2 (ja) * 2002-12-13 2010-07-07 株式会社ルネサステクノロジ 半導体集積回路及びicカード
US20060068030A1 (en) * 2003-01-06 2006-03-30 Nutri-Check Technologies, Llc Individual need-based system for providing supplements
EP1613737A4 (de) * 2003-03-28 2008-12-03 Receptors Llc Reversibel immobilisierte bausteine beinhaltend künstliche rezeptoren und verfahren
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
PT1664722E (pt) 2003-09-22 2011-12-28 Bioarray Solutions Ltd Polielectrólito imobilizado à superfície com grupos funcionais múltiplos capazes de se ligarem covalentemente às biomoléculas
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
US8883147B2 (en) 2004-10-21 2014-11-11 Xencor, Inc. Immunoglobulins insertions, deletions, and substitutions
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US7981362B2 (en) 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
US7687234B2 (en) * 2003-12-15 2010-03-30 Geneohm Sciences, Inc. Carbon electrode surface for attachment of DNA and protein molecules
EP1544602B1 (de) * 2003-12-19 2008-05-07 STMicroelectronics Limited Bio-optische Sensoren
US20050164375A1 (en) * 2004-01-23 2005-07-28 Sysmex Corporation Nucleic acid detection apparatus
US7481997B1 (en) 2004-02-12 2009-01-27 Montana State University Snow mountain virus genome sequence, virus-like particles and methods of use
US20050221279A1 (en) * 2004-04-05 2005-10-06 The Regents Of The University Of California Method for creating chemical sensors using contact-based microdispensing technology
US7501585B2 (en) * 2004-04-29 2009-03-10 Infineon Technologies Ag Semiconductor device support element with fluid-tight boundary
US8536661B1 (en) 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
US8206651B2 (en) * 2004-07-15 2012-06-26 Lockheed Martin Corporation System for detection of biological agents
CN101031655A (zh) 2004-07-26 2007-09-05 陶氏环球技术公司 通过株工程改进蛋白表达的方法
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7504365B2 (en) 2004-09-03 2009-03-17 Receptors Llc Combinatorial artificial receptors including tether building blocks
US7985715B2 (en) * 2004-09-11 2011-07-26 Receptors Llc Combinatorial artificial receptors including peptide building blocks
US9200079B2 (en) 2004-11-12 2015-12-01 Xencor, Inc. Fc variants with altered binding to FcRn
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US20060166285A1 (en) * 2005-01-26 2006-07-27 Jainamma Krotz Charged permeation layers for use on active electronic matrix devices
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007008943A2 (en) 2005-07-08 2007-01-18 Xencor, Inc. Optimized anti-ep-cam antibodies
US20070053794A1 (en) * 2005-09-08 2007-03-08 Beckman Coulter, Inc. Sample identification system having plural readers
US20070070342A1 (en) * 2005-09-27 2007-03-29 Treado Patrick J Ultrasonic spray deposition of analytes for improved molecular chemical imaging detection
US7226752B1 (en) * 2006-01-19 2007-06-05 Avago Technologies General Ip (Singapore) Pte. Ltd. Methods for detecting an analyte in a sample
EP3796002B1 (de) 2006-07-14 2023-11-22 The Regents of The University of California Krebsbiomarker und verfahren zur verwendung davon
EP2049901B1 (de) * 2006-07-19 2011-07-20 Koninklijke Philips Electronics N.V. Verfahren zur analyse von proben mit einem mittel zur gasentwicklung
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
US8680235B2 (en) * 2006-09-22 2014-03-25 Stowers Institute For Medical Research Branchiostoma derived fluorescent proteins
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
US20080081332A1 (en) * 2006-10-03 2008-04-03 Jun Amano Methods and devices for conducting diagnostic testing
US7602496B2 (en) * 2006-10-19 2009-10-13 Sporian Microsystems, Inc. Optical sensor with biologically reactive surface
US7652767B2 (en) * 2006-10-19 2010-01-26 Sporian Microsystems, Inc. Optical sensor with chemically reactive surface
FR2908888B1 (fr) * 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
EP2677309B9 (de) 2006-12-14 2014-11-19 Life Technologies Corporation Verfahren zur Sequenzierung einer Nukleinsäure mittels grosser FET-Arrays, geeignet zur Messung in einem begrenzten pH-Bereich
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
CA2682744C (en) * 2007-04-16 2015-10-06 Momenta Pharmaceuticals, Inc. Methods related to cell surface glyosylation
US9394571B2 (en) 2007-04-27 2016-07-19 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
KR100801448B1 (ko) 2007-05-16 2008-02-11 (주)실리콘화일 바이오칩
KR100822672B1 (ko) * 2007-06-27 2008-04-17 (주)실리콘화일 이미지센서를 이용한 진단장치 및 그 제조방법
JP5718640B2 (ja) 2007-08-21 2015-05-13 アムジエン・インコーポレーテツド ヒトc−fms抗原結合性タンパク質
EP2860247A1 (de) 2007-08-21 2015-04-15 Nodality, Inc. Diagnose-, Prognose- und Behandlungsverfahren
WO2009032218A1 (en) * 2007-08-29 2009-03-12 Biolume Inc. Bioluminescent endoscopy methods and compounds
TW200918553A (en) 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
CN104297506B (zh) 2007-10-02 2017-05-03 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
KR100882554B1 (ko) * 2007-11-08 2009-02-12 삼성전자주식회사 생분자 동정 방법
KR101616758B1 (ko) 2007-12-26 2016-04-29 젠코어 인코포레이티드 FcRn에 대한 변경된 결합성을 갖는 Fc 변이체
WO2010008480A2 (en) 2008-06-25 2010-01-21 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
GB2464747B (en) * 2008-10-10 2013-05-15 Hai Kang Life Corp Ltd Method for detection of analyte in microarray of samples and apparatus for performing such method
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010047804A1 (en) * 2008-10-22 2010-04-29 Ion Torrent Systems Incorporated Integrated sensor arrays for biological and chemical analysis
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
US8242248B2 (en) 2009-03-23 2012-08-14 Nodality, Inc. Kits for multiparametric phospho analysis
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
TW201117824A (en) 2009-10-12 2011-06-01 Amgen Inc Use of IL-17 receptor a antigen binding proteins
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
KR101138472B1 (ko) 2009-12-15 2012-04-25 가천대학교 산학협력단 바이오 칩의 미세환경 내에서 세포를 공배양하는 방법
US8562160B1 (en) * 2010-02-28 2013-10-22 Mario Knapp Chemiluminescent application system
WO2011130417A2 (en) 2010-04-15 2011-10-20 Amgen Inc. HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS
EP2564200B8 (de) 2010-04-27 2019-10-02 The Regents of The University of California Krebsbiomarker und anwendungsverfahren dafür
US20120001646A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Methods and apparatus for testing isfet arrays
US8432149B2 (en) 2010-06-30 2013-04-30 Life Technologies Corporation Array column integrator
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
CN103168341B (zh) 2010-07-03 2016-10-05 生命科技公司 具有轻度掺杂的排出装置的化学敏感的传感器
WO2012030738A2 (en) 2010-08-30 2012-03-08 Beckman Coulter, Inc. Complex phosphoprotein activation profiles
EP2617061B1 (de) 2010-09-15 2021-06-30 Life Technologies Corporation Verfahren und vorrichtung zur analytmessung
CN103299182A (zh) 2010-09-24 2013-09-11 生命科技公司 匹配的晶体管对电路
US8409866B2 (en) 2010-10-21 2013-04-02 Nokia Corporation Apparatus and associated methods
US20120167392A1 (en) * 2010-12-30 2012-07-05 Stmicroelectronics Pte. Ltd. Razor with chemical and biological sensor
CN103477197B (zh) 2011-01-21 2016-08-17 提拉诺斯公司 样品使用最大化的系统和方法
ES2726530T3 (es) 2011-03-16 2019-10-07 Univ Tohoku Sonda para analizar tejido biológico y método para utilizar la misma
WO2012155071A1 (en) 2011-05-12 2012-11-15 Gilead Biologics, Inc. Methods of identifying lysyl oxidase - like - 2 (loxl2) binding partners
US9574002B2 (en) 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
US8704610B2 (en) * 2011-08-01 2014-04-22 General Electric Company Apparatus for improving grounding for an electrical component and method of making same
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
AP2014007588A0 (en) 2011-09-22 2014-04-30 Amgen Inc CD27L antigen binding proteins
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對bcma之e3以及cd3的結合分子
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US9027400B2 (en) 2011-12-02 2015-05-12 Stmicroelectronics Pte Ltd. Tunable humidity sensor with integrated heater
US9019688B2 (en) 2011-12-02 2015-04-28 Stmicroelectronics Pte Ltd. Capacitance trimming with an integrated heater
WO2013086443A1 (en) 2011-12-08 2013-06-13 Amgen Inc. Agonistic human lcat antigen binding proteins and their use in therapy
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US9533302B2 (en) * 2012-03-09 2017-01-03 Lexmark International, Inc. Fluid cartridge and system for dispensing fluid
US9341592B2 (en) 2012-04-09 2016-05-17 Bharath Takulapalli Field effect transistor, device including the transistor, and methods of forming and using same
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
AR091069A1 (es) 2012-05-18 2014-12-30 Amgen Inc Proteinas de union a antigeno dirigidas contra el receptor st2
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9645151B2 (en) 2012-08-17 2017-05-09 California Institute Of Technology Targeting phosphofructokinase and its glycosylation form for cancer
EP2893327B1 (de) 2012-09-01 2020-11-04 Prolume, Ltd. Coelenterazinverbindungen und verfahren zur verwendung
JP5954872B2 (ja) * 2012-09-20 2016-07-20 ルネサスエレクトロニクス株式会社 半導体集積回路
US9562253B1 (en) 2012-11-09 2017-02-07 Point Of Care Diagnostics, Llc Distinguishing between a bacterial and non-bacterial infection at the point of care
TW201425336A (zh) 2012-12-07 2014-07-01 Amgen Inc Bcma抗原結合蛋白質
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
EP2948478B1 (de) 2013-01-25 2019-04-03 Amgen Inc. Antikörper gegen cdh19 für melanome
JO3519B1 (ar) 2013-01-25 2020-07-05 Amgen Inc تركيبات أجسام مضادة لأجل cdh19 و cd3
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
JP6461606B2 (ja) 2013-02-01 2019-01-30 国立大学法人東北大学 生体組織からの細胞の分離方法
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
WO2014159764A1 (en) 2013-03-14 2014-10-02 Amgen Inc. Chrdl-1 antigen binding proteins and methods of treatment
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
US9505849B2 (en) 2013-03-15 2016-11-29 Amgen Research (Munich) Gmbh Antibody constructs for influenza M2 and CD3
CN105283758B (zh) 2013-03-15 2018-06-05 生命科技公司 具有一致传感器表面区域的化学传感器
EP2972281B1 (de) 2013-03-15 2023-07-26 Life Technologies Corporation Chemische vorrichtung mit dünnem leitenden element
EP2973456A4 (de) * 2013-03-15 2016-11-16 Bharath Takulapalli Biomarkersensoranordnung und schaltkreis sowie verfahren zur verwendung und herstellung davon
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
UY35484A (es) 2013-03-15 2014-10-31 Amgen Res Munich Gmbh Molécula de unión de cadena simple que comprenden ABP de extremo N
US9850297B2 (en) 2013-03-15 2017-12-26 Amgen Inc. Secreted frizzle-related protein 5 (SFRP5) binding proteins
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
KR102215405B1 (ko) 2013-03-15 2021-02-10 암젠 인크 인간 pac1 항체
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
HUE056580T2 (hu) 2013-05-30 2022-02-28 Kiniksa Pharmaceuticals Ltd Onkosztatin-M-receptor antigénjét kötõ fehérjék
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US9770461B2 (en) 2013-08-02 2017-09-26 California Institute Of Technology Tailored glycopolymers as anticoagulant heparin mimetics
US10227370B2 (en) 2013-08-02 2019-03-12 California Institute Of Technology Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
US9683937B2 (en) * 2013-08-23 2017-06-20 Semiconductor Components Industries, Llc Imaging devices for molecule detection
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
AR097648A1 (es) 2013-09-13 2016-04-06 Amgen Inc Combinación de factores epigenéticos y compuestos biespecíficos que tienen como diana cd33 y cd3 en el tratamiento de leucemia mieloide
EP4220137A1 (de) 2013-12-10 2023-08-02 Illumina, Inc. Biosensoren zur biologischen oder chemischen analyse und verfahren zur herstellung davon
US9196591B2 (en) 2014-02-17 2015-11-24 International Business Machines Corporation Chip with shelf life
CA3177696A1 (en) 2014-02-20 2015-08-27 Allergan, Inc. Complement component c5 antibodies
AU2015223056B2 (en) 2014-02-27 2020-10-01 Allergan, Inc. Complement Factor Bb antibodies
US9245846B2 (en) 2014-05-06 2016-01-26 International Business Machines Corporation Chip with programmable shelf life
ES2980787T3 (es) 2014-07-31 2024-10-03 Amgen Res Munich Gmbh Constructo de anticuerpo de cadena sencilla biespecífico con distribución tisular potenciada
ES2743809T3 (es) 2014-07-31 2020-02-20 Amgen Res Munich Gmbh Constructos de anticuerpo monocatenarios biespecificos específicos de especies cruzadas optimizados
AR101669A1 (es) 2014-07-31 2017-01-04 Amgen Res Munich Gmbh Constructos de anticuerpos para cdh19 y cd3
WO2016040767A2 (en) 2014-09-12 2016-03-17 Amgen Inc. Chrdl-1 epitopes and antibodies
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
TWI756167B (zh) 2014-12-18 2022-03-01 美商生命技術公司 積體電路裝置、感測器裝置及積體電路
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
CN107407656B (zh) 2014-12-18 2020-04-07 生命科技公司 使用大规模 fet 阵列测量分析物的方法和装置
PL3283524T3 (pl) 2015-04-17 2023-06-12 Amgen Research (Munich) Gmbh Konstrukty biswoistego przeciwciała dla cdh3 i cd3
WO2016189118A1 (en) 2015-05-28 2016-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of prognosis and treatment of patients suffering from acute myeloid leukemia
US12650385B2 (en) 2015-07-08 2026-06-09 Shanghai E-Blot Photoelectric Technology Co., Ltd Method and apparatus for collecting signals, tracking cells, and imaging control using a photosensitive chip
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究(慕尼黑)公司 Flt3及cd3抗體構築體
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究(慕尼黑)公司 Msln及cd3抗體構築體
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究(慕尼黑)公司 Egfrviii及cd3抗體構築體
TWI717375B (zh) 2015-07-31 2021-02-01 德商安美基研究(慕尼黑)公司 Cd70及cd3抗體構築體
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
TWI793062B (zh) 2015-07-31 2023-02-21 德商安美基研究(慕尼黑)公司 Dll3及cd3抗體構築體
CN117106085A (zh) 2015-12-23 2023-11-24 美国安进公司 使用gipr结合蛋白与glp-1激动剂的组合来治疗或改善代谢病症的方法
JOP20170017B1 (ar) 2016-01-25 2021-08-17 Amgen Res Munich Gmbh تركيب صيدلي يتضمن تركيبات جسم مضاد ثنائي الاختصاص
UA126657C2 (uk) 2016-02-03 2023-01-11 Емджен Рісерч (Мюнік) Ґмбг ОДНОЛАНЦЮГОВА КОНСТРУКЦІЯ АНТИТІЛА ДО BCMA І CD3<font face="Symbol">e</font>
AR107582A1 (es) 2016-02-03 2018-05-16 Amgen Res Munich Gmbh Constructos de anticuerpo biespecíficos para psma y cd3 que se ligan a células t
US11977069B2 (en) 2016-04-19 2024-05-07 Bharath Takulapalli Nanopore sensor, structure and device including the sensor, and methods of forming and using same
JOP20170091B1 (ar) 2016-04-19 2021-08-17 Amgen Res Munich Gmbh إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية
CN110312808A (zh) 2016-06-30 2019-10-08 拜欧亿思有限公司 双链核酸信号探针以及利用上述双链核酸信号探针的靶分子检测方法
EP4480537A3 (de) 2017-01-17 2025-03-12 Amgen Inc. Verfahren zur behandlung oder linderung von stoffwechselerkrankungen mit glp-1-rezeptoragonisten, die mit antagonisten für den magenhemmenden peptidrezeptor (gipr) konjugiert sind
CR20190408A (es) 2017-02-02 2020-01-31 Amgen Inc Composición farmacéutica de bajo ph que comprende construcciones de anticuerpos que activan linfocitos t antecedentes
PT3583125T (pt) 2017-02-16 2025-04-04 Sonnet Biotherapeutics Inc Proteínas de fusão ao domínio de ligação à albumina
MA48763A (fr) 2017-05-05 2020-04-08 Amgen Inc Composition pharmaceutique comprenant des constructions d'anticorps bispécifiques pour un stockage et une administration améliorés
JOP20190259A1 (ar) 2017-05-31 2019-10-31 Amgen Inc بروتينات ربط مولد ضد مضادة لـ jagged1
UY37753A (es) 2017-06-02 2018-11-30 Amgen Inc Antagonistas de péptido pac1
CA3062194A1 (en) 2017-06-20 2018-12-27 Amgen Inc. Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
JP7250706B2 (ja) 2017-06-21 2023-04-03 アムジエン・インコーポレーテツド 胃抑制ペプチド受容体(gipr)に対するアンタゴニスト結合タンパク質/glp-1受容体アゴニスト融合タンパク質を使用した代謝障害の治療又は寛解方法
MA68842B1 (fr) 2017-08-04 2025-01-31 Amgen Inc. Procédé de conjugaison de cys-mabs
AU2018383679C1 (en) 2017-12-11 2026-05-28 Amgen Inc. Continuous manufacturing process for bispecific antibody products
AU2017444624B2 (en) 2017-12-26 2021-07-22 Illumina, Inc. Sensor system
TW201940518A (zh) 2017-12-29 2019-10-16 美商安進公司 針對muc17和cd3之雙特異性抗體構建體
WO2020025532A1 (en) 2018-07-30 2020-02-06 Amgen Research (Munich) Gmbh Prolonged administration of a bispecific antibody construct binding to cd33 and cd3
BR112021002032A2 (pt) 2018-08-03 2021-07-20 Amgen Research (Munich) Gmbh construtos de anticorpos para cldn18.2 e cd3
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
BR112021005669A2 (pt) 2018-09-28 2021-06-22 Amgen Inc. anticorpos contra bcma solúvel
MX2021003976A (es) 2018-10-11 2021-05-27 Amgen Inc Procesamiento posterior de constructos de anticuerpos biespecificos.
US20220025058A1 (en) 2018-11-06 2022-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of acute myeloid leukemia by eradicating leukemic stem cells
CN120005022A (zh) 2019-01-03 2025-05-16 因外泰克斯公司 用于增加治疗剂在犬中的半衰期的组合物及使用方法
KR102240669B1 (ko) * 2019-05-08 2021-04-16 (주)플렉솔루션 유기 전기화학 트랜지스터 소자 및 그 제조방법
US20220259547A1 (en) 2019-06-13 2022-08-18 Amgeng Inc. Automated biomass-based perfusion control in the manufacturing of biologics
US20220306741A1 (en) 2019-09-10 2022-09-29 Amgen Inc. Purification Method for Bispecific antigen-binding Polypeptides with Enhanced Protein L Capture Dynamic Binding Capacity
US11062187B1 (en) * 2019-09-15 2021-07-13 Gideon Samid Shapeless—a new language concept and related technology
WO2021097344A1 (en) 2019-11-13 2021-05-20 Amgen Inc. Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules
US20230093169A1 (en) 2020-01-22 2023-03-23 Amgen Research (Munch) Gmbh Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof
CN115427454A (zh) 2020-03-19 2022-12-02 安进公司 针对粘蛋白17的抗体及其用途
JP7832123B2 (ja) 2020-05-11 2026-03-17 インベテックス インコーポレイテッド 治療薬のイヌにおける半減期を増加させるための組成物及びその使用方法
WO2021236638A1 (en) 2020-05-19 2021-11-25 Amgen Inc. Mageb2 binding constructs
JP2023527972A (ja) 2020-05-29 2023-07-03 アムジエン・インコーポレーテツド Cd33及びcd3に結合する二重特異性コンストラクトの有害作用軽減投与
WO2022008488A1 (en) 2020-07-06 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of slamf1 as a biomarker in colorectal cancer
CN116096741B (zh) 2020-07-10 2024-10-18 因外泰克斯公司 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法
WO2022013256A1 (en) 2020-07-15 2022-01-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd160 as a biomarker in acute myeloid leukemia
US20230375558A1 (en) 2020-09-22 2023-11-23 3Helix, Inc. Methods for Using Collagen Hybridizing Peptides to Determine Collagen Content
TW202225188A (zh) 2020-11-06 2022-07-01 德商安美基研究(慕尼黑)公司 與cd3結合的多肽構建體
AU2021373318A1 (en) 2020-11-06 2023-05-25 Amgen Inc. Antigen binding domain with reduced clipping rate
EP4240770A1 (de) 2020-11-06 2023-09-13 Amgen Research (Munich) GmbH Polypeptidkonstrukte mit selektiver bindung an cldn6 und cd3
CA3200317A1 (en) 2020-11-06 2022-05-12 Amgen Inc. Multitargeting bispecific antigen-binding molecules of increased selectivity
CN112540034B (zh) * 2020-11-27 2025-04-01 同济大学 一种水下膜渗透传感器的防生物附着装置
EP4255933A4 (de) 2020-12-07 2025-07-23 Invetx Inc Zusammensetzungen zur erhöhung der halbwertszeit eines therapeutischen mittels bei nutztieren und verfahren zur verwendung
CA3203106A1 (en) 2021-01-20 2022-07-28 Parag Mallick Systems and methods for biomolecule quantitation
US20250282887A1 (en) 2021-04-02 2025-09-11 Amgen Inc. Mageb2 binding constructs
MX2023012931A (es) 2021-05-06 2023-11-13 Amgen Res Munich Gmbh Moleculas de union a antigeno dirigidas a cd20 y cd22 para su uso en enfermedades proliferativas.
AU2023268600A1 (en) 2022-05-12 2024-11-07 Amgen Research (Munich) Gmbh Multichain multitargeting bispecific antigen-binding molecules of increased selectivity
AU2023343470A1 (en) 2022-09-14 2025-02-06 Amgen Inc. Bispecific molecule stabilizing composition
WO2024104551A1 (en) 2022-11-14 2024-05-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of the population of slamf4+ ccr5+ effector memory cd4+ t cells as a biomarker in rheumatoid arthritis
KR20250137204A (ko) 2022-12-27 2025-09-17 인베티엑스 인코포레이티드 신생아 fc 수용체(fcrn)에 대한 결합이 변경된 폴리펩타이드 및 사용 방법
AU2023415535A1 (en) 2022-12-27 2025-07-10 Invetx, Inc. Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use
CN121002059A (zh) 2023-01-20 2025-11-21 因外泰克斯公司 用于伴侣动物的双特异性结合剂
TWI846309B (zh) * 2023-02-03 2024-06-21 旺矽科技股份有限公司 用於半導體測試之電路板及其製造方法
MX2025014635A (es) 2023-06-14 2026-02-03 Amgen Inc Moleculas captadoras de enmascaramiento de celulas t
WO2025181096A1 (en) 2024-02-26 2025-09-04 Institut National de la Santé et de la Recherche Médicale Use of vdac and lamp1 as markers for detecting pocked red blood cells
WO2026112167A1 (en) 2024-11-19 2026-05-28 Nonfiction Laboratories Inc. Compositions and methods comprising light-and-magnetoresponsive protein domains
WO2026136785A1 (en) 2024-12-19 2026-06-25 Amgen Inc. T cell engager masking molecules with reduced isomerization tendencies

Family Cites Families (284)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6606802A (de) 1966-05-18 1967-11-20
US3511612A (en) 1967-03-20 1970-05-12 American Cyanamid Co Chemiluminescent systems
US3539794A (en) 1967-09-12 1970-11-10 American Cyanamid Co Self-contained chemiluminescent lighting device
US3597877A (en) 1969-01-23 1971-08-10 Marvin Glass & Associates Multipurpose novelty item used as a decoration or toy
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US3859125A (en) 1972-10-10 1975-01-07 Gilbreth Co Soluble coated paper
CH594444A5 (de) 1972-12-04 1978-01-13 Gerd Birrenbach
US4006117A (en) 1973-01-24 1977-02-01 Hooker Chemicals & Plastics Corporation Amine phosphite antioxidants
US3843443A (en) 1973-03-30 1974-10-22 J Fishman Polypeptide materials bound to fluorocarbon polymers
CS175047B1 (de) 1974-04-25 1977-04-29
US3939123A (en) 1974-06-18 1976-02-17 Union Carbide Corporation Lightly cross-linked polyurethane hydrogels based on poly(alkylene ether) polyols
FR2289956A1 (fr) 1974-10-29 1976-05-28 Steigerwald Strahltech Dispositif de regulation du courant de faisceau dans un appareil a faisceau de porteurs de charge industriel
FR2292595A1 (fr) 1974-11-28 1976-06-25 Jourdain Jean Fontaine a mousse
DK143689C (da) 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4324683A (en) 1975-08-20 1982-04-13 Damon Corporation Encapsulation of labile biological material
US4016880A (en) 1976-03-04 1977-04-12 Alza Corporation Osmotically driven active agent dispenser
NZ187246A (en) 1976-03-04 1980-05-27 New Zealand Dev Finance Hydrophilic hydroxy c2-c4 alkylated crosslinked regenerated cellulose
DE2621974A1 (de) 1976-05-18 1977-11-24 Max Planck Gesellschaft Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials
US4162355A (en) 1976-06-30 1979-07-24 Board Of Regents, For And On Behalf Of The University Of Florida Copolymers of (a) aminimides and (b) vinyl pendant primary halomethy monomers useful for affinity chromatography
US4175183A (en) 1977-03-01 1979-11-20 Development Finance Corporation Of New Zealand Hydroxyalkylated cross-linked regenerated cellulose and method of preparation thereof
US4281645A (en) 1977-06-28 1981-08-04 Duke University, Inc. Method and apparatus for monitoring metabolism in body organs
SE7811630L (sv) 1977-11-17 1979-05-18 Welsh Nat School Med Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik
US4180524A (en) 1978-02-16 1979-12-25 Phillips Petroleum Company Disproportionation/double-bond isomerization of olefins
US4179402A (en) 1978-05-15 1979-12-18 Shell Oil Company Resin-metal-ligand composition
EP0007895B1 (de) 1978-07-19 1983-06-22 Patrick Couvreur Biologisch abbaubare Nanopartikeln, sie enthaltende pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung
US4322311A (en) 1978-08-04 1982-03-30 Damon Corporation Process for producing controlled porosity microcapsules
US4244721A (en) 1979-01-31 1981-01-13 Pedro Buarque De Macedo Method of making composite borosilicate glass articles
US4241537A (en) 1979-05-10 1980-12-30 W. R. Grace & Co. Plant growth media utilizing polyurethane hydrogel
EP0025350A3 (de) 1979-09-05 1981-06-10 Dynatech Ag Apparat zum Feststellen von Lumineszenz-Reaktionen
US4282287A (en) 1980-01-24 1981-08-04 Giese Roger W Biochemical avidin-biotin multiple-layer system
DE3011059A1 (de) 1980-03-21 1981-10-01 Siemens AG, 1000 Berlin und 8000 München Optischer stern-koppler mit planarem mischerelement
DE3026067A1 (de) 1980-07-10 1982-02-04 Henkel KGaA, 4000 Düsseldorf Dosiervorrichtung mit kugelventil und verfahren zum betrieb
DE3027198A1 (de) 1980-07-18 1982-02-11 Bayer Ag, 5090 Leverkusen Feste, in wasser dispergierbare, isocyanatgruppen aufweisende kunststoffvorlaeufer, ein verfahren zur herstellung von waessrigen kunststoffdispersionen unter verwendung dieser kunststoffvorlaeufer, sowie die verwendung der kunststoffvorlaeufer als vernetzungsmittel fuer waessrige kunststoffdispersionen
US4439585A (en) 1980-11-12 1984-03-27 Tyndale Plains-Hunter, Ltd. Polyurethane diacrylate compositions as carrier for pharmacological agents
GB2098719B (en) 1981-05-20 1984-11-21 Rolls Royce Gas turbine engine combustion apparatus
AU552068B2 (en) 1981-09-21 1986-05-22 Asama Chemical Co. Ltd. Preservation of edible oils
US4882165A (en) 1981-11-09 1989-11-21 The Regents Of The University Of California Light sensitive liposomes
US4565647B1 (en) 1982-04-26 1994-04-05 Procter & Gamble Foaming surfactant compositions
US4507230A (en) 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4512762A (en) 1982-11-23 1985-04-23 The Beth Israel Hospital Association Method of treatment of atherosclerosis and a balloon catheter for same
US4581335A (en) 1982-12-01 1986-04-08 Texas A&M University System Process for producing a cloned luciferase-synthesizing microorganism
US4523224A (en) 1982-12-27 1985-06-11 Welch Allyn Inc. Color filter wheel synchronizer
US4614712A (en) 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
US4849213A (en) 1983-03-01 1989-07-18 Schaeffer Hans A Dental preparation, article and method for storage and delivery therof
US4528180A (en) 1983-03-01 1985-07-09 Schaeffer Hans A Dental preparation, article and method for storage and delivery thereof
US4687663B1 (en) 1983-03-01 1997-10-07 Chesebrough Ponds Usa Co Dental preparation article and method for storage and delivery thereof
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4485227A (en) 1983-06-16 1984-11-27 Howmedica, Inc. Biocompatible poly-(ether-urethane-urea) and process for its preparation
US4542102A (en) 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
SE454391B (sv) 1983-07-07 1988-04-25 Simrad Optronics As Elektronisk nattkikare med spegelobjektiv och elektronisk bildforsterkare
DE8335529U1 (de) 1983-12-10 1984-03-08 Upat Gmbh & Co, 7830 Emmendingen Spritz-kartusche
US4665022A (en) 1984-02-17 1987-05-12 The Regents Of The University Of California Bioluminescent assay reagent and method
US4789633A (en) 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US5283122A (en) 1984-04-19 1994-02-01 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US4927916A (en) 1984-04-23 1990-05-22 The General Hospital Corporation Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides
GB8412587D0 (en) 1984-05-17 1986-12-17 Secr Defence Aircrew headgear
US4534317A (en) 1984-08-30 1985-08-13 Cape Cod Research Procedures for monitoring fish food consumption
US4657853A (en) 1984-09-14 1987-04-14 E. I. Du Pont De Nemours And Company Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
FR2571506B1 (fr) 1984-10-05 1987-01-23 Trt Telecom Radio Electr Systeme d'observation nocturne semi-actif a intensification de lumiere
JPH0823558B2 (ja) * 1984-11-27 1996-03-06 オ−ジエニクス リミテツド 検定装置
US4774189A (en) 1984-12-24 1988-09-27 Flow Cytometry Standards Corp. Fluorescent calibration microbeads simulating stained cells
US4767206A (en) 1984-12-24 1988-08-30 Flow Cytometry Standards Corporation Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof
NZ214563A (en) 1984-12-31 1991-05-28 Univ Georgia Production of apoaeqorin using recombinant dna
US5422266A (en) 1984-12-31 1995-06-06 University Of Georgia Research Foundation, Inc. Recombinant DNA vectors capable of expressing apoaequorin
DE3500180A1 (de) 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US4681870A (en) 1985-01-11 1987-07-21 Imre Corporation Protein A-silica immunoadsorbent and process for its production
US4772453A (en) * 1985-03-01 1988-09-20 Lisenbee Wayne F Luminiscence measurement arrangement
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US4921757A (en) 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4950588A (en) 1985-07-10 1990-08-21 Molecular Diagnostics, Inc. Prolonged enhanced chemiluminescence
US4853327A (en) 1985-07-10 1989-08-01 Molecular Diagnostics, Inc. Enhanced phthalazinedione chemiluminescence
DE3537877A1 (de) 1985-10-24 1987-04-30 Geiger Reinhard Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate
US4714682A (en) 1985-12-11 1987-12-22 Flow Cytometry Standards Corporation Fluorescent calibration microbeads simulating stained cells
JPS62171695A (ja) 1985-12-14 1987-07-28 Chisso Corp 発光蛋白アクアリン遺伝子を用いるアクアリン活性を有する蛋白質の製造法
GB2185360B (en) 1986-01-11 1989-10-25 Pilkington Perkin Elmer Ltd Display system
FR2597725B1 (fr) 1986-04-29 1990-06-15 Noirot Extraits Procede pour l'obtention d'un effet de phosphorescence et produits obtenus selon ce procede.
JPS62261942A (ja) 1986-05-08 1987-11-14 Chisso Corp 金属の検出方法
CA1340806C (en) 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5284646A (en) 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5342607A (en) 1986-07-03 1994-08-30 Advanced Magnetics, Inc. Receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5352432A (en) 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US5221623A (en) 1986-07-22 1993-06-22 Boyce Thompson Institute For Plant Research, Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
US4804403A (en) 1986-08-18 1989-02-14 Melamine Chemicals, Inc. Attrition-resistant, controlled release fertilizers
US4711659A (en) 1986-08-18 1987-12-08 Moore William P Attrition resistant controlled release fertilizers
US4867908A (en) 1986-08-29 1989-09-19 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
US5093240A (en) 1986-10-15 1992-03-03 Chisso Corporation Variant aequorin genes and process for producing variant aequorin proteins
US4861876A (en) 1986-11-26 1989-08-29 Wayne State University Hematoporphyrin derivative and method of preparation and purification
US4762881A (en) 1987-01-09 1988-08-09 E. I. Du Pont De Nemours And Company Photoreactive benzoylphenylalanines and related peptides
US4954444A (en) 1987-03-02 1990-09-04 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US4885250A (en) 1987-03-02 1989-12-05 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US5292814A (en) 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
US4891043A (en) 1987-05-28 1990-01-02 Board Of Trustees Of The University Of Illinois System for selective release of liposome encapsulated material via laser radiation
US4968613A (en) 1987-07-29 1990-11-06 Kikkoman Corporation Luciferase gene and novel recombinant DNA as well as a method of producing luciferase
DE3725291A1 (de) 1987-07-30 1989-02-09 Hilti Ag Kartuschenmagazin fuer fliessfaehige massen
JPS6447379A (en) 1987-08-19 1989-02-21 Chisso Corp Preparation of calcium-dependent oxygenation enzyme
US4822994A (en) 1987-09-23 1989-04-18 Itt Electro Optical Products A Division Of Itt Corporation Small arms sight for use during daylight and nighttime conditions
JP2592623B2 (ja) 1987-11-18 1997-03-19 チッソ株式会社 アポエクオリンの製造法
US5182202A (en) 1987-11-30 1993-01-26 Kikkoman Corporation Purified luciferase from luciola cruciata
US4895721A (en) 1988-01-22 1990-01-23 Carter-Wallace Inc. Peroxide gel dentifrice compositions
US4931498A (en) 1988-02-25 1990-06-05 Purdue Research Foundation Immobilized artificial membranes
US4927879A (en) 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
US5688657A (en) 1988-03-31 1997-11-18 International Bio-Immune Systems, Inc. Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
JPH088864B2 (ja) 1988-04-12 1996-01-31 キッコーマン株式会社 ルシフェラーゼ
US4963368A (en) 1988-04-18 1990-10-16 Nabisco Brands, Inc. Oxidoreductase enzyme stabilized highly unsaturated fatty acids and derivatives of such acids
US4948210A (en) 1988-06-20 1990-08-14 Murasa International Infrared zoom illuminator
US5272079A (en) 1988-07-06 1993-12-21 Applied Genetics, Inc. Purification and administration of DNA repair enzymes
US5077211A (en) 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
US5190762A (en) 1988-07-06 1993-03-02 Applied Genetics, Inc. Method of administering proteins to living skin cells
WO1990001541A1 (en) 1988-08-04 1990-02-22 Amrad Corporation Limited In vitro propagation of embryonic stem cells
US5604123A (en) 1988-08-09 1997-02-18 Toray Industries, Inc. Luciferase, gene encoding the same and production process of the same
EP0387355B1 (de) 1988-08-09 1996-11-06 Toray Industries, Inc. Verfahren zur herstellung von luciferase durch rekombinante expression eines luciferase-kodierenden gens
US4924358A (en) 1988-09-12 1990-05-08 Inventech Licensing Co. Safety-sparkler wand w/chemiluminescent or electric-light illumination
US4919140A (en) 1988-10-14 1990-04-24 Purdue Research Foundation Method and apparatus for regenerating nerves
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
CA2002860A1 (en) 1988-11-14 1990-05-14 Michael A. Gimbrone Antibodies specific for elam-1 and the use thereof
US4961920A (en) 1988-12-08 1990-10-09 Luminis Pty, Ltd. Phototherapeutic monovinyl and divinyl ether-linked dimers
US5196524A (en) 1989-01-06 1993-03-23 Eli Lilly And Company Fusion reporter gene for bacterial luciferase
US5148022A (en) 1989-02-15 1992-09-15 Hitachi, Ltd. Method for optically inspecting human body and apparatus for the same
JPH02234698A (ja) 1989-03-08 1990-09-17 Toyobo Co Ltd 細菌ルシフェラーゼ系によるdnaプローブの検出法
US5020694A (en) 1989-03-16 1991-06-04 Chesebrough-Pond's, Inc. Multi-cavity dispensing container
US5067019A (en) 1989-03-31 1991-11-19 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Programmable remapper for image processing
US5116868A (en) 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
US5068830A (en) 1989-05-09 1991-11-26 Advanced Micro Devices High speed static ram sensing system
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5092992A (en) 1989-06-07 1992-03-03 J. T. Baker Inc. Polyethyleneimine matrixes for affinity chromatography
US4999208A (en) 1989-06-07 1991-03-12 Nabisco Brands, Inc. Extrusion baking of cookies having liposome encapsulated ingredients
US5346455A (en) 1989-07-17 1994-09-13 Papermasters, Inc. Methods of making pop-up promotional items
US4953963A (en) 1989-08-17 1990-09-04 Miller Alan K Aviator's night vision system
JPH0378373A (ja) 1989-08-22 1991-04-03 Fuji Photo Optical Co Ltd テレビカメラ操作装置
US5023745A (en) 1989-09-06 1991-06-11 Erico International Corporation Surge arrestor apparatus and method
US5084780A (en) 1989-09-12 1992-01-28 Itt Corporation Telescopic sight for day/night viewing
US5360726A (en) 1989-09-12 1994-11-01 Board Of Trustees Operating Michigan State University Polypeptides enabling sorting of proteins to vacuoles in plants
JPH03122588A (ja) 1989-10-05 1991-05-24 Hitachi Medical Corp 放射線検出器,データ収集装置およびこれを用いる放射線ct装置
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5288623A (en) 1989-10-26 1994-02-22 Chisso Corporation Process for secretory production of a calcium-binding protein
US5215899A (en) 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5002392A (en) 1989-12-01 1991-03-26 Akzo N.V. Multichannel optical monitoring system
GB8927365D0 (en) 1989-12-04 1990-01-31 Ici Plc Reagent
US5292658A (en) 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
US5057296A (en) 1990-12-10 1991-10-15 Mobil Oil Corp. Method for synthesizing mesoporous crystalline material
US5108725A (en) 1990-01-25 1992-04-28 Mobil Oil Corp. Synthesis of mesoporous crystalline material
US5029963A (en) 1990-02-15 1991-07-09 Itt Corporation Replacement device for a driver's viewer
JP2626738B2 (ja) * 1990-03-13 1997-07-02 三共株式会社 化学発光検出装置
US5328603A (en) 1990-03-20 1994-07-12 The Center For Innovative Technology Lignocellulosic and cellulosic beads for use in affinity and immunoaffinity chromatography of high molecular weight proteins
US5219737A (en) 1990-03-27 1993-06-15 Kikkoman Corporation Mutant luciferase of a firefly, mutant luciferase genes, recombinant dnas containing the genes and a method of producing mutant luciferase
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5446157A (en) 1990-04-23 1995-08-29 Morgan; Lee R. Boron difluoride compounds useful in photodynamic therapy and production of laser light
US5189029A (en) 1990-04-23 1993-02-23 Bo-Dekk Ventures, Ltd. Indacene compounds and methods for using the same
US5016643A (en) 1990-05-02 1991-05-21 Board Of Regents, The University Of Texas System Vascular entoptoscope
US5192679A (en) 1990-05-03 1993-03-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Growing ehrlichia species in a continuous cell line
US5132101A (en) 1990-05-04 1992-07-21 Cytopharm, Inc. Acetylene-cumulene porphycene compounds for photodynamic therapy
US5416017A (en) 1990-05-18 1995-05-16 The Scripps Research Institute Cholera toxin gene regulated by tissue-specific promoters
US5117553A (en) 1990-06-25 1992-06-02 General Electric Company Method of assembling rotor magnets
US5059417A (en) 1990-06-26 1991-10-22 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Peroxide gel dentifrice
US5196318A (en) 1990-06-26 1993-03-23 The Texas A&M University System Precisely regulated expression of deleterious genes
EP0537270B1 (de) 1990-07-02 1998-09-09 The Regents Of The University Of California Bestimmung von analyten durch übertragung von fluoreszenzenergie
US5405206A (en) 1990-07-13 1995-04-11 Bedol; Mark A. Finger-mounted writing apparatus
US5374534A (en) 1990-07-19 1994-12-20 Charm Sciences, Inc. Method of preparing D-luciferin derivatives
BE1005073A7 (fr) 1990-08-30 1993-04-13 Collet Marcel Georges Procede d'illumination des liquides et dispositifs appropries a un tel procede.
JPH06501099A (ja) 1990-09-11 1994-01-27 ヴォアヒーズ・テクノロジース・インコーポレーテッド 被覆された毛管
EP0620761A1 (de) 1991-01-04 1994-10-26 Perseptive Biosystems, Inc. Durch sulfonamide gebundener hydrophiler überzug
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
GB9102325D0 (en) 1991-02-02 1991-03-20 Dextro North Limited Novelty device
US5403750A (en) 1991-03-06 1995-04-04 W. R. Grace & Co.-Conn. Biocompatible, low protein adsorption affinity matrix
FR2674223B1 (fr) 1991-03-13 1993-06-25 Dow Corning Sa Dispositifs pour melanger et distribuer une composition de silicone a plusieurs composants.
FR2673948B1 (fr) 1991-03-13 1995-03-10 Dow Corning Sa Compositions de silicone expansibles utiles a la realisation de pansements medicaux.
US5348392A (en) 1991-03-13 1994-09-20 Dow Corning France S.A. Apparatus for mixing and dispensing a multicomponent composition
US5146077A (en) 1991-03-19 1992-09-08 Itt Corporation Gated voltage apparatus for high light resolution and bright source protection of image intensifier tube
US5344928A (en) 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
US5422982A (en) 1991-05-02 1995-06-06 Dow Corning Corporation Neural networks containing variable resistors as synapses
US5313306A (en) 1991-05-13 1994-05-17 Telerobotics International, Inc. Omniview motionless camera endoscopy system
US5410962A (en) 1991-05-16 1995-05-02 Collier; Harry B. Special effects rotating rubber stamp
US5085853A (en) 1991-06-24 1992-02-04 Chesebrough-Pond's U.S.A., Division Of Conopco, Inc. Flavor for peroxide-bicarbonate oral compositions
US5229285A (en) 1991-06-27 1993-07-20 Kikkoman Corporation Thermostable luciferase of firefly, thermostable luciferase gene of firefly, novel recombinant dna, and process for the preparation of thermostable luciferase of firefly
US5179120A (en) 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
US5262401A (en) 1991-06-28 1993-11-16 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
US5158349A (en) 1991-07-03 1992-10-27 Lexington & Associates, Inc. Multi-color chemical lighting device
US5215898A (en) 1991-07-22 1993-06-01 The United States Of America As Represented By The Secretary Of Agriculture Cytotoxic protein from the yeast Pichia inositovora
US5383100A (en) 1991-08-02 1995-01-17 Kikos; J. Peter Multi-channel tubular display package
US5277913A (en) 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
US5331950A (en) 1991-10-22 1994-07-26 Welch Allyn, Inc. Video laparoscope with high-illuminance low-wattage light source
US5222797A (en) 1991-10-31 1993-06-29 Lexington & Associates Multi-chamber chemiluminescent optical display device
US5390086A (en) 1991-10-31 1995-02-14 Lexington & Associates, Inc. Multi-chamber chemiluminescent optical display device
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5619995A (en) 1991-11-12 1997-04-15 Lobodzinski; Suave M. Motion video transformation system and method
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5327666A (en) 1991-12-13 1994-07-12 Difranco Domenico Method for making a novelty item and the novelty item therefrom
US5413098A (en) 1991-12-24 1995-05-09 Sextant Medical Corporation Path constrained spectrophotometer and method for determination of spatial distribution of light or other radiation scattering and absorbing substances in a radiation scattering medium
DE4210759A1 (de) 1992-04-01 1993-10-07 Boehringer Mannheim Gmbh Substituierte Thiazolin-Dioxetan-Substrate, Verfahren zur Herstellung und Verwendung
DE4202302C2 (de) 1992-01-28 1999-06-10 Dietrich H W Prof Groenemeyer Computer-Tomograph
US5368518A (en) 1992-02-14 1994-11-29 Hitchcock; Elise G. Puppet head
US5400698A (en) 1992-03-05 1995-03-28 Scoope, Inc. Apparatus for molding and baking dough and batter
US5337745A (en) 1992-03-10 1994-08-16 Benaron David A Device and method for in vivo qualitative or quantative measurement of blood chromophore concentration using blood pulse spectrophotometry
US5334640A (en) 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5484589A (en) 1992-04-20 1996-01-16 Rufeld, Inc. Anti-viral methods using RNAse and DNAse
CA2095743A1 (en) 1992-05-07 1993-11-08 Thomas R. Russo Shampoos containing polyglyceryl esters
DE4223430C1 (de) 1992-06-24 1993-11-11 Siemens Ag Computertomograph mit Mitteln zur Darstellung von Schattenbildern
US5352448A (en) 1992-07-20 1994-10-04 Purdue Research Foundatioin Oral administration of antigens
US5511564A (en) 1992-07-29 1996-04-30 Valleylab Inc. Laparoscopic stretching instrument and associated method
US5177812A (en) 1992-08-10 1993-01-12 Demars Robert A Illuminated article of wearing apparel
US5323492A (en) 1992-08-10 1994-06-28 Demars Robert A Illuminated article of wearing apparel with afterglow
US5486161A (en) 1993-02-02 1996-01-23 Zomed International Medical probe device and method
US5419558A (en) 1992-09-04 1995-05-30 Jones; Timothy M. Puzzle box with hand tool
US5311859A (en) 1992-09-11 1994-05-17 Welch Allyn, Inc. Add-on video camera arrangement for optical laparoscope
US5407691A (en) 1992-09-16 1995-04-18 The Planning Factory, Inc. Chocolate candy imprinting process
US5482719A (en) 1992-10-30 1996-01-09 Guillet; James E. Drug delivery systems
US5360728A (en) 1992-12-01 1994-11-01 Woods Hole Oceanographic Institution (W.H.O.I.) Modified apoaequorin having increased bioluminescent activity
US5405958A (en) 1992-12-21 1995-04-11 Transitions Optical, Inc. Photochromic spiro(indoline)naphthoxazine compounds
US5292556A (en) 1992-12-22 1994-03-08 E. I. Du Pont De Nemours And Company Method for preparing negative-working wash-off relief images
US5399122A (en) 1993-01-07 1995-03-21 Aerobal Corp. Balloon with accompanying helium supplying cartridge
US5374292A (en) 1993-02-08 1994-12-20 Pursell Industries Machine system and process for producing attrition resistant slow release fertilizers
JPH08506897A (ja) 1993-02-12 1996-07-23 シーライト・サイエンシーズ・インコーポレーテツド 発光蛋白質複合体の調製法およびその使用法
US5366881A (en) 1993-02-23 1994-11-22 The United States Of America As Represented By The Secretary Of The Navy Polymerizable lipids for preparing vesicles that controllably release an encapsulant
US5341538A (en) 1993-03-05 1994-08-30 Sun Stix Incorporated Sun lotion applicator
US5397609A (en) 1993-03-11 1995-03-14 Chapman; Jeffrey A. Carvable novelty articles and methods
US5351931A (en) 1993-03-23 1994-10-04 Teresa Houben Paper-making kit with improved basin and web supporting screen
US5353378A (en) 1993-04-16 1994-10-04 Hilco Corporation Sound and light emitting face apparel
FI931858A0 (fi) * 1993-04-23 1993-04-23 Colin Gerald Potter Foerfarande foer uppmaetning av kemiluminescens i prov pao matris
US5411427A (en) 1993-04-26 1995-05-02 Premium Balloon Accessories Balloon weight and latch assembly
US5416193A (en) 1993-04-30 1995-05-16 Pfizer Inc. Coupling reagent and method
US5625049A (en) 1993-05-12 1997-04-29 Us Health Nucleic acids encoding human astrovirus serotype 2
US5407391A (en) 1993-05-14 1995-04-18 The Walt Disney Company Negative bust illusion and related method
US5364797A (en) 1993-05-20 1994-11-15 Mobil Oil Corp. Sensor device containing mesoporous crystalline material
US5465724A (en) 1993-05-28 1995-11-14 Acuson Corporation Compact rotationally steerable ultrasound transducer
JPH0779783A (ja) 1993-06-28 1995-03-28 Chisso Corp ビブリオ フィシエリ由来のフラビン還元酵素遺伝子
US5396069A (en) 1993-07-01 1995-03-07 The United States Of America As Represented By The Secretary Of The Air Force Portable monocular night vision apparatus
US5413454A (en) 1993-07-09 1995-05-09 Movsesian; Peter Mobile robotic arm
US5411730A (en) 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
US5389033A (en) 1993-07-23 1995-02-14 Rauch; Blair D. Toy sword made of foam material
US5363984A (en) 1993-07-23 1994-11-15 Gldrj Company Display device having an article dispenser therein
US5460022A (en) 1993-08-20 1995-10-24 Armament Systems And Procedures, Inc. Concealed handcuff key
US5381956A (en) 1993-08-26 1995-01-17 Wet Design Self activating falling water display
US5362865A (en) 1993-09-02 1994-11-08 Monsanto Company Enhanced expression in plants using non-translated leader sequences
US5458931A (en) 1993-09-07 1995-10-17 Leeman Designs Inc. Decorative medallions providing enhanced display of graphic matter
US5470881A (en) 1993-09-09 1995-11-28 West Virginia University Research Corporation Urea ophthalmic ointment and solution
US5491084A (en) 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US5432623A (en) 1993-09-27 1995-07-11 Egan; Michael S. Optical lens incorporating an integral hologram
US5540649A (en) 1993-10-08 1996-07-30 Leonard Medical, Inc. Positioner for medical instruments
US5412118A (en) 1993-10-12 1995-05-02 Lever Brothers Company, Division Of Conopco, Inc. Thickened foam stable compositions comprising alkyl(alkyl glycosid)uronamides
US5435010A (en) 1993-10-18 1995-07-25 May; Robert E. Moisture sensitive article of clothing and method of manufacturing the same
US5417431A (en) 1993-11-03 1995-05-23 Laservison Productions, Inc. Trading card with three-dimensional effect
US5405905A (en) 1993-11-26 1995-04-11 Hy-Tec Enterprises Artificial soil and soil-forming composition
US5397014A (en) 1993-12-22 1995-03-14 Aydt; Robert Dual aperture retained tab
US5396408A (en) 1994-01-03 1995-03-07 Szczech, Iii; John J. Detachable window decoration
FI95484C (fi) 1994-01-17 1996-02-12 Marko Virta Menetelmä näytteessä olevan metallin määrittämiseksi
WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
US5398972A (en) 1994-03-14 1995-03-21 Todaro; Frank S. Fortune telling card
US5383684A (en) 1994-03-28 1995-01-24 Smath; Jerome R. Book
US5405056A (en) 1994-04-01 1995-04-11 Mills; Gregory B. Stereo dispensing container and system
GB2288232A (en) * 1994-04-06 1995-10-11 Brf International Photosensitive derivatives of ATP as assay control standards
US5478501A (en) 1994-04-07 1995-12-26 The Andrew Jergens Company Bathing composition containing coated cationic polymer
US5653539A (en) 1994-05-02 1997-08-05 Rosengaus; Eliezer Method and apparatus for remotely measuring the temperature of a surface
US5536382A (en) 1994-05-23 1996-07-16 Advanced Molecular Systems, Inc. Capillary electrophoresis assay method useful for the determination of constituents of a clinical sample
US5413332A (en) 1994-05-26 1995-05-09 Amber Forrest, Inc. Eggball
JP3030678B2 (ja) 1994-06-17 2000-04-10 崇 近藤 自動車ドアの補助開閉機構
US5679773A (en) 1995-01-17 1997-10-21 Affymax Technologies N.V Reagants and methods for immobilized polymer synthesis and display
US5650135A (en) 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5792456A (en) 1994-08-04 1998-08-11 Bristol-Myers Squibb Company Mutant BR96 antibodies reactive with human carcinomas
US5686578A (en) 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
US5535053A (en) 1994-08-15 1996-07-09 Itt Corporation Night vision goggle assembly with independant monocular devices
US5795737A (en) 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5777079A (en) 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
JPH08136546A (ja) * 1994-11-15 1996-05-31 Bio Sensor Kenkyusho:Kk 物質分析法
US5630426A (en) 1995-03-03 1997-05-20 Neovision Corporation Apparatus and method for characterization and treatment of tumors
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5637463A (en) 1995-05-04 1997-06-10 Hoffmann-La Roche Inc. Method to detect protein-protein interactions
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US5553853A (en) 1995-08-28 1996-09-10 Sackitey; Solomon K. Game apparatus and method of play for teaching dna related technologies
US5622172A (en) 1995-09-29 1997-04-22 Siemens Medical Systems, Inc. Acoustic display system and method for ultrasonic imaging
US5619999A (en) 1995-12-28 1997-04-15 Siemens Medical Systems, Inc. Body surface position locator for ultrasound transducer
US5804387A (en) 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US5876995A (en) 1996-02-06 1999-03-02 Bryan; Bruce Bioluminescent novelty items
US5770371A (en) 1996-06-27 1998-06-23 Novo Nordisk Biotech, Inc. Modification of cryptic splice sites in heterologous genes expressed in fungi
US5747338A (en) 1996-08-15 1998-05-05 Chiron Corporation Method and construct for screening for inhibitors of transcriptional activation

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US20030059798A1 (en) 2003-03-27
JP3795533B2 (ja) 2006-07-12
WO1998026277A2 (en) 1998-06-18
US6649356B2 (en) 2003-11-18
DE69732667D1 (de) 2005-04-07
NZ335453A (en) 2001-07-27
JP2006145545A (ja) 2006-06-08
AU6012898A (en) 1998-07-03
US20030013103A1 (en) 2003-01-16
US6649357B2 (en) 2003-11-18
US6682899B2 (en) 2004-01-27
US6458547B1 (en) 2002-10-01
CA2271717A1 (en) 1998-06-18
JP2001511887A (ja) 2001-08-14
JP4287853B2 (ja) 2009-07-01
EP1015872A2 (de) 2000-07-05
US20030113741A1 (en) 2003-06-19
EP1015872B1 (de) 2005-03-02
AU741076B2 (en) 2001-11-22
IL129767A0 (en) 2000-02-29
DE69732667T2 (de) 2006-01-19
WO1998026277A3 (en) 1999-06-24

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