ATE340025T1 - Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse - Google Patents

Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse

Info

Publication number
ATE340025T1
ATE340025T1 AT00989616T AT00989616T ATE340025T1 AT E340025 T1 ATE340025 T1 AT E340025T1 AT 00989616 T AT00989616 T AT 00989616T AT 00989616 T AT00989616 T AT 00989616T AT E340025 T1 ATE340025 T1 AT E340025T1
Authority
AT
Austria
Prior art keywords
systems
analysis
thousands
methods
materials
Prior art date
Application number
AT00989616T
Other languages
English (en)
Inventor
Jeffrey A Wolk
Sherri Ann Biondi
John Wallace Parce
Morten J Jensen
Anne R Kopf-Sill
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Application granted granted Critical
Publication of ATE340025T1 publication Critical patent/ATE340025T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B01J2219/00587—High throughput processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00628—Ionic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/022—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/028—Sampling from a surface, swabbing, vaporising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1039—Micropipettes, e.g. microcapillary tubes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measurement Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
AT00989616T 2000-01-06 2000-12-28 Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse ATE340025T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17490200P 2000-01-06 2000-01-06
US19646800P 2000-04-11 2000-04-11

Publications (1)

Publication Number Publication Date
ATE340025T1 true ATE340025T1 (de) 2006-10-15

Family

ID=26870649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00989616T ATE340025T1 (de) 2000-01-06 2000-12-28 Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse

Country Status (6)

Country Link
US (2) US6620625B2 (de)
EP (1) EP1246698B1 (de)
AT (1) ATE340025T1 (de)
AU (1) AU2610201A (de)
DE (1) DE60030882T2 (de)
WO (1) WO2001049414A2 (de)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
US7112449B1 (en) * 2000-04-05 2006-09-26 Nanogram Corporation Combinatorial chemical synthesis
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6689323B2 (en) * 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
DE10017790A1 (de) * 2000-04-10 2001-10-11 Basf Ag Verfahren zur Herstellung von Biopolymer-Feldern mit Echtzeitkontrolle
DE10031587A1 (de) * 2000-06-29 2002-01-10 Basf Ag Dosierung von Suspensionen im Mikromaßstab zur Herstellung von Materialproben in der kombinatorischen Materialforschung sowie deren Prüfung
AU2002245047A1 (en) 2000-10-30 2002-07-24 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
WO2002040160A1 (de) * 2000-11-17 2002-05-23 Tecan Trading Ag Vorrichtung und verfahren zum abtrennen von proben aus einer flüssigkeit
US20020108860A1 (en) * 2001-01-15 2002-08-15 Staats Sau Lan Tang Fabrication of polymeric microfluidic devices
US6918309B2 (en) * 2001-01-17 2005-07-19 Irm Llc Sample deposition method and system
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6605438B1 (en) * 2001-03-26 2003-08-12 Louis Dischler Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US20030040119A1 (en) * 2001-04-11 2003-02-27 The Regents Of The University Of Michigan Separation devices and methods for separating particles
US20020168292A1 (en) * 2001-05-14 2002-11-14 Whisenhunt Donald Wayne Systems and methods for the high throughput preparation and analysis of chemical reactions
GB2379415A (en) * 2001-09-10 2003-03-12 Seiko Epson Corp Monitoring the deposition of organic polymer droplets onto a substrate
US6579724B2 (en) * 2001-09-13 2003-06-17 First Ten Angstroms Dispensing method and apparatus for dispensing very small quantities of fluid
JP3902939B2 (ja) * 2001-10-26 2007-04-11 株式会社日立ハイテクノロジーズ 標本中の微小領域測定装置及び方法
US20030148539A1 (en) * 2001-11-05 2003-08-07 California Institute Of Technology Micro fabricated fountain pen apparatus and method for ultra high density biological arrays
US6926864B2 (en) * 2001-11-09 2005-08-09 Protiveris Inc Microfluidics apparatus and methods for use thereof
AU2003212471A1 (en) * 2002-02-27 2003-09-09 Miragene, Inc. Improved substrate chemistry for protein immobilization on a rigid support
AU2003204160B2 (en) * 2002-05-13 2010-05-13 Corning Incorporated Self-aliquoting sample storage plate system
JP2005528612A (ja) * 2002-06-03 2005-09-22 パムジーン ビー．ブイ． 生体分子の相互作用をモニターするための新規方法
AU2003234885A1 (en) * 2002-06-07 2003-12-22 Picosep A/S Method and system for multi-stage isoelectric focussing
JP2004045241A (ja) * 2002-07-12 2004-02-12 Nisshinbo Ind Inc マイクロアレイの作製方法
US20050074898A1 (en) * 2002-07-31 2005-04-07 Caliper Technologies Corp. High density reagent array preparation methods
US20040067597A1 (en) * 2002-07-31 2004-04-08 Caliper Technologies Corp. High density reagent array preparation methods
GB0219457D0 (en) * 2002-08-21 2002-09-25 Amersham Biosciences Uk Ltd Fluorescence reference plate
CN101158447B (zh) * 2002-12-04 2012-12-26 斯宾克斯公司 流体的可程控微量控制用装置和方法
US7491272B2 (en) * 2002-12-05 2009-02-17 International Business Machines Corporation Confinement of liquids on surfaces
US20040151635A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Array fabrication using deposited drop splat size
GB0302281D0 (en) * 2003-01-31 2003-03-05 Biorobotics Ltd Liquid transfer system
US7820030B2 (en) 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
US7138050B2 (en) * 2003-05-29 2006-11-21 Shimadzu Corporation Fractionating/collecting device of liquid chromatograph
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
EP1694731B1 (de) 2003-09-23 2012-03-28 University Of North Carolina At Chapel Hill Photohärtbare perfluorpolyether zur verwendung als neue werkstoffe in mikrofluidischen vorrichtungen
DE102004062281A1 (de) * 2003-12-29 2005-07-28 Siemens Ag Verfahren und Spotting-Lösung zum Herstellen von Microarrays
US8592219B2 (en) * 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
ES2439225T3 (es) 2004-01-26 2014-01-22 President And Fellows Of Harvard College Sistema y método para el suministro de fluidos
US8158728B2 (en) 2004-02-13 2012-04-17 The University Of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP2345739B8 (de) 2004-05-03 2016-12-07 Handylab, Inc. Mikrofluidische Vorrichtung zur Verarbeitung polynukleotidhaltiger Proben
US20050247673A1 (en) 2004-05-07 2005-11-10 International Business Machines Corporation Confinement of fluids on surfaces
CA2569314A1 (en) * 2004-06-09 2005-12-22 The University Of British Columbia Reagent delivery apparatus and methods
WO2006039293A2 (en) * 2004-09-29 2006-04-13 University Of Virginia Patent Foundation Localized control of thermal properties on microdevices and applications thereof
US8173367B2 (en) * 2004-10-18 2012-05-08 Sherri Boucher In situ dilution of external controls for use in microarrays
US7364807B2 (en) * 2004-12-06 2008-04-29 General Electric Company Thermal barrier coating/environmental barrier coating system for a ceramic-matrix composite (CMC) article to improve high temperature capability
EP1849005A1 (de) * 2005-01-17 2007-10-31 Gyros Patent Ab Verfahren zum nachweis eines wenigstens bivalenten analyten unter verwendung von zwei affinitätsreaktanden
EP1846744A4 (de) * 2005-02-07 2009-11-11 Advion Biosystems Inc Entnahme und analyse minimaler volumsteile
KR100666825B1 (ko) * 2005-03-26 2007-01-11 한국표준과학연구원 전기전도성 관을 이용한 전기삼투압류 구동 극미세 피펫장치
US9097723B2 (en) * 2005-04-01 2015-08-04 Caliper Life Sciences, Inc. Method and apparatus for performing peptide digestion on a microfluidic device
AU2006240184A1 (en) * 2005-04-12 2006-11-02 Caliper Life Sciences, Inc. Compact optical detection system for a microfluidic devices
WO2006124975A1 (en) * 2005-05-18 2006-11-23 Nuclea Biomarkers Llc Antibody protein analysis chip
US7618590B2 (en) * 2005-06-29 2009-11-17 Cascade Microtech, Inc. Fluid dispensing system
EP1928571B1 (de) 2005-08-22 2013-03-13 Life Technologies Corporation Vorrichtung und verfahren zur mikrofluidischen steuerung eines ersten fluids in kontakt mit einem zweiten fluid, wobei das erste fluid und das zweite fluid nicht mischbar sind
US8916375B2 (en) * 2005-10-12 2014-12-23 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US7482939B2 (en) * 2005-11-15 2009-01-27 Roche Molecular Systems, Inc. Electrical drop surveillance
EP1957794B1 (de) 2005-11-23 2014-07-02 Eksigent Technologies, LLC Elektrokinetische pumpenausführungen und arzneimittelabgabesysteme
EP1790861A1 (de) * 2005-11-25 2007-05-30 Bonsens AB Mikrofluidisches System
JP2007147456A (ja) * 2005-11-28 2007-06-14 Seiko Epson Corp マイクロ流体システム、試料分析装置、及び標的物質の検出または測定方法
US20070132241A1 (en) * 2005-12-14 2007-06-14 Agilent Technologies, Inc. Coupling with layered sealing
US20070170056A1 (en) * 2006-01-26 2007-07-26 Arnold Don W Microscale electrochemical cell and methods incorporating the cell
WO2007112114A2 (en) 2006-03-24 2007-10-04 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
WO2007123908A2 (en) * 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US8389297B2 (en) * 2006-04-18 2013-03-05 Duke University Droplet-based affinity assay device and system
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
US20080182136A1 (en) * 2007-01-26 2008-07-31 Arnold Don W Microscale Electrochemical Cell And Methods Incorporating The Cell
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
US9152150B1 (en) 2007-02-22 2015-10-06 Applied Biosystems, Llc Compositions, systems, and methods for immiscible fluid discrete volume manipulation
CN103495439B (zh) 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
WO2009039122A2 (en) 2007-09-17 2009-03-26 Sequenom, Inc. Integrated robotic sample transfer device
US8251672B2 (en) 2007-12-11 2012-08-28 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
WO2009131677A1 (en) 2008-04-25 2009-10-29 Claros Diagnostics, Inc. Flow control in microfluidic systems
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
WO2010019920A2 (en) * 2008-08-15 2010-02-18 Arizona Board Of Regents For And On Behalf Of Arizona State University Porous materials for biological sample collection
ES2732948T3 (es) 2008-09-02 2019-11-26 Governing Council Univ Toronto Métodos que utilizan microelectrodos y dispositivos biosensores que incorporan los mismos
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
CN102405402A (zh) 2008-09-23 2012-04-04 阔达生命有限公司 基于液滴的测定系统
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9194861B2 (en) 2009-09-02 2015-11-24 Bio-Rad Laboratories, Inc. Method of mixing fluids by coalescence of multiple emulsions
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US8053239B2 (en) * 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
WO2010080115A2 (en) 2008-12-18 2010-07-15 Claros Diagnostics, Inc. Improved reagent storage in microfluidic systems and related articles and methods
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
ES2812260T3 (es) 2009-02-02 2021-03-16 Opko Diagnostics Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
US20100199750A1 (en) 2009-02-06 2010-08-12 Arnold Don W Microfludic Analysis System and Method
US20100224013A1 (en) * 2009-03-05 2010-09-09 Van Berkel Gary J Method and system for formation and withdrawal of a sample from a surface to be analyzed
FR2946269B1 (fr) * 2009-06-08 2012-07-06 Univ Paris Curie Dispositif micro-fluidique pour convoyer un produit par diffusion dans un substrat poreux
JP5663574B2 (ja) 2009-07-20 2015-02-04 シロアム バイオサイエンシズ, インコーポレイテッドSiloam Biosciences, Inc. 微小流体分析プラットホーム
JP5748228B2 (ja) * 2009-10-15 2015-07-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 放射化学のためのデジタル微小流体プラットフォーム
AU2010315867A1 (en) 2009-11-03 2012-06-21 University Of Virginia Patent Foundation Versatile, visible method for detecting polymeric analytes
PE20130172A1 (es) 2009-11-24 2013-03-03 Opko Diagnostics Llc Mezclado y entrega de fluidos en sistemas microfluidicos
EP2550528B1 (de) 2010-03-25 2019-09-11 Bio-Rad Laboratories, Inc. Tropfenerzeugung für tropfenbasierte prüfungen
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
EA022356B1 (ru) 2010-04-16 2015-12-30 Опкоу Дайагностикс, Ллк Способ управления средами в микрофлюидных системах с обратной связью
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
US20130203045A1 (en) 2010-05-26 2013-08-08 University Of Virginia Patent Foundation Method for detecting nucleic acids based on aggregate formation
WO2012016357A1 (en) 2010-08-06 2012-02-09 Capitalbio Corporation Microarray-based assay integrated with particles for analyzing molecular interactions
US9061279B2 (en) 2010-08-31 2015-06-23 Canon U.S. Life Sciences, Inc. Composition and method for in-system priming microfluidic devices
US8637813B2 (en) * 2010-10-01 2014-01-28 Ut-Battelle, Llc System and method for laser assisted sample transfer to solution for chemical analysis
US8519330B2 (en) 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
CA2816712C (en) 2010-11-01 2018-12-11 Donald A. Masquelier System for forming emulsions
EP3467487A1 (de) 2011-01-11 2019-04-10 The Governing Council Of The University Of Toronto Proteinnachweisverfahren
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
JP2014509865A (ja) 2011-03-18 2014-04-24 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド シグナルの組合せ使用による多重化デジタルアッセイ
AU2012242510B2 (en) 2011-04-15 2015-05-14 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
EP2702175B1 (de) 2011-04-25 2018-08-08 Bio-Rad Laboratories, Inc. Verfahren und zusammensetzungen zur nukleinsäureanalyse
WO2012151268A1 (en) 2011-05-02 2012-11-08 University Of Virginia Patent Foundation Method and system for high throughput optical and label free detection of analytes
WO2012151289A2 (en) 2011-05-02 2012-11-08 University Of Virginia Patent Foundation Method and system to detect aggregate formation on a substrate
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay
JP6117217B2 (ja) 2011-09-30 2017-04-19 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ ユニット化された試薬ストリップ
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
NL2009853A (en) * 2011-12-23 2013-06-26 Asml Netherlands Bv Methods and apparatus for measuring a property of a substrate.
ES2978107T3 (es) 2012-02-03 2024-09-05 Becton Dickinson Co Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas
FI3312749T3 (fi) 2012-03-05 2024-05-31 Oy Arctic Partners Ab Menetelmiä ja laitteita eturauhassyövän riskin ja eturauhasen tilavuuden ennustamiseen
WO2013181506A1 (en) 2012-05-31 2013-12-05 The University Of North Carolina At Chapel Hill Dissolution guided wetting of structured surfaces
US10519434B2 (en) 2012-07-13 2019-12-31 Diomics Corporation Biologic sample collection devices and methods of production and use thereof
US9518977B2 (en) * 2012-10-19 2016-12-13 University Of Washington Through Its Center For Commercialization Microfluidic assay apparatus and methods of use
US9254487B2 (en) * 2012-12-17 2016-02-09 Taiwan Semiconductor Manufacturing Company, Ltd. Systems and methods for an integrated bio-entity manipulation and processing semiconductor device
US9254485B2 (en) 2012-12-17 2016-02-09 Taiwan Semiconductor Manufacturing Company, Ltd. Systems and methods for an integrated bio-entity manipulation and processing device
CA2900708C (en) 2013-03-13 2021-06-15 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US10234425B2 (en) 2013-03-15 2019-03-19 Qorvo Us, Inc. Thin film bulk acoustic resonator with signal enhancement
AT514210B1 (de) * 2013-04-25 2016-08-15 Greiner Bio-One Gmbh Dispenser-befülltes mikrofluidisches Testsystem und Verfahren dazu
EP3919896B1 (de) * 2013-05-23 2024-07-03 Zomedica Biotechnologies LLC Zweiteilige anordnung
GB201318814D0 (en) * 2013-10-24 2013-12-11 Petroleum & Chemical Corp Microfluidic devices and arrangements for supplying such devices with reagents and biological samples
EP3179912B1 (de) 2014-08-15 2020-10-14 Diomics Corporation Filme zur entnahme und analyse biologischer analyten sowie verfahren zur herstellung
EA038479B1 (ru) 2014-12-12 2021-09-03 Опкоу Дайагностикс, Ллк Устройство для проведения анализа пробы и способ эксплуатации указанного устройства
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
WO2017100457A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation samples and/or reagents
WO2018146699A1 (en) * 2017-02-07 2018-08-16 Shilps Sciences Private Limited A system for microdroplet manipulation
EP3381560A1 (de) * 2017-03-28 2018-10-03 Eppendorf AG Verfahren und dosiervorrichtung zum kontaktdosieren von flüssigkeiten
CN111093830A (zh) * 2017-07-18 2020-05-01 分子装置有限公司 具有基于成像的移液管吸头定位的对象挑取设备
WO2019136319A1 (en) * 2018-01-05 2019-07-11 Worcester Polytechnic Institute Modular robotic systems for delivering fluid to microfluidic devices
EP3818371B1 (de) 2018-07-06 2026-03-18 Zomedica Biotechnologies LLC Piezoelektrischer dünnfilm-volumenwellenschallresonator mit vergrössertem dynamikbereich
US11541385B2 (en) * 2018-07-06 2023-01-03 Qorvo Us, Inc. Methods of measuring hematocrit in fluidic channels including conductivity sensor
GB201905181D0 (en) * 2019-04-11 2019-05-29 Arrayjet Ltd Method and apparatus for substrate handling and printing
CN110787848B (zh) * 2019-11-13 2021-05-04 南京理工大学 一种微流控进样系统
WO2021234674A1 (en) * 2020-05-22 2021-11-25 Dh Technologies Development Pte. Ltd. Overflow sensor for open port sampling probe
US12531224B2 (en) 2020-05-22 2026-01-20 Dh Technologies Development Pte. Ltd. High flowrate flushing for open port sampling probe
CN119909778B (zh) * 2025-01-22 2025-11-04 北京工业大学 一种微流控芯片及其进行双气相自由基同时富集的方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077845A (en) 1977-04-20 1978-03-07 Miles Laboratories, Inc. Disposable inoculation device and process of using same
US4298345A (en) * 1977-11-21 1981-11-03 Damon Corporation Method and apparatus for chemical spot test analysis
US4520086A (en) * 1980-11-18 1985-05-28 The United States Of America As Represented By The United States Department Of Energy Rechargeable solid polymer electrolyte battery cell
US4452903A (en) * 1981-02-17 1984-06-05 Lee Jin P Assay method and reagent kit means for lipid-containing body fluid
JPS57208998A (en) * 1981-06-17 1982-12-22 Fuji Photo Film Co Ltd Multi-layered analytical film for determination of transaminase
DK429682A (da) 1982-09-28 1984-03-29 Inflow Aps Integrerede mikroroersystemer til kontinuerlig gennemstroemningsanalyse
US6265176B1 (en) * 1985-10-29 2001-07-24 Cordis Corporation Dot immunoassay on plastic sheets
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5720928A (en) * 1988-09-15 1998-02-24 New York University Image processing and analysis of individual nucleic acid molecules
US6610256B2 (en) * 1989-04-05 2003-08-26 Wisconsin Alumni Research Foundation Image processing and analysis of individual nucleic acid molecules
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
CH679952A5 (de) 1990-03-20 1992-05-15 Ciba Geigy Ag
WO1991016675A1 (en) 1990-04-06 1991-10-31 Applied Biosystems, Inc. Automated molecular biology laboratory
JPH04160356A (ja) 1990-10-24 1992-06-03 Shimadzu Corp キャピラリー電気泳動装置の試料注入装置
US6017722A (en) * 1991-04-04 2000-01-25 Board Of Regents, The University Of Texas System Luminous bacteria and methods for the isolation, identification and quantitation of toxicants
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5438556A (en) * 1992-03-26 1995-08-01 Asulab S.A. Horological piece comprising a photovoltaic cell having a photelectrochemical region
CH686206A5 (it) * 1992-03-26 1996-01-31 Asulab Sa Cellule photoelectrochimique regeneratrice transparente.
US5443988A (en) * 1992-09-02 1995-08-22 Fuji Photo Film Co., Ltd. Method for high speed analysis of a dry analytical element
US5302264A (en) 1992-09-02 1994-04-12 Scientronix, Inc. Capillary eletrophoresis method and apparatus
JPH06265447A (ja) 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
WO1995011437A1 (en) * 1993-10-21 1995-04-27 Abbott Laboratories Apparatus and method for transfer of a fluid sample
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5516487A (en) * 1994-06-22 1996-05-14 Isolab, Inc. Absorbent paper for liquid sampling and impregnated paper calibrators and controls
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5677197A (en) * 1994-11-14 1997-10-14 Hewlett-Packard Company Biochemical assay plate and method for making the same
US5560811A (en) 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
US5922534A (en) * 1995-03-28 1999-07-13 Hewlett-Packard Company Dry biochemical assay plate and method for making the same
US5811306A (en) * 1995-09-04 1998-09-22 Fuji Photo Film Co., Ltd. Liquid spotting method
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5766959A (en) * 1996-05-24 1998-06-16 The Dow Chemical Company Method for determining a component using a liquid film or droplet
NZ333345A (en) * 1996-06-28 2000-09-29 Caliper Techn Corp Electropipettor and compensation for electrophoretic bias during electroosmotic microfluid transport
US6429025B1 (en) * 1996-06-28 2002-08-06 Caliper Technologies Corp. High-throughput screening assay systems in microscale fluidic devices
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
JP2882377B2 (ja) 1996-08-23 1999-04-12 日本電気株式会社 金属の回収容器及び金属の回収方法
US6458547B1 (en) * 1996-12-12 2002-10-01 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
US5890745A (en) 1997-01-29 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Micromachined fluidic coupler
US6235471B1 (en) * 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
AU746892B2 (en) 1997-04-04 2002-05-02 Caliper Life Sciences, Inc. Closed-loop biochemical analyzers
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
DE19754978C2 (de) * 1997-12-11 2000-07-13 Bruker Daltonik Gmbh Probenträger für die MALDI-Massenspektrometrie nebst Verfahren zur Herstellung der Platten und zum Aufbringen der Proben
US6790652B1 (en) * 1998-01-08 2004-09-14 Bioimage A/S Method and apparatus for high density format screening for bioactive molecules
US6722395B2 (en) * 1998-01-13 2004-04-20 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
US20040126895A1 (en) * 1998-01-13 2004-07-01 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
JP4387588B2 (ja) * 1998-02-04 2009-12-16 メルク エンド カムパニー インコーポレーテッド 高スループットスクリーニングアッセイ用仮想ウェル
US6756019B1 (en) * 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6306590B1 (en) * 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US20010039010A1 (en) * 1998-09-03 2001-11-08 Leigh Alexander Burgoyne Sample collection medium incorporating material for sample visualization
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
JP3984748B2 (ja) * 1999-03-17 2007-10-03 株式会社日立製作所 化学分析装置と化学分析システム
US6245297B1 (en) * 1999-04-16 2001-06-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
US6306599B1 (en) * 1999-07-16 2001-10-23 Agilent Technologies Inc. Biopolymer arrays and their fabrication
JP2001186880A (ja) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Ｄｎａチップの製造方法
US20020151040A1 (en) * 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
IL142026A (en) * 2000-03-14 2008-04-13 Yissum Res Dev Co IN VITRO DEVELOPMENT FACILITY AND METHOD
US6805998B2 (en) * 2000-03-24 2004-10-19 Cymbet Corporation Method and apparatus for integrated-battery devices
ATE418733T1 (de) * 2000-05-04 2009-01-15 Blood Res Center Kolloidzusammensetzungen für festphasen- biomolekulare analytische systeme
US7024281B1 (en) * 2000-12-11 2006-04-04 Callper Life Sciences, Inc. Software for the controlled sampling of arrayed materials
US6605438B1 (en) * 2001-03-26 2003-08-12 Louis Dischler Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents
WO2002089984A1 (en) * 2001-05-03 2002-11-14 Affymetrix, Inc. High throughput microarray spotting system and method
US7101508B2 (en) * 2002-07-31 2006-09-05 Agilent Technologies, Inc. Chemical array fabrication errors
US7208124B2 (en) * 2002-11-19 2007-04-24 Genetix Limited Microarraying process and apparatus
US20050220675A1 (en) * 2003-09-19 2005-10-06 Reed Mark T High density plate filler
US20060024209A1 (en) * 2004-07-30 2006-02-02 Agnew Brian J Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte

Also Published As

Publication number Publication date
WO2001049414A3 (en) 2002-02-21
WO2001049414A2 (en) 2001-07-12
EP1246698A2 (de) 2002-10-09
AU2610201A (en) 2001-07-16
EP1246698B1 (de) 2006-09-20
DE60030882D1 (de) 2006-11-02
US20010049148A1 (en) 2001-12-06
US20040014239A1 (en) 2004-01-22
DE60030882T2 (de) 2007-04-05
US6620625B2 (en) 2003-09-16

Similar Documents

Publication Publication Date Title
ATE340025T1 (de) Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse
Jenkins et al. Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries
WO2004079338A3 (en) Methods and systems for dissolution testing
DK2082239T3 (da) Sekventiel analyse af biologiske prøver med intermediær blegning af fluorescerensdetektor
DE69739036D1 (de) Screening-Testsystem mit hohem Durchfluss durch mikrofluidische Vorrichtungen
IS7611A (is) Örfylki og aðferð til þess að framkvæma blöndunarhvörf fyrir fjölda sýna á einu örfylki
DE60325847D1 (de) Verbindungen und verfahren für die analyse des proteoms
DK1370690T3 (da) Arrays og fremgangsmåder til anvendelse heraf
DK1639130T3 (da) Prober, biblioteker og kits til analyse af blandinger af nukleinsyrer og metoder til opbygning af disse
NO20051474L (no) Fremgangsmate for maling av fluidkjemien under boreoperasjoner og produksjon
ATE423317T1 (de) Biomolekulares substrat und testvorrichtung
DE60332948D1 (de) Strategien zur genexpressionsanalyse
EP1500937A4 (de) Analyseinstrument; probenanalyseverfahren und analyseeinrichtung mit dem instrument und verfahren zur bildung einer öffnung in dem instrument
ATE510208T1 (de) Probenanalyseverfahren und probenanalyseeinrichtung
Willison et al. Quantitative single cell and single molecule proteomics for clinical studies
EP1365240A3 (de) Immunologische Verfahren, Vorrichtungen und Reagenzien
ATE263375T1 (de) Multiple analyse von zytokinen
ATE359517T1 (de) Chemisches und biochemisches nachweisverfahren und vorrichtung
WO2013010134A3 (en) Systems, apparatus and methods for biochemical analysis
ATE496294T1 (de) Analyseset mit stechhilfe und messgerät
US8728398B2 (en) Hydrodynamic isolation method and apparatus
ATE494547T1 (de) Probennahmeautomat mit hohem durchsatz
WO2004077043A3 (en) Robotic friendly external loading system for electrophoresis instrument and method
Kämpfe Investigation of residual stresses in microsystems using X-ray diffraction
ES2173465T3 (es) Nuevo dispositivo de analisis para exploraciones masivas.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties