JP2009537608A5 - - Google Patents

Info

Publication number

JP2009537608A5

JP2009537608A5 JP2009511524A JP2009511524A JP2009537608A5 JP 2009537608 A5 JP2009537608 A5 JP 2009537608A5 JP 2009511524 A JP2009511524 A JP 2009511524A JP 2009511524 A JP2009511524 A JP 2009511524A JP 2009537608 A5 JP2009537608 A5 JP 2009537608A5

Authority

JP

Japan

Prior art keywords

antibody

seq

light chain

heavy chain

interleukin

Prior art date

2007-05-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001413 amino acids Chemical class 0.000 claims description 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 9
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 8
• 238000010494 dissociation reaction Methods 0.000 claims 7
• 230000005593 dissociations Effects 0.000 claims 7
• 230000027455 binding Effects 0.000 claims 6
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 6
• 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 claims 5
• -1 aromatic amino acid Chemical class 0.000 claims 5
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• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
• 239000000427 antigen Substances 0.000 claims 4
• 102000036639 antigens Human genes 0.000 claims 4
• 108091007433 antigens Proteins 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
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• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
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• COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
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• 239000012679 serum free medium Substances 0.000 claims 1
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• 238000001890 transfection Methods 0.000 claims 1
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• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 4
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