AU2007267213B2 - Modified humanised anti-interleukin-18 antibodies - Google Patents
Modified humanised anti-interleukin-18 antibodies Download PDFInfo
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- AU2007267213B2 AU2007267213B2 AU2007267213A AU2007267213A AU2007267213B2 AU 2007267213 B2 AU2007267213 B2 AU 2007267213B2 AU 2007267213 A AU2007267213 A AU 2007267213A AU 2007267213 A AU2007267213 A AU 2007267213A AU 2007267213 B2 AU2007267213 B2 AU 2007267213B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Analytical Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0610438.4 | 2006-05-25 | ||
| GB0610438A GB0610438D0 (en) | 2006-05-25 | 2006-05-25 | Immunoglobulins |
| GB0611046.4 | 2006-06-05 | ||
| GB0611046A GB0611046D0 (en) | 2006-06-05 | 2006-06-05 | Immunoglobulins |
| PCT/EP2007/055029 WO2007137984A2 (en) | 2006-05-25 | 2007-05-23 | Modified humanised anti-interleukin-18 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2007267213A1 AU2007267213A1 (en) | 2007-12-06 |
| AU2007267213B2 true AU2007267213B2 (en) | 2012-03-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007267213A Ceased AU2007267213B2 (en) | 2006-05-25 | 2007-05-23 | Modified humanised anti-interleukin-18 antibodies |
Country Status (22)
| Country | Link |
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| EP (1) | EP2027157B1 (enExample) |
| JP (1) | JP5420399B2 (enExample) |
| KR (1) | KR101416078B1 (enExample) |
| AR (1) | AR061115A1 (enExample) |
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| EA (1) | EA017303B1 (enExample) |
| ES (1) | ES2514495T3 (enExample) |
| IL (1) | IL194995A0 (enExample) |
| MA (1) | MA30486B1 (enExample) |
| MX (1) | MX2008014842A (enExample) |
| MY (1) | MY157173A (enExample) |
| NO (1) | NO341921B1 (enExample) |
| NZ (1) | NZ572565A (enExample) |
| PE (1) | PE20080262A1 (enExample) |
| SG (1) | SG172625A1 (enExample) |
| TW (1) | TWI422387B (enExample) |
| WO (1) | WO2007137984A2 (enExample) |
| ZA (1) | ZA200809662B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| KR101463631B1 (ko) | 2006-03-31 | 2014-11-19 | 추가이 세이야쿠 가부시키가이샤 | 항체의 혈중 동태를 제어하는 방법 |
| EP2027157B1 (en) | 2006-05-25 | 2014-08-06 | Glaxo Group Limited | Modified humanised anti-interleukin-18 antibodies |
| PH12021552811A1 (en) | 2007-09-26 | 2022-11-21 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
| RU2510400C9 (ru) | 2007-09-26 | 2014-07-20 | Чугаи Сейяку Кабусики Кайся | Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr |
| US20110111406A1 (en) | 2008-04-11 | 2011-05-12 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| WO2010020593A1 (en) * | 2008-08-18 | 2010-02-25 | Glaxo Group Limited | Treatment of an autoimmune disease using il-18 antagonists |
| EP2685238B1 (en) * | 2008-08-27 | 2018-06-13 | F. Hoffmann-La Roche AG | Method to screen high affinity antibody |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| WO2010040736A2 (en) * | 2008-10-07 | 2010-04-15 | Ablynx Nv | Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling |
| EP3674317B1 (en) | 2009-03-19 | 2024-12-11 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| CA2770173C (en) | 2009-08-25 | 2018-04-24 | F. Hoffmann-La Roche Ag | Velocity factor |
| CA2788758A1 (en) * | 2010-02-09 | 2011-08-18 | Andrew Ian Bayliffe | Treatment of a metabolic disorder |
| RU2012147249A (ru) | 2010-04-07 | 2014-05-20 | Эббви Инк. | TNF-α- СВЯЗЫВАЮЩИЕ БЕЛКИ |
| SMT201800397T1 (it) * | 2010-11-23 | 2018-09-13 | Glaxo Group Ltd | Proteine leganti l'antigene per oncostatina m (osm) |
| WO2012073992A1 (ja) | 2010-11-30 | 2012-06-07 | 中外製薬株式会社 | 複数分子の抗原に繰り返し結合する抗原結合分子 |
| US20130149308A1 (en) * | 2011-08-12 | 2013-06-13 | Genentech, Inc. | Antibodies to il-1beta and il-18, for treatment of disease |
| JOP20200308A1 (ar) | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| US10570199B2 (en) | 2012-11-21 | 2020-02-25 | Km Biologics Co., Ltd. | Human antibody against IL-18 |
| WO2014186350A1 (en) * | 2013-05-15 | 2014-11-20 | Medimmune Limited | Purification of recombinantly produced polypeptides |
| US10782290B2 (en) | 2013-06-11 | 2020-09-22 | National Center Of Neurology And Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy |
| CA2972393A1 (en) | 2015-02-27 | 2016-09-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
| EP3299810B1 (en) | 2015-05-19 | 2021-07-07 | National Center of Neurology and Psychiatry | Method for determining application of novel therapy to multiple sclerosis (ms) patient |
| WO2017076805A1 (en) * | 2015-11-02 | 2017-05-11 | Glaxosmithkline Intellectual Property Development Limited | Use of an inhibitor of il18 for treatment of acute kidney injury |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| EP3698808B1 (en) | 2017-10-20 | 2025-01-01 | Hyogo College Of Medicine | Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
| WO2021206766A1 (en) | 2020-04-09 | 2021-10-14 | Children's Hospital Medical Center | Sars-cov-2 infection biomarkers and uses thereof |
| EP3892280A3 (en) | 2020-04-09 | 2022-01-12 | Children's Hospital Medical Center | Sars-cov-2 infection biomarkers and uses thereof |
| US11324750B2 (en) | 2020-04-09 | 2022-05-10 | Children's Hospital Medical Center | Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection |
| TW202233237A (zh) | 2020-11-18 | 2022-09-01 | 瑞士商諾華公司 | 用於在治療ｎｌｒｃ４－ｇｏｆ炎性體病變中使用的雙特異性抗體 |
| JPWO2023286694A1 (enExample) | 2021-07-13 | 2023-01-19 | ||
| US20240425560A1 (en) * | 2021-09-29 | 2024-12-26 | Chimera Bioengineering, Inc. | IL-18 Variants and Uses Thereof |
| WO2024261470A1 (en) | 2023-06-20 | 2024-12-26 | Apollo Ap43 Limited | Anti-il-18 antibody therapy for treating atopic dermatitis |
| WO2025229563A1 (en) * | 2024-05-03 | 2025-11-06 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating inflammatory bowel disease |
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| WO2000056771A1 (en) * | 1999-03-19 | 2000-09-28 | Smithkline Beecham Corporation | Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders |
| US20050147610A1 (en) * | 2003-11-12 | 2005-07-07 | Tariq Ghayur | IL-18 binding proteins |
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| ATE181575T1 (de) * | 1991-04-25 | 1999-07-15 | Chugai Pharmaceutical Co Ltd | Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor |
| DE69230545T2 (de) | 1991-08-21 | 2000-07-06 | Novartis Ag, Basel | Antikörperderivate |
| GB9125979D0 (en) | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
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| EP0692536B1 (en) | 1994-07-14 | 2000-11-22 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | IFN-Y production inducing protein and monoclonal antibody of the same |
| TW464656B (en) | 1994-11-15 | 2001-11-21 | Hayashibara Biochem Lab | Interferon-gamma production inducing polypeptide monoclonal antibody, and agent for interferon-gamma susceptive disease |
| JP2952750B2 (ja) * | 1995-02-23 | 1999-09-27 | 株式会社林原生物化学研究所 | モノクローナル抗体 |
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| IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| CA2276216A1 (en) | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| EP1257585A2 (en) * | 2000-02-10 | 2002-11-20 | Basf Aktiengesellschaft | Antibodies that bind human interleukin-18 and methods of making and using |
| TR200502508T2 (tr) | 2000-02-21 | 2007-04-24 | Applied Research Systems Ar� Holding N.V. | IL-18 İnhibitörlerinin kullanımı. |
| US20020025317A1 (en) | 2000-07-20 | 2002-02-28 | Schering Ag | Bispecific monoclonal antibodies to IL-12 and IL-18 |
| WO2002030986A2 (en) * | 2000-10-13 | 2002-04-18 | Biogen, Inc. | HUMANIZED ANTI-LT-β-R ANTIBODIES |
| WO2002032374A2 (en) | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| WO2002066063A1 (en) | 2001-02-23 | 2002-08-29 | Nippon Organon K.K. | Remedies for metabolic bone diseases |
| CN1671416B (zh) | 2001-07-12 | 2013-01-02 | 杰斐逊·富特 | 超人源化抗体 |
| UA78516C2 (en) | 2001-08-10 | 2007-04-10 | Applied Research Systems | Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity |
| WO2004097019A1 (ja) | 2003-04-30 | 2004-11-11 | Japan Science And Technology Agency | ヒト抗ヒトインターロイキン－１８抗体およびその断片、並びにそれらの利用方法 |
| US20050100965A1 (en) * | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| NZ550225A (en) * | 2004-03-30 | 2010-11-26 | Glaxo Group Ltd | Immunoglobulins that bind oncostatin and inhibit or block interaction between hOSM and pg130 |
| GB0425556D0 (en) | 2004-11-19 | 2004-12-22 | Glaxo Group Ltd | Novel compounds |
| GB0600488D0 (en) | 2006-01-11 | 2006-02-22 | Glaxo Group Ltd | Immunoglobulins |
| AU2007217563A1 (en) | 2006-02-22 | 2007-08-30 | University Of Zurich | Methods for treating autoimmune or demyelinating diseases |
| EP2027157B1 (en) * | 2006-05-25 | 2014-08-06 | Glaxo Group Limited | Modified humanised anti-interleukin-18 antibodies |
| WO2010020593A1 (en) | 2008-08-18 | 2010-02-25 | Glaxo Group Limited | Treatment of an autoimmune disease using il-18 antagonists |
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- 2007-05-23 WO PCT/EP2007/055029 patent/WO2007137984A2/en not_active Ceased
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- 2007-05-23 EA EA200802182A patent/EA017303B1/ru not_active IP Right Cessation
- 2007-05-23 AR ARP070102237A patent/AR061115A1/es not_active Application Discontinuation
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2008
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- 2008-11-12 ZA ZA2008/09662A patent/ZA200809662B/en unknown
- 2008-11-27 CR CR10468A patent/CR10468A/es unknown
- 2008-12-01 MA MA31429A patent/MA30486B1/fr unknown
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2011
- 2011-12-09 US US13/315,358 patent/US8637018B2/en active Active
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2013
- 2013-12-19 US US14/133,751 patent/US9499617B2/en active Active
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2016
- 2016-10-14 US US15/293,823 patent/US20170029497A1/en not_active Abandoned
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2018
- 2018-10-16 US US16/161,175 patent/US10703814B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000056771A1 (en) * | 1999-03-19 | 2000-09-28 | Smithkline Beecham Corporation | Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders |
| US20050147610A1 (en) * | 2003-11-12 | 2005-07-07 | Tariq Ghayur | IL-18 binding proteins |
Non-Patent Citations (1)
| Title |
|---|
| CHEN Y ET AL: "Selection and analysis of an optimised anti-VEGF antibody: crystal structure of an affinity-matured fab in complex with antigen" JOURNAL OF MOLECULAR BIOLOGY, vol. 293, no. 4, 5 November 1999, pages 865-881, * |
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