|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4754065A
(en)
|
1984-12-18 |
1988-06-28 |
Cetus Corporation |
Precursor to nucleic acid probe
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
US5047335A
(en)
|
1988-12-21 |
1991-09-10 |
The Regents Of The University Of Calif. |
Process for controlling intracellular glycosylation of proteins
|
|
EP0401384B1
(en)
|
1988-12-22 |
1996-03-13 |
Kirin-Amgen, Inc. |
Chemically modified granulocyte colony stimulating factor
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5278299A
(en)
|
1991-03-18 |
1994-01-11 |
Scripps Clinic And Research Foundation |
Method and composition for synthesizing sialylated glycosyl compounds
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
GB9115364D0
(en)
|
1991-07-16 |
1991-08-28 |
Wellcome Found |
Antibody
|
|
AU669124B2
(en)
|
1991-09-18 |
1996-05-30 |
Kyowa Hakko Kirin Co., Ltd. |
Process for producing humanized chimera antibody
|
|
JP3540315B2
(ja)
|
1991-09-23 |
2004-07-07 |
メディカル リサーチ カウンシル |
キメラ抗体の製造−組合せアプローチ
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
AU3144193A
(en)
|
1991-11-21 |
1993-06-15 |
Board Of Trustees Of The Leland Stanford Junior University |
Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
US5786158A
(en)
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US6210671B1
(en)
|
1992-12-01 |
2001-04-03 |
Protein Design Labs, Inc. |
Humanized antibodies reactive with L-selectin
|
|
WO1994029351A2
(en)
|
1993-06-16 |
1994-12-22 |
Celltech Limited |
Antibodies
|
|
US6180377B1
(en)
|
1993-06-16 |
2001-01-30 |
Celltech Therapeutics Limited |
Humanized antibodies
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6265150B1
(en)
|
1995-06-07 |
2001-07-24 |
Becton Dickinson & Company |
Phage antibodies
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
JP4334141B2
(ja)
|
1998-04-20 |
2009-09-30 |
グリカート バイオテクノロジー アクチェンゲゼルシャフト |
抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
EP1117778A2
(en)
*
|
1998-10-02 |
2001-07-25 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein
|
|
US20030035798A1
(en)
|
2000-08-16 |
2003-02-20 |
Fang Fang |
Humanized antibodies
|
|
BR0008758A
(pt)
|
1999-01-15 |
2001-12-04 |
Genentech Inc |
Variantes de polipeptìdeos parentais com funçãoefetora alterada, polipeptìdeos, composição ácidonucleico isolado, vetor, célula hospedeira,método para produzir uma variante depolipeptìdeo, método para o tratamento de umadesordem em mamìferos e método para produziruma região fc variante
|
|
CA2369292C
(en)
|
1999-04-09 |
2010-09-21 |
Kyowa Hakko Kogyo Co. Ltd. |
Method of modulating the activity of functional immune molecules
|
|
US6849425B1
(en)
|
1999-10-14 |
2005-02-01 |
Ixsys, Inc. |
Methods of optimizing antibody variable region binding affinity
|
|
CN1331214A
(zh)
*
|
2000-06-30 |
2002-01-16 |
上海博德基因开发有限公司 |
一种新的多肽——人缺刻蛋白24.64和编码这种多肽的多核苷酸
|
|
US7399633B2
(en)
|
2000-10-27 |
2008-07-15 |
Fred Hutchinson Cancer Research Center |
Methods for immortalizing cells
|
|
CN1376686A
(zh)
*
|
2001-03-22 |
2002-10-30 |
上海博德基因开发有限公司 |
一种多肽——缺刻蛋白－34.32和编码这种多肽的多核苷酸
|
|
ATE430580T1
(de)
|
2001-10-25 |
2009-05-15 |
Genentech Inc |
Glycoprotein-zusammensetzungen
|
|
US20030148954A1
(en)
|
2001-11-02 |
2003-08-07 |
Wisconsin Alumni Research Foundation |
Agents and methods for modulating activator protein-1-mediated cellular processes
|
|
JP2005526701A
(ja)
|
2001-11-14 |
2005-09-08 |
ロランティス リミテッド |
内科療法
|
|
CN1930288B
(zh)
|
2002-04-09 |
2012-08-08 |
协和发酵麒麟株式会社 |
基因组被修饰的细胞
|
|
US7666982B2
(en)
|
2002-07-18 |
2010-02-23 |
Masayasu Okochi |
Notch-origin polypeptides and biomarkers and reagents using the same
|
|
CN101014364B
(zh)
|
2002-12-24 |
2012-01-18 |
里纳特神经系统学公司 |
抗ngf抗体及其使用方法
|
|
US7282203B2
(en)
|
2003-11-26 |
2007-10-16 |
Health Research, Inc. |
Use of NOTCH pathway interfering agents for treatment of plasma cell disorders
|
|
US20080220416A1
(en)
|
2004-05-20 |
2008-09-11 |
The Board Of Trustees Of The University Of Illinoi |
Compositions for Inhibiting Cell Growth and Inducing Apoptosis in Cancer Cells and Methods of Use Thereof
|
|
US20070077245A1
(en)
|
2004-08-04 |
2007-04-05 |
The Brigham And Women's Hospital, Inc. |
NOTCH mutations leading to increased receptor signaling
|
|
WO2006053063A2
(en)
|
2004-11-05 |
2006-05-18 |
The Regents Of The University Of California |
Notch-1 assay to detect neurodegenerative diseases
|
|
RU2392961C2
(ru)
*
|
2004-11-10 |
2010-06-27 |
Хубрехт Лабораториум |
Лечение аденомы и/или аденокарциномы кишечника с помощью ингибирования активации пути notch
|
|
HRP20110859T1
(hr)
|
2004-12-21 |
2011-12-31 |
Medimmune Limited |
Protutijela usmjerena na angiopoietin-2 i njihova upotreba
|
|
CA2600908A1
(en)
|
2005-03-04 |
2006-09-08 |
The Hospital For Sick Children |
Methods for cancer prognosis
|
|
US20070072222A1
(en)
|
2005-09-23 |
2007-03-29 |
Franziska Boess |
FABP4 as biomarker for toxic effect
|
|
US20090305310A1
(en)
|
2005-11-22 |
2009-12-10 |
University Of Vermont And State Agricultural College |
Methods for Determining Notch Signaling and Uses Thereof
|
|
US20080241150A1
(en)
|
2006-05-15 |
2008-10-02 |
The Brigham And Women's Hospital, Inc. |
Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1
|
|
PL2032166T3
(pl)
|
2006-06-13 |
2013-09-30 |
Oncomed Pharm Inc |
Kompozycje i sposoby diagnozowania i leczenia nowotworów
|
|
ZA200904382B
(en)
*
|
2006-12-18 |
2010-08-25 |
Genentech Inc |
Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-retaled diseases
|
|
EP2134356A2
(en)
|
2007-03-05 |
2009-12-23 |
Board of Regents, The University of Texas System |
Negative genetic regulation of cancer cell renewal in synergy with notch- or numb-specific immunotherapy
|
|
PE20090321A1
(es)
*
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
|
|
US8119366B2
(en)
|
2007-10-05 |
2012-02-21 |
Trojan Technologies, Ltd. |
Antennapedia-dominant negative mastermind-like construct
|
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
US8834875B2
(en)
|
2010-01-13 |
2014-09-16 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
CN102316897B
(zh)
|
2008-07-08 |
2014-11-05 |
昂考梅德药品有限公司 |
Notch结合剂和拮抗剂及其应用方法
|
|
US20110286916A1
(en)
*
|
2008-11-20 |
2011-11-24 |
Jose Miguel Aste-Amezaga |
Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use
|
|
WO2010146550A1
(en)
|
2009-06-18 |
2010-12-23 |
Pfizer Inc. |
Anti notch-1 antibodies
|
|
PH12012500574A1
(en)
|
2009-09-30 |
2012-10-22 |
Genentech Inc |
Notch1-antagonist-resistant cancer(s) using notch3 antagonists
|
|
WO2012080891A1
(en)
|
2010-12-15 |
2012-06-21 |
Rinat Neuroscience Corp. |
Anti-notch-1 antibodies
|
|
JP6016800B2
(ja)
|
2010-12-15 |
2016-10-26 |
ワイス・エルエルシー |
抗ノッチ１抗体
|