AU2011342799B2 - Anti-Notch1 antibodies - Google Patents
Anti-Notch1 antibodies Download PDFInfo
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- AU2011342799B2 AU2011342799B2 AU2011342799A AU2011342799A AU2011342799B2 AU 2011342799 B2 AU2011342799 B2 AU 2011342799B2 AU 2011342799 A AU2011342799 A AU 2011342799A AU 2011342799 A AU2011342799 A AU 2011342799A AU 2011342799 B2 AU2011342799 B2 AU 2011342799B2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2016219704A AU2016219704A1 (en) | 2010-12-15 | 2016-08-26 | Anti-Notch1 antibodies |
Applications Claiming Priority (5)
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| US42357810P | 2010-12-15 | 2010-12-15 | |
| US61/423,578 | 2010-12-15 | ||
| US201161552578P | 2011-10-28 | 2011-10-28 | |
| US61/552,578 | 2011-10-28 | ||
| PCT/IB2011/055595 WO2012080926A2 (en) | 2010-12-15 | 2011-12-09 | Anti-notch1 antibodies |
Related Child Applications (1)
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|---|---|---|---|
| AU2016219704A Division AU2016219704A1 (en) | 2010-12-15 | 2016-08-26 | Anti-Notch1 antibodies |
Publications (2)
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| AU2011342799A1 AU2011342799A1 (en) | 2013-07-04 |
| AU2011342799B2 true AU2011342799B2 (en) | 2016-06-09 |
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Family Applications (2)
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| AU2011342799A Ceased AU2011342799B2 (en) | 2010-12-15 | 2011-12-09 | Anti-Notch1 antibodies |
| AU2016219704A Abandoned AU2016219704A1 (en) | 2010-12-15 | 2016-08-26 | Anti-Notch1 antibodies |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016219704A Abandoned AU2016219704A1 (en) | 2010-12-15 | 2016-08-26 | Anti-Notch1 antibodies |
Country Status (19)
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|---|---|
| US (2) | US9127060B2 (enExample) |
| EP (1) | EP2651977A2 (enExample) |
| JP (1) | JP6016800B2 (enExample) |
| KR (2) | KR20150088334A (enExample) |
| CN (2) | CN105884896A (enExample) |
| AR (1) | AR084315A1 (enExample) |
| AU (2) | AU2011342799B2 (enExample) |
| BR (1) | BR112013015122A2 (enExample) |
| CA (1) | CA2821130C (enExample) |
| CO (1) | CO6791565A2 (enExample) |
| MX (1) | MX346995B (enExample) |
| NZ (1) | NZ611785A (enExample) |
| PE (1) | PE20141109A1 (enExample) |
| PH (2) | PH12013501255A1 (enExample) |
| RU (1) | RU2622083C2 (enExample) |
| SA (1) | SA111330060B1 (enExample) |
| SG (1) | SG191039A1 (enExample) |
| TW (1) | TWI471333B (enExample) |
| WO (1) | WO2012080926A2 (enExample) |
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| PL2032166T3 (pl) | 2006-06-13 | 2013-09-30 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworów |
| CA2661848C (en) | 2006-09-01 | 2015-02-03 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| CA2676008A1 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
| CA2765989C (en) | 2009-06-18 | 2016-11-29 | Pfizer Inc. | Anti notch-1 antibodies |
| CN105884896A (zh) | 2010-12-15 | 2016-08-24 | 惠氏有限责任公司 | 抗缺刻蛋白1抗体 |
| WO2014039908A1 (en) | 2012-09-07 | 2014-03-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells |
| WO2014047426A1 (en) * | 2012-09-21 | 2014-03-27 | Oncomed Pharmaceuticals, Inc. | Methods of treating hematological malignancies with notch1 antibodies |
| TWI589590B (zh) | 2012-11-07 | 2017-07-01 | 輝瑞股份有限公司 | 抗切口３（ａｎｔｉ-ｎｏｔｃｈ３）抗體及抗體-藥物共軛體 |
| CN106488775A (zh) | 2014-07-11 | 2017-03-08 | 基因泰克公司 | Notch途径抑制 |
| EP3212773B1 (en) | 2014-10-29 | 2021-09-15 | Massachusetts Eye and Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| CN113862300A (zh) * | 2015-10-29 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 具有共同轻链的转基因兔 |
| CN105585636B (zh) * | 2015-11-24 | 2020-03-03 | 南方医科大学 | 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用 |
| US11590152B2 (en) | 2018-01-26 | 2023-02-28 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
| WO2019199165A1 (en) * | 2018-04-10 | 2019-10-17 | Stichting Sanquin Bloedvoorziening | Chimeric notch receptors |
| EP3856343A1 (en) * | 2018-09-25 | 2021-08-04 | Biolegend, Inc. | Anti-tlr9 agents and compositions and methods for making and using the same |
| KR102499678B1 (ko) * | 2020-02-27 | 2023-02-15 | 주식회사 베르티스 | 암의 진단용 조성물 |
| US20240067711A1 (en) * | 2020-08-31 | 2024-02-29 | Medytox Inc. | Anti-vegf hexameric antibody and composition comprising same |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Citations (1)
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| WO2008150525A1 (en) * | 2007-06-04 | 2008-12-11 | Genentech, Inc. | Anti-notch1 nrr antibodies and methods using same |
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