KR101580726B1 - 항-노치1 항체 - Google Patents

항-노치1 항체 Download PDF

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Publication number
KR101580726B1
KR101580726B1 KR1020137018236A KR20137018236A KR101580726B1 KR 101580726 B1 KR101580726 B1 KR 101580726B1 KR 1020137018236 A KR1020137018236 A KR 1020137018236A KR 20137018236 A KR20137018236 A KR 20137018236A KR 101580726 B1 KR101580726 B1 KR 101580726B1
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South Korea
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ser
notch
leu
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Expired - Fee Related
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KR1020137018236A
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English (en)
Korean (ko)
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KR20130108430A (ko
Inventor
케네쓰 지. 겔레스
빈-빙 스티븐 조우
리오우드밀라 겐나디에브나 트치스티아코바
이지에 가오
조엘 바드
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와이어쓰 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
KR1020137018236A 2010-12-15 2011-12-09 항-노치1 항체 Expired - Fee Related KR101580726B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42357810P 2010-12-15 2010-12-15
US61/423,578 2010-12-15
US201161552578P 2011-10-28 2011-10-28
US61/552,578 2011-10-28
PCT/IB2011/055595 WO2012080926A2 (en) 2010-12-15 2011-12-09 Anti-notch1 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020157019740A Division KR20150088334A (ko) 2010-12-15 2011-12-09 항-노치1 항체

Publications (2)

Publication Number Publication Date
KR20130108430A KR20130108430A (ko) 2013-10-02
KR101580726B1 true KR101580726B1 (ko) 2015-12-29

Family

ID=45444674

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020137018236A Expired - Fee Related KR101580726B1 (ko) 2010-12-15 2011-12-09 항-노치1 항체
KR1020157019740A Ceased KR20150088334A (ko) 2010-12-15 2011-12-09 항-노치1 항체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020157019740A Ceased KR20150088334A (ko) 2010-12-15 2011-12-09 항-노치1 항체

Country Status (19)

Country Link
US (2) US9127060B2 (enExample)
EP (1) EP2651977A2 (enExample)
JP (1) JP6016800B2 (enExample)
KR (2) KR101580726B1 (enExample)
CN (2) CN105884896A (enExample)
AR (1) AR084315A1 (enExample)
AU (2) AU2011342799B2 (enExample)
BR (1) BR112013015122A2 (enExample)
CA (1) CA2821130C (enExample)
CO (1) CO6791565A2 (enExample)
MX (1) MX346995B (enExample)
NZ (1) NZ611785A (enExample)
PE (1) PE20141109A1 (enExample)
PH (2) PH12013501255A1 (enExample)
RU (1) RU2622083C2 (enExample)
SA (1) SA111330060B1 (enExample)
SG (1) SG191039A1 (enExample)
TW (1) TWI471333B (enExample)
WO (1) WO2012080926A2 (enExample)

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PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
WO2008027986A2 (en) 2006-09-01 2008-03-06 Therapeutic Human Polyclonals, Inc. Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
JP5618544B2 (ja) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
WO2010146550A1 (en) 2009-06-18 2010-12-23 Pfizer Inc. Anti notch-1 antibodies
JP6016800B2 (ja) 2010-12-15 2016-10-26 ワイス・エルエルシー 抗ノッチ１抗体
JP6486272B2 (ja) 2012-09-07 2019-03-20 マサチューセッツ・アイ・アンド・イア・インファーマリー 有毛細胞および／または支持細胞再生のための方法および組成物
EP2897643A4 (en) * 2012-09-21 2016-04-20 Oncomed Pharm Inc METHOD FOR THE TREATMENT OF MOLECULAR BLOOD DISEASES WITH NOTCH1 ANTIBODIES
BR112015010436A2 (pt) 2012-11-07 2017-08-22 Pfizer Anticorpos anti-notch3 e conjugados anticorpo-fármaco
KR20170029490A (ko) 2014-07-11 2017-03-15 제넨테크, 인크. 노치 경로 억제
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
CN113862300A (zh) * 2015-10-29 2021-12-31 豪夫迈·罗氏有限公司 具有共同轻链的转基因兔
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
US11590152B2 (en) 2018-01-26 2023-02-28 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
EP3774867A1 (en) * 2018-04-10 2021-02-17 Stichting Sanquin Bloedvoorziening Chimeric notch receptors
WO2020068557A1 (en) * 2018-09-25 2020-04-02 BioLegend, Inc. Anti-tlr9 agents and compositions and methods for making and using the same
KR102499678B1 (ko) * 2020-02-27 2023-02-15 주식회사 베르티스 암의 진단용 조성물
WO2022045865A1 (ko) * 2020-08-31 2022-03-03 (주)메디톡스 항-ｖｅｇｆ 육량체 항체, 및 이를 포함하는 조성물
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Also Published As

Publication number Publication date
TWI471333B (zh) 2015-02-01
SA111330060B1 (ar) 2015-06-04
CA2821130C (en) 2017-11-07
WO2012080926A3 (en) 2012-10-04
JP2014503205A (ja) 2014-02-13
RU2622083C2 (ru) 2017-06-09
CN105884896A (zh) 2016-08-24
RU2013126494A (ru) 2015-01-20
US20160002331A1 (en) 2016-01-07
EP2651977A2 (en) 2013-10-23
CN103547594B (zh) 2016-05-11
HK1194388A1 (zh) 2014-10-17
MX346995B (es) 2017-04-06
US9127060B2 (en) 2015-09-08
WO2012080926A2 (en) 2012-06-21
BR112013015122A2 (pt) 2017-05-30
PH12017500864A1 (en) 2017-12-11
AU2011342799A1 (en) 2013-07-04
AU2011342799B2 (en) 2016-06-09
CO6791565A2 (es) 2013-11-14
CN103547594A (zh) 2014-01-29
AR084315A1 (es) 2013-05-08
JP6016800B2 (ja) 2016-10-26
MX2013006875A (es) 2013-07-05
NZ611785A (en) 2015-04-24
KR20150088334A (ko) 2015-07-31
TW201302787A (zh) 2013-01-16
PH12013501255A1 (en) 2013-08-05
PE20141109A1 (es) 2014-09-24
CA2821130A1 (en) 2012-06-21
US20130266594A1 (en) 2013-10-10
SG191039A1 (en) 2013-08-30
AU2016219704A1 (en) 2016-09-15
KR20130108430A (ko) 2013-10-02

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