KR20150088334A - 항-노치1 항체 - Google Patents

항-노치1 항체 Download PDF

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Publication number
KR20150088334A
KR20150088334A KR1020157019740A KR20157019740A KR20150088334A KR 20150088334 A KR20150088334 A KR 20150088334A KR 1020157019740 A KR1020157019740 A KR 1020157019740A KR 20157019740 A KR20157019740 A KR 20157019740A KR 20150088334 A KR20150088334 A KR 20150088334A
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KR
South Korea
Prior art keywords
ser
leu
gly
antibody
notch1
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Ceased
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KR1020157019740A
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English (en)
Korean (ko)
Inventor
케네쓰 지. 겔레스
빈-빙 스티븐 조우
리오우드밀라 겐나디에브나 트치스티아코바
이지에 가오
조엘 바드
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와이어쓰 엘엘씨
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Application filed by 와이어쓰 엘엘씨 filed Critical 와이어쓰 엘엘씨
Publication of KR20150088334A publication Critical patent/KR20150088334A/ko
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
KR1020157019740A 2010-12-15 2011-12-09 항-노치1 항체 Ceased KR20150088334A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42357810P 2010-12-15 2010-12-15
US61/423,578 2010-12-15
US201161552578P 2011-10-28 2011-10-28
US61/552,578 2011-10-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020137018236A Division KR101580726B1 (ko) 2010-12-15 2011-12-09 항-노치1 항체

Publications (1)

Publication Number Publication Date
KR20150088334A true KR20150088334A (ko) 2015-07-31

Family

ID=45444674

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020137018236A Expired - Fee Related KR101580726B1 (ko) 2010-12-15 2011-12-09 항-노치1 항체
KR1020157019740A Ceased KR20150088334A (ko) 2010-12-15 2011-12-09 항-노치1 항체

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020137018236A Expired - Fee Related KR101580726B1 (ko) 2010-12-15 2011-12-09 항-노치1 항체

Country Status (19)

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US (2) US9127060B2 (enExample)
EP (1) EP2651977A2 (enExample)
JP (1) JP6016800B2 (enExample)
KR (2) KR101580726B1 (enExample)
CN (2) CN103547594B (enExample)
AR (1) AR084315A1 (enExample)
AU (2) AU2011342799B2 (enExample)
BR (1) BR112013015122A2 (enExample)
CA (1) CA2821130C (enExample)
CO (1) CO6791565A2 (enExample)
MX (1) MX346995B (enExample)
NZ (1) NZ611785A (enExample)
PE (1) PE20141109A1 (enExample)
PH (2) PH12013501255A1 (enExample)
RU (1) RU2622083C2 (enExample)
SA (1) SA111330060B1 (enExample)
SG (1) SG191039A1 (enExample)
TW (1) TWI471333B (enExample)
WO (1) WO2012080926A2 (enExample)

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CA2655362A1 (en) 2006-06-13 2007-12-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
CN101506235B (zh) 2006-09-01 2012-07-25 人类多细胞株治疗学公司 人或人源化免疫球蛋白在非人转基因动物中增强的表达
AU2008209482B2 (en) 2007-01-24 2014-05-01 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
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WO2010146550A1 (en) 2009-06-18 2010-12-23 Pfizer Inc. Anti notch-1 antibodies
WO2012080926A2 (en) 2010-12-15 2012-06-21 Wyeth Llc Anti-notch1 antibodies
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AU2013317886A1 (en) * 2012-09-21 2015-04-09 Oncomed Pharmaceuticals, Inc. Methods of treating hematological malignancies with NOTCH1 antibodies
BR112015010436A2 (pt) 2012-11-07 2017-08-22 Pfizer Anticorpos anti-notch3 e conjugados anticorpo-fármaco
MX2017000363A (es) 2014-07-11 2017-04-27 Genentech Inc Inhibicion de la via de notch.
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
EP3367786A1 (en) * 2015-10-29 2018-09-05 H. Hoffnabb-La Roche Ag Transgenic rabbit with common light chain
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
EP3743057A4 (en) 2018-01-26 2021-11-17 Massachusetts Eye & Ear Infirmary TREATMENT OF HEARING LOSS
KR20210008840A (ko) * 2018-04-10 2021-01-25 스티흐팅 산퀸 불드포르지닝 키메라 노치 수용체
CN113365697B (zh) * 2018-09-25 2024-07-19 百进生物科技公司 抗tlr9药剂和组合物及其制备方法和使用方法
KR102499678B1 (ko) * 2020-02-27 2023-02-15 주식회사 베르티스 암의 진단용 조성물
WO2022045865A1 (ko) * 2020-08-31 2022-03-03 (주)메디톡스 항-vegf 육량체 항체, 및 이를 포함하는 조성물
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Also Published As

Publication number Publication date
JP6016800B2 (ja) 2016-10-26
US20160002331A1 (en) 2016-01-07
PH12013501255A1 (en) 2013-08-05
PE20141109A1 (es) 2014-09-24
AU2016219704A1 (en) 2016-09-15
AU2011342799A1 (en) 2013-07-04
CO6791565A2 (es) 2013-11-14
MX2013006875A (es) 2013-07-05
PH12017500864A1 (en) 2017-12-11
EP2651977A2 (en) 2013-10-23
CA2821130C (en) 2017-11-07
RU2622083C2 (ru) 2017-06-09
JP2014503205A (ja) 2014-02-13
US20130266594A1 (en) 2013-10-10
SA111330060B1 (ar) 2015-06-04
HK1194388A1 (zh) 2014-10-17
AR084315A1 (es) 2013-05-08
MX346995B (es) 2017-04-06
KR20130108430A (ko) 2013-10-02
SG191039A1 (en) 2013-08-30
KR101580726B1 (ko) 2015-12-29
CA2821130A1 (en) 2012-06-21
TW201302787A (zh) 2013-01-16
CN103547594B (zh) 2016-05-11
WO2012080926A3 (en) 2012-10-04
CN103547594A (zh) 2014-01-29
TWI471333B (zh) 2015-02-01
AU2011342799B2 (en) 2016-06-09
WO2012080926A2 (en) 2012-06-21
US9127060B2 (en) 2015-09-08
BR112013015122A2 (pt) 2017-05-30
NZ611785A (en) 2015-04-24
CN105884896A (zh) 2016-08-24
RU2013126494A (ru) 2015-01-20

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