JP2014503209A5 - - Google Patents
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- Publication number
- JP2014503209A5 JP2014503209A5 JP2013544971A JP2013544971A JP2014503209A5 JP 2014503209 A5 JP2014503209 A5 JP 2014503209A5 JP 2013544971 A JP2013544971 A JP 2013544971A JP 2013544971 A JP2013544971 A JP 2013544971A JP 2014503209 A5 JP2014503209 A5 JP 2014503209A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- antibody
- fusion protein
- construct
- igg4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108060003951 Immunoglobulin Proteins 0.000 claims 37
- 102000018358 immunoglobulin Human genes 0.000 claims 37
- 108020001507 fusion proteins Proteins 0.000 claims 17
- 102000037865 fusion proteins Human genes 0.000 claims 17
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 4
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002327 eosinophilic effect Effects 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 208000028185 Angioedema Diseases 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000005577 Gastroenteritis Diseases 0.000 claims 1
- 208000006968 Helminthiasis Diseases 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 208000016300 Idiopathic chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 241000243981 Onchocerca Species 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 208000023819 chronic asthma Diseases 0.000 claims 1
- 201000009323 chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 230000002497 edematous effect Effects 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 206010057271 eosinophilic colitis Diseases 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 201000001561 eosinophilic gastritis Diseases 0.000 claims 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 1
- 208000024711 extrinsic asthma Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 208000037916 non-allergic rhinitis Diseases 0.000 claims 1
- 208000001797 obstructive sleep apnea Diseases 0.000 claims 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000015768 polyposis Diseases 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 230000007863 steatosis Effects 0.000 claims 1
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061425858P | 2010-12-22 | 2010-12-22 | |
| US61/425,858 | 2010-12-22 | ||
| PCT/AU2011/001662 WO2012083370A1 (en) | 2010-12-22 | 2011-12-22 | Modified antibody with improved half-life |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016255652A Division JP6334669B2 (ja) | 2010-12-22 | 2016-12-28 | 改善された半減期を有する修飾された抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503209A JP2014503209A (ja) | 2014-02-13 |
| JP2014503209A5 true JP2014503209A5 (enExample) | 2015-02-19 |
| JP6147670B2 JP6147670B2 (ja) | 2017-06-14 |
Family
ID=46312907
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544971A Active JP6147670B2 (ja) | 2010-12-22 | 2011-12-22 | 改善された半減期を有する修飾された抗体 |
| JP2016255652A Active JP6334669B2 (ja) | 2010-12-22 | 2016-12-28 | 改善された半減期を有する修飾された抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016255652A Active JP6334669B2 (ja) | 2010-12-22 | 2016-12-28 | 改善された半減期を有する修飾された抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9505826B2 (enExample) |
| EP (1) | EP2654790B1 (enExample) |
| JP (2) | JP6147670B2 (enExample) |
| KR (1) | KR101941514B1 (enExample) |
| CN (1) | CN103429261A (enExample) |
| AU (1) | AU2011349049B2 (enExample) |
| BR (1) | BR112013016235B1 (enExample) |
| CA (1) | CA2824279A1 (enExample) |
| EA (1) | EA201390923A1 (enExample) |
| ES (1) | ES2720136T3 (enExample) |
| IL (1) | IL227081B (enExample) |
| MX (1) | MX2013007392A (enExample) |
| PT (1) | PT2654790T (enExample) |
| WO (1) | WO2012083370A1 (enExample) |
| ZA (1) | ZA201305123B (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6147670B2 (ja) * | 2010-12-22 | 2017-06-14 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 改善された半減期を有する修飾された抗体 |
| EP3559049B1 (en) | 2011-10-28 | 2025-06-11 | Teva Pharmaceuticals Australia Pty Ltd | Polypeptide constructs and uses thereof |
| CN104870475B (zh) | 2012-10-25 | 2019-11-08 | 美国比奥维拉迪维股份有限公司 | 抗补体C1s抗体和其用途 |
| CA2889197A1 (en) | 2012-11-02 | 2014-05-08 | True North Therapeutics, Inc. | Anti-complement c1s antibodies and uses thereof |
| US9969789B2 (en) * | 2012-12-17 | 2018-05-15 | Trillium Therapeutics Inc. | Treatment of CD47+ disease cells with SIRP alpha-Fc fusions |
| ITTO20130012A1 (it) * | 2013-01-09 | 2014-07-10 | Metheresis Translational Res S A | Nuovi frammenti anticorpali, relative composizioni ed usi |
| US20160068613A1 (en) | 2013-04-29 | 2016-03-10 | Hoffmann-La Roche Inc. | Fc-receptor binding modified asymmetric antibodies and methods of use |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| FI3677591T3 (fi) | 2013-04-29 | 2023-04-03 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd38-vasta-aineet ja fuusiot heikennetylle interferonille alfa-2b |
| EP3628685A1 (en) | 2013-04-29 | 2020-04-01 | F. Hoffmann-La Roche AG | Human fcrn-binding modified antibodies and methods of use |
| KR101895634B1 (ko) * | 2013-05-31 | 2018-09-05 | 한미약품 주식회사 | 변이된 힌지 영역을 포함하는 IgG4 Fc 단편 |
| JP6673200B2 (ja) | 2013-07-05 | 2020-03-25 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 骨髄異形成症候群（ｍｄｓ）を治療するための可溶性ｃｄ３３ |
| JP6623353B2 (ja) | 2013-09-13 | 2019-12-25 | ベイジーン スウィッツァーランド ゲーエムベーハー | 抗ｐｄ−１抗体並びにその治療及び診断のための使用 |
| CA2932364A1 (en) | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with improved protein a-binding |
| UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
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| SMT202100263T1 (it) | 2014-07-10 | 2021-07-12 | Eisai R&D Man Co Ltd | Anticorpi leganti protofibrille a-beta migliorati |
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| EA037749B1 (ru) | 2014-10-29 | 2021-05-18 | Тева Фармасьютикалз Острэйлиа Пти Лтд | ВАРИАНТЫ ИНТЕРФЕРОНА 2b |
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| CN116554320A (zh) | 2016-10-12 | 2023-08-08 | 美国比奥维拉迪维股份有限公司 | 抗C1s抗体及其使用方法 |
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| TWI799417B (zh) * | 2017-05-26 | 2023-04-21 | 英商葛蘭素史克智慧財產發展有限公司 | 生物製藥組成物及相關方法 |
| KR102757960B1 (ko) | 2017-06-26 | 2025-01-22 | 베이진 엘티디 | 간세포암(hepatocellular carcinoma: HCC)에 대한 면역 치료 |
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| CN110297093B (zh) * | 2019-03-18 | 2022-04-22 | 山西瑞豪生物科技有限公司 | 一种检测人免疫球蛋白g4的方法和试剂盒 |
| KR20210145187A (ko) | 2019-03-29 | 2021-12-01 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | Il-5에 대한 항체를 함유하는 약학적 조성물 및 이의 용도 |
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| CN113307870B (zh) * | 2020-10-30 | 2022-12-23 | 上海洛启生物医药技术有限公司 | 抗il5纳米抗体及其应用 |
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- 2011-12-22 CA CA2824279A patent/CA2824279A1/en not_active Abandoned
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