JP2020506898A5 - - Google Patents
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- JP2020506898A5 JP2020506898A5 JP2019538383A JP2019538383A JP2020506898A5 JP 2020506898 A5 JP2020506898 A5 JP 2020506898A5 JP 2019538383 A JP2019538383 A JP 2019538383A JP 2019538383 A JP2019538383 A JP 2019538383A JP 2020506898 A5 JP2020506898 A5 JP 2020506898A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- polypeptide
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022168448A JP7585272B2 (ja) | 2017-01-17 | 2022-10-20 | 改善された血清アルブミン結合剤 |
| JP2024194438A JP2025024012A (ja) | 2017-01-17 | 2024-11-06 | 改善された血清アルブミン結合剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762446992P | 2017-01-17 | 2017-01-17 | |
| US62/446,992 | 2017-01-17 | ||
| PCT/EP2018/051082 WO2018134234A1 (en) | 2017-01-17 | 2018-01-17 | Improved serum albumin binders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022168448A Division JP7585272B2 (ja) | 2017-01-17 | 2022-10-20 | 改善された血清アルブミン結合剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506898A JP2020506898A (ja) | 2020-03-05 |
| JP2020506898A5 true JP2020506898A5 (enExample) | 2021-01-07 |
| JP7300385B2 JP7300385B2 (ja) | 2023-06-29 |
Family
ID=61163666
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538383A Active JP7300385B2 (ja) | 2017-01-17 | 2018-01-17 | 改善された血清アルブミン結合剤 |
| JP2022168448A Active JP7585272B2 (ja) | 2017-01-17 | 2022-10-20 | 改善された血清アルブミン結合剤 |
| JP2024194438A Pending JP2025024012A (ja) | 2017-01-17 | 2024-11-06 | 改善された血清アルブミン結合剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022168448A Active JP7585272B2 (ja) | 2017-01-17 | 2022-10-20 | 改善された血清アルブミン結合剤 |
| JP2024194438A Pending JP2025024012A (ja) | 2017-01-17 | 2024-11-06 | 改善された血清アルブミン結合剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11897944B2 (enExample) |
| EP (3) | EP4471058A3 (enExample) |
| JP (3) | JP7300385B2 (enExample) |
| KR (2) | KR20230165374A (enExample) |
| CN (2) | CN117327175A (enExample) |
| AU (2) | AU2018209150B2 (enExample) |
| BR (1) | BR112019014600A2 (enExample) |
| CA (1) | CA3050574A1 (enExample) |
| DK (1) | DK3571224T3 (enExample) |
| ES (1) | ES2994387T3 (enExample) |
| FI (1) | FI3571224T3 (enExample) |
| HR (1) | HRP20241501T1 (enExample) |
| HU (1) | HUE068820T2 (enExample) |
| IL (3) | IL316293A (enExample) |
| LT (1) | LT3571224T (enExample) |
| MX (4) | MX2019008536A (enExample) |
| PL (1) | PL3571224T3 (enExample) |
| PT (1) | PT3571224T (enExample) |
| RS (1) | RS66173B1 (enExample) |
| SG (2) | SG10202108973SA (enExample) |
| SI (1) | SI3571224T1 (enExample) |
| WO (1) | WO2018134234A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL318433A (en) | 2014-05-16 | 2025-03-01 | Ablynx Nv | Improved immunoglobulin variable complexes |
| SG11201609162SA (en) | 2014-05-16 | 2016-12-29 | Ablynx Nv | Improved immunoglobulin variable domains |
| EP3551656A1 (en) * | 2016-12-07 | 2019-10-16 | Ablynx NV | Improved serum albumin binding immunoglobulin single variable domains |
| DK3571224T3 (da) * | 2017-01-17 | 2024-11-11 | Ablynx Nv | Forbedrede serumalbuminbindere |
| CN117285623A (zh) * | 2017-01-17 | 2023-12-26 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合物 |
| JP7657797B2 (ja) | 2019-12-06 | 2025-04-07 | アブリンクス エン．ヴェー． | ＴＮＦαおよびＩＬ－２３を標的化する免疫グロブリン単一可変ドメインを含むポリペプチド |
| MX2022006881A (es) | 2019-12-06 | 2022-07-11 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina dirigidos a tnf alfa y ox40l. |
| IL293548A (en) | 2019-12-09 | 2022-08-01 | Ablynx Nv | Polypeptides comprising immunoglobulin with single variable domains targeting 13 il and tsl |
| CA3175873A1 (en) | 2020-03-30 | 2021-10-07 | Ablynx Nv | Method for the production and purification of multivalent immunoglobulin single variable domains |
| WO2024133935A1 (en) | 2022-12-23 | 2024-06-27 | Ablynx Nv | Protein-based conjugation carriers |
| WO2022063984A1 (en) | 2020-09-25 | 2022-03-31 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-13 and ox40l |
| EP4237438A4 (en) * | 2020-10-27 | 2024-11-27 | Beijing QL Biopharmaceutical Co., Ltd. | GDF15 FUSION PROTEINS AND THEIR USE |
| CA3203141A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
| JP7842101B2 (ja) | 2020-12-18 | 2026-04-07 | アブリンクス エン．ヴェー． | ＩＬ－６およびＴＮＦ－αを標的化する免疫グロブリン単一可変ドメインを含むポリペプチド |
| TW202241947A (zh) | 2020-12-18 | 2022-11-01 | 比利時商艾伯霖克斯公司 | 包含靶向磷脂醯肌醇蛋白聚糖—３和ｔ細胞受體的免疫球蛋白單可變結構域的多肽 |
| AU2022409733A1 (en) | 2021-12-17 | 2024-08-01 | Ablynx Nv | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123 |
| CN119604536A (zh) * | 2022-05-23 | 2025-03-11 | 塞雷乌斯股份有限公司 | Her2结合剂及其用途 |
| CA3259417A1 (en) | 2022-06-14 | 2023-12-21 | Ablynx Nv | UNIQUE VARIABLE DOMAINS OF IMMUNOGLOBULIN TARGETING THE T LYMPHOCYTE RECEPTOR |
| KR20250042176A (ko) | 2022-07-27 | 2025-03-26 | 아블린쓰 | 신생아 fc 수용체의 특정 에피토프에 결합하는 폴리펩타이드 |
| CN120529914A (zh) | 2023-01-09 | 2025-08-22 | 奥德赛治疗股份有限公司 | 抗tnfr2抗原结合蛋白及其用途 |
| AR131869A1 (es) | 2023-02-17 | 2025-05-07 | Ablynx Nv | POLIPÉPTIDOS QUE SE UNEN AL RECEPTOR DE Fc NEONATAL |
| IL323035A (en) | 2023-03-14 | 2025-10-01 | Odyssey Therapeutics Inc | Anti-CD25 antigen-binding proteins and their uses |
| CN121511255A (zh) | 2023-05-17 | 2026-02-10 | 奥德赛治疗股份有限公司 | 经修饰的单结构域抗体 |
| EP4731770A1 (en) | 2023-06-22 | 2026-04-29 | Ablynx NV | Chimeric proteins for modulating cytokine receptor activity |
| KR20260032566A (ko) | 2023-06-29 | 2026-03-09 | 오디세이 테라퓨틱스, 인코포레이티드 | 항-trailr2 항원-결합 단백질 및 그의 용도 |
| CN121443644A (zh) | 2023-07-05 | 2026-01-30 | 阿布林克斯有限公司 | 用于治疗IgG相关疾病和障碍的改善的FcRn拮抗剂 |
| AR133725A1 (es) | 2023-09-04 | 2025-10-29 | Sanofi Sa | Polipéptidos para uso en el tratamiento de tumores que expresan glipicano-3 |
| CN121986112A (zh) | 2023-09-22 | 2026-05-05 | 阿布林克斯有限公司 | 二价和多价白蛋白结合剂 |
| WO2025080751A2 (en) | 2023-10-13 | 2025-04-17 | Odyssey Therapeutics, Inc. | Anti-cdh17 antigen-binding proteins and uses thereof |
| WO2025099632A1 (en) | 2023-11-08 | 2025-05-15 | Sanofi | Cd25 based lysosomal degrader and uses thereof |
| AR134512A1 (es) | 2023-12-01 | 2026-01-21 | Ablynx Nv | Polipéptidos activados con precisión |
| TW202543670A (zh) | 2023-12-22 | 2025-11-16 | 比利時商艾伯霖克斯公司 | 用於核內投予之基於蛋白質的接合載劑 |
| AR134804A1 (es) | 2023-12-22 | 2026-04-01 | Ablynx Nv | Portadores a base de proteínas para la conjugación de aminas específicas de sitio |
| TW202602941A (zh) | 2024-04-10 | 2026-01-16 | 美商奧迪希治療公司 | 抗tnfr2抗原結合蛋白及其用途 |
| WO2025255558A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Anti-thymic stromal lymphopoietin (tslp) antigen-binding proteins and uses thereof |
| WO2025255435A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Antigen-binding proteins against serum albumin and uses thereof |
| WO2026006809A1 (en) | 2024-06-27 | 2026-01-02 | Odyssey Therapeutics, Inc. | Multispecific molecules binding tnfr2 and cd25 and uses thereof |
| WO2026006708A2 (en) | 2024-06-27 | 2026-01-02 | Odyssey Therapeutics, Inc. | Anti-cd25 antigen-binding proteins and uses thereof |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
| WO2026052756A1 (en) | 2024-09-05 | 2026-03-12 | Ablynx Nv | Her2 binding immunoglobulin single variable domains, constructs comprising the same and uses thereof |
| WO2026078159A1 (en) | 2024-10-10 | 2026-04-16 | Ablynx Nv | Immune cell engagers and methods comprising the same |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| WO1999023221A2 (en) | 1997-10-27 | 1999-05-14 | Unilever Plc | Multivalent antigen-binding proteins |
| US6742038B2 (en) | 2000-04-07 | 2004-05-25 | Danger, Inc. | System and method of linking user identification to a subscriber identification module |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| EP1600459A3 (en) | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| CA2588892A1 (en) | 2004-12-02 | 2006-06-08 | Dormantis Limited | Anti-il-1r1 single domain antibodies and therapeutic uses |
| AU2006249144B2 (en) | 2005-05-18 | 2011-11-17 | Ablynx Nv | Improved NanobodiesTM against Tumor Necrosis Factor-alpha |
| MX2007014564A (es) | 2005-05-20 | 2008-02-07 | Ablynx Nv | Anticuerpos de vhh de dominio unico contra el factor de von willebrand. |
| CN101454344A (zh) | 2005-12-01 | 2009-06-10 | 杜门蒂斯有限公司 | 与白细胞介素-1受体1型结合的非竞争性域抗体形式 |
| KR20080077237A (ko) | 2005-12-01 | 2008-08-21 | 도만티스 리미티드 | 인터루킨 1 수용체 타입 1에 결합하는 경쟁적 도메인 항체포맷 |
| FR2894741B1 (fr) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | Chaine de reception par satellite |
| WO2007085814A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Fusion proteins that contain natural junctions |
| CA2666599A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| CN101646689A (zh) | 2006-09-08 | 2010-02-10 | 埃博灵克斯股份有限公司 | 具有长半衰期的血清清蛋白结合蛋白 |
| KR101264473B1 (ko) | 2007-05-24 | 2013-05-29 | 아블린쓰 엔.브이. | Ｒａｎｋ-ｌ에 대한 아미노산 서열, 및 이를 포함하는 골 질환 및 장애 치료용 폴리펩티드 |
| WO2009068631A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| DE102008023620A1 (de) | 2008-05-15 | 2009-11-19 | Mettler-Toledo (Albstadt) Gmbh | Funktionseinheit mit einer aufrufbaren Funktion und Verfahren zu deren Aufruf |
| NZ589036A (en) | 2008-05-16 | 2012-07-27 | Ablynx Nv | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
| WO2010035012A1 (en) | 2008-09-26 | 2010-04-01 | Ucb Pharma S.A. | Biological products |
| WO2010130832A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
| EP2454285A2 (en) | 2009-07-16 | 2012-05-23 | Glaxo Group Limited | Improved anti-serum albumin binding single variable domains |
| SG10201406063XA (en) | 2009-09-30 | 2014-11-27 | Glaxo Group Ltd | Drug fusions and conjugates with extended half life |
| US9012609B2 (en) | 2010-08-13 | 2015-04-21 | Glaxosmithkline Intellectual Property Development Limited | Anti-serum albumin binding variants |
| SG188204A1 (en) | 2010-08-20 | 2013-04-30 | Glaxo Group Ltd | Improved anti-serum albumin binding variants |
| US11644471B2 (en) * | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2621953B1 (en) * | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| EP3466972B1 (en) | 2011-06-23 | 2026-03-04 | Ablynx NV | Serum albumin binding proteins |
| HUE031828T2 (en) * | 2011-06-23 | 2017-08-28 | Ablynx Nv | Procedures for Predicting, Detecting, and Reducing Aspiration Protein Interference in Assays Containing Immunoglobulin Variable Single Domain |
| US20150344568A1 (en) * | 2011-06-23 | 2015-12-03 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| WO2012174741A1 (en) | 2011-06-24 | 2012-12-27 | Google Inc. | Determining cross-language query suggestion based on query translations |
| PE20141522A1 (es) | 2011-08-17 | 2014-11-17 | Glaxo Group Ltd | Proteinas y peptidos modificados |
| US20130129727A1 (en) | 2011-11-17 | 2013-05-23 | Nanjingjinsirui Science & Technology Biology Corporation | Methods and systems for increasing protein stability |
| WO2014037419A1 (en) * | 2012-09-04 | 2014-03-13 | Vib Vzw | Immunoglobulin single variable domains directed against cd74 and uses derived thereof |
| US20140186365A1 (en) * | 2013-01-03 | 2014-07-03 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Antibodies that specifically bind to serum albumin without interfering with albumin's capability to interact with the fcrn |
| WO2014111550A1 (en) | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
| SG11201609162SA (en) | 2014-05-16 | 2016-12-29 | Ablynx Nv | Improved immunoglobulin variable domains |
| JP7001474B2 (ja) | 2015-01-21 | 2022-01-19 | インヒブルクス，インコーポレイティド | 非免疫原性単一ドメイン抗体 |
| PT3294768T (pt) | 2015-05-13 | 2019-11-05 | Ablynx Nv | Polipétidos de recrutamento de células t com base na reatividade do tcr alfa/beta |
| AU2016342048B2 (en) | 2015-10-22 | 2022-09-08 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| CN108473561B (zh) | 2015-11-27 | 2022-12-16 | 埃博灵克斯股份有限公司 | 抑制cd40l的多肽 |
| WO2017189964A2 (en) * | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3551656A1 (en) * | 2016-12-07 | 2019-10-16 | Ablynx NV | Improved serum albumin binding immunoglobulin single variable domains |
| CN117285623A (zh) * | 2017-01-17 | 2023-12-26 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合物 |
| DK3571224T3 (da) | 2017-01-17 | 2024-11-11 | Ablynx Nv | Forbedrede serumalbuminbindere |
-
2018
- 2018-01-17 DK DK18703213.1T patent/DK3571224T3/da active
- 2018-01-17 EP EP24191396.1A patent/EP4471058A3/en active Pending
- 2018-01-17 PL PL18703213.1T patent/PL3571224T3/pl unknown
- 2018-01-17 SG SG10202108973SA patent/SG10202108973SA/en unknown
- 2018-01-17 AU AU2018209150A patent/AU2018209150B2/en active Active
- 2018-01-17 IL IL316293A patent/IL316293A/en unknown
- 2018-01-17 IL IL267897A patent/IL267897B2/en unknown
- 2018-01-17 LT LTEPPCT/EP2018/051082T patent/LT3571224T/lt unknown
- 2018-01-17 MX MX2019008536A patent/MX2019008536A/es unknown
- 2018-01-17 WO PCT/EP2018/051082 patent/WO2018134234A1/en not_active Ceased
- 2018-01-17 JP JP2019538383A patent/JP7300385B2/ja active Active
- 2018-01-17 SI SI201831172T patent/SI3571224T1/sl unknown
- 2018-01-17 KR KR1020237040677A patent/KR20230165374A/ko not_active Ceased
- 2018-01-17 CN CN202311114345.5A patent/CN117327175A/zh active Pending
- 2018-01-17 US US16/477,927 patent/US11897944B2/en active Active
- 2018-01-17 CA CA3050574A patent/CA3050574A1/en active Pending
- 2018-01-17 EP EP18703213.1A patent/EP3571224B1/en active Active
- 2018-01-17 SG SG11201906341XA patent/SG11201906341XA/en unknown
- 2018-01-17 IL IL305912A patent/IL305912B2/en unknown
- 2018-01-17 HR HRP20241501TT patent/HRP20241501T1/hr unknown
- 2018-01-17 RS RS20241239A patent/RS66173B1/sr unknown
- 2018-01-17 CN CN201880015687.2A patent/CN110461870B/zh active Active
- 2018-01-17 ES ES18703213T patent/ES2994387T3/es active Active
- 2018-01-17 EP EP24191390.4A patent/EP4442708A3/en active Pending
- 2018-01-17 PT PT187032131T patent/PT3571224T/pt unknown
- 2018-01-17 BR BR112019014600-8A patent/BR112019014600A2/pt unknown
- 2018-01-17 FI FIEP18703213.1T patent/FI3571224T3/fi active
- 2018-01-17 KR KR1020197024114A patent/KR102653724B1/ko active Active
- 2018-01-17 HU HUE18703213A patent/HUE068820T2/hu unknown
-
2019
- 2019-07-17 MX MX2024013316A patent/MX2024013316A/es unknown
- 2019-07-17 MX MX2025010630A patent/MX2025010630A/es unknown
- 2019-07-17 MX MX2024008521A patent/MX2024008521A/es unknown
-
2022
- 2022-10-20 JP JP2022168448A patent/JP7585272B2/ja active Active
-
2024
- 2024-01-04 US US18/404,145 patent/US20240294617A1/en active Pending
- 2024-11-06 JP JP2024194438A patent/JP2025024012A/ja active Pending
-
2025
- 2025-04-07 AU AU2025202453A patent/AU2025202453A1/en active Pending
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