JP2019511457A5 - - Google Patents
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- Publication number
- JP2019511457A5 JP2019511457A5 JP2018538749A JP2018538749A JP2019511457A5 JP 2019511457 A5 JP2019511457 A5 JP 2019511457A5 JP 2018538749 A JP2018538749 A JP 2018538749A JP 2018538749 A JP2018538749 A JP 2018538749A JP 2019511457 A5 JP2019511457 A5 JP 2019511457A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- vwf
- polypeptide
- sdab
- sequence shown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 108010047303 von Willebrand Factor Proteins 0.000 claims 15
- 102100036537 von Willebrand factor Human genes 0.000 claims 15
- 229960001134 von willebrand factor Drugs 0.000 claims 15
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 3
- 108010054218 Factor VIII Proteins 0.000 claims 3
- 102000001690 Factor VIII Human genes 0.000 claims 3
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 3
- 229960000301 factor viii Drugs 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 208000031169 hemorrhagic disease Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 1
- 208000019838 Blood disease Diseases 0.000 claims 1
- 102100022641 Coagulation factor IX Human genes 0.000 claims 1
- 102100023804 Coagulation factor VII Human genes 0.000 claims 1
- 108010023321 Factor VII Proteins 0.000 claims 1
- 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 101800004937 Protein C Proteins 0.000 claims 1
- 102000017975 Protein C Human genes 0.000 claims 1
- 229940096437 Protein S Drugs 0.000 claims 1
- 102000029301 Protein S Human genes 0.000 claims 1
- 108010066124 Protein S Proteins 0.000 claims 1
- 101800001700 Saposin-D Proteins 0.000 claims 1
- 239000003114 blood coagulation factor Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940012413 factor vii Drugs 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 208000018706 hematopoietic system disease Diseases 0.000 claims 1
- 208000009429 hemophilia B Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 229960000856 protein c Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305071.9 | 2016-01-26 | ||
| EP16305071 | 2016-01-26 | ||
| PCT/EP2017/051569 WO2017129630A1 (en) | 2016-01-26 | 2017-01-25 | Anti-vwf d'd3 single-domain antibodies and polypeptides comprising thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511457A JP2019511457A (ja) | 2019-04-25 |
| JP2019511457A5 true JP2019511457A5 (enExample) | 2020-02-27 |
| JP7096458B2 JP7096458B2 (ja) | 2022-07-06 |
Family
ID=55409787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538749A Active JP7096458B2 (ja) | 2016-01-26 | 2017-01-25 | 抗ｖｗｆ ｄ’ｄ３単一ドメイン抗体及びそれを含むポリペプチド |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US10626186B2 (enExample) |
| EP (1) | EP3408299A1 (enExample) |
| JP (1) | JP7096458B2 (enExample) |
| WO (1) | WO2017129630A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| NZ780183A (en) | 2011-06-23 | 2024-12-20 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| CN108997501A (zh) * | 2018-09-01 | 2018-12-14 | 无锡傲锐东源生物科技有限公司 | 抗vwf蛋白单克隆抗体及其用途 |
| WO2024038112A1 (en) | 2022-08-17 | 2024-02-22 | Institut National de la Santé et de la Recherche Médicale | Improved anti-albumin nanobodies and their uses |
| WO2025038813A1 (en) * | 2023-08-16 | 2025-02-20 | Beam Therapeutics Inc. | Cd5-binding polypeptides, compositions comprising the same, and methods for use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ540771A (en) * | 2003-01-10 | 2009-05-31 | Ablynx Nv | Recombinant VHH single domain antibody from camelidae against von willebrand factor (vWF) or against collagen |
| CN101213214B (zh) | 2005-05-20 | 2014-06-25 | 埃博灵克斯股份有限公司 | 针对冯威勒布兰特因子的单一结构域vhh抗体 |
| DK3091997T5 (da) | 2014-01-10 | 2024-10-14 | Bioverativ Therapeutics Inc | Kimære faktor viii-proteiner og anvendelser deraf |
-
2017
- 2017-01-25 US US16/072,784 patent/US10626186B2/en active Active
- 2017-01-25 EP EP17702059.1A patent/EP3408299A1/en active Pending
- 2017-01-25 JP JP2018538749A patent/JP7096458B2/ja active Active
- 2017-01-25 WO PCT/EP2017/051569 patent/WO2017129630A1/en not_active Ceased
-
2020
- 2020-03-13 US US16/818,463 patent/US11560436B2/en active Active
-
2022
- 2022-12-20 US US18/068,694 patent/US20230203195A1/en active Pending
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