JP2008538564A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008538564A5 JP2008538564A5 JP2008507883A JP2008507883A JP2008538564A5 JP 2008538564 A5 JP2008538564 A5 JP 2008538564A5 JP 2008507883 A JP2008507883 A JP 2008507883A JP 2008507883 A JP2008507883 A JP 2008507883A JP 2008538564 A5 JP2008538564 A5 JP 2008538564A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence represented
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 5
- 229910052698 phosphorus Inorganic materials 0.000 claims 4
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 101500025614 Homo sapiens Transforming growth factor beta-1 Proteins 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67408205P | 2005-04-22 | 2005-04-22 | |
| US60/674,082 | 2005-04-22 | ||
| PCT/US2006/014943 WO2006116002A2 (en) | 2005-04-22 | 2006-04-20 | Tgf beta 1 specific antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008538564A JP2008538564A (ja) | 2008-10-30 |
| JP2008538564A5 true JP2008538564A5 (enExample) | 2009-06-18 |
| JP5070200B2 JP5070200B2 (ja) | 2012-11-07 |
Family
ID=37192643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008507883A Expired - Fee Related JP5070200B2 (ja) | 2005-04-22 | 2006-04-20 | Ｔｇｆベータ１に特異的な抗体 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7619069B2 (enExample) |
| EP (1) | EP1874818B1 (enExample) |
| JP (1) | JP5070200B2 (enExample) |
| KR (1) | KR100978684B1 (enExample) |
| CN (1) | CN101163719A (enExample) |
| AT (1) | ATE505489T1 (enExample) |
| AU (1) | AU2006240056B2 (enExample) |
| BR (1) | BRPI0608376A8 (enExample) |
| CA (1) | CA2607448C (enExample) |
| CY (1) | CY1111518T1 (enExample) |
| DE (1) | DE602006021292D1 (enExample) |
| DK (1) | DK1874818T3 (enExample) |
| EA (1) | EA016038B1 (enExample) |
| ES (1) | ES2361269T3 (enExample) |
| HR (1) | HRP20110334T1 (enExample) |
| IL (1) | IL186775A (enExample) |
| NO (1) | NO20076003L (enExample) |
| PL (1) | PL1874818T3 (enExample) |
| PT (1) | PT1874818E (enExample) |
| RS (1) | RS51845B (enExample) |
| SI (1) | SI1874818T1 (enExample) |
| UA (1) | UA93201C2 (enExample) |
| WO (1) | WO2006116002A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010036460A2 (en) * | 2008-09-29 | 2010-04-01 | Centocor Ortho Biotech Inc. | Anti-cd147 antibodies, methods, and uses |
| EP2364370B1 (en) * | 2008-11-22 | 2014-09-03 | Astute Medical, Inc. | Methods for prognosis of acute renal failure |
| WO2010077831A1 (en) * | 2008-12-16 | 2010-07-08 | Tod Lauerman | Targeted cytokine for treatment of diseases |
| EP2376110B1 (en) | 2009-01-09 | 2019-03-13 | Seattle Genetics, Inc. | Weekly dosing regimens for anti-cd30 vc-pab-mmae antibody drug-conjugates |
| EP2688908B1 (en) | 2011-03-23 | 2017-06-21 | Option Pharmaceuticals, LLC | Targeted cytokine for treatment of musculoskeletal diseases |
| LT2714735T (lt) * | 2011-06-03 | 2021-12-10 | Xoma Technology Ltd. | Tgf beta specifiniai antikūnai |
| HK1198689A1 (en) | 2011-10-25 | 2015-05-29 | Prothena Biosciences Limited | Antibody formulations and methods |
| EP2822592B1 (en) * | 2012-03-08 | 2018-08-15 | Ludwig Institute for Cancer Research Limited | Tgf- 1 specific antibodies and methods and uses thereof |
| WO2013134665A1 (en) | 2012-03-08 | 2013-09-12 | Selig Sealing Products, Inc. | Container sealing member with protected security component and removal tab |
| CN104662044B (zh) | 2012-08-24 | 2018-10-30 | 加利福尼亚大学董事会 | 用于治疗ror1癌症并抑制转移的抗体和疫苗 |
| PL2981822T3 (pl) | 2013-05-06 | 2021-07-12 | Scholar Rock, Inc. | Kompozycje i sposoby modulacji czynnika wzrostu |
| JP6416926B2 (ja) * | 2014-02-19 | 2018-10-31 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ガン標的化ｉｌ−１２免疫療法 |
| HK1245134A1 (zh) | 2015-01-14 | 2018-08-24 | The Brigham And Women's Hospital, Inc. | 用抗lap单克隆抗体治疗癌症 |
| TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體 |
| TWI726870B (zh) * | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體 |
| US11180546B2 (en) | 2016-02-17 | 2021-11-23 | Novartis Ag | TGFbeta 2 antibodies |
| WO2017143451A1 (en) * | 2016-02-26 | 2017-08-31 | Western University | Anti-cd11d antibodies and uses thereof |
| BR112018068340A2 (pt) | 2016-03-11 | 2019-01-15 | Scholar Rock Inc | imunoglobulinas de ligação ao tgfss1 e usos destas |
| AU2017268234A1 (en) | 2016-05-17 | 2018-12-13 | Genentech, Inc. | Stromal gene signatures for diagnosis and use in immunotherapy |
| AU2017268469C1 (en) * | 2016-05-20 | 2025-01-02 | President And Fellows Of Harvard College | Gene therapy methods for age-related diseases and conditions |
| KR20240113990A (ko) | 2016-06-27 | 2024-07-23 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 암 치료 조합 |
| WO2018043734A1 (en) * | 2016-09-05 | 2018-03-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-tgf-beta 1 antibodies and methods of use |
| EP3565839A4 (en) | 2017-01-05 | 2021-04-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| WO2019045086A1 (ja) * | 2017-08-29 | 2019-03-07 | 林化成株式会社 | 活性型もしくは潜在型ＴＧＦ−β１特異的抗体の用途 |
| WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | ANTI-LAP ANTIBODIES AND USES THEREOF |
| CA3077664A1 (en) | 2017-11-06 | 2019-05-09 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| US11001635B2 (en) | 2018-06-29 | 2021-05-11 | Gensun Biopharma Inc. | Antitumor antagonists |
| JP2022504839A (ja) | 2018-10-10 | 2022-01-13 | ティロス・セラピューティクス・インコーポレイテッド | 抗ｌａｐ抗体変異体及びその使用 |
| KR20210089215A (ko) | 2018-11-07 | 2021-07-15 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항-pd-1 항체의 공동-제제 |
| TW202043267A (zh) | 2019-01-30 | 2020-12-01 | 美商供石公司 | TGFβ之LTBP複合物專一性抑制劑及其用途 |
| EP3990116A1 (en) | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| WO2021142427A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | TGFβ INHIBITORS AND USE THEREOF |
| JP2023511255A (ja) | 2020-01-11 | 2023-03-17 | スカラー ロック インコーポレイテッド | ＴＧＦ－β阻害剤及びその使用 |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| IL309310A (en) * | 2021-06-18 | 2024-02-01 | Genzyme Corp | Antibody formulations against TGF-beta and their use |
| EP4370148A1 (en) | 2021-07-14 | 2024-05-22 | Scholar Rock, Inc. | Ltbp complex-specific inhibitors of tgf beta1 and uses thereof |
| WO2023080900A1 (en) | 2021-11-05 | 2023-05-11 | Genentech, Inc. | Methods and compositions for classifying and treating kidney cancer |
| EP4599088A1 (en) | 2022-10-05 | 2025-08-13 | Genentech, Inc. | Methods and compositions for classifying and treating lung cancer |
| WO2024077095A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating bladder cancer |
| WO2024187051A1 (en) | 2023-03-07 | 2024-09-12 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US7368111B2 (en) | 1995-10-06 | 2008-05-06 | Cambridge Antibody Technology Limited | Human antibodies specific for TGFβ2 |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| US7763580B2 (en) | 1999-01-05 | 2010-07-27 | University Of Utah Research Foundation | Methods for treating conditions associated with the accumulation of excess extracellular matrix |
| AU771635B2 (en) | 1999-01-05 | 2004-04-01 | American National Red Cross, The | Methods for treating conditions associated with the accumulation of excess extracellular matrix |
| US6492497B1 (en) * | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
| JP2006525362A (ja) | 2003-04-30 | 2006-11-09 | ジェンザイム コーポレーション | 腎機能不全を治療するためのＴＧＦ−βアンタゴニストとレニン−アンジオテンシン−アルドステロン系アンタゴニストとの併用 |
| EP1646655A2 (en) * | 2003-07-09 | 2006-04-19 | Eli Lilly And Company | Tgf-beta1 ligands |
| WO2005097832A2 (en) | 2004-03-31 | 2005-10-20 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
| AR049292A1 (es) | 2004-06-04 | 2006-07-12 | Genentech Inc | Metodo para tratar lupus con un anticuerpo cd20 |
| EP1931709B1 (en) | 2005-10-03 | 2016-12-07 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
-
2006
- 2006-04-20 AT AT06750860T patent/ATE505489T1/de active
- 2006-04-20 HR HR20110334T patent/HRP20110334T1/hr unknown
- 2006-04-20 UA UAA200711364A patent/UA93201C2/ru unknown
- 2006-04-20 AU AU2006240056A patent/AU2006240056B2/en not_active Ceased
- 2006-04-20 PT PT06750860T patent/PT1874818E/pt unknown
- 2006-04-20 ES ES06750860T patent/ES2361269T3/es active Active
- 2006-04-20 WO PCT/US2006/014943 patent/WO2006116002A2/en not_active Ceased
- 2006-04-20 SI SI200631049T patent/SI1874818T1/sl unknown
- 2006-04-20 CN CNA2006800135110A patent/CN101163719A/zh active Pending
- 2006-04-20 RS RS20110195A patent/RS51845B/sr unknown
- 2006-04-20 EA EA200702278A patent/EA016038B1/ru not_active IP Right Cessation
- 2006-04-20 JP JP2008507883A patent/JP5070200B2/ja not_active Expired - Fee Related
- 2006-04-20 BR BRPI0608376A patent/BRPI0608376A8/pt not_active IP Right Cessation
- 2006-04-20 DK DK06750860.6T patent/DK1874818T3/da active
- 2006-04-20 EP EP06750860A patent/EP1874818B1/en active Active
- 2006-04-20 PL PL06750860T patent/PL1874818T3/pl unknown
- 2006-04-20 CA CA2607448A patent/CA2607448C/en not_active Expired - Fee Related
- 2006-04-20 KR KR1020077024149A patent/KR100978684B1/ko not_active Expired - Fee Related
- 2006-04-20 DE DE602006021292T patent/DE602006021292D1/de active Active
-
2007
- 2007-10-18 IL IL186775A patent/IL186775A/en not_active IP Right Cessation
- 2007-10-19 US US11/874,952 patent/US7619069B2/en not_active Expired - Fee Related
- 2007-11-21 NO NO20076003A patent/NO20076003L/no not_active Application Discontinuation
-
2009
- 2009-10-15 US US12/579,447 patent/US8128927B2/en not_active Expired - Fee Related
-
2011
- 2011-05-13 CY CY20111100455T patent/CY1111518T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008538564A5 (enExample) | ||
| JP2009511480A5 (enExample) | ||
| JP2015522252A5 (enExample) | ||
| RU2421464C2 (ru) | Человеческие антитела к il-13 и их терапевтическое применение | |
| JP2022031635A5 (enExample) | ||
| JP2020518599A5 (enExample) | ||
| HRP20110334T1 (hr) | PROTUTIJELA SPECIFIČNA ZA TGF-ß1 | |
| JP2020002171A5 (enExample) | ||
| JP2006512899A5 (enExample) | ||
| JP2018127467A5 (enExample) | ||
| IL180364A (en) | Use of antibodies specifically related to amyloid-beta peptide in the manufacture of drugs for the treatment of diseases characterized by amyloid-beta deficiency, pharmaceutical compositions including them and methods for their preparation and methods for use thereof | |
| JP2006522830A5 (enExample) | ||
| JP2020500538A5 (enExample) | ||
| JP2011219478A5 (enExample) | ||
| JP2018507220A5 (enExample) | ||
| JP2007500236A5 (enExample) | ||
| RU2011142183A (ru) | Средство для лечения ревматоидного артрита | |
| JP2010500371A5 (enExample) | ||
| JP2013520996A5 (enExample) | ||
| JP2009505676A5 (enExample) | ||
| JP2009532336A5 (enExample) | ||
| WO2007115049A3 (en) | Humanized monoclonal antibodies to hepatocyte growth factor | |
| HRP20140604T1 (hr) | Sredstva koja djeluju na cd138 i njihova upotreba | |
| NZ615012A (en) | Combinatorial therapy involving alpha5beta1 antagonists | |
| JP2011501671A5 (enExample) |