JP2007500236A5 - - Google Patents

Info

Publication number

JP2007500236A5

JP2007500236A5 JP2006533495A JP2006533495A JP2007500236A5 JP 2007500236 A5 JP2007500236 A5 JP 2007500236A5 JP 2006533495 A JP2006533495 A JP 2006533495A JP 2006533495 A JP2006533495 A JP 2006533495A JP 2007500236 A5 JP2007500236 A5 JP 2007500236A5

Authority

JP

Japan

Prior art keywords

antibody

seq

amino acid

chain variable

acid sequence

Prior art date

2004-05-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 21
• 239000003814 drug Substances 0.000 claims 10
• 239000000611 antibody drug conjugate Substances 0.000 claims 9
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 9
• 229940079593 drug Drugs 0.000 claims 7
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 208000017604 Hodgkin disease Diseases 0.000 claims 3
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 3
• 125000006850 spacer group Chemical group 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1