|
US4331647A
(en)
|
1980-03-03 |
1982-05-25 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
|
|
DK368882A
(da)
|
1981-08-25 |
1983-02-26 |
Alan John Kingsman |
Expessions vektorer
|
|
US4579821A
(en)
|
1981-11-23 |
1986-04-01 |
University Patents, Inc. |
Control of DNA sequence transcription
|
|
US4656134A
(en)
|
1982-01-11 |
1987-04-07 |
Board Of Trustees Of Leland Stanford Jr. University |
Gene amplification in eukaryotic cells
|
|
US4486533A
(en)
|
1982-09-02 |
1984-12-04 |
St. Louis University |
Filamentous fungi functional replicating extrachromosomal element
|
|
US4599311A
(en)
|
1982-08-13 |
1986-07-08 |
Kawasaki Glenn H |
Glycolytic promotersfor regulated protein expression: protease inhibitor
|
|
US4977092A
(en)
|
1985-06-26 |
1990-12-11 |
Amgen |
Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
US5139936A
(en)
|
1983-02-28 |
1992-08-18 |
Collaborative Research, Inc. |
Use of the GAL1 yeast promoter
|
|
US4661454A
(en)
|
1983-02-28 |
1987-04-28 |
Collaborative Research, Inc. |
GAL1 yeast promoter linked to non galactokinase gene
|
|
US4870008A
(en)
|
1983-08-12 |
1989-09-26 |
Chiron Corporation |
Secretory expression in eukaryotes
|
|
US4931373A
(en)
|
1984-05-25 |
1990-06-05 |
Zymogenetics, Inc. |
Stable DNA constructs for expression of α-1 antitrypsin
|
|
US4766073A
(en)
|
1985-02-25 |
1988-08-23 |
Zymogenetics Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
ATE54167T1
(de)
|
1984-12-06 |
1990-07-15 |
Fina Research |
Promotoren fuer die expression von fremden genen in hefe, plasmide, die diese promotoren enthalten, sowie deren verwendung zur herstellung von polypeptiden.
|
|
US4751181A
(en)
|
1984-12-31 |
1988-06-14 |
Duke University |
Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
|
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
US4882279A
(en)
|
1985-10-25 |
1989-11-21 |
Phillips Petroleum Company |
Site selective genomic modification of yeast of the genus pichia
|
|
US4935349A
(en)
|
1986-01-17 |
1990-06-19 |
Zymogenetics, Inc. |
Expression of higher eucaryotic genes in aspergillus
|
|
GB8611832D0
(en)
|
1986-05-15 |
1986-06-25 |
Holland I B |
Polypeptide
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5063154A
(en)
|
1987-06-24 |
1991-11-05 |
Whitehead Institute For Biomedical Research |
Pheromone - inducible yeast promoter
|
|
US5637677A
(en)
|
1987-07-16 |
1997-06-10 |
The Trustees Of The University Of Pennsylvania |
Biologically active compounds and methods of constructing and using the same
|
|
EP0325224B1
(en)
|
1988-01-22 |
1996-07-31 |
ZymoGenetics, Inc. |
Methods of producing secreted receptor analogs
|
|
US5567584A
(en)
|
1988-01-22 |
1996-10-22 |
Zymogenetics, Inc. |
Methods of using biologically active dimerized polypeptide fusions to detect PDGF
|
|
US4956288A
(en)
|
1988-04-22 |
1990-09-11 |
Biogen, Inc. |
Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
|
|
US5037743A
(en)
|
1988-08-05 |
1991-08-06 |
Zymogenetics, Inc. |
BAR1 secretion signal
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5162228A
(en)
|
1988-12-28 |
1992-11-10 |
Takeda Chemical Industries, Ltd. |
Gylceraldehyde-3-phosphate dehydrogenase gene and promoter
|
|
US5162222A
(en)
|
1989-07-07 |
1992-11-10 |
Guarino Linda A |
Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
|
|
SG46445A1
(en)
|
1990-01-26 |
1998-02-20 |
Immunomedics Inc |
Vaccines against cancer and infectious diseases
|
|
EP0514488B1
(en)
|
1990-02-09 |
2000-09-13 |
The Salk Institute For Biological Studies |
Retinoid receptor compositions and methods
|
|
US5208146A
(en)
|
1990-11-05 |
1993-05-04 |
The Regents Of The University Of California |
Murine monoclonal anti-idiotype antibodies
|
|
AU5103293A
(en)
|
1992-09-14 |
1994-04-12 |
Oklahoma State University |
Immortalized cells and uses therefor
|
|
WO1994009137A1
(en)
|
1992-10-15 |
1994-04-28 |
Genentech, Inc. |
Antibodies against type 2 tumor necrosis factor receptor
|
|
US5595721A
(en)
|
1993-09-16 |
1997-01-21 |
Coulter Pharmaceutical, Inc. |
Radioimmunotherapy of lymphoma using anti-CD20
|
|
US5650550A
(en)
|
1993-10-01 |
1997-07-22 |
The United States Of America As Represented By The Department Of Health And Human Services |
Mutant mice having a deficit of functional estrogen receptors
|
|
US5523227A
(en)
|
1994-06-17 |
1996-06-04 |
The Board Of Trustees Of The Leland Stanford Junior Univ. |
DNA encoding calcium-signal modulating cyclophilin ligand
|
|
CN1105725C
(zh)
|
1994-12-15 |
2003-04-16 |
耶达研究与发展有限公司 |
Fas/ap01受体功能的调节物
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
DE19533447C1
(de)
|
1995-09-09 |
1996-12-05 |
Bbs Kraftfahrzeugtechnik |
Verfahren und Vorrichtung zum Befüllen eines Gießwerkzeugs mit einer Metallschmelze
|
|
US5965389A
(en)
|
1995-11-09 |
1999-10-12 |
Zymogenetics, Inc. |
Production of GAD65 in methylotrophic yeast
|
|
US5716808A
(en)
|
1995-11-09 |
1998-02-10 |
Zymogenetics, Inc. |
Genetic engineering of pichia methanolica
|
|
PT897390E
(pt)
|
1996-03-14 |
2004-03-31 |
Human Genome Sciences Inc |
Factor delta e epsilon de necrose tumoral humana
|
|
JP2002514049A
(ja)
|
1996-07-17 |
2002-05-14 |
ザイモジェネティクス,インコーポレイティド |
ピヒア・メタノリカの栄養要求性突然変異体の製造
|
|
JP2002515746A
(ja)
|
1996-07-17 |
2002-05-28 |
ザイモジェネティクス,インコーポレイティド |
ピヒア・メタノリカの形質転換
|
|
US5736383A
(en)
|
1996-08-26 |
1998-04-07 |
Zymogenetics, Inc. |
Preparation of Pichia methanolica auxotrophic mutants
|
|
US6689579B1
(en)
|
1996-10-25 |
2004-02-10 |
Human Genome Sciences, Inc. |
Polynucleotides encoding neutrokine-α
|
|
EP0939804B2
(en)
|
1996-10-25 |
2011-06-15 |
Human Genome Sciences, Inc. |
NEUTROKINE alpha
|
|
AU5705898A
(en)
|
1996-12-17 |
1998-07-15 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
US5969102A
(en)
|
1997-03-03 |
1999-10-19 |
St. Jude Children's Research Hospital |
Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
|
|
CA2232743A1
(en)
|
1997-04-02 |
1998-10-02 |
Smithkline Beecham Corporation |
A tnf homologue, tl5
|
|
WO1998055620A1
(en)
|
1997-06-06 |
1998-12-10 |
Regeneron Pharmaceuticals, Inc. |
Ntn-2 member of tnf ligand family
|
|
JP2002517977A
(ja)
|
1997-06-06 |
2002-06-18 |
リジェネロン ファーマシューティカルズ,インコーポレイテッド |
Tnfリガンドファミリーのntn−2メンバー
|
|
AU9013998A
(en)
|
1997-07-21 |
1999-02-10 |
Zymogenetics Inc. |
Tumor necrosis factor receptor ztnfr-5
|
|
US6015801A
(en)
|
1997-07-22 |
2000-01-18 |
Merck & Co., Inc. |
Method for inhibiting bone resorption
|
|
AU9376498A
(en)
|
1997-09-05 |
1999-03-22 |
University Of Washington |
Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
|
|
CZ294615B6
(cs)
|
1997-09-12 |
2005-02-16 |
Apotech R & D Sa |
Léčivo obsahující protilátky reaktivní s polypeptidovým ligandem APRIL pro léčení rakoviny
|
|
AU9315298A
(en)
|
1997-09-12 |
1999-03-29 |
Apotech S.A. |
Kay - a novel immune system protein
|
|
DE19831987A1
(de)
|
1998-07-16 |
2000-01-20 |
Bayer Ag |
Diphenylimidazoline
|
|
GB9828628D0
(en)
|
1998-12-23 |
1999-02-17 |
Glaxo Group Ltd |
Novel ligand
|
|
AU781577B2
(en)
|
1998-12-30 |
2005-06-02 |
Lakewood-Amedex, Inc. |
Therapeutic phosphodiesterase inhibitors
|
|
US20060067933A1
(en)
|
1999-01-07 |
2006-03-30 |
Gross Jane A |
Soluble receptor BR43x2 and methods of using
|
|
US7833529B1
(en)
|
1999-01-07 |
2010-11-16 |
Zymogenetics, Inc. |
Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
|
|
SK288176B6
(sk)
|
1999-01-07 |
2014-04-02 |
Zymogenetics, Inc. |
Farmaceutický prostriedok obsahujúci fúzny proteín, izolovaná molekula polynukleotidu, expresný vektor, kultivovaná bunka, spôsob prípravy polypeptidu a izolovaný polypeptid
|
|
MXPA01007464A
(es)
|
1999-01-25 |
2003-06-06 |
Apoxis Sa |
Baff, inhibidores del mismo y su uso en la modulacion de la respuesta de celula b.
|
|
NZ513290A
(en)
|
1999-02-23 |
2004-05-28 |
Human Genome Sciences Inc |
Neutrokine-alpha and neutrokine-alpha splice variant
|
|
WO2000062790A2
(en)
|
1999-04-19 |
2000-10-26 |
Immunex Corporation |
Soluble tumor necrosis factor receptor treatment of medical disorders
|
|
US20030022233A1
(en)
|
1999-04-30 |
2003-01-30 |
Raymond G. Goodwin |
Methods of use of the taci/taci-l interaction
|
|
JP2003501043A
(ja)
*
|
1999-05-28 |
2003-01-14 |
ターゲティッド ジェネティクス コーポレイション |
腫瘍壊死因子(tnf)関連障害において、tnfのレベルを低下させるための方法および組成物
|
|
KR20090016772A
(ko)
|
1999-08-17 |
2009-02-17 |
바이오겐 아이덱 엠에이 인코포레이티드 |
Baff 수용체(bcma), 면역조절제
|
|
UA74798C2
(uk)
|
1999-10-06 |
2006-02-15 |
Байоджен Айдек Ма Інк. |
Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
|
|
JP5062606B2
(ja)
|
2000-02-16 |
2012-10-31 |
ジェネンテック, インコーポレイテッド |
Tnf関連分子の活性を調節するためのアゴニスト及びアンタゴニストの使用
|
|
AU2006201471B2
(en)
*
|
2000-02-16 |
2009-07-23 |
Genentech, Inc. |
Uses of agonists and antagonists to modulate activity of TNF-related molecules
|
|
ES2637801T3
(es)
|
2000-04-11 |
2017-10-17 |
Genentech, Inc. |
Anticuerpos multivalentes y usos de los mismos
|
|
US20040013674A1
(en)
*
|
2001-04-27 |
2004-01-22 |
Christine Ambrose |
Taci as an anti-tumor agent
|
|
SI1297013T1
(sl)
|
2000-04-27 |
2007-06-30 |
Biogen Idec Inc |
Uporaba TACI kot protitumorskega sredstva
|
|
EP1280826B1
(en)
|
2000-05-12 |
2007-05-02 |
Amgen Inc. |
Polypeptides for inhibiting april-mediated b- and t-cell proliferation.
|
|
EP1310554B1
(en)
|
2000-08-11 |
2010-05-26 |
Kyowa Hakko Kirin Co., Ltd. |
Polypeptides controlling phosphoric acid metabolism, calcium metabolism, calcification and vitamin d metabolism and dnas encoding the same
|
|
CA2428242A1
(en)
|
2000-11-07 |
2002-05-16 |
Zymogenetics, Inc. |
Human tumor necrosis factor receptor
|
|
WO2002066516A2
(en)
|
2001-02-20 |
2002-08-29 |
Zymogenetics, Inc. |
Antibodies that bind both bcma and taci
|
|
KR100976743B1
(ko)
|
2001-05-24 |
2010-08-19 |
지모제넥틱스, 인코포레이티드 |
Taci-면역글로불린 융합 단백질
|
|
CN1636067A
(zh)
*
|
2001-08-03 |
2005-07-06 |
杰南技术公司 |
TACls和BR3多肽及其用途
|
|
US8263637B2
(en)
|
2002-05-17 |
2012-09-11 |
Celgene Corporation |
Methods for treatment of multiple myeloma using cyclopropane carboxylic acid {2-[(is)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1 h-isoindol-4-yl}-amide
|
|
AU2004256042A1
(en)
*
|
2003-06-05 |
2005-01-20 |
Genentech, Inc. |
BlyS antagonists and uses thereof
|
|
US20050163775A1
(en)
|
2003-06-05 |
2005-07-28 |
Genentech, Inc. |
Combination therapy for B cell disorders
|
|
KR20070001880A
(ko)
*
|
2003-10-20 |
2007-01-04 |
바이오겐 아이덱 엠에이 인코포레이티드 |
Bαff 길항제를 위한 치료 섭생법
|
|
AU2006278229B2
(en)
|
2005-08-09 |
2011-10-27 |
Ares Trading S.A. |
Methods for treating B-cell malignancies using TACI-Ig fusion molecule
|
|
WO2007019573A2
(en)
|
2005-08-09 |
2007-02-15 |
Zymogenetics, Inc. |
Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
|