UA98462C2 - Способы лечения аутоиммунных заболеваний с использованием слитой молекулы taci-ig - Google Patents
Способы лечения аутоиммунных заболеваний с использованием слитой молекулы taci-igInfo
- Publication number
- UA98462C2 UA98462C2 UAA200814333A UAA200814333A UA98462C2 UA 98462 C2 UA98462 C2 UA 98462C2 UA A200814333 A UAA200814333 A UA A200814333A UA A200814333 A UAA200814333 A UA A200814333A UA 98462 C2 UA98462 C2 UA 98462C2
- Authority
- UA
- Ukraine
- Prior art keywords
- taci
- autoimmune diseases
- fusion molecule
- methods
- treating autoimmune
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 230000004927 fusion Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000037396 body weight Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108700002718 TACI receptor-IgG Fc fragment fusion Proteins 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/242—Gold; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Заявленное изобретение раскрывает способы и композиции для лечения аутоиммунных заболеваний, в том числе ревматоидного артрита, предусматривающих введение нуждающемуся в таком лечении пациенту слитой молекулы TACI-Ig, где указанную композицию вводят в количестве от 0,01 до 10 мг/кг массы тела пациента 7 раз на протяжении двенадцатинедельного интервала; или 3 раза на протяжении четырехнедельного интервала; или каждую вторую неделю на протяжении 2-30 недель; или один раз в неделю.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74727006P | 2006-05-15 | 2006-05-15 | |
PCT/US2007/068982 WO2007134326A2 (en) | 2006-05-15 | 2007-05-15 | Methods for treating autoimmune diseases using a taci-ig fusion molecule |
Publications (1)
Publication Number | Publication Date |
---|---|
UA98462C2 true UA98462C2 (ru) | 2012-05-25 |
Family
ID=38694783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200814333A UA98462C2 (ru) | 2006-05-15 | 2007-05-15 | Способы лечения аутоиммунных заболеваний с использованием слитой молекулы taci-ig |
Country Status (17)
Country | Link |
---|---|
US (1) | US8784812B2 (ru) |
EP (1) | EP2035028A2 (ru) |
JP (2) | JP2009537563A (ru) |
KR (1) | KR20090016707A (ru) |
CN (1) | CN101489573B (ru) |
AR (1) | AR060935A1 (ru) |
AU (1) | AU2007249223B2 (ru) |
BR (1) | BRPI0711823A2 (ru) |
CA (1) | CA2651791A1 (ru) |
EA (1) | EA015342B1 (ru) |
EC (1) | ECSP088982A (ru) |
IL (1) | IL195243A0 (ru) |
MX (1) | MX2008014365A (ru) |
NZ (1) | NZ572373A (ru) |
UA (1) | UA98462C2 (ru) |
WO (1) | WO2007134326A2 (ru) |
ZA (1) | ZA200809202B (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA030313B1 (ru) | 2007-03-27 | 2018-07-31 | Займодженетикс, Инк. | СПОСОБ СНИЖЕНИЯ УРОВНЕЙ IgM, IgG И IgA У МЛЕКОПИТАЮЩИХ И КОМПОЗИЦИЯ ДЛЯ ОСУЩЕСТВЛЕНИЯ ЭТОГО СПОСОБА |
PL2167038T3 (pl) * | 2007-06-13 | 2018-10-31 | Zymogenetics, Inc. | Zastosowanie białka fuzyjnego TACI-lg, takiego jak atacicept, do wytwarzania leku do leczenia tocznia rumieniowatego |
WO2009052293A1 (en) | 2007-10-16 | 2009-04-23 | Zymogenetics, Inc. | Combination of blys inhibition and anti-cd 20 agents for treatment of autoimmune disease |
WO2011109280A1 (en) * | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Methods and compositions to treat immune-mediated disorders |
RU2594433C2 (ru) * | 2010-11-26 | 2016-08-20 | Хемикс Б.В. | Устройство и способ определения активности болезни |
WO2016003876A1 (en) | 2014-07-03 | 2016-01-07 | Oklahoma Medical Research Foundation | Treatment of multiple sclerosis and neuromyelitis optica |
KR20230029622A (ko) | 2020-05-08 | 2023-03-03 | 알파인 이뮨 사이언시즈, 인코포레이티드 | April 및 baff 억제 면역조절 단백질 및 사용 방법 |
IL308336A (en) * | 2021-05-07 | 2024-01-01 | Alpine Immune Sciences Inc | Methods of dosing and treatment with TACI-FC modulatory fusion protein |
WO2023051660A1 (zh) * | 2021-09-30 | 2023-04-06 | 荣昌生物制药(烟台)股份有限公司 | 用TACI-Fc融合蛋白治疗干燥综合征的方法 |
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-
2007
- 2007-05-15 NZ NZ572373A patent/NZ572373A/en not_active IP Right Cessation
- 2007-05-15 EP EP07797482A patent/EP2035028A2/en not_active Ceased
- 2007-05-15 US US11/748,978 patent/US8784812B2/en not_active Expired - Fee Related
- 2007-05-15 UA UAA200814333A patent/UA98462C2/ru unknown
- 2007-05-15 AR ARP070102090A patent/AR060935A1/es unknown
- 2007-05-15 WO PCT/US2007/068982 patent/WO2007134326A2/en active Application Filing
- 2007-05-15 BR BRPI0711823-6A patent/BRPI0711823A2/pt not_active IP Right Cessation
- 2007-05-15 CN CN2007800262144A patent/CN101489573B/zh not_active Expired - Fee Related
- 2007-05-15 AU AU2007249223A patent/AU2007249223B2/en not_active Ceased
- 2007-05-15 KR KR1020087030524A patent/KR20090016707A/ko not_active Application Discontinuation
- 2007-05-15 CA CA002651791A patent/CA2651791A1/en not_active Abandoned
- 2007-05-15 MX MX2008014365A patent/MX2008014365A/es not_active Application Discontinuation
- 2007-05-15 EA EA200870535A patent/EA015342B1/ru not_active IP Right Cessation
- 2007-05-15 JP JP2009511209A patent/JP2009537563A/ja active Pending
-
2008
- 2008-10-27 ZA ZA2008/09202A patent/ZA200809202B/en unknown
- 2008-11-12 IL IL195243A patent/IL195243A0/en not_active IP Right Cessation
- 2008-12-12 EC EC2008008982A patent/ECSP088982A/es unknown
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2013
- 2013-01-04 JP JP2013000231A patent/JP2013100313A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN101489573B (zh) | 2013-05-22 |
EA200870535A1 (ru) | 2009-04-28 |
WO2007134326A3 (en) | 2008-04-17 |
KR20090016707A (ko) | 2009-02-17 |
US20070274984A1 (en) | 2007-11-29 |
MX2008014365A (es) | 2008-11-27 |
US8784812B2 (en) | 2014-07-22 |
WO2007134326A2 (en) | 2007-11-22 |
ECSP088982A (es) | 2009-01-30 |
BRPI0711823A2 (pt) | 2012-01-17 |
EA015342B1 (ru) | 2011-06-30 |
AU2007249223A1 (en) | 2007-11-22 |
ZA200809202B (en) | 2009-12-30 |
AR060935A1 (es) | 2008-07-23 |
JP2013100313A (ja) | 2013-05-23 |
EP2035028A2 (en) | 2009-03-18 |
IL195243A0 (en) | 2011-08-01 |
JP2009537563A (ja) | 2009-10-29 |
AU2007249223B2 (en) | 2012-08-02 |
CA2651791A1 (en) | 2007-11-22 |
NZ572373A (en) | 2012-02-24 |
CN101489573A (zh) | 2009-07-22 |
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