JP2003519228A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003519228A5 JP2003519228A5 JP2001550222A JP2001550222A JP2003519228A5 JP 2003519228 A5 JP2003519228 A5 JP 2003519228A5 JP 2001550222 A JP2001550222 A JP 2001550222A JP 2001550222 A JP2001550222 A JP 2001550222A JP 2003519228 A5 JP2003519228 A5 JP 2003519228A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- general formula
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 21
- 150000003839 salts Chemical class 0.000 description 21
- 0 CC(C(C)(CC1*(*)*)CN1C(NCc1c(*)c(I)c(C(*)=O)c(*)c1*)=C)IC* Chemical compound CC(C(C)(CC1*(*)*)CN1C(NCc1c(*)c(I)c(C(*)=O)c(*)c1*)=C)IC* 0.000 description 10
- 125000000217 alkyl group Chemical group 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 229910052717 sulfur Inorganic materials 0.000 description 6
- 239000000203 mixture Substances 0.000 description 4
- 206010046543 Urinary incontinence Diseases 0.000 description 3
- 208000031169 hemorrhagic disease Diseases 0.000 description 3
- 206010029446 nocturia Diseases 0.000 description 3
- 208000003450 Neurogenic Diabetes Insipidus Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 208000028235 central diabetes insipidus Diseases 0.000 description 2
- 201000010064 diabetes insipidus Diseases 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 201000005119 neurohypophyseal diabetes insipidus Diseases 0.000 description 2
- -1 2-methyl-4- (2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl) benzylcarbamoyl Chemical group 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000001538 azepines Chemical class 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000005346 nocturnal enuresis Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0000079.4A GB0000079D0 (en) | 2000-01-05 | 2000-01-05 | Novel antidiuretic agents |
| GB0000079.4 | 2000-01-05 | ||
| PCT/GB2001/000023 WO2001049682A1 (en) | 2000-01-05 | 2001-01-04 | Condensed azepines as vasopressin agonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005366100A Division JP3813629B2 (ja) | 2000-01-05 | 2005-12-20 | バソプレッシン・アゴニストとしての縮合アゼピン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003519228A JP2003519228A (ja) | 2003-06-17 |
| JP2003519228A5 true JP2003519228A5 (enExample) | 2006-02-23 |
| JP3869723B2 JP3869723B2 (ja) | 2007-01-17 |
Family
ID=9883168
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001550222A Expired - Fee Related JP3869723B2 (ja) | 2000-01-05 | 2001-01-04 | バソプレッシン・アゴニストとしての縮合アゼピン |
| JP2005366100A Expired - Fee Related JP3813629B2 (ja) | 2000-01-05 | 2005-12-20 | バソプレッシン・アゴニストとしての縮合アゼピン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005366100A Expired - Fee Related JP3813629B2 (ja) | 2000-01-05 | 2005-12-20 | バソプレッシン・アゴニストとしての縮合アゼピン |
Country Status (34)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5803659A (en) | 1995-12-08 | 1998-09-08 | Chattey; Nigel | Modular caissons for use in constructing, expanding and modernizing ports and harbors. |
| US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
| GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
| AU2001252222B2 (en) * | 2000-03-27 | 2006-11-02 | Merck Serono Sa | Pharmaceutically active pyrrolidine derivatives as bax inhibitors |
| EA006424B1 (ru) * | 2000-03-27 | 2005-12-29 | Апплайд Резеч Системз Арс Холдинг Н.В. | Фармацевтически активные производные пирролидина |
| GB0015601D0 (en) | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
| GB0115515D0 (en) * | 2001-06-25 | 2001-08-15 | Ferring Bv | Oxytocin agonisys |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| NZ542815A (en) | 2003-04-28 | 2009-01-31 | Astellas Pharma Inc | 4,4-Difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof |
| DE60305043T2 (de) * | 2003-11-13 | 2006-11-30 | Ferring B.V. | Blisterverpackung und feste Dosierungsform enthaltend Desmopressin |
| EP1813603A1 (en) * | 2004-11-17 | 2007-08-01 | Kissei Pharmaceutical Co., Ltd. | Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both |
| JP5009785B2 (ja) * | 2005-03-25 | 2012-08-22 | キッセイ薬品工業株式会社 | ウレア誘導体、それを含有する医薬組成物およびそれらの医薬用途 |
| WO2007052517A1 (ja) * | 2005-10-31 | 2007-05-10 | Sumitomo Chemical Company, Limited | ヒドロキシ－２－ピロリジンカルボキシアミド化合物の製法 |
| WO2008038600A1 (en) * | 2006-09-25 | 2008-04-03 | Kissei Pharmaceutical Co., Ltd. | 1,4-benzodiazepine derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes |
| CN101686983A (zh) * | 2007-05-10 | 2010-03-31 | Amr科技公司 | 芳基和杂芳基取代的四氢苯并-1,4-二氮杂䓬及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途 |
| RU2472539C2 (ru) | 2007-08-06 | 2013-01-20 | Аллерган, Инк. | Способы и устройства для доставки препарата десмопрессина |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| DK3225250T3 (da) * | 2008-05-21 | 2019-11-04 | Ferring Bv | Orodispersibel desmopressin til forlængelse af den indledende søvnperiode, som ikke forstyrres af nykturi |
| GB201005623D0 (en) | 2010-04-01 | 2010-05-19 | Vantia Ltd | New polymorph |
| GB201105537D0 (en) * | 2011-03-31 | 2011-05-18 | Vantia Ltd | New process |
| WO2020154581A1 (en) | 2019-01-24 | 2020-07-30 | Assia Chemical Industries Ltd | Solid state forms of fedovapagon-salicyclic acid co-crystal |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960886A (en) | 1968-07-03 | 1976-06-01 | Sterling Drug Inc. | Substituted N-arylanilines |
| CH599752A5 (enExample) | 1973-04-18 | 1978-05-31 | Ciba Geigy Ag | |
| CA1047490A (en) | 1973-04-18 | 1979-01-30 | Friedrich Karrer | Ethers |
| DE2355454A1 (de) | 1973-11-07 | 1976-10-07 | Paul Geisslinger | Lochmaschine |
| EP0186817B1 (en) | 1984-12-10 | 1989-08-02 | Nissan Chemical Industries Ltd. | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
| WO1991005549A1 (en) | 1989-10-20 | 1991-05-02 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
| US5753677A (en) | 1989-10-20 | 1998-05-19 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
| CA2066104C (en) | 1991-04-19 | 2003-05-27 | Hidenori Ogawa | Benzazepine derivatives as vasopressin antagonists |
| JPH05320135A (ja) * | 1992-05-19 | 1993-12-03 | Yamanouchi Pharmaceut Co Ltd | テトラヒドロベンズアゼピン誘導体 |
| US5498609A (en) | 1992-08-20 | 1996-03-12 | Otsuka Pharmaceutical Company, Limited | Benzoazepinyl compounds as oxytocin and vasopressin antagonists |
| TW270927B (enExample) * | 1992-10-16 | 1996-02-21 | Otsuka Pharma Co Ltd | |
| WO1994012476A1 (fr) * | 1992-11-25 | 1994-06-09 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de benzanilide |
| WO1994020473A1 (fr) * | 1993-03-11 | 1994-09-15 | Yamanouchi Pharmaceutical Co., Ltd. | Compose avec action antagoniste de la vasopressine |
| GB9307527D0 (en) | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| US5760031A (en) | 1993-07-29 | 1998-06-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5968930A (en) | 1993-07-29 | 1999-10-19 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5516774A (en) | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5843952A (en) | 1993-07-29 | 1998-12-01 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US6403577B1 (en) * | 1993-11-17 | 2002-06-11 | Eli Lilly And Company | Hexamethyleneiminyl tachykinin receptor antagonists |
| FI1215U1 (fi) * | 1993-12-03 | 1994-02-21 | Valmet Paper Machinery Inc | Anlaeggning i samband med styrningen av en vira |
| FR2716194B1 (fr) * | 1994-02-14 | 1996-05-31 | Sanofi Elf | Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
| WO1995031034A2 (en) * | 1994-05-06 | 1995-11-16 | Philips Electronics N.V. | Microwave transmission system |
| DK1221440T3 (da) | 1994-06-15 | 2007-09-17 | Otsuka Pharma Co Ltd | Benzoheterocykliske derivater der er nyttige som vasopressin- eller oxytocinmodulatorer |
| JP2926335B2 (ja) * | 1997-06-13 | 1999-07-28 | 大塚製薬株式会社 | 医薬組成物 |
| EP1000059B1 (en) * | 1997-07-30 | 2004-09-29 | Wyeth | Tricyclic vasopressin agonists |
| JP4338305B2 (ja) * | 1997-07-30 | 2009-10-07 | ワイス | 三環系バソプレシンアゴニスト |
| ES2216579T3 (es) | 1998-10-09 | 2004-10-16 | Janssen Pharmaceutica N.V. | Derivados de 4,5-dihidro-isoxazol y su uso farmaceutico. |
| GB2355454A (en) | 1999-10-20 | 2001-04-25 | Ferring Bv | Antidiuretic agents |
| GB0000079D0 (en) | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
| GB0015601D0 (en) | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
| DE10033337A1 (de) | 2000-07-08 | 2002-01-17 | Boehringer Ingelheim Pharma | Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| GB0120051D0 (en) | 2001-08-16 | 2001-10-10 | Ferring Bv | Oxytocin agonists |
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| EP1449844A1 (en) | 2003-02-14 | 2004-08-25 | Ferring B.V. | benzamide derivatives as oxytocin agonists and vasopressin antagonists |
| EP1627876A1 (en) | 2004-08-20 | 2006-02-22 | Ferring B.V. | Heterocyclic condensed compounds useful as antidiuretic agents |
| US7341963B2 (en) * | 2005-05-17 | 2008-03-11 | Milliken & Company | Non-woven material with barrier skin |
-
2000
- 2000-01-05 GB GBGB0000079.4A patent/GB0000079D0/en not_active Ceased
-
2001
- 2001-01-04 MY MYPI20010027A patent/MY140467A/en unknown
- 2001-01-04 PT PT01900169T patent/PT1248784E/pt unknown
- 2001-01-04 AR ARP010100035A patent/AR035327A1/es active IP Right Grant
- 2001-01-04 KR KR1020027006382A patent/KR100605466B1/ko not_active Expired - Fee Related
- 2001-01-04 SK SK911-2002A patent/SK287005B6/sk not_active IP Right Cessation
- 2001-01-04 CZ CZ20022305A patent/CZ303444B6/cs not_active IP Right Cessation
- 2001-01-04 US US10/130,749 patent/US7074781B2/en not_active Expired - Lifetime
- 2001-01-04 HR HR20020481A patent/HRP20020481B1/xx not_active IP Right Cessation
- 2001-01-04 UY UY26521A patent/UY26521A1/es not_active IP Right Cessation
- 2001-01-04 DK DK01900169T patent/DK1248784T3/da active
- 2001-01-04 BR BRPI0107414-8A patent/BR0107414B1/pt not_active IP Right Cessation
- 2001-01-04 EP EP01900169A patent/EP1248784B1/en not_active Expired - Lifetime
- 2001-01-04 AT AT01900169T patent/ATE366730T1/de active
- 2001-01-04 PL PL355808A patent/PL211341B1/pl unknown
- 2001-01-04 NZ NZ518803A patent/NZ518803A/xx not_active IP Right Cessation
- 2001-01-04 RU RU2002120798/04A patent/RU2259367C2/ru not_active IP Right Cessation
- 2001-01-04 IL IL14952801A patent/IL149528A0/xx active IP Right Grant
- 2001-01-04 EE EEP200200367A patent/EE200200367A/xx unknown
- 2001-01-04 MX MXPA02006546A patent/MXPA02006546A/es active IP Right Grant
- 2001-01-04 JP JP2001550222A patent/JP3869723B2/ja not_active Expired - Fee Related
- 2001-01-04 WO PCT/GB2001/000023 patent/WO2001049682A1/en not_active Ceased
- 2001-01-04 ES ES01900169T patent/ES2288923T3/es not_active Expired - Lifetime
- 2001-01-04 CA CA2396277A patent/CA2396277C/en not_active Expired - Lifetime
- 2001-01-04 SI SI200130766T patent/SI1248784T1/sl unknown
- 2001-01-04 CN CNB018031323A patent/CN1183129C/zh not_active Expired - Fee Related
- 2001-01-04 DE DE60129298T patent/DE60129298T2/de not_active Expired - Lifetime
- 2001-01-04 AU AU23846/01A patent/AU777538B2/en not_active Ceased
- 2001-01-04 HK HK02108525.5A patent/HK1046910B/en not_active IP Right Cessation
- 2001-01-04 HU HU0203917A patent/HU229937B1/hu not_active IP Right Cessation
- 2001-04-01 UA UA2002075517A patent/UA73152C2/uk unknown
-
2002
- 2002-06-27 NO NO20023137A patent/NO322571B1/no not_active IP Right Cessation
- 2002-06-27 ZA ZA200205180A patent/ZA200205180B/en unknown
-
2005
- 2005-12-20 JP JP2005366100A patent/JP3813629B2/ja not_active Expired - Fee Related
-
2006
- 2006-03-09 US US11/370,861 patent/US7560454B2/en not_active Expired - Fee Related
-
2007
- 2007-10-04 CY CY20071101261T patent/CY1108034T1/el unknown
-
2008
- 2008-06-23 US US12/213,651 patent/US20080261951A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003519228A5 (enExample) | ||
| JP2002532392A5 (enExample) | ||
| JP2006526590A5 (enExample) | ||
| JP2003509349A5 (enExample) | ||
| JP2004514663A5 (enExample) | ||
| JP2001526218A5 (enExample) | ||
| JP2006503850A5 (enExample) | ||
| JP2008501705A5 (enExample) | ||
| JP2006523216A5 (enExample) | ||
| JP2002519434A5 (enExample) | ||
| JP2004504406A5 (enExample) | ||
| JP2012525393A5 (enExample) | ||
| JP2006507220A5 (enExample) | ||
| RU2002120798A (ru) | Конденсированные азепины в качестве агонистов вазопрессина | |
| JP2010511701A5 (enExample) | ||
| JP2002519425A5 (enExample) | ||
| JP2006516643A5 (enExample) | ||
| JP2002544227A5 (enExample) | ||
| JP2002534477A (ja) | メラガトランの新規使用 | |
| JP2002534477A5 (enExample) | ||
| CA2589744A1 (en) | Pyrrolinidium derivatives as m3 muscarinic receptors | |
| JP2007525533A5 (enExample) | ||
| JP2002540148A5 (enExample) | ||
| JP2003528144A5 (enExample) | ||
| JPH1087484A5 (enExample) |