UY26521A1 - Nuevos agentes antidiuréticos - Google Patents

Nuevos agentes antidiuréticos

Info

Publication number
UY26521A1
UY26521A1 UY26521A UY26521A UY26521A1 UY 26521 A1 UY26521 A1 UY 26521A1 UY 26521 A UY26521 A UY 26521A UY 26521 A UY26521 A UY 26521A UY 26521 A1 UY26521 A1 UY 26521A1
Authority
UY
Uruguay
Prior art keywords
lower alkyl
new
ome
acyl
vasopressin
Prior art date
Application number
UY26521A
Other languages
English (en)
Spanish (es)
Inventor
Doreen M Ashworth
Gary R W Pitt
Peter Hudson
Richard J Franklin
Christopher M Yea
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of UY26521A1 publication Critical patent/UY26521A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UY26521A 2000-01-05 2001-01-04 Nuevos agentes antidiuréticos UY26521A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0000079.4A GB0000079D0 (en) 2000-01-05 2000-01-05 Novel antidiuretic agents

Publications (1)

Publication Number Publication Date
UY26521A1 true UY26521A1 (es) 2001-03-16

Family

ID=9883168

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26521A UY26521A1 (es) 2000-01-05 2001-01-04 Nuevos agentes antidiuréticos

Country Status (34)

Country Link
US (3) US7074781B2 (enExample)
EP (1) EP1248784B1 (enExample)
JP (2) JP3869723B2 (enExample)
KR (1) KR100605466B1 (enExample)
CN (1) CN1183129C (enExample)
AR (1) AR035327A1 (enExample)
AT (1) ATE366730T1 (enExample)
AU (1) AU777538B2 (enExample)
BR (1) BR0107414B1 (enExample)
CA (1) CA2396277C (enExample)
CY (1) CY1108034T1 (enExample)
CZ (1) CZ303444B6 (enExample)
DE (1) DE60129298T2 (enExample)
DK (1) DK1248784T3 (enExample)
EE (1) EE200200367A (enExample)
ES (1) ES2288923T3 (enExample)
GB (1) GB0000079D0 (enExample)
HK (1) HK1046910B (enExample)
HR (1) HRP20020481B1 (enExample)
HU (1) HU229937B1 (enExample)
IL (1) IL149528A0 (enExample)
MX (1) MXPA02006546A (enExample)
MY (1) MY140467A (enExample)
NO (1) NO322571B1 (enExample)
NZ (1) NZ518803A (enExample)
PL (1) PL211341B1 (enExample)
PT (1) PT1248784E (enExample)
RU (1) RU2259367C2 (enExample)
SI (1) SI1248784T1 (enExample)
SK (1) SK287005B6 (enExample)
UA (1) UA73152C2 (enExample)
UY (1) UY26521A1 (enExample)
WO (1) WO2001049682A1 (enExample)
ZA (1) ZA200205180B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5803659A (en) 1995-12-08 1998-09-08 Chattey; Nigel Modular caissons for use in constructing, expanding and modernizing ports and harbors.
US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
AU2001252222B2 (en) * 2000-03-27 2006-11-02 Merck Serono Sa Pharmaceutically active pyrrolidine derivatives as bax inhibitors
EA006424B1 (ru) * 2000-03-27 2005-12-29 Апплайд Резеч Системз Арс Холдинг Н.В. Фармацевтически активные производные пирролидина
GB0015601D0 (en) 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
NZ542815A (en) 2003-04-28 2009-01-31 Astellas Pharma Inc 4,4-Difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof
DE60305043T2 (de) * 2003-11-13 2006-11-30 Ferring B.V. Blisterverpackung und feste Dosierungsform enthaltend Desmopressin
EP1813603A1 (en) * 2004-11-17 2007-08-01 Kissei Pharmaceutical Co., Ltd. Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both
JP5009785B2 (ja) * 2005-03-25 2012-08-22 キッセイ薬品工業株式会社 ウレア誘導体、それを含有する医薬組成物およびそれらの医薬用途
WO2007052517A1 (ja) * 2005-10-31 2007-05-10 Sumitomo Chemical Company, Limited ヒドロキシ-2-ピロリジンカルボキシアミド化合物の製法
WO2008038600A1 (en) * 2006-09-25 2008-04-03 Kissei Pharmaceutical Co., Ltd. 1,4-benzodiazepine derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes
CN101686983A (zh) * 2007-05-10 2010-03-31 Amr科技公司 芳基和杂芳基取代的四氢苯并-1,4-二氮杂䓬及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途
RU2472539C2 (ru) 2007-08-06 2013-01-20 Аллерган, Инк. Способы и устройства для доставки препарата десмопрессина
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
DK3225250T3 (da) * 2008-05-21 2019-11-04 Ferring Bv Orodispersibel desmopressin til forlængelse af den indledende søvnperiode, som ikke forstyrres af nykturi
GB201005623D0 (en) 2010-04-01 2010-05-19 Vantia Ltd New polymorph
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
WO2020154581A1 (en) 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Solid state forms of fedovapagon-salicyclic acid co-crystal

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960886A (en) 1968-07-03 1976-06-01 Sterling Drug Inc. Substituted N-arylanilines
CH599752A5 (enExample) 1973-04-18 1978-05-31 Ciba Geigy Ag
CA1047490A (en) 1973-04-18 1979-01-30 Friedrich Karrer Ethers
DE2355454A1 (de) 1973-11-07 1976-10-07 Paul Geisslinger Lochmaschine
EP0186817B1 (en) 1984-12-10 1989-08-02 Nissan Chemical Industries Ltd. 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it
WO1991005549A1 (en) 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
US5753677A (en) 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
CA2066104C (en) 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
JPH05320135A (ja) * 1992-05-19 1993-12-03 Yamanouchi Pharmaceut Co Ltd テトラヒドロベンズアゼピン誘導体
US5498609A (en) 1992-08-20 1996-03-12 Otsuka Pharmaceutical Company, Limited Benzoazepinyl compounds as oxytocin and vasopressin antagonists
TW270927B (enExample) * 1992-10-16 1996-02-21 Otsuka Pharma Co Ltd
WO1994012476A1 (fr) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Derive de benzanilide
WO1994020473A1 (fr) * 1993-03-11 1994-09-15 Yamanouchi Pharmaceutical Co., Ltd. Compose avec action antagoniste de la vasopressine
GB9307527D0 (en) 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5760031A (en) 1993-07-29 1998-06-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5968930A (en) 1993-07-29 1999-10-19 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5516774A (en) 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5843952A (en) 1993-07-29 1998-12-01 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US6403577B1 (en) * 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
FI1215U1 (fi) * 1993-12-03 1994-02-21 Valmet Paper Machinery Inc Anlaeggning i samband med styrningen av en vira
FR2716194B1 (fr) * 1994-02-14 1996-05-31 Sanofi Elf Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant.
WO1995031034A2 (en) * 1994-05-06 1995-11-16 Philips Electronics N.V. Microwave transmission system
DK1221440T3 (da) 1994-06-15 2007-09-17 Otsuka Pharma Co Ltd Benzoheterocykliske derivater der er nyttige som vasopressin- eller oxytocinmodulatorer
JP2926335B2 (ja) * 1997-06-13 1999-07-28 大塚製薬株式会社 医薬組成物
EP1000059B1 (en) * 1997-07-30 2004-09-29 Wyeth Tricyclic vasopressin agonists
JP4338305B2 (ja) * 1997-07-30 2009-10-07 ワイス 三環系バソプレシンアゴニスト
ES2216579T3 (es) 1998-10-09 2004-10-16 Janssen Pharmaceutica N.V. Derivados de 4,5-dihidro-isoxazol y su uso farmaceutico.
GB2355454A (en) 1999-10-20 2001-04-25 Ferring Bv Antidiuretic agents
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
DE10033337A1 (de) 2000-07-08 2002-01-17 Boehringer Ingelheim Pharma Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
GB0120051D0 (en) 2001-08-16 2001-10-10 Ferring Bv Oxytocin agonists
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
EP1449844A1 (en) 2003-02-14 2004-08-25 Ferring B.V. benzamide derivatives as oxytocin agonists and vasopressin antagonists
EP1627876A1 (en) 2004-08-20 2006-02-22 Ferring B.V. Heterocyclic condensed compounds useful as antidiuretic agents
US7341963B2 (en) * 2005-05-17 2008-03-11 Milliken & Company Non-woven material with barrier skin

Also Published As

Publication number Publication date
EP1248784B1 (en) 2007-07-11
US20030087892A1 (en) 2003-05-08
WO2001049682A1 (en) 2001-07-12
GB0000079D0 (en) 2000-02-23
CN1392875A (zh) 2003-01-22
US7074781B2 (en) 2006-07-11
AU2384601A (en) 2001-07-16
ATE366730T1 (de) 2007-08-15
EE200200367A (et) 2003-12-15
DK1248784T3 (da) 2007-10-29
US20080261951A1 (en) 2008-10-23
JP2006137767A (ja) 2006-06-01
MXPA02006546A (es) 2002-12-09
AU777538B2 (en) 2004-10-21
NO20023137D0 (no) 2002-06-27
AR035327A1 (es) 2004-05-12
SK9112002A3 (en) 2003-01-09
HRP20020481A2 (en) 2004-08-31
KR20020063191A (ko) 2002-08-01
SI1248784T1 (sl) 2007-12-31
NO322571B1 (no) 2006-10-30
PL355808A1 (en) 2004-05-17
PL211341B1 (pl) 2012-05-31
US20060154916A1 (en) 2006-07-13
RU2002120798A (ru) 2004-01-10
ZA200205180B (en) 2004-02-05
PT1248784E (pt) 2007-10-02
CN1183129C (zh) 2005-01-05
MY140467A (en) 2009-12-31
US7560454B2 (en) 2009-07-14
EP1248784A1 (en) 2002-10-16
HK1046910A1 (en) 2003-01-30
CA2396277A1 (en) 2001-07-12
HK1046910B (en) 2007-08-31
HRP20020481B1 (hr) 2009-03-31
NO20023137L (no) 2002-06-27
JP2003519228A (ja) 2003-06-17
JP3813629B2 (ja) 2006-08-23
CZ303444B6 (cs) 2012-09-19
HUP0203917A2 (hu) 2003-03-28
KR100605466B1 (ko) 2006-07-28
CZ20022305A3 (cs) 2002-10-16
UA73152C2 (en) 2005-06-15
CA2396277C (en) 2012-03-20
BR0107414A (pt) 2002-10-08
JP3869723B2 (ja) 2007-01-17
HU229937B1 (hu) 2015-01-28
DE60129298T2 (de) 2008-01-03
IL149528A0 (en) 2002-11-10
SK287005B6 (sk) 2009-09-07
CY1108034T1 (el) 2013-09-04
BR0107414B1 (pt) 2014-09-16
NZ518803A (en) 2003-03-28
DE60129298D1 (de) 2007-08-23
ES2288923T3 (es) 2008-02-01
HUP0203917A3 (en) 2004-07-28
RU2259367C2 (ru) 2005-08-27

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Effective date: 20120927

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Effective date: 20210104