WO1994020473A1 - Compose avec action antagoniste de la vasopressine - Google Patents

Compose avec action antagoniste de la vasopressine Download PDF

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Publication number
WO1994020473A1
WO1994020473A1 PCT/JP1994/000391 JP9400391W WO9420473A1 WO 1994020473 A1 WO1994020473 A1 WO 1994020473A1 JP 9400391 W JP9400391 W JP 9400391W WO 9420473 A1 WO9420473 A1 WO 9420473A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
formula
tetrahydro
benzodiazepine
substituent
Prior art date
Application number
PCT/JP1994/000391
Other languages
English (en)
Japanese (ja)
Inventor
Akira Matsuhisa
Akihiro Tanaka
Ken-Ichiro Sakamoto
Yuzo Matsumoto
Kazumi Kikuchi
Nobuaki Taniguchi
Takeyuki Yatsu
Isao Yanagisawa
Original Assignee
Yamanouchi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.
Priority to AU62199/94A priority Critical patent/AU6219994A/en
Publication of WO1994020473A1 publication Critical patent/WO1994020473A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

L'invention se rapporte à un dérivé de dihydrobenzazépine représenté par la formule générale (I-A), à un dérivé de tétrahydrobenzodiazépine représenté par la formule générale (I-B) ou à un dérivé de tétrahydrobenzazépine représenté par la formule générale (I-C), à un sel pharmaceutiquement acceptable de ces dérivés, ainsi qu'à une composition pharmaceutique de ces dérivés, qui sont utiles comme agent antagoniste de la vasopressine d'arginine.
PCT/JP1994/000391 1993-03-11 1994-03-10 Compose avec action antagoniste de la vasopressine WO1994020473A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62199/94A AU6219994A (en) 1993-03-11 1994-03-10 Compound with vasopressin antagonism

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP7770593 1993-03-11
JP5/77705 1993-03-11
JP5/100321 1993-04-02
JP10032193 1993-04-02
JP11095793 1993-04-13
JP11095893 1993-04-13
JP5/110957 1993-04-13
JP5/110958 1993-04-13
JP11229393 1993-04-15
JP5/112293 1993-04-15
JP6/16795 1994-02-10
JP1679594 1994-02-10

Publications (1)

Publication Number Publication Date
WO1994020473A1 true WO1994020473A1 (fr) 1994-09-15

Family

ID=27548683

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1994/000391 WO1994020473A1 (fr) 1993-03-11 1994-03-10 Compose avec action antagoniste de la vasopressine

Country Status (2)

Country Link
AU (1) AU6219994A (fr)
WO (1) WO1994020473A1 (fr)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521170A (en) * 1993-04-13 1996-05-28 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives and pharmaceutical composition comprising the same
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
US5532235A (en) * 1995-01-17 1996-07-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5536718A (en) * 1995-01-17 1996-07-16 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5654297A (en) * 1995-01-17 1997-08-05 American Cyanamid Company Tricyclic thieno-azepine vasopressin antagonists
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5849735A (en) * 1995-01-17 1998-12-15 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
EP0892797A1 (fr) * 1996-02-26 1999-01-27 Bristol-Myers Squibb Company Inhibiteurs de la farnesyl-transferase
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
US6096736A (en) * 1995-12-15 2000-08-01 Otsuka Pharmaceutical Company, Limited Benzazepine derivatives with vasopressin agonistic activity
WO2001029005A1 (fr) * 1999-10-20 2001-04-26 Ferring Bv Agonistes de la vasopressine bicyclique
WO2001049682A1 (fr) * 2000-01-05 2001-07-12 Ferring Bv Azepines condensees en tant qu'agonistes de vasopressine
US6632814B1 (en) 1998-12-23 2003-10-14 Aventis Pharma Ltd. Dihydro-benzo(1,4)oxazines
JP2005507906A (ja) * 2001-10-12 2005-03-24 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペリジン類、およびヒスタミンｈ３受容体関連疾患の治療のためのその使用
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6977254B2 (en) 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
US7064120B2 (en) 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7202239B2 (en) 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7326700B2 (en) 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US9241942B2 (en) 2007-06-08 2016-01-26 Mannkind Corporation IRE-1α inhibitors
CN111187227A (zh) * 2020-01-20 2020-05-22 河南农业大学 一种用于小麦全蚀病病菌抑制的2-(1,2,4-三氮唑)苯甲酰芳胺类活性化合物
CN115141153A (zh) * 2022-05-05 2022-10-04 徐州医科大学 一种苯并二氮杂䓬类化合物及其制备方法与应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04154765A (ja) * 1989-10-20 1992-05-27 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH04321669A (ja) * 1991-04-19 1992-11-11 Otsuka Pharmaceut Co Ltd バソプレシン拮抗剤
JPH05132466A (ja) * 1991-04-19 1993-05-28 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH05320135A (ja) * 1992-05-19 1993-12-03 Yamanouchi Pharmaceut Co Ltd テトラヒドロベンズアゼピン誘導体
JPH0616643A (ja) * 1992-07-03 1994-01-25 Yamanouchi Pharmaceut Co Ltd ビフェニル誘導体
JPH0680641A (ja) * 1992-09-01 1994-03-22 Otsuka Pharmaceut Co Ltd 光学活性な５−ヒドロキシベンゾアゼピン誘導体の製造法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04154765A (ja) * 1989-10-20 1992-05-27 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH04321669A (ja) * 1991-04-19 1992-11-11 Otsuka Pharmaceut Co Ltd バソプレシン拮抗剤
JPH05132466A (ja) * 1991-04-19 1993-05-28 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH05320135A (ja) * 1992-05-19 1993-12-03 Yamanouchi Pharmaceut Co Ltd テトラヒドロベンズアゼピン誘導体
JPH0616643A (ja) * 1992-07-03 1994-01-25 Yamanouchi Pharmaceut Co Ltd ビフェニル誘導体
JPH0680641A (ja) * 1992-09-01 1994-03-22 Otsuka Pharmaceut Co Ltd 光学活性な５−ヒドロキシベンゾアゼピン誘導体の製造法

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521170A (en) * 1993-04-13 1996-05-28 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives and pharmaceutical composition comprising the same
US5654297A (en) * 1995-01-17 1997-08-05 American Cyanamid Company Tricyclic thieno-azepine vasopressin antagonists
US5532235A (en) * 1995-01-17 1996-07-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5536718A (en) * 1995-01-17 1996-07-16 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5610156A (en) * 1995-01-17 1997-03-11 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5612334A (en) * 1995-01-17 1997-03-18 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5696112A (en) * 1995-01-17 1997-12-09 American Cyanamid Company Fused heterocyclic azepines as vasopressin antagonists
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5719278A (en) * 1995-01-17 1998-02-17 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5780471A (en) * 1995-01-17 1998-07-14 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5849735A (en) * 1995-01-17 1998-12-15 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
US6096736A (en) * 1995-12-15 2000-08-01 Otsuka Pharmaceutical Company, Limited Benzazepine derivatives with vasopressin agonistic activity
EP1481975A1 (fr) * 1996-02-26 2004-12-01 Bristol-Myers Squibb Company Inhibiteurs de la farnésyl protéine transférase
EP0892797A1 (fr) * 1996-02-26 1999-01-27 Bristol-Myers Squibb Company Inhibiteurs de la farnesyl-transferase
EP0892797A4 (fr) * 1996-02-26 2004-10-20 Bristol Myers Squibb Co Inhibiteurs de la farnesyl-transferase
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
US6632814B1 (en) 1998-12-23 2003-10-14 Aventis Pharma Ltd. Dihydro-benzo(1,4)oxazines
JP4694747B2 (ja) * 1999-10-20 2011-06-08 バンテイア・リミテツド 二環式バソプレッシン・アゴニスト
JP2003512356A (ja) * 1999-10-20 2003-04-02 フェリング ベスローテン フェンノートシャップ 二環式バソプレッシン・アゴニスト
CZ304069B6 (cs) * 1999-10-20 2013-09-18 Vantia Limited Bicyklické agonisty vasopresinu
WO2001029005A1 (fr) * 1999-10-20 2001-04-26 Ferring Bv Agonistes de la vasopressine bicyclique
US6664249B1 (en) 1999-10-20 2003-12-16 Ferring Bv Bicyclic vasopressin agonists
US7074781B2 (en) 2000-01-05 2006-07-11 Ferring Bv Condensed azepines as vasopressin agonists
WO2001049682A1 (fr) * 2000-01-05 2001-07-12 Ferring Bv Azepines condensees en tant qu'agonistes de vasopressine
US7560454B2 (en) 2000-01-05 2009-07-14 Vantia Limited Condensed azepines as vasopressin agonists
HRP20020481B1 (en) * 2000-01-05 2009-03-31 Vantia Limited Condensed azepines as vasopressin agonists
US7326700B2 (en) 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7064120B2 (en) 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7202239B2 (en) 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US6977254B2 (en) 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
EP2243776A1 (fr) * 2001-10-12 2010-10-27 High Point Pharmaceuticals, LLC Piperidines substituées et leur utilisation dans le traitement de maladies liées au recepteur histaminique H3
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
JP2005507906A (ja) * 2001-10-12 2005-03-24 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペリジン類、およびヒスタミンｈ３受容体関連疾患の治療のためのその使用
US9241942B2 (en) 2007-06-08 2016-01-26 Mannkind Corporation IRE-1α inhibitors
US9546149B2 (en) 2007-06-08 2017-01-17 Mannkind Corporation IRE-1α inhibitors
US9981901B2 (en) 2007-06-08 2018-05-29 Fosun Orinove Pharmatech, Inc. IRE-1α inhibitors
CN111187227A (zh) * 2020-01-20 2020-05-22 河南农业大学 一种用于小麦全蚀病病菌抑制的2-(1,2,4-三氮唑)苯甲酰芳胺类活性化合物
CN115141153A (zh) * 2022-05-05 2022-10-04 徐州医科大学 一种苯并二氮杂䓬类化合物及其制备方法与应用
CN115141153B (zh) * 2022-05-05 2023-11-14 徐州医科大学 一种苯并二氮杂䓬类化合物及其制备方法与应用

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Publication number Publication date
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