KR100605466B1 - 바소프레신 작용제로서의 축합 아제핀 - Google Patents

바소프레신 작용제로서의 축합 아제핀 Download PDF

Info

Publication number
KR100605466B1
KR100605466B1 KR1020027006382A KR20027006382A KR100605466B1 KR 100605466 B1 KR100605466 B1 KR 100605466B1 KR 1020027006382 A KR1020027006382 A KR 1020027006382A KR 20027006382 A KR20027006382 A KR 20027006382A KR 100605466 B1 KR100605466 B1 KR 100605466B1
Authority
KR
South Korea
Prior art keywords
pharmaceutically acceptable
methyl
acceptable salt
proline
ylcarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020027006382A
Other languages
English (en)
Korean (ko)
Other versions
KR20020063191A (ko
Inventor
도린마리 애쉬워스
게리로버트윌리엄 피트
피터 허드슨
크리스토퍼마르틴 예이
리차드제레미 프랭클린
Original Assignee
훼링 비.브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 훼링 비.브이. filed Critical 훼링 비.브이.
Publication of KR20020063191A publication Critical patent/KR20020063191A/ko
Application granted granted Critical
Publication of KR100605466B1 publication Critical patent/KR100605466B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020027006382A 2000-01-05 2001-01-04 바소프레신 작용제로서의 축합 아제핀 Expired - Fee Related KR100605466B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0000079.4 2000-01-05
GBGB0000079.4A GB0000079D0 (en) 2000-01-05 2000-01-05 Novel antidiuretic agents

Publications (2)

Publication Number Publication Date
KR20020063191A KR20020063191A (ko) 2002-08-01
KR100605466B1 true KR100605466B1 (ko) 2006-07-28

Family

ID=9883168

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027006382A Expired - Fee Related KR100605466B1 (ko) 2000-01-05 2001-01-04 바소프레신 작용제로서의 축합 아제핀

Country Status (34)

Country Link
US (3) US7074781B2 (enExample)
EP (1) EP1248784B1 (enExample)
JP (2) JP3869723B2 (enExample)
KR (1) KR100605466B1 (enExample)
CN (1) CN1183129C (enExample)
AR (1) AR035327A1 (enExample)
AT (1) ATE366730T1 (enExample)
AU (1) AU777538B2 (enExample)
BR (1) BR0107414B1 (enExample)
CA (1) CA2396277C (enExample)
CY (1) CY1108034T1 (enExample)
CZ (1) CZ303444B6 (enExample)
DE (1) DE60129298T2 (enExample)
DK (1) DK1248784T3 (enExample)
EE (1) EE200200367A (enExample)
ES (1) ES2288923T3 (enExample)
GB (1) GB0000079D0 (enExample)
HK (1) HK1046910B (enExample)
HR (1) HRP20020481B1 (enExample)
HU (1) HU229937B1 (enExample)
IL (1) IL149528A0 (enExample)
MX (1) MXPA02006546A (enExample)
MY (1) MY140467A (enExample)
NO (1) NO322571B1 (enExample)
NZ (1) NZ518803A (enExample)
PL (1) PL211341B1 (enExample)
PT (1) PT1248784E (enExample)
RU (1) RU2259367C2 (enExample)
SI (1) SI1248784T1 (enExample)
SK (1) SK287005B6 (enExample)
UA (1) UA73152C2 (enExample)
UY (1) UY26521A1 (enExample)
WO (1) WO2001049682A1 (enExample)
ZA (1) ZA200205180B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5803659A (en) 1995-12-08 1998-09-08 Chattey; Nigel Modular caissons for use in constructing, expanding and modernizing ports and harbors.
US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
PT1268418E (pt) * 2000-03-27 2006-08-31 Applied Research Systems Derivados da pirrolidina farmacologicamente activos com inibidores bax
HK1054031B (zh) * 2000-03-27 2007-05-04 Merck Serono Sa 具有药物活性的吡咯烷衍生物
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
WO2004096775A1 (ja) 2003-04-28 2004-11-11 Astellas Pharma Inc. ４，４－ジフルオロ－１，２，３，４－テトラヒドロ－５ｈ－１－ベンゾアゼピン誘導体又はその塩
ES2260563T3 (es) * 2003-11-13 2006-11-01 Ferring B.V. Paquete de blister y forma farmaceutica solida para ello.
JP4943858B2 (ja) * 2004-11-17 2012-05-30 キッセイ薬品工業株式会社 芳香族アミド誘導体、それを含有する医薬組成物およびそれらの医薬用途
JP5009785B2 (ja) * 2005-03-25 2012-08-22 キッセイ薬品工業株式会社 ウレア誘導体、それを含有する医薬組成物およびそれらの医薬用途
WO2007052517A1 (ja) * 2005-10-31 2007-05-10 Sumitomo Chemical Company, Limited ヒドロキシ－２－ピロリジンカルボキシアミド化合物の製法
WO2008038600A1 (en) * 2006-09-25 2008-04-03 Kissei Pharmaceutical Co., Ltd. 1,4-benzodiazepine derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes
EP2146722A4 (en) * 2007-05-10 2011-08-03 Amr Technology Inc ARYL AND HETEROARYL SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND THEIR USE FOR BLOCKING THE RECOVERY OF NOREPINEPHRIN, DOPAMINE AND SEROTONINE
CA2988753A1 (en) 2007-08-06 2009-02-12 Serenity Pharmaceuticals, Llc Methods and devices for desmopressin drug delivery
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
JP5767103B2 (ja) * 2008-05-21 2015-08-19 フエリング・インターナシヨナル・センター・エス・アー 夜間頻尿によって妨げられない睡眠の初期期間を増加させるための口腔内崩壊デスモプレシン
GB201005623D0 (en) * 2010-04-01 2010-05-19 Vantia Ltd New polymorph
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
WO2020154581A1 (en) 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Solid state forms of fedovapagon-salicyclic acid co-crystal

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960886A (en) * 1968-07-03 1976-06-01 Sterling Drug Inc. Substituted N-arylanilines
CA1047490A (en) * 1973-04-18 1979-01-30 Friedrich Karrer Ethers
CH599752A5 (enExample) * 1973-04-18 1978-05-31 Ciba Geigy Ag
DE2355454A1 (de) 1973-11-07 1976-10-07 Paul Geisslinger Lochmaschine
JPH0641455B2 (ja) 1984-12-10 1994-06-01 日産化学工業株式会社 ピリダジノン誘導体
WO1991005549A1 (en) 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
US5753677A (en) * 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
JPH05320135A (ja) 1992-05-19 1993-12-03 Yamanouchi Pharmaceut Co Ltd テトラヒドロベンズアゼピン誘導体
EP0612319A1 (en) * 1992-08-20 1994-08-31 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
TW270927B (enExample) 1992-10-16 1996-02-21 Otsuka Pharma Co Ltd
WO1994012476A1 (fr) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Derive de benzanilide
AU6219994A (en) * 1993-03-11 1994-09-26 Yamanouchi Pharmaceutical Co., Ltd. Compound with vasopressin antagonism
GB9307527D0 (en) 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5760031A (en) * 1993-07-29 1998-06-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5968930A (en) * 1993-07-29 1999-10-19 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5843952A (en) * 1993-07-29 1998-12-01 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5516774A (en) 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US6403577B1 (en) * 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
FI1215U1 (fi) * 1993-12-03 1994-02-21 Valmet Paper Machinery Inc Anlaeggning i samband med styrningen av en vira
FR2716194B1 (fr) * 1994-02-14 1996-05-31 Sanofi Elf Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant.
CA2166556A1 (en) * 1994-05-06 1995-11-16 Leo Kool Microwave transmission system
DE69535486T2 (de) 1994-06-15 2008-04-10 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclische Verbindungen verwendbar als Vasopressin- oder Oxytocin-Modulatoren
JP2926335B2 (ja) 1997-06-13 1999-07-28 大塚製薬株式会社 医薬組成物
SI1000062T1 (en) * 1997-07-30 2004-12-31 Wyeth Tricyclic vasopressin agonists
NZ502448A (en) * 1997-07-30 2002-12-20 Wyeth Corp Tricyclic vasopressin agonists and medicaments containing these compounds
EP1119568B1 (en) * 1998-10-09 2004-02-18 Janssen Pharmaceutica N.V. 4,5-dihydro-isoxazole derivatives and their pharmaceutical use
GB2355454A (en) * 1999-10-20 2001-04-25 Ferring Bv Antidiuretic agents
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
DE10033337A1 (de) 2000-07-08 2002-01-17 Boehringer Ingelheim Pharma Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
GB0120051D0 (en) 2001-08-16 2001-10-10 Ferring Bv Oxytocin agonists
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
EP1449844A1 (en) * 2003-02-14 2004-08-25 Ferring B.V. benzamide derivatives as oxytocin agonists and vasopressin antagonists
EP1627876A1 (en) * 2004-08-20 2006-02-22 Ferring B.V. Heterocyclic condensed compounds useful as antidiuretic agents
US7341963B2 (en) * 2005-05-17 2008-03-11 Milliken & Company Non-woven material with barrier skin

Also Published As

Publication number Publication date
HUP0203917A3 (en) 2004-07-28
EE200200367A (et) 2003-12-15
US20080261951A1 (en) 2008-10-23
HU229937B1 (hu) 2015-01-28
UY26521A1 (es) 2001-03-16
CA2396277A1 (en) 2001-07-12
BR0107414B1 (pt) 2014-09-16
GB0000079D0 (en) 2000-02-23
PT1248784E (pt) 2007-10-02
EP1248784B1 (en) 2007-07-11
JP2006137767A (ja) 2006-06-01
US7074781B2 (en) 2006-07-11
UA73152C2 (en) 2005-06-15
PL211341B1 (pl) 2012-05-31
SK287005B6 (sk) 2009-09-07
NO20023137D0 (no) 2002-06-27
JP3869723B2 (ja) 2007-01-17
HRP20020481B1 (hr) 2009-03-31
RU2002120798A (ru) 2004-01-10
US20030087892A1 (en) 2003-05-08
DE60129298T2 (de) 2008-01-03
MXPA02006546A (es) 2002-12-09
ZA200205180B (en) 2004-02-05
AU777538B2 (en) 2004-10-21
DK1248784T3 (da) 2007-10-29
IL149528A0 (en) 2002-11-10
ATE366730T1 (de) 2007-08-15
CA2396277C (en) 2012-03-20
MY140467A (en) 2009-12-31
US7560454B2 (en) 2009-07-14
CN1183129C (zh) 2005-01-05
HUP0203917A2 (hu) 2003-03-28
PL355808A1 (en) 2004-05-17
US20060154916A1 (en) 2006-07-13
CZ20022305A3 (cs) 2002-10-16
RU2259367C2 (ru) 2005-08-27
SK9112002A3 (en) 2003-01-09
DE60129298D1 (de) 2007-08-23
WO2001049682A1 (en) 2001-07-12
HRP20020481A2 (en) 2004-08-31
AR035327A1 (es) 2004-05-12
CZ303444B6 (cs) 2012-09-19
AU2384601A (en) 2001-07-16
BR0107414A (pt) 2002-10-08
SI1248784T1 (sl) 2007-12-31
KR20020063191A (ko) 2002-08-01
HK1046910A1 (en) 2003-01-30
JP2003519228A (ja) 2003-06-17
NO20023137L (no) 2002-06-27
JP3813629B2 (ja) 2006-08-23
ES2288923T3 (es) 2008-02-01
EP1248784A1 (en) 2002-10-16
CY1108034T1 (el) 2013-09-04
CN1392875A (zh) 2003-01-22
HK1046910B (en) 2007-08-31
NZ518803A (en) 2003-03-28
NO322571B1 (no) 2006-10-30

Similar Documents

Publication Publication Date Title
KR100605466B1 (ko) 바소프레신 작용제로서의 축합 아제핀
JP3935071B2 (ja) 融合アゼピン誘導体および抗利尿剤としての使用
KR100725555B1 (ko) 바이사이클릭 바소프레신 작용제

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20130701

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

FPAY Annual fee payment

Payment date: 20140703

Year of fee payment: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

FPAY Annual fee payment

Payment date: 20150619

Year of fee payment: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

FPAY Annual fee payment

Payment date: 20160616

Year of fee payment: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

FPAY Annual fee payment

Payment date: 20170616

Year of fee payment: 12

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 13

FPAY Annual fee payment

Payment date: 20190617

Year of fee payment: 14

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 14

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20200721

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20200721