AR035327A1 - Agonistas no peptidicos de la vasopresina, selectivos para los receptores del subtipo v2; uso de dichos compuestos en la preparacion de composiciones farmaceuticas utilizables en el tratamiento de enfermedades del hombre, caracterizadas por poliuria; dichas composiciones y metodos para el tratamient - Google Patents

Agonistas no peptidicos de la vasopresina, selectivos para los receptores del subtipo v2; uso de dichos compuestos en la preparacion de composiciones farmaceuticas utilizables en el tratamiento de enfermedades del hombre, caracterizadas por poliuria; dichas composiciones y metodos para el tratamient

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Publication number
AR035327A1
AR035327A1 ARP010100035A ARP010100035A AR035327A1 AR 035327 A1 AR035327 A1 AR 035327A1 AR P010100035 A ARP010100035 A AR P010100035A AR P010100035 A ARP010100035 A AR P010100035A AR 035327 A1 AR035327 A1 AR 035327A1
Authority
AR
Argentina
Prior art keywords
treatment
independently selected
compounds
pharmaceutical compositions
vasopresine
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Application number
ARP010100035A
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English (en)
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Ferring Bv
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Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of AR035327A1 publication Critical patent/AR035327A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen y reivindican compuestos novedosos que responden a la fórmula general (1), en donde A es un derivado de azepina bicíclico o tricíclico seleccionado entre las fórmulas generales (2) a (7); A1, A4, A7 y A10 son cada uno independientemente seleccionados entre CH2, O y NR8; A2, A3, A9, A11, A14 y A15 son cada uno independientemente seleccionados entre CH y N; A5 es un enlace covalente y A6 es S, o A5 es N=CH y A6 es un enlace covalente; A8 y A12 son cada uno independientemente seleccionados entre NH y S; A16 y A17 son ambos CH2, o uno entre A16 y A17 es CH2 y el otro es seleccionado entre O, SOx y NR8; V1 y V2 son ambos H, OMe o F, o uno entre V1 y V2 es Br, Cl, F, OH, OMe, OBn, OPh, O-acilo, N3, NH2, NHBn o NH-acilo y el otro es H, o V1 y V2 juntos son =O, -O(CH2)pO- o -S(CH2)pS-; W1 es O ó S; X1 y X2 son ambos H, o juntos son =O ó =S; Y es OR5 o NR6R7; Z es S o -CH=CH-; R1, R2, R3 y R4 son independientemente seleccionados entre H, alquilo inferior, alquiloxi inferior, F, Cl y Br; R6 y R7 son independientemente seleccionados entre H y alquilo inferior, o juntos son -(CH2)n-; R8 es H o alquilo inferior; n = 3, 4, 5 ó 6; p es 2 ó 3; y x es 0, 1 ó 2. Los compuestos son agonistas en el receptor de vasopresina V2 y son útiles como antidiuréticos y pro-coagulantes. La presente comprende además composiciones farmacéuticas que incorporan dichos agonistas de vasopresina, en donde dichas composiciones son particularmente útiles en el tratamiento de diabetes insípida central, enuresis nocturna y nocturia.
ARP010100035A 2000-01-05 2001-01-04 Agonistas no peptidicos de la vasopresina, selectivos para los receptores del subtipo v2; uso de dichos compuestos en la preparacion de composiciones farmaceuticas utilizables en el tratamiento de enfermedades del hombre, caracterizadas por poliuria; dichas composiciones y metodos para el tratamient AR035327A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0000079.4A GB0000079D0 (en) 2000-01-05 2000-01-05 Novel antidiuretic agents

Publications (1)

Publication Number Publication Date
AR035327A1 true AR035327A1 (es) 2004-05-12

Family

ID=9883168

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100035A AR035327A1 (es) 2000-01-05 2001-01-04 Agonistas no peptidicos de la vasopresina, selectivos para los receptores del subtipo v2; uso de dichos compuestos en la preparacion de composiciones farmaceuticas utilizables en el tratamiento de enfermedades del hombre, caracterizadas por poliuria; dichas composiciones y metodos para el tratamient

Country Status (34)

Country Link
US (3) US7074781B2 (es)
EP (1) EP1248784B1 (es)
JP (2) JP3869723B2 (es)
KR (1) KR100605466B1 (es)
CN (1) CN1183129C (es)
AR (1) AR035327A1 (es)
AT (1) ATE366730T1 (es)
AU (1) AU777538B2 (es)
BR (1) BR0107414B1 (es)
CA (1) CA2396277C (es)
CY (1) CY1108034T1 (es)
CZ (1) CZ303444B6 (es)
DE (1) DE60129298T2 (es)
DK (1) DK1248784T3 (es)
EE (1) EE200200367A (es)
ES (1) ES2288923T3 (es)
GB (1) GB0000079D0 (es)
HK (1) HK1046910B (es)
HR (1) HRP20020481B1 (es)
HU (1) HU229937B1 (es)
IL (1) IL149528A0 (es)
MX (1) MXPA02006546A (es)
MY (1) MY140467A (es)
NO (1) NO322571B1 (es)
NZ (1) NZ518803A (es)
PL (1) PL211341B1 (es)
PT (1) PT1248784E (es)
RU (1) RU2259367C2 (es)
SI (1) SI1248784T1 (es)
SK (1) SK287005B6 (es)
UA (1) UA73152C2 (es)
UY (1) UY26521A1 (es)
WO (1) WO2001049682A1 (es)
ZA (1) ZA200205180B (es)

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Also Published As

Publication number Publication date
HU229937B1 (hu) 2015-01-28
UA73152C2 (en) 2005-06-15
EE200200367A (et) 2003-12-15
US20080261951A1 (en) 2008-10-23
EP1248784A1 (en) 2002-10-16
US20060154916A1 (en) 2006-07-13
JP2006137767A (ja) 2006-06-01
BR0107414A (pt) 2002-10-08
NO322571B1 (no) 2006-10-30
UY26521A1 (es) 2001-03-16
PT1248784E (pt) 2007-10-02
US7074781B2 (en) 2006-07-11
CA2396277A1 (en) 2001-07-12
RU2259367C2 (ru) 2005-08-27
CZ20022305A3 (cs) 2002-10-16
DK1248784T3 (da) 2007-10-29
CA2396277C (en) 2012-03-20
ATE366730T1 (de) 2007-08-15
BR0107414B1 (pt) 2014-09-16
WO2001049682A1 (en) 2001-07-12
CZ303444B6 (cs) 2012-09-19
JP3869723B2 (ja) 2007-01-17
AU2384601A (en) 2001-07-16
SK9112002A3 (en) 2003-01-09
HRP20020481B1 (en) 2009-03-31
CY1108034T1 (el) 2013-09-04
JP2003519228A (ja) 2003-06-17
MXPA02006546A (es) 2002-12-09
EP1248784B1 (en) 2007-07-11
HRP20020481A2 (en) 2004-08-31
CN1183129C (zh) 2005-01-05
ZA200205180B (en) 2004-02-05
KR20020063191A (ko) 2002-08-01
NO20023137D0 (no) 2002-06-27
PL355808A1 (en) 2004-05-17
DE60129298D1 (de) 2007-08-23
SK287005B6 (sk) 2009-09-07
GB0000079D0 (en) 2000-02-23
IL149528A0 (en) 2002-11-10
HK1046910A1 (en) 2003-01-30
HUP0203917A3 (en) 2004-07-28
US20030087892A1 (en) 2003-05-08
MY140467A (en) 2009-12-31
US7560454B2 (en) 2009-07-14
SI1248784T1 (sl) 2007-12-31
HUP0203917A2 (hu) 2003-03-28
CN1392875A (zh) 2003-01-22
KR100605466B1 (ko) 2006-07-28
ES2288923T3 (es) 2008-02-01
RU2002120798A (ru) 2004-01-10
NZ518803A (en) 2003-03-28
PL211341B1 (pl) 2012-05-31
DE60129298T2 (de) 2008-01-03
JP3813629B2 (ja) 2006-08-23
AU777538B2 (en) 2004-10-21
HK1046910B (zh) 2007-08-31
NO20023137L (no) 2002-06-27

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