BR0107414A - Azepinas condensadas como agonistas de vasopressina - Google Patents

Azepinas condensadas como agonistas de vasopressina

Info

Publication number
BR0107414A
BR0107414A BR0107414-8A BR0107414A BR0107414A BR 0107414 A BR0107414 A BR 0107414A BR 0107414 A BR0107414 A BR 0107414A BR 0107414 A BR0107414 A BR 0107414A
Authority
BR
Brazil
Prior art keywords
vasopressin
agonists
lower alkyl
vasopressin agonists
ome
Prior art date
Application number
BR0107414-8A
Other languages
English (en)
Other versions
BR0107414B1 (pt
Inventor
Doreen Mary Ashworth
Gary Robert William Pitt
Peter Hudson
Christopher Martyn Yea
Richard Jeremy Franklin
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of BR0107414A publication Critical patent/BR0107414A/pt
Publication of BR0107414B1 publication Critical patent/BR0107414B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"AZEPINAS CONDENSADAS COMO AGONISTAS DE VASOPRESSINA". Esta invenção proporciona novos compostos de acordo com a fórmula geral (1) em que A é um derivado de azepina bicíclico ou tricíclico , V^ 1^ e V^ 2^ são ambos H, OMe ou F, ou um de V^ 1^ e V^ 2^ é Br, Cl, F, OH, OMe, OBn, OPh, O-acila, N~ 3~, NH~ 2~, NHBn ou NH-acila e o outro é H, ou V^ 1^ e V^ 2^ juntamente são =O,- O(CH~ 2~)~ p~O- ou -S(CH~ 2~)~ p~S-; W^ 1^ é O ou S; X^ 1^ e X^ 2^ são ambos H, ou juntamente são =O ou =S; Y é OR^ 5^ ou NR^ 6^R^ 7^; R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são, independentemente, selecionados de H, alquila inferior, alquilóxi inferior, F, CI e Br; R^ 5^ é selecionado de H e alquila inferior; R^ 6^ e R^ 7^ são, independentemente, selecionados de H e alquila inferior, ou juntamente são -(CH~ 2~)~ n-~; n = 3, 4, 5, 6; e p é 2 ou 3. Os compostos são agonistas do receptor V~ 2~ de vasopressina e são úteis como antidiuréticos e pró-coagulantes. A invenção compreende adicionalmente composições farmacêuticas que incorporam esses agonistas de vasopressina, composições estas que são particularmente úteis no tratamento de diabetes insípida central, enurese noturna e noctúria.
BRPI0107414-8A 2000-01-05 2001-01-04 Azepinas condensadas como agonistas de vasopressina, composição farmacêutica e uso dos referidos compostos BR0107414B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0000079.4 2000-01-05
GBGB0000079.4A GB0000079D0 (en) 2000-01-05 2000-01-05 Novel antidiuretic agents
PCT/GB2001/000023 WO2001049682A1 (en) 2000-01-05 2001-01-04 Condensed azepines as vasopressin agonists

Publications (2)

Publication Number Publication Date
BR0107414A true BR0107414A (pt) 2002-10-08
BR0107414B1 BR0107414B1 (pt) 2014-09-16

Family

ID=9883168

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0107414-8A BR0107414B1 (pt) 2000-01-05 2001-01-04 Azepinas condensadas como agonistas de vasopressina, composição farmacêutica e uso dos referidos compostos

Country Status (34)

Country Link
US (3) US7074781B2 (pt)
EP (1) EP1248784B1 (pt)
JP (2) JP3869723B2 (pt)
KR (1) KR100605466B1 (pt)
CN (1) CN1183129C (pt)
AR (1) AR035327A1 (pt)
AT (1) ATE366730T1 (pt)
AU (1) AU777538B2 (pt)
BR (1) BR0107414B1 (pt)
CA (1) CA2396277C (pt)
CY (1) CY1108034T1 (pt)
CZ (1) CZ303444B6 (pt)
DE (1) DE60129298T2 (pt)
DK (1) DK1248784T3 (pt)
EE (1) EE200200367A (pt)
ES (1) ES2288923T3 (pt)
GB (1) GB0000079D0 (pt)
HK (1) HK1046910B (pt)
HR (1) HRP20020481B1 (pt)
HU (1) HU229937B1 (pt)
IL (1) IL149528A0 (pt)
MX (1) MXPA02006546A (pt)
MY (1) MY140467A (pt)
NO (1) NO322571B1 (pt)
NZ (1) NZ518803A (pt)
PL (1) PL211341B1 (pt)
PT (1) PT1248784E (pt)
RU (1) RU2259367C2 (pt)
SI (1) SI1248784T1 (pt)
SK (1) SK287005B6 (pt)
UA (1) UA73152C2 (pt)
UY (1) UY26521A1 (pt)
WO (1) WO2001049682A1 (pt)
ZA (1) ZA200205180B (pt)

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Also Published As

Publication number Publication date
CZ20022305A3 (cs) 2002-10-16
SK9112002A3 (en) 2003-01-09
PT1248784E (pt) 2007-10-02
NO322571B1 (no) 2006-10-30
ZA200205180B (en) 2004-02-05
ATE366730T1 (de) 2007-08-15
WO2001049682A1 (en) 2001-07-12
AR035327A1 (es) 2004-05-12
RU2002120798A (ru) 2004-01-10
US20080261951A1 (en) 2008-10-23
HK1046910A1 (en) 2003-01-30
US20060154916A1 (en) 2006-07-13
CY1108034T1 (el) 2013-09-04
NO20023137D0 (no) 2002-06-27
DE60129298D1 (de) 2007-08-23
AU777538B2 (en) 2004-10-21
DE60129298T2 (de) 2008-01-03
RU2259367C2 (ru) 2005-08-27
US7074781B2 (en) 2006-07-11
HRP20020481B1 (en) 2009-03-31
UA73152C2 (en) 2005-06-15
UY26521A1 (es) 2001-03-16
HUP0203917A2 (hu) 2003-03-28
IL149528A0 (en) 2002-11-10
HRP20020481A2 (en) 2004-08-31
JP3813629B2 (ja) 2006-08-23
NO20023137L (no) 2002-06-27
PL355808A1 (en) 2004-05-17
EP1248784B1 (en) 2007-07-11
JP2006137767A (ja) 2006-06-01
BR0107414B1 (pt) 2014-09-16
NZ518803A (en) 2003-03-28
PL211341B1 (pl) 2012-05-31
US20030087892A1 (en) 2003-05-08
DK1248784T3 (da) 2007-10-29
GB0000079D0 (en) 2000-02-23
JP3869723B2 (ja) 2007-01-17
ES2288923T3 (es) 2008-02-01
CA2396277C (en) 2012-03-20
EE200200367A (et) 2003-12-15
EP1248784A1 (en) 2002-10-16
AU2384601A (en) 2001-07-16
HK1046910B (zh) 2007-08-31
CZ303444B6 (cs) 2012-09-19
MXPA02006546A (es) 2002-12-09
CA2396277A1 (en) 2001-07-12
HUP0203917A3 (en) 2004-07-28
KR20020063191A (ko) 2002-08-01
KR100605466B1 (ko) 2006-07-28
SK287005B6 (sk) 2009-09-07
JP2003519228A (ja) 2003-06-17
HU229937B1 (hu) 2015-01-28
SI1248784T1 (sl) 2007-12-31
CN1392875A (zh) 2003-01-22
CN1183129C (zh) 2005-01-05
MY140467A (en) 2009-12-31
US7560454B2 (en) 2009-07-14

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