DK1619185T3 - 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf - Google Patents

4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf

Info

Publication number
DK1619185T3
DK1619185T3 DK04729502.7T DK04729502T DK1619185T3 DK 1619185 T3 DK1619185 T3 DK 1619185T3 DK 04729502 T DK04729502 T DK 04729502T DK 1619185 T3 DK1619185 T3 DK 1619185T3
Authority
DK
Denmark
Prior art keywords
difluoro
tetrahydro
salt
benzazepine derivative
benzazepine
Prior art date
Application number
DK04729502.7T
Other languages
English (en)
Inventor
Hiroyuki Koshio
Issei Tsukamoto
Akio Kakefuda
Seijiro Akamatsu
Chikashi Saitoh
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of DK1619185T3 publication Critical patent/DK1619185T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DK04729502.7T 2003-04-28 2004-04-26 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf DK1619185T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003123032 2003-04-28
JP2003401126 2003-12-01
PCT/JP2004/005998 WO2004096775A1 (ja) 2003-04-28 2004-04-26 4,4-ジフルオロ-1,2,3,4-テトラヒドロ-5h-1-ベンゾアゼピン誘導体又はその塩

Publications (1)

Publication Number Publication Date
DK1619185T3 true DK1619185T3 (da) 2011-07-18

Family

ID=33422056

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04729502.7T DK1619185T3 (da) 2003-04-28 2004-04-26 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf

Country Status (17)

Country Link
US (2) US7183271B2 (da)
EP (1) EP1619185B1 (da)
KR (1) KR100882154B1 (da)
AT (1) ATE512951T1 (da)
AU (1) AU2004234258B2 (da)
BR (1) BRPI0409718A (da)
CA (1) CA2521492C (da)
DK (1) DK1619185T3 (da)
IL (1) IL171332A (da)
MX (1) MXPA05011521A (da)
NO (1) NO333505B1 (da)
NZ (1) NZ542815A (da)
PL (1) PL1619185T3 (da)
PT (1) PT1619185E (da)
RU (1) RU2326868C2 (da)
SI (1) SI1619185T1 (da)
WO (1) WO2004096775A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP1619185B1 (en) 2003-04-28 2011-06-15 Astellas Pharma Inc. 4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof
US7910751B2 (en) 2005-07-22 2011-03-22 Mochida Pharmaceutical Co., Ltd. Heterocyclidene acetamide derivative
EP2197532A1 (en) 2007-08-06 2010-06-23 Serenity Pharmaceuticals Corporation Methods and devices for desmopressin drug delivery
NO2296686T3 (da) * 2008-05-21 2014-07-12
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
PT2860175T (pt) 2012-06-11 2018-02-02 Tacurion Método para a produção do composto 4,4,7-trifluoro--1,2,3,4-tetra-hidro-5h-1-benzazepina e intermediários para a sua síntese
EP3484876A1 (en) 2016-07-14 2019-05-22 Pfizer Inc Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100340145B1 (ko) 1993-08-26 2002-10-18 야마노우치세이야쿠 가부시키가이샤 벤즈아제핀유도체및이의중간체화합물
DE69530690T2 (de) 1994-06-15 2004-03-18 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclische derivate verwendbar als vasopressin- oder oxytocin-modulatoren
JP3215910B2 (ja) 1994-06-15 2001-10-09 大塚製薬株式会社 ベンゾヘテロ環誘導体
JPH11349570A (ja) 1994-06-15 1999-12-21 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環誘導体
TW359669B (en) 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
JPH09221476A (ja) * 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
JPH09221475A (ja) 1996-02-13 1997-08-26 Yamanouchi Pharmaceut Co Ltd 新規なオキシム誘導体
AR011913A1 (es) 1997-03-06 2000-09-13 Yamano Masaki Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos.
JP2926335B2 (ja) 1997-06-13 1999-07-28 大塚製薬株式会社 医薬組成物
WO1999006409A1 (en) 1997-07-30 1999-02-11 American Home Products Corporation Tricyclic vasopressin agonists
CN1162429C (zh) 1997-07-30 2004-08-18 惠氏公司 三环后叶加压素激动剂
US6547395B1 (en) 1998-02-06 2003-04-15 Wavefront Sciences, Inc. Methods of measuring moving objects and reducing exposure during wavefront measurements
DK1149096T3 (da) 1999-02-04 2003-04-07 Wyeth Corp Tricykliske pyridin-N-oxider som vasopressinagonister
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
KR100632882B1 (ko) 2001-11-16 2006-10-13 아스텔라스세이야쿠 가부시키가이샤 4, 4-디플루오로-1, 2, 3,4-테트라하이드로-5h-1-벤즈아제핀 유도체 또는 그 염
EP1619185B1 (en) 2003-04-28 2011-06-15 Astellas Pharma Inc. 4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof

Also Published As

Publication number Publication date
WO2004096775A1 (ja) 2004-11-11
PT1619185E (pt) 2011-08-25
KR20060007402A (ko) 2006-01-24
CA2521492C (en) 2010-09-21
EP1619185A1 (en) 2006-01-25
KR100882154B1 (ko) 2009-02-06
SI1619185T1 (sl) 2011-09-30
EP1619185A4 (en) 2008-07-23
PL1619185T3 (pl) 2011-12-30
RU2326868C2 (ru) 2008-06-20
ATE512951T1 (de) 2011-07-15
US7807664B2 (en) 2010-10-05
US20060122170A1 (en) 2006-06-08
IL171332A (en) 2011-03-31
US7183271B2 (en) 2007-02-27
NO333505B1 (no) 2013-06-24
US20070167429A1 (en) 2007-07-19
MXPA05011521A (es) 2006-01-23
NO20055602L (no) 2006-01-24
NZ542815A (en) 2009-01-31
AU2004234258A1 (en) 2004-11-11
RU2005136863A (ru) 2006-04-20
AU2004234258B2 (en) 2009-04-09
NO20055602D0 (no) 2005-11-25
CA2521492A1 (en) 2004-11-11
EP1619185B1 (en) 2011-06-15
BRPI0409718A (pt) 2006-05-02

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