KR20060007402A - 4,4-디플루오로-1,2,3,4-테트라하이드로-5h-1-벤즈아제핀유도체 또는 이의 염 - Google Patents
4,4-디플루오로-1,2,3,4-테트라하이드로-5h-1-벤즈아제핀유도체 또는 이의 염 Download PDFInfo
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- KR20060007402A KR20060007402A KR1020057020359A KR20057020359A KR20060007402A KR 20060007402 A KR20060007402 A KR 20060007402A KR 1020057020359 A KR1020057020359 A KR 1020057020359A KR 20057020359 A KR20057020359 A KR 20057020359A KR 20060007402 A KR20060007402 A KR 20060007402A
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (12)
- 화학식 I의 4,4-디플루오로-1,2,3,4-테트라하이드로-5H-1-벤즈아제핀 유도체 또는 약제학적으로 허용되는 이의 염.화학식 I상기 화학식 I에서,R1은 치환될 수 있는 아미노, -OH 또는 -O-저급 알킬이고,R2는 CF3 또는 할로겐이고,R3은 H 또는 할로겐이고,a 및 b는 각각 단일 결합 또는 이중 결합으로, 한 쪽은 단일 결합이고, 다른 쪽은 이중 결합이고,-X-는(1) a가 단일 결합이고 b가 이중 결합인 경우, -CH=CH-, -CH=N-, -N=CH-, -N=N- 또는 -S-이고,(2) a가 이중 결합이고 b가 단일 결합인 경우, -N-이고,Y는(1) a가 단일 결합이고 b가 이중 결합인 경우, CH 또는 N이고,(2) a가 이중 결합이고 b가 단일 결합인 경우, S이고,-A-는 -0-, -S-, -NH- 또는 -N(저급 알킬)-이고,B는 각각 치환될 수 있는 저급 알킬, 저급 알케닐, 저급 알키닐, 사이클로알킬 또는 아릴이다.
- 제1항에 있어서, R1이 화학식 II의 그룹, 화학식 III의 그룹, -OH 또는 -O-저급 알킬인 화합물.화학식 II화학식 III상기 화학식 II 및 III에서,Z1은 단일 결합, 저급 알킬렌 또는 -저급 알킬렌-C(=0)-이고,R11은 -OH, -O-저급 알킬, -CO2H, -CO2-저급 알킬 및 1개 또는 2개의 저급 알킬로 치환될 수 있는 카바모일로 이루어진 그룹으로부터 선택된 그룹으로 치환될 수 있는 저급 알킬, 또는 -H이고,R12는(1) Z1이 단일 결합 또는 저급 알킬렌을 나타내는 경우,-H, -OH, -O-저급 알킬, -CO2H, -CO2-저급 알킬, 1개 또는 2개의 저급 알킬로 치환될 수 있는 카바모일, 치환될 수 있는 아릴, 치환될 수 있는 사이클로알킬, 치환될 수 있는 방향족 헤테로환 또는 치환될 수 있는 비방향족 헤테로환이고,(2) Z1이 -저급 알킬렌-C(=O)-를 나타내는 경우,화학식 III 또는 화학식 IV의 그룹이다.화학식 III화학식 IV상기 화학식 III 및 IV에서,Z2는 단일 결합 또는 저급 알킬렌이고,R15는 -H, -OH, -O-저급 알킬, -CO2H, -CO2-저급 알킬, 1개 또는 2개의 저급 알킬로 치환될 수 있는 카바모일, 치환될 수 있는 아릴, 치환될 수 있는 사이클로알킬, 치환될 수 있는 방향족 헤테로환 또는 치환될 수 있는 비방향족 헤테로환이고,R13 및 R14는 인접하는 질소원자와 일체가 되어 치환될 수 있는 비방향족 환상 아미노 그룹을 형성한다.
- 제2항에 있어서, R1이 화학식 II 또는 화학식 III의 그룹인 화합물.
- 제3항에 있어서, a가 단일 결합이고, b가 이중 결합이고, -X-가 -CH=CH-이고, -Y-가 -CH-인 화합물.
- 제4항에 있어서, R1이 화학식 II의 그룹인 화합물.
- 제5항에 있어서, -A-가 -O-인 화합물.
- 제6항에 있어서, -B가 치환될 수 있는 저급 알킬인 화합물.
- 제7항에 있어서, R2가 트리플루오로메틸이고, R3이 -H 또는 -F인 화합물.
- 제1항에 있어서,(2Z)-N-(2-아미노-2-옥소에틸)-2-{4,4,7-트리플루오로-1-[4-{[(2R)-2-플루오로프로필]옥시}-2-(트리플루오로메틸)벤조일]-1,2,3,4-테트라하이드로-5H-1-벤즈아제핀-5-일리덴}아세트아미드,(2Z)-N-(2-하이드록시에틸)-2-{4,4,7-트리플루오로-1-[4-{[(2S)-2-플루오로프로필]옥시}-2-(트리플루오로메틸)벤조일]-1,2,3,4-테트라하이드로-5H-1-벤즈아제핀-5-일리덴}아세트아미드,(2Z)-N-(2-하이드록시에틸)-2-{4,4,7-트리플루오로-1-[4-{[(2R)-2-플루오로프로필]옥시}-2-(트리플루오로메틸)벤조일]-1,2,3,4-테트라하이드로-5H-1-벤즈아제핀-5-일리덴}아세트아미드,(2Z)-2-{4,4-디플루오로-1-[4-{[(2R)-2-플루오로프로필]옥시}-2-(트리플루오로메틸)벤조일]-1,2,3,4-테트라하이드로-5H-1-벤즈아제핀-5-일리덴}-N-[(2S)-2,3-디하이드록시프로필]아세트아미드,3-[((2Z)-2-{4,4,7-트리플루오로-1-[4-{[(2R)-2-플루오로프로필]옥시}-2-(트리플루오로메틸)벤조일]-1,2,3,4-테트라하이드로-5H-1-벤즈아제핀-5-일리덴}아세틸)아미노]프로판아미드 또는(2Z)-N-[(2R)-2,3-디하이드록시프로필]-2-{4,4,7-트리플루오로-1-[4-{[(2R)- 2-플루오로프로필]옥시}-2-(트리플루오로메틸)벤조일]-1,2,3,4-테트라하이드로-5H-1-벤즈아제핀-5-일리덴}아세트아미드인 화합물 또는 약제학적으로 허용되는 이의 염.
- 제1항에 따르는 화합물을 유효 성분으로 하는 의약 조성물.
- 제10항에 있어서, 아르기닌바소프레신 V2 수용체 자극약인 의약 조성물.
- 제10항에 있어서, 야간 빈뇨 치료제 또는 중추성 요붕증 치료제인 의약 조성물.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2003-00123032 | 2003-04-28 | ||
JP2003123032 | 2003-04-28 | ||
JP2003401126 | 2003-12-01 | ||
JPJP-P-2003-00401126 | 2003-12-01 |
Publications (2)
Publication Number | Publication Date |
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KR20060007402A true KR20060007402A (ko) | 2006-01-24 |
KR100882154B1 KR100882154B1 (ko) | 2009-02-06 |
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Application Number | Title | Priority Date | Filing Date |
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KR1020057020359A KR100882154B1 (ko) | 2003-04-28 | 2004-04-26 | 4,4-디플루오로-1,2,3,4-테트라하이드로-5h-1-벤즈아제핀 유도체 또는 이의 염 및 이를 포함하는 의약 조성물 |
Country Status (17)
Country | Link |
---|---|
US (2) | US7183271B2 (ko) |
EP (1) | EP1619185B1 (ko) |
KR (1) | KR100882154B1 (ko) |
AT (1) | ATE512951T1 (ko) |
AU (1) | AU2004234258B2 (ko) |
BR (1) | BRPI0409718A (ko) |
CA (1) | CA2521492C (ko) |
DK (1) | DK1619185T3 (ko) |
IL (1) | IL171332A (ko) |
MX (1) | MXPA05011521A (ko) |
NO (1) | NO333505B1 (ko) |
NZ (1) | NZ542815A (ko) |
PL (1) | PL1619185T3 (ko) |
PT (1) | PT1619185E (ko) |
RU (1) | RU2326868C2 (ko) |
SI (1) | SI1619185T1 (ko) |
WO (1) | WO2004096775A1 (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
BRPI0409718A (pt) | 2003-04-28 | 2006-05-02 | Astellas Pharma Inc | derivado de 4,4-difluoro-1,2,3,4-tetraidro-5h-1-benzazepina ou seu sal |
US7910751B2 (en) | 2005-07-22 | 2011-03-22 | Mochida Pharmaceutical Co., Ltd. | Heterocyclidene acetamide derivative |
KR101522747B1 (ko) | 2007-08-06 | 2015-05-26 | 알레간 인코포레이티드 | 데스모프레신 약물 전달을 위한 방법 및 장치 |
US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
LT2712622T (lt) * | 2008-05-21 | 2016-09-26 | Ferring B.V. | Burnoje disperguojamas desmopresinas, skirtas nikturijos netrikdomo miego pirminio periodo pailginimui |
US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
HUE035391T2 (en) | 2012-06-11 | 2018-05-02 | Tacurion | Process for the preparation of 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound and intermediate of synthesis |
EP3484876A1 (en) | 2016-07-14 | 2019-05-22 | Pfizer Inc | Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme |
Family Cites Families (16)
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RU2137760C1 (ru) | 1993-08-26 | 1999-09-20 | Яманоути Фармасьютикал Ко., Лтд. | Производное бензазепина, фармацевтическая композиция, производное дифторбензазепина и производное (замещенного) аминобензоилдифторбензазепина |
JPH11349570A (ja) | 1994-06-15 | 1999-12-21 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環誘導体 |
JP3215910B2 (ja) * | 1994-06-15 | 2001-10-09 | 大塚製薬株式会社 | ベンゾヘテロ環誘導体 |
CN100384825C (zh) | 1994-06-15 | 2008-04-30 | 大塚制药株式会社 | 苯并杂环衍生物 |
JPH09221476A (ja) * | 1995-12-15 | 1997-08-26 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
TW359669B (en) | 1995-12-15 | 1999-06-01 | Otsuka Pharma Co Ltd | Benzazepine derivatives |
JPH09221475A (ja) | 1996-02-13 | 1997-08-26 | Yamanouchi Pharmaceut Co Ltd | 新規なオキシム誘導体 |
AR011913A1 (es) | 1997-03-06 | 2000-09-13 | Yamano Masaki | Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos. |
JP2926335B2 (ja) | 1997-06-13 | 1999-07-28 | 大塚製薬株式会社 | 医薬組成物 |
NZ502448A (en) | 1997-07-30 | 2002-12-20 | Wyeth Corp | Tricyclic vasopressin agonists and medicaments containing these compounds |
IL133788A0 (en) | 1997-07-30 | 2001-04-30 | American Home Prod | Tricyclic vasopressin agonists |
US6547395B1 (en) | 1998-02-06 | 2003-04-15 | Wavefront Sciences, Inc. | Methods of measuring moving objects and reducing exposure during wavefront measurements |
DE60001054T2 (de) | 1999-02-04 | 2003-07-24 | Wyeth, Madison | Trizyclische pyridin n-oxide vasopressin agonisten |
GB0000079D0 (en) | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
MXPA04004501A (es) | 2001-11-16 | 2004-08-11 | Yamanouchi Pharma Co Ltd | Derivados de 4-4-difluoro-1,2,3,4-tetrahidro-5h-1-benzazepina o sales de los mismos. |
BRPI0409718A (pt) | 2003-04-28 | 2006-05-02 | Astellas Pharma Inc | derivado de 4,4-difluoro-1,2,3,4-tetraidro-5h-1-benzazepina ou seu sal |
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Also Published As
Publication number | Publication date |
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SI1619185T1 (sl) | 2011-09-30 |
IL171332A (en) | 2011-03-31 |
RU2005136863A (ru) | 2006-04-20 |
PL1619185T3 (pl) | 2011-12-30 |
RU2326868C2 (ru) | 2008-06-20 |
CA2521492A1 (en) | 2004-11-11 |
AU2004234258B2 (en) | 2009-04-09 |
NO20055602L (no) | 2006-01-24 |
US7807664B2 (en) | 2010-10-05 |
NO20055602D0 (no) | 2005-11-25 |
EP1619185B1 (en) | 2011-06-15 |
PT1619185E (pt) | 2011-08-25 |
US20060122170A1 (en) | 2006-06-08 |
NZ542815A (en) | 2009-01-31 |
MXPA05011521A (es) | 2006-01-23 |
DK1619185T3 (da) | 2011-07-18 |
EP1619185A1 (en) | 2006-01-25 |
BRPI0409718A (pt) | 2006-05-02 |
EP1619185A4 (en) | 2008-07-23 |
US7183271B2 (en) | 2007-02-27 |
AU2004234258A1 (en) | 2004-11-11 |
ATE512951T1 (de) | 2011-07-15 |
CA2521492C (en) | 2010-09-21 |
NO333505B1 (no) | 2013-06-24 |
KR100882154B1 (ko) | 2009-02-06 |
WO2004096775A1 (ja) | 2004-11-11 |
US20070167429A1 (en) | 2007-07-19 |
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