NO20055602L - 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepin-derivat og salt derav - Google Patents

4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepin-derivat og salt derav

Info

Publication number
NO20055602L
NO20055602L NO20055602A NO20055602A NO20055602L NO 20055602 L NO20055602 L NO 20055602L NO 20055602 A NO20055602 A NO 20055602A NO 20055602 A NO20055602 A NO 20055602A NO 20055602 L NO20055602 L NO 20055602L
Authority
NO
Norway
Prior art keywords
difluoro
tetrahydro
salt
benzazepine derivative
benzazepine
Prior art date
Application number
NO20055602A
Other languages
English (en)
Other versions
NO20055602D0 (no
NO333505B1 (no
Inventor
Hiroyuki Koshio
Issei Tsukamoto
Akio Kakefuda
Seijiro Akamatsu
Chikashi Saitoh
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of NO20055602D0 publication Critical patent/NO20055602D0/no
Publication of NO20055602L publication Critical patent/NO20055602L/no
Publication of NO333505B1 publication Critical patent/NO333505B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

En nytt 4,4-difluor-l,2,3,4-tetrahydro-5H-l-benzazepinderivat representert ved den følgende formel (I) eller et farmasøytisk akseptabelt salt av derivatet. De er anvendelige som et terapeutisk eller forebyggende middel mot nokturnal pollakisuri og/eller diabetes insipidus.
NO20055602A 2003-04-28 2005-11-25 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt derav, og anvendelse derav for fremstilling av et medikament NO333505B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003123032 2003-04-28
JP2003401126 2003-12-01
PCT/JP2004/005998 WO2004096775A1 (ja) 2003-04-28 2004-04-26 ４，４－ジフルオロ－１，２，３，４－テトラヒドロ－５ｈ－１－ベンゾアゼピン誘導体又はその塩

Publications (3)

Publication Number Publication Date
NO20055602D0 NO20055602D0 (no) 2005-11-25
NO20055602L true NO20055602L (no) 2006-01-24
NO333505B1 NO333505B1 (no) 2013-06-24

Family

ID=33422056

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055602A NO333505B1 (no) 2003-04-28 2005-11-25 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt derav, og anvendelse derav for fremstilling av et medikament

Country Status (17)

Country Link
US (2) US7183271B2 (no)
EP (1) EP1619185B1 (no)
KR (1) KR100882154B1 (no)
AT (1) ATE512951T1 (no)
AU (1) AU2004234258B2 (no)
BR (1) BRPI0409718A (no)
CA (1) CA2521492C (no)
DK (1) DK1619185T3 (no)
IL (1) IL171332A (no)
MX (1) MXPA05011521A (no)
NO (1) NO333505B1 (no)
NZ (1) NZ542815A (no)
PL (1) PL1619185T3 (no)
PT (1) PT1619185E (no)
RU (1) RU2326868C2 (no)
SI (1) SI1619185T1 (no)
WO (1) WO2004096775A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
AU2004234258B2 (en) 2003-04-28 2009-04-09 Tacurion 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof
KR101136183B1 (ko) 2005-07-22 2012-04-17 모찌다 세이야쿠 가부시끼가이샤 신규 헤테로시클리덴 아세트아미드 유도체
JP5451613B2 (ja) 2007-08-06 2014-03-26 アラーガン、インコーポレイテッド デスモプレシン薬物送達のための方法及びデバイス
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
ES2710454T3 (es) * 2008-05-21 2019-04-25 Ferring Bv Desmopresina bucodispersable para aumentar el periodo inicial de sueño ininterrumpido por nocturia
DK2860175T3 (da) 2012-06-11 2018-01-29 Tacurion Fremgangsmåde til fremstilling af 4,4,7-trifluor-1,2,3,4-tetrahydro-5h-1-benzazepin-forbindelse og intermediat til syntese deraf
AU2017296338A1 (en) 2016-07-14 2019-01-03 Pfizer Inc. Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0716083A4 (en) 1993-08-26 1996-08-28 Yamanouchi Pharma Co Ltd BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND INTERMEDIATES THEREOF
JPH11349570A (ja) 1994-06-15 1999-12-21 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環誘導体
CN100384825C (zh) 1994-06-15 2008-04-30 大塚制药株式会社 苯并杂环衍生物
JP3215910B2 (ja) 1994-06-15 2001-10-09 大塚製薬株式会社 ベンゾヘテロ環誘導体
JPH09221476A (ja) * 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
TW359669B (en) 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
JPH09221475A (ja) 1996-02-13 1997-08-26 Yamanouchi Pharmaceut Co Ltd 新規なオキシム誘導体
AR011913A1 (es) * 1997-03-06 2000-09-13 Yamano Masaki Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos.
JP2926335B2 (ja) 1997-06-13 1999-07-28 大塚製薬株式会社 医薬組成物
BR9811585A (pt) 1997-07-30 2000-09-26 American Home Prod Agonistas de vasopressinas tricìclicas
PT1000059E (pt) 1997-07-30 2004-12-31 Wyeth Corp Agonistas triciclicos de vasopressina
US6547395B1 (en) 1998-02-06 2003-04-15 Wavefront Sciences, Inc. Methods of measuring moving objects and reducing exposure during wavefront measurements
DE60001054T2 (de) 1999-02-04 2003-07-24 Wyeth, Madison Trizyclische pyridin n-oxide vasopressin agonisten
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
ES2327620T3 (es) 2001-11-16 2009-11-02 Astellas Pharma Inc. Derivado de 4,4-difluoro-1,2,3,4-tetraidro-5h-1-benzacepina o sales del mismo.
AU2004234258B2 (en) 2003-04-28 2009-04-09 Tacurion 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof

Also Published As

Publication number Publication date
CA2521492A1 (en) 2004-11-11
ATE512951T1 (de) 2011-07-15
MXPA05011521A (es) 2006-01-23
NO20055602D0 (no) 2005-11-25
WO2004096775A1 (ja) 2004-11-11
EP1619185A4 (en) 2008-07-23
PT1619185E (pt) 2011-08-25
NO333505B1 (no) 2013-06-24
AU2004234258B2 (en) 2009-04-09
BRPI0409718A (pt) 2006-05-02
CA2521492C (en) 2010-09-21
RU2005136863A (ru) 2006-04-20
RU2326868C2 (ru) 2008-06-20
KR100882154B1 (ko) 2009-02-06
PL1619185T3 (pl) 2011-12-30
IL171332A (en) 2011-03-31
US20070167429A1 (en) 2007-07-19
EP1619185A1 (en) 2006-01-25
AU2004234258A1 (en) 2004-11-11
KR20060007402A (ko) 2006-01-24
SI1619185T1 (sl) 2011-09-30
US7807664B2 (en) 2010-10-05
EP1619185B1 (en) 2011-06-15
DK1619185T3 (da) 2011-07-18
US20060122170A1 (en) 2006-06-08
NZ542815A (en) 2009-01-31
US7183271B2 (en) 2007-02-27

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