DE602005011113D1 - Morphinanderivate als mittel gegen juckreiz - Google Patents

Morphinanderivate als mittel gegen juckreiz

Info

Publication number
DE602005011113D1
DE602005011113D1 DE602005011113T DE602005011113T DE602005011113D1 DE 602005011113 D1 DE602005011113 D1 DE 602005011113D1 DE 602005011113 T DE602005011113 T DE 602005011113T DE 602005011113 T DE602005011113 T DE 602005011113T DE 602005011113 D1 DE602005011113 D1 DE 602005011113D1
Authority
DE
Germany
Prior art keywords
morphinan
cyclopropylmethyl
dihydroxy
epoxy
morphinanderivates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005011113T
Other languages
English (en)
Inventor
Naoki Izumimoto
Toshikazu Komagata
Toshiyuki Honda
Koji Kawai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of DE602005011113D1 publication Critical patent/DE602005011113D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
DE602005011113T 2004-03-30 2005-03-30 Morphinanderivate als mittel gegen juckreiz Active DE602005011113D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004097798 2004-03-30
PCT/JP2005/006015 WO2005094826A1 (ja) 2004-03-30 2005-03-30 止痒剤

Publications (1)

Publication Number Publication Date
DE602005011113D1 true DE602005011113D1 (de) 2009-01-02

Family

ID=35063503

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005011113T Active DE602005011113D1 (de) 2004-03-30 2005-03-30 Morphinanderivate als mittel gegen juckreiz

Country Status (12)

Country Link
US (1) US7718664B2 (de)
EP (1) EP1736157B1 (de)
JP (1) JP4882744B2 (de)
KR (1) KR101233289B1 (de)
CN (1) CN100586434C (de)
AT (1) ATE414516T1 (de)
CA (1) CA2561509C (de)
DE (1) DE602005011113D1 (de)
ES (1) ES2317219T3 (de)
PT (1) PT1736157E (de)
TW (1) TW200533355A (de)
WO (1) WO2005094826A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200621785A (en) 2004-11-04 2006-07-01 Toray Industries Analgesic
EP1762569A1 (de) * 2005-09-12 2007-03-14 Alcasynn Pharmaceuticals Gmbh Neue 6-Amino-morphinanderivate, Herstellungsverfahren dafür und deren Verwendung als Analgetika
KR20080065664A (ko) * 2005-11-09 2008-07-14 도레이 가부시끼가이샤 기능성 장장해의 치료 또는 예방제
WO2007072749A1 (ja) * 2005-12-21 2007-06-28 Toray Industries, Inc. 鎮咳剤
FR2898124B1 (fr) * 2006-03-03 2008-09-12 Centre Nat Rech Scient Derive de resveratol a longue chaine hydroxylee utiles comme neurotrophiques
AU2008254038B2 (en) * 2007-05-21 2013-01-10 Toray Industries, Inc. Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation
US8198446B2 (en) * 2007-05-21 2012-06-12 Toray Industries, Inc. Crystalline micropowder particles
WO2008143241A1 (ja) * 2007-05-21 2008-11-27 Toray Industries, Inc. 医薬錠剤の製造法
CN101786990B (zh) * 2010-03-04 2012-01-18 合肥工业大学 一种具有抗痒活性的化合物
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
US20160361393A1 (en) * 2015-06-11 2016-12-15 Biostat Research, Llc Topical sting/bite formulation and method of use
EP3761982A4 (de) 2018-03-08 2021-12-15 Victoria Link Ltd Behandlung von demyelinisierungskrankheiten
JP2021531299A (ja) 2018-07-23 2021-11-18 トレビ セラピューティクス インコーポレイテッド 慢性咳嗽、息切れ、及び呼吸困難の治療

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4118826Y1 (de) 1964-01-24 1966-09-02
JPS416905B1 (de) * 1964-02-03 1966-04-19
JPS417786B1 (de) * 1964-02-03 1966-04-25
JPS4118823B1 (de) * 1964-02-03 1966-10-31
US3318885A (en) * 1965-07-21 1967-05-09 American Cyanamid Co Substituted 6-amino-6, 14-endoethen-ocodides and morphides
EP0116538A4 (de) * 1982-08-25 1985-04-25 Joel E Bernstein Verfahren zur behandlung von pruritis und zusammensetzung dazu.
ES2285733T3 (es) 1996-11-25 2007-11-16 Toray Industries, Inc. Agente antipruritico.
US5760023A (en) 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
MXPA99011298A (es) 1997-07-14 2004-10-28 Adolor Corp Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas.
JP4370683B2 (ja) * 2000-05-08 2009-11-25 東レ株式会社 そう痒疾患の検査方法
JP2002308769A (ja) * 2001-04-12 2002-10-23 Toray Ind Inc 止痒剤
JP4656081B2 (ja) * 2002-10-09 2011-03-23 東レ株式会社 含窒素環状置換基を有するモルヒナン誘導体
US7320984B2 (en) * 2002-10-09 2008-01-22 Toray Industries, Inc. Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group
JP4118823B2 (ja) 2003-11-10 2008-07-16 シャープ株式会社 画像処理装置、画像形成装置、画像処理方法、画像処理プログラム、および記録媒体
JP4118824B2 (ja) 2004-02-24 2008-07-16 株式会社日立製作所 優先パケットの遅延を最小化するシェーピング装置
JP4118826B2 (ja) 2004-03-01 2008-07-16 リオン株式会社 補聴器用ケースなどの製造方法及びその装置

Also Published As

Publication number Publication date
KR101233289B1 (ko) 2013-02-14
CN100586434C (zh) 2010-02-03
ATE414516T1 (de) 2008-12-15
EP1736157A4 (de) 2007-06-13
CA2561509A1 (en) 2005-10-13
CA2561509C (en) 2012-08-28
JPWO2005094826A1 (ja) 2008-02-14
EP1736157B1 (de) 2008-11-19
US7718664B2 (en) 2010-05-18
US20080275074A1 (en) 2008-11-06
WO2005094826A1 (ja) 2005-10-13
CN1938028A (zh) 2007-03-28
EP1736157A1 (de) 2006-12-27
KR20060132953A (ko) 2006-12-22
TW200533355A (en) 2005-10-16
ES2317219T3 (es) 2009-04-16
PT1736157E (pt) 2008-12-31
JP4882744B2 (ja) 2012-02-22

Similar Documents

Publication Publication Date Title
DE602005011113D1 (de) Morphinanderivate als mittel gegen juckreiz
BR0308452A (pt) composições farmacêuticas e métodos de preparação de composição farmacêutica
MXPA06009475A (es) Derivados de quinazolina y usos terapeuticos de los mismos.
BR0312934A (pt) Derivados de 8-hidróxi quinolina
PT2385053E (pt) Intermediários para a preparação de compostos bicíclicos condensados como inibidores mtor
MA29135B1 (fr) Potentialisateurs de recepteurs du glutamate
EA200801998A1 (ru) ПИРИДИН[3,4-b]ПИРАЗИНОНЫ
BR0307058A (pt) N-óxidos de derivados de n-fenil-2-pirimidina-amina
UA84712C2 (en) N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors
TW200505881A (en) Tri(cyclo) substituted amide compounds
MY132566A (en) Benzimidazolone histamine h3 antagonists
WO2001066534A3 (en) Cyclic and bicyclic diamino histamine-3 receptor antagonists
GB0413087D0 (en) Therapeutic compounds
DE69838662D1 (de) Morphinanderivate und ihre medizinische Anwendung
NO20053046D0 (no) 4-okso-1(3-substituerte fenyl-1,4-dihydro-1,8-naftyridin-3-karboksamidfosfodiesterase-4-inhibitorer.
DK1543010T3 (da) N-substituerede hydromorphoner og anvendelse deraf
EA200301142A1 (ru) Производные гетероциклилокси-, -тиокси- и -аминобензазола в качестве лигандов 5-гидрокситриптамина-6
WO2005021544A3 (en) N3-substituted imidazopyridine-derivatives as c-kit inhibitors
TW200503712A (en) (2-carboxamido)(3-amino)thiophene compounds
PE20030061A1 (es) 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4
ATE498600T1 (de) Inden derivate als pharmazeutika
NO20055602L (no) 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepin-derivat og salt derav
TW200621785A (en) Analgesic
NO20070550L (no) Fremgangsmate for fremstilling av pyrrolotriazinforbindelser
TW200806294A (en) Therapeutic or prophylactic agent for functional intestinal injury

Legal Events

Date Code Title Description
8364 No opposition during term of opposition