DK1222922T3 - Fremgangsmåde til stabilisering af benzimidazolforbindelser - Google Patents

Fremgangsmåde til stabilisering af benzimidazolforbindelser

Info

Publication number
DK1222922T3
DK1222922T3 DK00969905T DK00969905T DK1222922T3 DK 1222922 T3 DK1222922 T3 DK 1222922T3 DK 00969905 T DK00969905 T DK 00969905T DK 00969905 T DK00969905 T DK 00969905T DK 1222922 T3 DK1222922 T3 DK 1222922T3
Authority
DK
Denmark
Prior art keywords
stabilizing
benzimidazole compounds
benzimidazole
acceptable salt
physiologically acceptable
Prior art date
Application number
DK00969905T
Other languages
English (en)
Inventor
Koji Ukai
Satoshi Fujioka
Mitsuru Mizuno
Makoto Yokoyama
Shigeru Aoki
Masao Kawamura
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of DK1222922T3 publication Critical patent/DK1222922T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00969905T 1999-10-20 2000-10-19 Fremgangsmåde til stabilisering af benzimidazolforbindelser DK1222922T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29806399 1999-10-20
PCT/JP2000/007285 WO2001028559A1 (fr) 1999-10-20 2000-10-19 Procede de stabilisation de composes benzimidazoles

Publications (1)

Publication Number Publication Date
DK1222922T3 true DK1222922T3 (da) 2007-12-03

Family

ID=17854666

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00969905T DK1222922T3 (da) 1999-10-20 2000-10-19 Fremgangsmåde til stabilisering af benzimidazolforbindelser

Country Status (19)

Country Link
US (1) US7220762B1 (da)
EP (1) EP1222922B1 (da)
JP (1) JP4081273B2 (da)
KR (1) KR20020038759A (da)
CN (1) CN1197574C (da)
AT (1) ATE369857T1 (da)
AU (1) AU782538B2 (da)
CA (1) CA2387746C (da)
CY (1) CY1107506T1 (da)
DE (1) DE60036014T2 (da)
DK (1) DK1222922T3 (da)
ES (1) ES2288876T3 (da)
HU (1) HU229213B1 (da)
MX (1) MXPA02003762A (da)
NO (1) NO329940B1 (da)
PT (1) PT1222922E (da)
RU (1) RU2259828C2 (da)
TW (1) TWI268779B (da)
WO (1) WO2001028559A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100627614B1 (ko) * 1998-04-20 2006-09-25 에자이 가부시키가이샤 안정화된 벤즈이미다졸계 화합물 함유 조성물로 이루어지는 의약제제
AR036354A1 (es) * 2001-08-31 2004-09-01 Takeda Chemical Industries Ltd Preparacion solida
US20050163846A1 (en) * 2001-11-21 2005-07-28 Eisai Co., Ltd. Preparation composition containing acid-unstable physiologically active compound, and process for producing same
CN1589156A (zh) * 2001-11-21 2005-03-02 卫材株式会社 含有对酸不稳定的生理活性化合物的制剂组合物及其制法
EP1518240B1 (en) 2002-06-28 2014-05-07 LG Electronics, Inc. Recording medium having data structure for managing recording and reproduction of multiple path data recorded thereon and recording and reproducing methods and apparatus
US7720356B2 (en) 2002-11-12 2010-05-18 Lg Electronics Inc Recording medium having data structure for managing reproduction of multiple reproduction path video data recorded thereon and recording and reproducing methods and apparatuses
US7664372B2 (en) 2002-11-20 2010-02-16 Lg Electronics Inc. Recording medium having data structure for managing reproduction of multiple component data recorded thereon and recording and reproducing methods and apparatuses
TW200503783A (en) * 2003-04-11 2005-02-01 Altana Pharma Ag Oral pharmaceutical preparation for proton pump antagonists
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
RU2337687C2 (ru) * 2004-03-26 2008-11-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Фармацевтическая композиция с контролируемым высвобождением и способ ее получения
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1930030A1 (en) * 2005-09-29 2008-06-11 Eisai R&D Management Co., Ltd. Pulse preparation having improved disintegration properties in vivo
US20100105738A1 (en) * 2006-10-06 2010-04-29 Mitsuru Mizuno Extended release formulations of a proton pump inhibitor
CN100411613C (zh) * 2006-12-08 2008-08-20 中国药科大学 一种奥美拉唑速释固体制剂及其制备方法
WO2008129517A2 (en) * 2007-04-23 2008-10-30 Ranbaxy Laboratories Limited A stabilized delayed release pharmaceutical composition of rabeprazole
JP5399749B2 (ja) * 2008-03-27 2014-01-29 沢井製薬株式会社 プロトンポンプ阻害剤を含有する被覆微粒子
WO2010117756A2 (en) * 2009-03-31 2010-10-14 Dr. Reddy's Laboratories Ltd Substituted benzimidazole pharmaceutical formulations
WO2014016754A2 (en) * 2012-07-26 2014-01-30 Lupin Limited Pharmaceutical compositions of proton pump inhibitor
RU2554735C1 (ru) * 2014-08-20 2015-06-27 Открытое Акционерное Общество "Татхимфармпрепараты" Фармацевтическая композиция, содержащая рабепразол натрия, и способ ее получения
KR102227486B1 (ko) * 2017-06-30 2021-03-12 롯데정밀화학 주식회사 프로톤 펌프 저해제를 포함하는 경구용 고형제제 조성물, 이를 포함하는 경구용 고형제제 및 그 제조방법

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB189698A (en) 1921-12-29 1922-12-07 Miniere & Ind Franco Bresilien Method for the treatment of monazite and other phosphate ores
US4471638A (en) * 1982-03-26 1984-09-18 Steelcase Inc. Front removable lock
JPS62277322A (ja) 1986-02-13 1987-12-02 Takeda Chem Ind Ltd 安定化された腸溶性抗潰瘍固形組成物
CA1327010C (en) * 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
ZA871177B (en) 1986-02-21 1988-10-26 Nihon Nohyaku Co Ltd 1,3-diketone derivatives and their use
GB2189699A (en) 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
AU619444B2 (en) 1986-06-02 1992-01-30 Nippon Chemiphar Co. Ltd. 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives
SE8804629D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
YU48263B (sh) 1991-06-17 1997-09-30 Byk Gulden Lomberg Chemische Fabrik Gmbh. Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola
JPH0656665A (ja) * 1992-08-03 1994-03-01 Nippon Chemiphar Co Ltd イミダゾール誘導体を含有する胃溶性抗潰瘍剤
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
SE9302395D0 (sv) 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
CA2170647C (en) 1994-07-08 2001-03-13 Pontus John Arvid Bergstrand Multiple unit tableted dosage form i
ES2094694B1 (es) 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
US5708017A (en) 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
SK284291B6 (sk) * 1995-09-21 2005-01-03 Pharma Pass L.L.C. Farmaceutická kompozícia vo forme tabliet alebo mikrotabliet obsahujúca acidolabilný omeprazol a spôsob jej prípravy
BE1009764A3 (nl) 1995-11-06 1997-08-05 Dsm Nv Werkwijze voor de bereiding van een alpha-alkylkaneelaldehyde.
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9600071D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral formulation of two active ingredients I
JPH09216817A (ja) 1996-02-08 1997-08-19 Amano Pharmaceut Co Ltd 防湿性且つ易水崩壊性コーティング製剤
ATE220543T1 (de) 1996-04-23 2002-08-15 Janssen Pharmaceutica Nv Rasch-freisetzende ph-unabhängige feste dosisformen enthaltend cisaprid
CA2248784A1 (en) 1996-06-25 1997-12-31 Takeda Chemical Industries, Ltd. Oxazolone derivatives and their use
GB9710800D0 (en) * 1997-05-23 1997-07-23 Cipla Limited Pharmaceutical composition and method of preparing it
TW580397B (en) * 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
SE9702000D0 (sv) 1997-05-28 1997-05-28 Astra Ab New pharmaceutical formulation
US6296876B1 (en) 1997-10-06 2001-10-02 Isa Odidi Pharmaceutical formulations for acid labile substances
US20050244497A1 (en) 1997-11-05 2005-11-03 Wockhardt Limited Delayed delivery system for acid-sensitive drugs
KR100627614B1 (ko) 1998-04-20 2006-09-25 에자이 가부시키가이샤 안정화된 벤즈이미다졸계 화합물 함유 조성물로 이루어지는 의약제제
ZA9810765B (en) 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20040028737A1 (en) 2002-08-12 2004-02-12 Kopran Research Laboratories Limited Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same

Also Published As

Publication number Publication date
KR20020038759A (ko) 2002-05-23
RU2259828C2 (ru) 2005-09-10
NO329940B1 (no) 2011-01-24
AU7950200A (en) 2001-04-30
MXPA02003762A (es) 2002-09-30
US7220762B1 (en) 2007-05-22
CN1382049A (zh) 2002-11-27
NO20021875D0 (no) 2002-04-19
HUP0203333A2 (hu) 2003-02-28
EP1222922A1 (en) 2002-07-17
CA2387746A1 (en) 2001-04-26
PT1222922E (pt) 2007-09-12
WO2001028559A1 (fr) 2001-04-26
ES2288876T3 (es) 2008-02-01
AU782538B2 (en) 2005-08-04
CA2387746C (en) 2010-06-29
EP1222922B1 (en) 2007-08-15
EP1222922A4 (en) 2006-04-12
ATE369857T1 (de) 2007-09-15
DE60036014D1 (de) 2007-09-27
HU229213B1 (en) 2013-09-30
CN1197574C (zh) 2005-04-20
DE60036014T2 (de) 2008-04-30
HUP0203333A3 (en) 2004-01-28
NO20021875L (no) 2002-06-04
CY1107506T1 (el) 2013-03-13
TWI268779B (en) 2006-12-21
JP4081273B2 (ja) 2008-04-23

Similar Documents

Publication Publication Date Title
DK1222922T3 (da) Fremgangsmåde til stabilisering af benzimidazolforbindelser
NO20041504L (no) Lactamderivater som antagonister for humane 11CBY reseptorer.
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
CY1105387T1 (el) Υποκατεστημενα παραγωγα 2-διαλκυλαμινοαλκυλοδιφαινθλιου
PT911333E (pt) Derivados de pirazolo¬4,3-d|pirimidina e composicoes farmaceuticas que os contenham
NO20054787L (no) Indenderivater som farmasotiske midler
HRP20090281T1 (en) 1,2,3,4-tetrasubstituted indole for the treatment of respiratory diseases
ATE283253T1 (de) Substituierte aminopropoxyarylderivate als lxr agonisten
ES2182234T3 (es) Inhibidores de metaloproteasa.
NO982606L (no) Naftylsubstituerte benzimidazolderivater som antikoagulanter
EP1191025A4 (en) CRYSTALS OF BENZIMIDAZOLE DERIVATIVES
NO20050664L (no) 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer
SE0102843D0 (sv) Stabilized oral pharmaceutical composition containing lodide and lodate and method
EA200400259A1 (ru) Дезинфицирующий раствор на основе гипохлорита натрия и способ его получения
NO20055602D0 (no) 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepin-derivat og salt derav
EE200200591A (et) Püridiin-1-oksiidderivaat ja meetod selle muutmiseks farmatseutiliselt efektiivseteks ühenditeks
NO20014855D0 (no) N-(2-fenyl-4-aminobutyl)-1-naftamider som neurokinin-1- reseptorantagonister
IT1320107B1 (it) Procedimento per la preparazione di derivati tassanici.
FI952420A0 (fi) Glukopyranosidibentsotiofeenit
WO2004048381A3 (en) Pyrazoloazepine compounds as pharmaceutical agents
ATE205835T1 (de) Akarizid und insektizid wirksame, substituierte pyrimidine und verfahren zu ihrer herstellung
DK0888340T3 (da) 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin
ATE282608T1 (de) Chinoxalindionen
AR022598A1 (es) Procedimiento para la preparacion de compuestos 6-(perfluoralquil)uracilo para compuestos carbamato
ES2149691A1 (es) 2-4-[4-(4,5-dicloro-2metilimidazol-1-il)butil]-1-piperacinil -5-fluoropirimidina, su preparacion y su utilizacion terapeutica.