DK0888340T3 - 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin - Google Patents

4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin

Info

Publication number
DK0888340T3
DK0888340T3 DK97905897T DK97905897T DK0888340T3 DK 0888340 T3 DK0888340 T3 DK 0888340T3 DK 97905897 T DK97905897 T DK 97905897T DK 97905897 T DK97905897 T DK 97905897T DK 0888340 T3 DK0888340 T3 DK 0888340T3
Authority
DK
Denmark
Prior art keywords
enodthelin
dioxolyl
pyrrolidine
benzo
antagonists
Prior art date
Application number
DK97905897T
Other languages
English (en)
Inventor
Andrew S Tasker
Steven A Boyd
Bryan K Sorensen
Martin Winn
Hwan-Soo Jae
Geldern Thomas W Von
Kenneth J Henry
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK0888340T3 publication Critical patent/DK0888340T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK97905897T 1996-02-13 1997-02-10 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin DK0888340T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60072496A 1996-02-13 1996-02-13
US79450597A 1997-02-04 1997-02-04
PCT/US1997/002128 WO1997030046A1 (en) 1996-02-13 1997-02-10 4-(benzo-1,3-dioxolyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists

Publications (1)

Publication Number Publication Date
DK0888340T3 true DK0888340T3 (da) 2002-11-04

Family

ID=27083691

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97905897T DK0888340T3 (da) 1996-02-13 1997-02-10 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin

Country Status (18)

Country Link
EP (1) EP0888340B1 (da)
JP (1) JP2000504727A (da)
CN (1) CN1079397C (da)
AR (1) AR005801A1 (da)
AT (1) ATE220673T1 (da)
AU (1) AU714597B2 (da)
BR (1) BR9707394A (da)
CA (1) CA2245684A1 (da)
CZ (1) CZ253698A3 (da)
DE (1) DE69714024T2 (da)
DK (1) DK0888340T3 (da)
ES (1) ES2182029T3 (da)
HU (1) HUP9902316A3 (da)
IL (1) IL125453A0 (da)
NZ (2) NZ503383A (da)
PT (1) PT888340E (da)
WO (1) WO1997030046A1 (da)
ZA (1) ZA971184B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162927A (en) 1994-08-19 2000-12-19 Abbott Laboratories Endothelin antagonists
US7208517B1 (en) 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
US6124341A (en) * 1996-02-13 2000-09-26 Abbott Laboratories Endothelin antagonists
WO1998057933A1 (en) * 1997-06-17 1998-12-23 Abbott Laboratories Pyrrolidine carboxylic acid derivatives as endothelin antagonists
TR200101233T2 (tr) * 1997-08-04 2002-06-21 Abbott Laboratories Endotelin antagonistleri.
BR0112655A (pt) 2000-07-19 2003-06-24 Hoffmann La Roche Derivados de pirrolidino como inibidores de metaloproteases
WO2002017912A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Endothelin antagonists
RU2259825C9 (ru) * 2001-06-18 2006-04-10 БиоДием Лимитед Вещества, проявляющие антимикробную, антигрибковую, антипротозойную активности

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2125980C1 (ru) * 1991-11-05 1999-02-10 Смитклайн Бичам Корпорейшн Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов
WO1994002474A1 (en) * 1992-07-17 1994-02-03 Smithkline Beecham Corporation Endothelin receptor antagonists
ATE219077T1 (de) * 1994-08-19 2002-06-15 Abbott Lab Endothelin antagoniste

Also Published As

Publication number Publication date
ZA971184B (en) 1997-08-27
IL125453A0 (en) 1999-03-12
CN1215401A (zh) 1999-04-28
NZ503383A (en) 2002-02-01
HUP9902316A2 (hu) 1999-11-29
CZ253698A3 (cs) 1999-03-17
BR9707394A (pt) 1999-04-06
JP2000504727A (ja) 2000-04-18
ATE220673T1 (de) 2002-08-15
DE69714024D1 (de) 2002-08-22
AU714597B2 (en) 2000-01-06
DE69714024T2 (de) 2003-03-20
AU2267897A (en) 1997-09-02
HUP9902316A3 (en) 2001-12-28
PT888340E (pt) 2002-12-31
AR005801A1 (es) 1999-07-14
EP0888340B1 (en) 2002-07-17
WO1997030046A1 (en) 1997-08-21
CA2245684A1 (en) 1997-08-21
NZ331124A (en) 2000-05-26
CN1079397C (zh) 2002-02-20
ES2182029T3 (es) 2003-03-01
EP0888340A1 (en) 1999-01-07

Similar Documents

Publication Publication Date Title
DK1244647T3 (da) Quinzolinderivater som VIGF-inhibitorer
DK0912559T3 (da) Kondenserede heterocykliske forbindelser som proteintyrosinkinaseinhibitorer
NO992725D0 (no) 6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer
NO982907D0 (no) Tyrosinderivater som <alfa>-v-integrininhibitorer
DK2253620T3 (da) Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
NO20031540L (no) Benzamidforbindelser som Apo-B-sekresjonsinhibitorer
NO20011575L (no) Substituerte 3-cyanokinoliner som proteintyrosin-kinase- inhibitorer
FI962800A0 (fi) Fenyyliheterosyklisiä yhdisteitä COX-2 inhibiittoreina
DK1001934T3 (da) Indolforbindelser som COX-2-inhibitorer
EE9900053A (et) 4-(5-metüül-3-fenüülisoksasool-4-üül)benseensulfoonamiidi kristalliline vorm
ID17275A (id) N-[4-(heteroarilmetil)fenil]-heteroarilamina
NO983603D0 (no) Substituerte sulfonsyre N-£(aminoiminometyl)-fenylalkyl|-azaheterocyklamid-forbindelser
NO971137D0 (no) Dimetyl-(3-aryl-but-3-enyl)-aminforbindelse som farmasöytiske forbindelser
DK0858452T3 (da) Thiazolderivater som proteinkinase C-inhibitorer
DK0885215T3 (da) Nye benzo-1,3-dioxolyl- og benzofuranyl-substituerede pyrrolidinderivater som endthelinantagonister
DK0891362T3 (da) Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase
NO20010331D0 (no) Ftalazinderivater som fosfodiesterase 4-inhibitorer
DK0799223T3 (da) Piperidineddikesyrederivater til anvendelse som fibrinogenantagonistmidler
NO991994D0 (no) Substituerte 4-bifenyl-4-hydroksysm°rsyrederivater som matriks-metalloproteaseinhibitorer
DK0888340T3 (da) 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin
DE59712294D1 (de) Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3-phenyl-propionsäure-ethylesters
NO961333D0 (no) Nye pyrazolderivater som angiotensin-II-antagonister
NO996244D0 (no) Pyrrolidinkarboksylsyrederivater som endotelinantagonister
NO983829L (no) Nye substituerte N-metyl-N-(4-(4-(1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)-2-(aryl)butyl)benzamider som er anvendbare for behandling av allergiske sykdommer
DE59914948D1 (de) Verwendung von 1-(aminoalkyl)-3-chinoxalin-2-on-derivaten zur herstellung von als antioxidantien wirkenden zusammensetzungen