AR005801A1 - Antagonistas de la endotelina, composicion farmaceutica que los contiene y uso de un compuesto antagonista para preparar un medicamento o composicionfarmaceutica - Google Patents
Antagonistas de la endotelina, composicion farmaceutica que los contiene y uso de un compuesto antagonista para preparar un medicamento o composicionfarmaceuticaInfo
- Publication number
- AR005801A1 AR005801A1 ARP970100554A ARP970100554A AR005801A1 AR 005801 A1 AR005801 A1 AR 005801A1 AR P970100554 A ARP970100554 A AR P970100554A AR P970100554 A ARP970100554 A AR P970100554A AR 005801 A1 AR005801 A1 AR 005801A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical composition
- alkylene
- lower alkyl
- alkenyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Antagonistas de la endotelina que comprende la fórmula (I) en la cual R es -(CH2)mW en donde m es un número entero de 0 a 6 y W es (a) -C(O)2-G en dondeG es H o un grupo protector del carbonilo; (b) -PC3H2; (c) -P(O)(OH)E en donde E es H, alquiloi nferior o arialquilo; (d)-CN; (e)-C(O)NHR17, en donde R17 esalquilo inferior; (f)alquilaminocarbonilo; (g)dialquilaminocarbonilo; (h) tetrazolilo; (i)hidroxi; (j)alcoxi; (k)sulfonamaido; (l)C(O)NH-SIOR14, en dondeR14 es alquilo inferiorhaloalq uilo, arilo o dialquilamino inferior; (m) -SiO2NHC(O)R15;(n)fórmulas (o),(p),(q),(r),(s),(t),(u);R1 y R2 son seleccionadoindependientemente a partir de hidrógeno, alquilo inferior, alquenilo, alquinilo, alcoxialquilo,alcoxicarbonil, hidroxialquilo, haloalquilo,haloalcoxialquilo, alcoxialcoxialquilo, tioalcoxialcoxialquilo, cicloalquilo, cicloalquilalquilo, aminocarbonilalquilo, alquilaminocarbonilalquilo,dialquilaminocarbonilalquilo, aminocarbonilalquenilo,alquilaminocarbonil alquenilo, dialquilaminocarbonilalquenilo, hidroxialquenilo, arilo,arilalquilo, ariloxialquilo, arilalcoxialquilo, heterocíclico, alquilo heterocíclico y (Raa)(Rbb)N-Rcc en donde Raa es arilo, o arilalquilo;Rbbes H o alcanoil o y Rcc es alquileno, con la condición de que uno ambos R1 y R2 no sean H; R3 es R4-C(O)-R5-o R6-S(O)2-R7, en donde R5 es (i) una unióncovalente (ii) alquileno (iii) alquenileno (iv)N(R20)-R8 o R8a-N(R20-R8-, en donde R8 yR8a son seleccionad os independientemente a partir de grupo formadopor alquileno y alquenileno; R20 es H, alquilo inferior, alquenilo, haloalquilo, alcoxialquilo,haloalcoxialquilo, cicloalquilo o cicloalquilalquiloo (v) -O-R9- o-R9a-O-R9, en donde R9 y R9a son seleccionados independientemente a partir de alquileno; R7 es (i) una unión covalente; (ii)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60072496A | 1996-02-13 | 1996-02-13 | |
| US79450597A | 1997-02-04 | 1997-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005801A1 true AR005801A1 (es) | 1999-07-14 |
Family
ID=27083691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100554A AR005801A1 (es) | 1996-02-13 | 1997-02-12 | Antagonistas de la endotelina, composicion farmaceutica que los contiene y uso de un compuesto antagonista para preparar un medicamento o composicionfarmaceutica |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0888340B1 (es) |
| JP (1) | JP2000504727A (es) |
| CN (1) | CN1079397C (es) |
| AR (1) | AR005801A1 (es) |
| AT (1) | ATE220673T1 (es) |
| AU (1) | AU714597B2 (es) |
| BR (1) | BR9707394A (es) |
| CA (1) | CA2245684A1 (es) |
| CZ (1) | CZ253698A3 (es) |
| DE (1) | DE69714024T2 (es) |
| DK (1) | DK0888340T3 (es) |
| ES (1) | ES2182029T3 (es) |
| HU (1) | HUP9902316A3 (es) |
| IL (1) | IL125453A0 (es) |
| NZ (2) | NZ331124A (es) |
| PT (1) | PT888340E (es) |
| WO (1) | WO1997030046A1 (es) |
| ZA (1) | ZA971184B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7208517B1 (en) | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
| US6162927A (en) | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
| US6124341A (en) * | 1996-02-13 | 2000-09-26 | Abbott Laboratories | Endothelin antagonists |
| HUP0002681A3 (en) * | 1997-06-17 | 2001-09-28 | Abbott Lab | Pyrrolidine carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing the same |
| TR200101234T2 (tr) * | 1997-08-04 | 2002-06-21 | Abbott Laboratories | Endotelin antagonistleri. |
| WO2002008185A1 (en) * | 2000-07-19 | 2002-01-31 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives as metalloprotease inhibitors |
| WO2002017912A1 (en) * | 2000-08-31 | 2002-03-07 | Abbott Laboratories | Endothelin antagonists |
| RU2259825C9 (ru) * | 2001-06-18 | 2006-04-10 | БиоДием Лимитед | Вещества, проявляющие антимикробную, антигрибковую, антипротозойную активности |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2125980C1 (ru) * | 1991-11-05 | 1999-02-10 | Смитклайн Бичам Корпорейшн | Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов |
| WO1994002474A1 (en) * | 1992-07-17 | 1994-02-03 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| CA2517691A1 (en) * | 1994-08-19 | 1996-02-29 | Abbott Laboratories | Endothelin antagonists |
-
1997
- 1997-02-10 BR BR9707394A patent/BR9707394A/pt not_active Application Discontinuation
- 1997-02-10 IL IL12545397A patent/IL125453A0/xx unknown
- 1997-02-10 CA CA002245684A patent/CA2245684A1/en not_active Abandoned
- 1997-02-10 ES ES97905897T patent/ES2182029T3/es not_active Expired - Lifetime
- 1997-02-10 NZ NZ331124A patent/NZ331124A/xx unknown
- 1997-02-10 DE DE69714024T patent/DE69714024T2/de not_active Expired - Lifetime
- 1997-02-10 AU AU22678/97A patent/AU714597B2/en not_active Ceased
- 1997-02-10 NZ NZ503383A patent/NZ503383A/en unknown
- 1997-02-10 CN CN97193633A patent/CN1079397C/zh not_active Expired - Fee Related
- 1997-02-10 EP EP97905897A patent/EP0888340B1/en not_active Expired - Lifetime
- 1997-02-10 JP JP9529436A patent/JP2000504727A/ja active Pending
- 1997-02-10 DK DK97905897T patent/DK0888340T3/da active
- 1997-02-10 HU HU9902316A patent/HUP9902316A3/hu unknown
- 1997-02-10 WO PCT/US1997/002128 patent/WO1997030046A1/en not_active Application Discontinuation
- 1997-02-10 PT PT97905897T patent/PT888340E/pt unknown
- 1997-02-10 AT AT97905897T patent/ATE220673T1/de not_active IP Right Cessation
- 1997-02-10 CZ CZ982536A patent/CZ253698A3/cs unknown
- 1997-02-12 AR ARP970100554A patent/AR005801A1/es unknown
- 1997-02-12 ZA ZA9701184A patent/ZA971184B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2267897A (en) | 1997-09-02 |
| HUP9902316A3 (en) | 2001-12-28 |
| ES2182029T3 (es) | 2003-03-01 |
| DE69714024T2 (de) | 2003-03-20 |
| BR9707394A (pt) | 1999-04-06 |
| CN1079397C (zh) | 2002-02-20 |
| NZ331124A (en) | 2000-05-26 |
| CZ253698A3 (cs) | 1999-03-17 |
| AU714597B2 (en) | 2000-01-06 |
| HUP9902316A2 (hu) | 1999-11-29 |
| DE69714024D1 (de) | 2002-08-22 |
| ATE220673T1 (de) | 2002-08-15 |
| NZ503383A (en) | 2002-02-01 |
| PT888340E (pt) | 2002-12-31 |
| CA2245684A1 (en) | 1997-08-21 |
| EP0888340A1 (en) | 1999-01-07 |
| WO1997030046A1 (en) | 1997-08-21 |
| CN1215401A (zh) | 1999-04-28 |
| DK0888340T3 (da) | 2002-11-04 |
| EP0888340B1 (en) | 2002-07-17 |
| IL125453A0 (en) | 1999-03-12 |
| JP2000504727A (ja) | 2000-04-18 |
| ZA971184B (en) | 1997-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |