DE68929372T2 - Thieno[3,2-f] (1,2,4- triazolo)[4,3-a] 1,4- diazepinderivate als PAF-Antagonisten - Google Patents

Thieno[3,2-f] (1,2,4- triazolo)[4,3-a] 1,4- diazepinderivate als PAF-Antagonisten

Info

Publication number
DE68929372T2
DE68929372T2 DE68929372T DE68929372T DE68929372T2 DE 68929372 T2 DE68929372 T2 DE 68929372T2 DE 68929372 T DE68929372 T DE 68929372T DE 68929372 T DE68929372 T DE 68929372T DE 68929372 T2 DE68929372 T2 DE 68929372T2
Authority
DE
Germany
Prior art keywords
triazolo
hydrogen
thieno
paf antagonists
diazepine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68929372T
Other languages
English (en)
Other versions
DE68929372D1 (de
Inventor
Kazuo Okano
Shuhei Miyazawa
Richard Stephen J Clark
Shinya Abe
Tetsuya Kawahara
Naoyuki Shimomura
Osamu Asano
Hiroyuki Yoshimura
Mitsuaki Miyamoto
Yoshinori Sakuma
Kenzo Muramoto
Hiroshi Obaishi
Koukichi Harada
Hajime Tsunoda
Satoshi Katayama
Kouji Yamada
Shigeru Souda
Yoshimasa Machida
Kouichi Katayama
Isao Yamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DE68929372D1 publication Critical patent/DE68929372D1/de
Application granted granted Critical
Publication of DE68929372T2 publication Critical patent/DE68929372T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE68929372T 1988-10-31 1989-10-26 Thieno[3,2-f] (1,2,4- triazolo)[4,3-a] 1,4- diazepinderivate als PAF-Antagonisten Expired - Fee Related DE68929372T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP27546088 1988-10-31
JP29706888 1988-11-24
JP31801688 1988-12-16
JP33162288 1988-12-28

Publications (2)

Publication Number Publication Date
DE68929372D1 DE68929372D1 (de) 2002-03-21
DE68929372T2 true DE68929372T2 (de) 2002-10-02

Family

ID=27479049

Family Applications (3)

Application Number Title Priority Date Filing Date
DE68929372T Expired - Fee Related DE68929372T2 (de) 1988-10-31 1989-10-26 Thieno[3,2-f] (1,2,4- triazolo)[4,3-a] 1,4- diazepinderivate als PAF-Antagonisten
DE68929455T Expired - Fee Related DE68929455T2 (de) 1988-10-31 1989-10-26 Thieno 3,2-f 1,2,4 triazolo 4,3-a 1,4 diazepinderivate als PAF-Antagonisten
DE68929049T Expired - Fee Related DE68929049T2 (de) 1988-10-31 1989-10-26 1,4-Diazepin-Derivate und deren pharmazeutische Verwendung

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE68929455T Expired - Fee Related DE68929455T2 (de) 1988-10-31 1989-10-26 Thieno 3,2-f 1,2,4 triazolo 4,3-a 1,4 diazepinderivate als PAF-Antagonisten
DE68929049T Expired - Fee Related DE68929049T2 (de) 1988-10-31 1989-10-26 1,4-Diazepin-Derivate und deren pharmazeutische Verwendung

Country Status (15)

Country Link
EP (3) EP0606103B1 (de)
JP (1) JP2756004B2 (de)
KR (1) KR910009332B1 (de)
CN (1) CN1036520C (de)
AT (3) ATE234306T1 (de)
AU (1) AU621413B2 (de)
CA (1) CA2000985C (de)
DE (3) DE68929372T2 (de)
DK (1) DK540689A (de)
FI (1) FI95708C (de)
HU (1) HU217127B (de)
NO (1) NO175259C (de)
NZ (1) NZ231188A (de)
PH (1) PH27461A (de)
PT (1) PT92153B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
GB8907257D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-paf and anti-ischemic agents
GB8907256D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors
AT394563B (de) * 1990-05-09 1992-05-11 Scras Verfahren zur herstellung von thieno-triazolodiazepinderivaten
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
DE4107521A1 (de) * 1991-03-08 1992-09-10 Boehringer Ingelheim Kg Neue acylaminosubstituierte hetrazepine
US5686479A (en) * 1991-12-11 1997-11-11 Yoshitomi Pharmaceutical Industries, Ltd. Immunosuppressive drug
TW219935B (de) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5530141A (en) * 1992-03-04 1996-06-25 Center For Innovative Technology 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5648486A (en) * 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
PT650485E (pt) 1992-07-13 2001-03-30 Millennium Pharm Inc 2,5-diaril-tetra-hidro-tiofenos -furanos e analogos para o tratamento de desordens inflamatorias e imunitarias
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
ES2061406B1 (es) * 1993-05-07 1995-06-01 Uriach & Cia Sa J Nuevos derivados de la 2-(quinolina) con actividad farmacologica.
JP2523259B2 (ja) * 1993-06-30 1996-08-07 エスオーエンジニアリング株式会社 フォ―ハ―ス内のガラス温度制御方法
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
WO1998058930A1 (fr) * 1997-06-25 1998-12-30 Nikken Chemicals Co., Ltd. Composes de triazolo-1,4-diazepine et composition medicinale les contenant
FR2779652B1 (fr) * 1998-06-15 2001-06-08 Sod Conseils Rech Applic Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique
SG109000A1 (en) 2003-07-16 2005-02-28 Asml Netherlands Bv Lithographic apparatus and device manufacturing method
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2705039B1 (de) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomainhemmer und ihre verwendung
EP2721031B1 (de) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomainhemmer und ihre verwendungen
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
JP6682522B2 (ja) 2014-06-20 2020-04-15 コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ２−（（４ｓ）−６−（４−クロロフェニル）−１−メチル−４ｈ−ベンゾ［ｃ］イソオキサゾロ［４，５−ｅ］アゼピン−４−イル）アセトアミドの結晶形態

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) * 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.
DE3724031A1 (de) 1986-07-22 1988-01-28 Boehringer Ingelheim Kg Neue hetrazepine und verfahren zu ihrer herstellung
PH30676A (en) 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
EP0268242B1 (de) * 1986-11-17 1992-03-18 Yoshitomi Pharmaceutical Industries, Ltd. PAF-antagonistische Thienotriazoldiazepin-Verbindungen und deren pharmazeutische Anwendung
EP0368175A1 (de) * 1988-11-06 1990-05-16 Boehringer Ingelheim Kg 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin.
GB8911030D0 (en) * 1989-05-13 1989-06-28 Scras Hetrazepine derivatives
YU133090A (sh) * 1989-07-12 1993-10-20 Boehringer Ingelheim Kg. Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo
AT394563B (de) * 1990-05-09 1992-05-11 Scras Verfahren zur herstellung von thieno-triazolodiazepinderivaten

Also Published As

Publication number Publication date
ATE213247T1 (de) 2002-02-15
NO175259C (no) 1994-09-21
DE68929455T2 (de) 2004-01-08
DE68929049D1 (de) 1999-09-16
EP0367110B1 (de) 1999-08-11
FI95708C (fi) 1996-03-11
ATE234306T1 (de) 2003-03-15
PT92153B (pt) 1995-06-30
EP0606103B1 (de) 2003-03-12
KR900006342A (ko) 1990-05-08
PH27461A (en) 1993-07-09
NO894287L (no) 1990-05-02
HU217127B (hu) 1999-11-29
DE68929455D1 (de) 2003-04-17
JP2756004B2 (ja) 1998-05-25
CN1036520C (zh) 1997-11-26
KR910009332B1 (ko) 1991-11-11
HUT53106A (en) 1990-09-28
NO894287D0 (no) 1989-10-27
NZ231188A (en) 1991-06-25
CA2000985C (en) 2000-01-18
HU895609D0 (en) 1990-01-28
EP0606103A1 (de) 1994-07-13
AU621413B2 (en) 1992-03-12
DE68929372D1 (de) 2002-03-21
EP0677524B1 (de) 2002-02-13
EP0677524A1 (de) 1995-10-18
CA2000985A1 (en) 1990-04-30
DK540689D0 (da) 1989-10-30
NO175259B (no) 1994-06-13
ATE183187T1 (de) 1999-08-15
JPH02256682A (ja) 1990-10-17
CN1121076A (zh) 1996-04-24
AU4376189A (en) 1990-05-03
DK540689A (da) 1990-05-01
FI894867A0 (fi) 1989-10-13
EP0367110A1 (de) 1990-05-09
DE68929049T2 (de) 2000-01-27
FI95708B (fi) 1995-11-30
PT92153A (pt) 1990-05-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee