MX9802679A - Derivados de ditiolan, su preparacion y su efecto terapeutico. - Google Patents
Derivados de ditiolan, su preparacion y su efecto terapeutico.Info
- Publication number
- MX9802679A MX9802679A MX9802679A MX9802679A MX9802679A MX 9802679 A MX9802679 A MX 9802679A MX 9802679 A MX9802679 A MX 9802679A MX 9802679 A MX9802679 A MX 9802679A MX 9802679 A MX9802679 A MX 9802679A
- Authority
- MX
- Mexico
- Prior art keywords
- con
- group
- formula
- substituents alpha
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos de la formula (I): en donde uno de m y n es 0, y el otro es 0, 1 o 2; k es 0 o un entero de 1 a 12; R1 es hidrogeno, uno de los substituyentes A, que se define más adelante, u opcionalmente un grupo alquilo substituido, A representa un solo enlace, un átomo de oxígeno, un grupo carbonilo o un grupo de formula -N(R2)CO-, -N(R2)C, -N(R2)SO2-, -CON(R2)N(R3)CO-, -CON(R2)CO-, -CON(R2)CS, -CON(R2)SO2-, -O-CO-, -ON(R2)CO-, -ON(R2)CO-, -ON(RW)SO2-, -O-CON(R2)N(R3)CO-, -O-CON(R2)CO-, -O-CON(R2)SO2-, -CO-O-, -CO-CO-, -CO-CON(R2)N(R3)CO-, -CO-CON(R2)CO-, -CO-CON(R2)SO2, -N(R2)O-, -N(R2)COCO-, -N(R2)N(R3)CO-, -N(R2)N(R3)SO2 -N(R2)CON(R3)N(R4)CO-, -N(R2)CON(R3)CO-, -N(R2)CON(R3SO2, o N(R2)CON(R3)SOWN(R4)CO-, en donde R2, R3 y R4 son los mismos o diferentes y cada uno es hidrogeno, alquilo, arilo, aralquilo, acilo o uno de los substituyentes A; B es un solo enlace, o un grupo de la formula -N(R5)- o N(R6)N(R5)- en donde R5 y R6 son los mismos o diferentes y cada uno es hidrogeno, alquilo, arilo, aralquilo, acilo o uno de los substituyentes A, o R5 junto con R1 y el átomo de nitrogeno al cual están unidos, puede formar un anillo heterocíclico que tiene de 5 a 7 átomos en el anillo; o R1 puede representar un grupo de la formula OR7, en la cual R7 es alquilo, alquenilo, aralquilo o uno de los substituyentes A; o R1 puede representar un grupo hidroxilo o un grupo de la formula -OR7; y dichos substituyentes A se seleccionan de grupos arilo y grupos heterocíclicos y sales farmacéuticamente aceptables de los mismos que tiene una excelente capacidad para incrementar la actividad de la glutation reductasa y por lo tanto se pueden usar para el tratamiento o prevencion de una variedad de enfermedades, incluyendo cataratas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP83749/1997 | 1997-04-02 | ||
JP8374997 | 1997-04-02 | ||
JP883798 | 1998-01-20 | ||
JP8837/1998 | 1998-01-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9802679A true MX9802679A (es) | 1998-12-31 |
MXPA98002679A MXPA98002679A (es) | 1999-02-01 |
Family
ID=
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1070710A3 (en) | Dithiolan derivatives, their preparation and their therapeutic effect | |
HUP0003921A2 (hu) | VLA-4 által közvetített leukocitaadhéziót gátló szulfonilezett dipeptidszármazékok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
DE69507476D1 (de) | Farnesyl-transferase-inhibitoren, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen | |
DE10199003I2 (es) | ||
RU95108387A (ru) | Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина | |
ATE242231T1 (de) | Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase | |
HUP0001154A2 (hu) | 3-Piperidil-4-oxo-kinazolin-származékok és a vegyületeket tartalmazó gyógyászati készítmények | |
MX9605156A (es) | Inhibidor de angiogenesis. | |
DE60005502D1 (de) | 4'-c-ethynyl-purin-nukleoside | |
NZ214787A (en) | Arylcyclobutylalkylamines and pharmaceutical compositions | |
DE69227088D1 (de) | Verwendung von 1-(aminoalkyl)-3-Quinoxalin-2-on Derivaten zur Herstellung von neuroprotektiven Mitteln | |
MD1560F2 (en) | Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses. | |
HUP0303279A2 (hu) | Indolo-pirrolo-karbazolok cukorszármazékai, mint topoizomeráz inhibitorok és ezeket tartalmazó gyógyszerkészítmények | |
IL112098A0 (en) | Sulfamate derivatives and pharmaceutical compositions containing them | |
ATE81655T1 (de) | Cephemverbindungen und verfahren zu ihrer herstellung. | |
ES2055235T3 (es) | Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation. | |
HUP9700810A2 (hu) | Diozmetinsavak és -észterek, és a vegyületeket tartalmazó gyógyszerkészítmények | |
ATE86866T1 (de) | Antikrebs-zusammensetzung. | |
IL111725A0 (en) | 3'-aziridino-anthracycline derivatives, their preparation and pharmaceutical compositions containing them | |
DE3162053D1 (en) | N-acyl peptide compounds, processes for the preparation thereof and pharmaceutical compositions containing them | |
ATE86117T1 (de) | Zusammensetzung gegen leberkrankheiten. | |
ATE123487T1 (de) | Derivate der kaffeinsäure und sie enthaltende pharmazeutische zusammensetzungen. | |
AU2002214320A1 (en) | Imidazole derivatives, process for their preparation and their use | |
BG102429A (en) | Derivatives of 5-naphthalen-1-yl-1,3-dioxan, their preparation and usage as therapeutical means | |
IL147307A0 (en) | Indolocarbazole alkaloid derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |