ES8507536A1 - Un procedimiento para la preparacion de estimulantes cardiacos de quinazolinas. - Google Patents
Un procedimiento para la preparacion de estimulantes cardiacos de quinazolinas.Info
- Publication number
- ES8507536A1 ES8507536A1 ES534824A ES534824A ES8507536A1 ES 8507536 A1 ES8507536 A1 ES 8507536A1 ES 534824 A ES534824 A ES 534824A ES 534824 A ES534824 A ES 534824A ES 8507536 A1 ES8507536 A1 ES 8507536A1
- Authority
- ES
- Spain
- Prior art keywords
- dioxide
- substituted
- group
- piperidine ring
- hydroxy group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000496 cardiotonic agent Substances 0.000 title abstract 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003386 piperidinyl group Chemical group 0.000 abstract 3
- ADBZIZGMAVRJPN-UHFFFAOYSA-N 1,2,5-thiadiazolidine 1,1-dioxide Chemical compound O=S1(=O)NCCN1 ADBZIZGMAVRJPN-UHFFFAOYSA-N 0.000 abstract 1
- XGYCWCIGCYGQFU-UHFFFAOYSA-N 1,2-thiazolidine 1,1-dioxide Chemical compound O=S1(=O)CCCN1 XGYCWCIGCYGQFU-UHFFFAOYSA-N 0.000 abstract 1
- FUSWEIKLDYAKEC-UHFFFAOYSA-N 2h-1,2,6-thiadiazine 1,1-dioxide Chemical compound O=S1(=O)NC=CC=N1 FUSWEIKLDYAKEC-UHFFFAOYSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- -1 Substituted-4-piperidino-quinazolines Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 abstract 1
- KISXBSWDCSYUKO-UHFFFAOYSA-N thiadiazinane 1,1-dioxide Chemical group O=S1(=O)CCCNN1 KISXBSWDCSYUKO-UHFFFAOYSA-N 0.000 abstract 1
- DNGMYXZLJGHHOM-UHFFFAOYSA-N thiazinane 1,1-dioxide Chemical compound O=S1(=O)CCCCN1 DNGMYXZLJGHHOM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINAZOLINA, Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X E Y PUEDEN SER VARIOS TIPOS DE RADICALES; COMPUESTOS QUE TIENEN APLICACIONES FARMACOLOGICAS COMO ESTIMULANTES CARDIACOS, PARA EL TRATAMIENTO DEL FALLO CARDIACO.COMPRENDE LA REACCION DE UN COMPUESTO, DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN LAS QUE Q ES UN GRUPO SALIENTE Y X E Y TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, TAL COMO ETANOL, EN PRESENCIA DE UNA BASE NO NUCLEOFILA, TAL COMO UNA AMINA TERCIARIA, A UNA TEMPERATURA INFERIOR A LA DE REFLUJO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838320958A GB8320958D0 (en) | 1983-08-03 | 1983-08-03 | Quinazoline cardiac stimulants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8507536A1 true ES8507536A1 (es) | 1985-09-01 |
| ES534824A0 ES534824A0 (es) | 1985-09-01 |
Family
ID=10546755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES534824A Granted ES534824A0 (es) | 1983-08-03 | 1984-08-02 | Un procedimiento para la preparacion de estimulantes cardiacos de quinazolinas. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4542132A (es) |
| EP (1) | EP0135318B1 (es) |
| JP (1) | JPS6069081A (es) |
| KR (1) | KR870000905B1 (es) |
| AU (1) | AU555482B2 (es) |
| CS (1) | CS253714B2 (es) |
| DD (1) | DD223452A5 (es) |
| DE (1) | DE3472677D1 (es) |
| DK (1) | DK375584A (es) |
| ES (1) | ES534824A0 (es) |
| FI (1) | FI843047A (es) |
| GB (1) | GB8320958D0 (es) |
| GR (1) | GR82659B (es) |
| HU (1) | HUT37421A (es) |
| IL (1) | IL72562A (es) |
| NO (1) | NO158941C (es) |
| NZ (1) | NZ209095A (es) |
| PH (1) | PH20835A (es) |
| PL (1) | PL249025A1 (es) |
| PT (1) | PT79001B (es) |
| YU (1) | YU135884A (es) |
| ZA (1) | ZA845944B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61215389A (ja) * | 1985-03-20 | 1986-09-25 | Kyowa Hakko Kogyo Co Ltd | キナゾリン誘導体およびそれを含有する強心剤 |
| FR2582513B1 (fr) * | 1985-05-28 | 1988-08-05 | Synthelabo | Compositions pharmaceutiques contenant de l'alfuzosine |
| EP0669324A4 (en) * | 1993-09-10 | 1996-04-03 | Eisai Co Ltd | CHINAZOLIN DERIVATIVES. |
| US8071768B2 (en) * | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
| US7825244B2 (en) * | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
| JP2009213594A (ja) * | 2008-03-10 | 2009-09-24 | Okamura Chikuzai:Kk | 葬祭用祭壇装置 |
| CN104860870A (zh) * | 2014-02-26 | 2015-08-26 | 欧美嘉股份有限公司 | 具有不同取代基的哌啶的制备方法 |
| US11274501B2 (en) | 2020-07-08 | 2022-03-15 | Saudi Arabian Oil Company | Flow management systems and related methods for oil and gas applications |
| US11314266B2 (en) | 2020-07-08 | 2022-04-26 | Saudi Arabian Oil Company | Flow management systems and related methods for oil and gas applications |
| US11131158B1 (en) | 2020-07-08 | 2021-09-28 | Saudi Arabian Oil Company | Flow management systems and related methods for oil and gas applications |
| US11802645B2 (en) | 2020-07-08 | 2023-10-31 | Saudi Arabian Oil Company | Flow management systems and related methods for oil and gas applications |
| US11256273B2 (en) | 2020-07-08 | 2022-02-22 | Saudi Arabian Oil Company | Flow management systems and related methods for oil and gas applications |
| US11294401B2 (en) | 2020-07-08 | 2022-04-05 | Saudi Arabian Oil Company | Flow management systems and related methods for oil and gas applications |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517005A (en) * | 1967-10-26 | 1970-06-23 | Pfizer & Co C | Certain 2- and 4-substituted quinazolines |
| US4101548A (en) * | 1977-02-22 | 1978-07-18 | Bristol-Myers Company | 1,2,3-Thiadiazole amides |
| IN148482B (es) * | 1977-06-03 | 1981-03-07 | Pfizer | |
| US4370328A (en) * | 1977-11-03 | 1983-01-25 | Pfizer Inc. | Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines |
| US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
| US4489075A (en) * | 1982-05-15 | 1984-12-18 | Pfizer Inc. | Cyclic sulfonamidoalkyl substituted 4-piperidinoquinazoline cardiac stimulants |
-
1983
- 1983-08-03 GB GB838320958A patent/GB8320958D0/en active Pending
-
1984
- 1984-07-30 EP EP84305151A patent/EP0135318B1/en not_active Expired
- 1984-07-30 DE DE8484305151T patent/DE3472677D1/de not_active Expired
- 1984-07-30 PT PT79001A patent/PT79001B/pt unknown
- 1984-07-31 US US06/636,197 patent/US4542132A/en not_active Expired - Lifetime
- 1984-07-31 GR GR75460A patent/GR82659B/el unknown
- 1984-07-31 JP JP59161498A patent/JPS6069081A/ja active Pending
- 1984-08-01 PL PL24902584A patent/PL249025A1/xx unknown
- 1984-08-01 ZA ZA845944A patent/ZA845944B/xx unknown
- 1984-08-01 IL IL72562A patent/IL72562A/xx unknown
- 1984-08-01 FI FI843047A patent/FI843047A/fi not_active Application Discontinuation
- 1984-08-01 PH PH31057A patent/PH20835A/en unknown
- 1984-08-01 YU YU01358/84A patent/YU135884A/xx unknown
- 1984-08-01 DD DD84265888A patent/DD223452A5/de unknown
- 1984-08-02 KR KR1019840004616A patent/KR870000905B1/ko active IP Right Grant
- 1984-08-02 AU AU31419/84A patent/AU555482B2/en not_active Ceased
- 1984-08-02 NZ NZ209095A patent/NZ209095A/xx unknown
- 1984-08-02 DK DK375584A patent/DK375584A/da not_active Application Discontinuation
- 1984-08-02 NO NO843117A patent/NO158941C/no unknown
- 1984-08-02 HU HU842948A patent/HUT37421A/hu unknown
- 1984-08-02 ES ES534824A patent/ES534824A0/es active Granted
- 1984-08-03 CS CS845918A patent/CS253714B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6069081A (ja) | 1985-04-19 |
| FI843047A0 (fi) | 1984-08-01 |
| NO158941B (no) | 1988-08-08 |
| NO843117L (no) | 1985-02-04 |
| YU135884A (en) | 1986-10-31 |
| DD223452A5 (de) | 1985-06-12 |
| NZ209095A (en) | 1986-11-12 |
| HUT37421A (en) | 1985-12-28 |
| CS591884A2 (en) | 1987-05-14 |
| PH20835A (en) | 1987-04-30 |
| KR850001746A (ko) | 1985-04-01 |
| GB8320958D0 (en) | 1983-09-07 |
| NO158941C (no) | 1988-11-16 |
| EP0135318B1 (en) | 1988-07-13 |
| GR82659B (es) | 1985-02-07 |
| KR870000905B1 (ko) | 1987-05-04 |
| CS253714B2 (en) | 1987-12-17 |
| AU3141984A (en) | 1985-02-07 |
| EP0135318A1 (en) | 1985-03-27 |
| ES534824A0 (es) | 1985-09-01 |
| ZA845944B (en) | 1986-07-30 |
| IL72562A (en) | 1987-03-31 |
| PT79001A (en) | 1984-08-01 |
| US4542132A (en) | 1985-09-17 |
| DE3472677D1 (de) | 1988-08-18 |
| DK375584A (da) | 1985-02-04 |
| DK375584D0 (da) | 1984-08-02 |
| AU555482B2 (en) | 1986-09-25 |
| PT79001B (en) | 1986-10-23 |
| PL249025A1 (en) | 1985-08-27 |
| IL72562A0 (en) | 1984-11-30 |
| FI843047A (fi) | 1985-02-04 |
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