YU133090A - Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo - Google Patents

Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo

Info

Publication number
YU133090A
YU133090A YU133090A YU133090A YU133090A YU 133090 A YU133090 A YU 133090A YU 133090 A YU133090 A YU 133090A YU 133090 A YU133090 A YU 133090A YU 133090 A YU133090 A YU 133090A
Authority
YU
Yugoslavia
Prior art keywords
preparation
paf
heteroasepines
antaganostic
procedure
Prior art date
Application number
YU133090A
Other languages
English (en)
Inventor
K.H. Weber
W. Stransky
G. Walther
U. Kuefner-Muehl
H. Hauer
F. Birke
G. Maučević
W.D. Bechtel
Original Assignee
Boehringer Ingelheim Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg. filed Critical Boehringer Ingelheim Kg.
Publication of YU133090A publication Critical patent/YU133090A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/49—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with carbon monoxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Abstract

NOVI HETEROAZEPINI S PAF-ANTAGANOSTIČNIM UČINKOM IN POSTOPEK ZA NJIHOVO PRIPRAVO, izum se nanaša na heterazepinoidne PAF-antagoniste - formule 1 z nenavadnim substitucijskim vzorcem, na postopek za njihovo pripravo kot tudi na njihovo uporabo kot zdravila.
YU133090A 1989-07-12 1990-07-10 Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo YU133090A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3922944 1989-07-12
DE4011345 1990-04-07

Publications (1)

Publication Number Publication Date
YU133090A true YU133090A (sh) 1993-10-20

Family

ID=25882911

Family Applications (1)

Application Number Title Priority Date Filing Date
YU133090A YU133090A (sh) 1989-07-12 1990-07-10 Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo

Country Status (14)

Country Link
EP (1) EP0407955A1 (sh)
JP (1) JPH03215489A (sh)
KR (1) KR910002863A (sh)
AU (1) AU636155B2 (sh)
CA (1) CA2020806A1 (sh)
FI (1) FI903509A0 (sh)
HU (1) HUT59144A (sh)
IE (1) IE902526A1 (sh)
IL (1) IL95045A0 (sh)
NO (1) NO903088L (sh)
NZ (1) NZ234476A (sh)
PL (1) PL286019A1 (sh)
PT (1) PT94673A (sh)
YU (1) YU133090A (sh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95708C (fi) * 1988-10-31 1996-03-11 Eisai Co Ltd Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
DE4101146A1 (de) * 1991-01-16 1992-07-23 Boehringer Ingelheim Kg Neue in 6-position substituierte diazepine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE4107521A1 (de) * 1991-03-08 1992-09-10 Boehringer Ingelheim Kg Neue acylaminosubstituierte hetrazepine
KR100338144B1 (ko) * 1996-09-13 2002-05-24 가마쿠라 아키오 티에노트리아졸로디아제핀 화합물 및 그의 약제학적 용도
US6323214B1 (en) 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US6727258B2 (en) 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
JP5008796B2 (ja) * 2001-01-19 2012-08-22 ダイト株式会社 芳香族カルボン酸の製造方法
US8044042B2 (en) 2005-05-30 2011-10-25 Mitsubishi Tanabe Pharma Corporation Thienotriazolodiazepine compound and medicinal use thereof
EP2571875A4 (en) 2010-05-14 2013-10-30 Dana Farber Cancer Inst Inc CONTRACEPTIVE COMPOSITIONS FOR MEN AND METHODS OF USE THEREOF
CN105582014B (zh) 2010-05-14 2019-06-14 达那-法伯癌症研究所 用于治疗白血病的组合物和方法
MX362384B (es) 2010-05-14 2019-01-15 Dana Farber Cancer Inst Inc Composiciones y metodos para tratar neoplasias, enfermedades inflamatorias y otros trastornos.
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
EP2864336B1 (en) 2012-06-06 2016-11-23 Constellation Pharmaceuticals, Inc. Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof
CN105611835A (zh) 2013-07-25 2016-05-25 达纳-法伯癌症研究所股份有限公司 转录因子抑制剂及其用途
US11446309B2 (en) 2013-11-08 2022-09-20 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
US10793571B2 (en) 2014-01-31 2020-10-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
JP2017504653A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアミノピリミジンベンゼンスルホン誘導体およびその使用
CN106456653A (zh) 2014-02-28 2017-02-22 腾沙治疗公司 高胰岛素血症相关病症的治疗
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide
MX2017001757A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de dihidropteridinona y sus usos.
WO2016022902A1 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
KR20170068597A (ko) 2014-10-27 2017-06-19 텐샤 세러퓨틱스 인코포레이티드 브로모도메인 저해제
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. ASSOCIATION THERAPY USING TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
JP2018526421A (ja) 2015-09-11 2018-09-13 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド シアノチエノトリアゾロジアゼピンおよびこれらの使用
BR112018004617A2 (pt) 2015-09-11 2018-09-25 Dana Farber Cancer Inst Inc acetamida tienotriazoldiazepinas e usos das mesmas
KR20180081809A (ko) 2015-11-25 2018-07-17 다나-파버 캔서 인스티튜트 인크. 2가 브로모도메인 억제제 및 그의 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2712951A1 (de) * 1977-03-24 1978-10-05 Bosch Gmbh Robert Bimetall mit einem elektrischen heizelement
DE3701344A1 (de) * 1986-01-21 1987-07-23 Boehringer Ingelheim Kg Neue thieno-1,4-diazepine
EP0230942B1 (de) * 1986-01-21 1992-04-29 Boehringer Ingelheim Kg Thieno-1,4-diazepine
DE3610848A1 (de) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg Neue 1,4-diazepine
DE3724031A1 (de) * 1986-07-22 1988-01-28 Boehringer Ingelheim Kg Neue hetrazepine und verfahren zu ihrer herstellung
DE3624779C2 (de) * 1986-07-22 1996-03-07 Boehringer Ingelheim Kg Verfahren zur Herstellung von Thieno-triazolo-1,4-diazepino-2- carbonsäureamiden

Also Published As

Publication number Publication date
JPH03215489A (ja) 1991-09-20
FI903509A0 (fi) 1990-07-11
AU5892490A (en) 1991-01-17
HU904169D0 (en) 1990-12-28
AU636155B2 (en) 1993-04-22
NZ234476A (en) 1992-08-26
NO903088L (no) 1991-01-14
IL95045A0 (en) 1991-06-10
PT94673A (pt) 1991-03-20
CA2020806A1 (en) 1991-01-13
PL286019A1 (en) 1991-10-21
NO903088D0 (no) 1990-07-11
HUT59144A (en) 1992-04-28
KR910002863A (ko) 1991-02-26
IE902526A1 (en) 1991-02-13
EP0407955A1 (de) 1991-01-16

Similar Documents

Publication Publication Date Title
YU133090A (sh) Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo
DE3062187D1 (en) Cleaning composition, process for its production and its use
ES8402290A1 (es) Procedimiento para la preparacion de nuevos 6,11-dihidrodibenzo (b,e)-tiepin-11-n-alcohilnorescopin-eteres cuaternarios.
IL55423A0 (en) New 3,4,5-trihydroxypiperidine compounds,their production and pharmaceutical compositions containing them
ZA796357B (en) New hydroxyethyl-azole compounds, their production and their medicinal use
DE3069587D1 (en) 1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof
DE69102615D1 (de) Natriumborohydridzusammensetzungen und Verfahren zur Herstellung von kompaktem Natriumborohydrid.
ES475633A1 (es) Procedimiento para la obtencion de derivados de 1-n-4,6-di-0-(aminoglicosil)-1,3-diamino-ciclitol.
IL57229A0 (en) Hydroxypropyl-imidazole derivatives,their production and pharmaceutical compositions containing them
ES478048A1 (es) Procedimiento para la obtencion de difenil-imidazolil-meta- nos sustituidos.
DE2964109D1 (en) Polyamides having the transparency of glass, process for their production and their use
IL54069A0 (en) New 20,21-dinoreburnamenine derivatives,process for preparing them and pharmaceutical compositions
DE3070264D1 (en) Diphenylalkanoether and diphenylalkanone oximeether derivatives, a process for their production, pharmaceutical compositions and their use
DE3163199D1 (en) Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
ZA848303B (en) 1,2-dithiolan derivatives,process for their production,pharmaceutical compositions containing them and their use
IL58125A (en) N-phenylindoline derivatives,their production and pharmaceutical compositions containing them
ES8504166A1 (es) Un metodo de preparar derivados de 6,11-dihidrodibenz(b,e) oxepina.
ZA807943B (en) New pyrrolobenzotriazepines,their production and pharmaceutical compositions containing them
YU41697B (en) Process for producing 2,2-dimethyl-1,2-dimethyl-1,2-dihydroguinoline derivatives used as antioxidates
IL56696A0 (en) Nitroso-urea derivatives,their production and pharmaceutical compositions containing them
HUT53659A (en) Process for producing new, organic platinum complexes and pharmaceutical compositions comprising same
DE2860709D1 (en) 1-substituted aminoindolines, process for their production and pharmaceutical compositions containing them
AT374215B (de) Papiermaschine, insbesondere zur herstellung von tissue-papier
DE3160933D1 (en) Imidazolyl-indene-thiophenes, process for their preparation and their use as medicaments
DE3070729D1 (en) Des-a-steroids, their production and some des-a-steroids for use as medicines