PT92153A - Processo para a preparacao de derivados de 1,4-diazepina e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de derivados de 1,4-diazepina e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT92153A PT92153A PT92153A PT9215389A PT92153A PT 92153 A PT92153 A PT 92153A PT 92153 A PT92153 A PT 92153A PT 9215389 A PT9215389 A PT 9215389A PT 92153 A PT92153 A PT 92153A
- Authority
- PT
- Portugal
- Prior art keywords
- hydrogen
- preparation
- pharmaceutical compositions
- compositions containing
- diazepine derivatives
- Prior art date
Links
- 150000004911 1,4-diazepines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27546088 | 1988-10-31 | ||
JP29706888 | 1988-11-24 | ||
JP31801688 | 1988-12-16 | ||
JP33162288 | 1988-12-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT92153A true PT92153A (pt) | 1990-05-31 |
PT92153B PT92153B (pt) | 1995-06-30 |
Family
ID=27479049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT92153A PT92153B (pt) | 1988-10-31 | 1989-10-30 | Processo para a preparacao de derivados de 1,4-diazepina e de composicoes farmaceuticas que os contem |
Country Status (15)
Country | Link |
---|---|
EP (3) | EP0367110B1 (pt) |
JP (1) | JP2756004B2 (pt) |
KR (1) | KR910009332B1 (pt) |
CN (1) | CN1036520C (pt) |
AT (3) | ATE213247T1 (pt) |
AU (1) | AU621413B2 (pt) |
CA (1) | CA2000985C (pt) |
DE (3) | DE68929455T2 (pt) |
DK (1) | DK540689A (pt) |
FI (1) | FI95708C (pt) |
HU (1) | HU217127B (pt) |
NO (1) | NO175259C (pt) |
NZ (1) | NZ231188A (pt) |
PH (1) | PH27461A (pt) |
PT (1) | PT92153B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
GB8907257D0 (en) * | 1989-03-31 | 1989-05-17 | Rech Et D Applic Scient Scras | New derivatives of hetrazepine as anti-paf and anti-ischemic agents |
GB8907256D0 (en) * | 1989-03-31 | 1989-05-17 | Rech Et D Applic Scient Scras | New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors |
AT394563B (de) * | 1990-05-09 | 1992-05-11 | Scras | Verfahren zur herstellung von thieno-triazolodiazepinderivaten |
DE4027470A1 (de) * | 1990-08-30 | 1992-03-05 | Boehringer Ingelheim Kg | Neue hetrazepinoide amide |
DE4107521A1 (de) * | 1991-03-08 | 1992-09-10 | Boehringer Ingelheim Kg | Neue acylaminosubstituierte hetrazepine |
DK0656361T3 (da) * | 1991-12-11 | 2000-07-24 | Yoshitomi Pharmaceutical | Lægemiddel til behandling af autoimmune sygdomme |
TW219935B (pt) * | 1991-12-25 | 1994-02-01 | Mitsubishi Chemicals Co Ltd | |
US5530141A (en) * | 1992-03-04 | 1996-06-25 | Center For Innovative Technology | 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5639782A (en) * | 1992-03-04 | 1997-06-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
JPH08502243A (ja) | 1992-07-13 | 1996-03-12 | サイトメッド,インコーポレイテッド | 炎症性および免疫性疾患の治療のための2,5‐ジアリールテトラヒドロ‐チオフェン、‐フランおよび類似体 |
US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5648486A (en) * | 1992-07-13 | 1997-07-15 | Cytomed, Inc. | Compounds and methods for the treatment of inflammatory and immune disorders |
US5358938A (en) * | 1992-07-13 | 1994-10-25 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5463083A (en) * | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
ES2061406B1 (es) * | 1993-05-07 | 1995-06-01 | Uriach & Cia Sa J | Nuevos derivados de la 2-(quinolina) con actividad farmacologica. |
JP2523259B2 (ja) * | 1993-06-30 | 1996-08-07 | エスオーエンジニアリング株式会社 | フォ―ハ―ス内のガラス温度制御方法 |
US5750565A (en) * | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
EP0995752A4 (en) * | 1997-06-25 | 2001-08-16 | Nikken Chemicals Co Ltd | TRIAZOLO-1,4-DIAZEPINE COMPOUNDS AND MEDICINAL COMPOSITION CONTAINING THEM |
FR2779652B1 (fr) * | 1998-06-15 | 2001-06-08 | Sod Conseils Rech Applic | Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique |
US7738074B2 (en) | 2003-07-16 | 2010-06-15 | Asml Netherlands B.V. | Lithographic apparatus and device manufacturing method |
US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
PT3157928T (pt) | 2014-06-20 | 2019-05-30 | Constellation Pharmaceuticals Inc | Formas cristalinas de 2-((4s)-6-(4-clorofenil)-1-metil-4h-benzo[c] isoxazolo[4,5-e]azepin-4-il)acetamida |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
DE3502392A1 (de) | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
ES2037013T3 (es) | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | Procedimiento para preparar tieno-1,4-diazepinas. |
PH30676A (en) | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
DE3724031A1 (de) | 1986-07-22 | 1988-01-28 | Boehringer Ingelheim Kg | Neue hetrazepine und verfahren zu ihrer herstellung |
DE3777541D1 (de) * | 1986-11-17 | 1992-04-23 | Yoshitomi Pharmaceutical | Paf-antagonistische thienotriazoldiazepin-verbindungen und deren pharmazeutische anwendung. |
EP0368175A1 (de) * | 1988-11-06 | 1990-05-16 | Boehringer Ingelheim Kg | 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin. |
GB8911030D0 (en) * | 1989-05-13 | 1989-06-28 | Scras | Hetrazepine derivatives |
YU133090A (sh) * | 1989-07-12 | 1993-10-20 | Boehringer Ingelheim Kg. | Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo |
AT394563B (de) * | 1990-05-09 | 1992-05-11 | Scras | Verfahren zur herstellung von thieno-triazolodiazepinderivaten |
-
1989
- 1989-10-13 FI FI894867A patent/FI95708C/fi not_active IP Right Cessation
- 1989-10-18 CA CA002000985A patent/CA2000985C/en not_active Expired - Fee Related
- 1989-10-18 PH PH39380A patent/PH27461A/en unknown
- 1989-10-26 AT AT95111206T patent/ATE213247T1/de not_active IP Right Cessation
- 1989-10-26 DE DE68929455T patent/DE68929455T2/de not_active Expired - Fee Related
- 1989-10-26 DE DE68929372T patent/DE68929372T2/de not_active Expired - Fee Related
- 1989-10-26 EP EP89119910A patent/EP0367110B1/en not_active Expired - Lifetime
- 1989-10-26 DE DE68929049T patent/DE68929049T2/de not_active Expired - Fee Related
- 1989-10-26 AT AT94101416T patent/ATE234306T1/de not_active IP Right Cessation
- 1989-10-26 EP EP95111206A patent/EP0677524B1/en not_active Expired - Lifetime
- 1989-10-26 AT AT89119910T patent/ATE183187T1/de active
- 1989-10-26 EP EP94101416A patent/EP0606103B1/en not_active Expired - Lifetime
- 1989-10-26 AU AU43761/89A patent/AU621413B2/en not_active Ceased
- 1989-10-27 NZ NZ231188A patent/NZ231188A/xx unknown
- 1989-10-27 JP JP1281300A patent/JP2756004B2/ja not_active Expired - Lifetime
- 1989-10-27 NO NO894287A patent/NO175259C/no not_active IP Right Cessation
- 1989-10-30 PT PT92153A patent/PT92153B/pt not_active IP Right Cessation
- 1989-10-30 HU HU895609A patent/HU217127B/hu not_active IP Right Cessation
- 1989-10-30 DK DK540689A patent/DK540689A/da not_active Application Discontinuation
- 1989-10-31 KR KR1019890015723A patent/KR910009332B1/ko not_active IP Right Cessation
-
1994
- 1994-01-17 CN CN94100504A patent/CN1036520C/zh not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT92153A (pt) | Processo para a preparacao de derivados de 1,4-diazepina e de composicoes farmaceuticas que os contem | |
BR9806296A (pt) | Derivados de ácido sulfìnico e sua preparação e uso | |
ES2082805T3 (es) | Derivados de tiazol, procedimientos para su produccion y composiciones farmaceuticas que comprenden los mismos. | |
DE69332634D1 (de) | Enantiomere hydroxylierte xanthinverbindungen | |
ES2060910T3 (es) | Peptidos que tienen actividad antagonista de taquiquinina, un procedimiento para su preparacion y composiciones farmaceuticas que los comprenden. | |
DK12087A (da) | Decahydroquinolinderivater, deres fremstilling og anvendelse samt praeparater med indhold deraf | |
EA199801028A1 (ru) | Применение производных п-аминофенола для проготовления фармацевтических композиций, используемых при лечении нейродегенеративных заболеваний | |
ES2055235T3 (es) | Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation. | |
ATE66673T1 (de) | 2-pyrrolidonderivate, verfahren zur herstellung, pharmazeutische zusammensetzungen und anwendung. | |
PT97286A (pt) | Processo para a preparacao de novos derivados do 3-aminocromano e de composicoes farmaceuticas que os contem | |
AR007052A1 (es) | Un derivado de carbohidrato, su uso y una composicion farmaceutica que lo comprende | |
PT90813A (pt) | Processo de preparacao de derivados da fenotiazina e de composicoes farmaceuticas que os contem | |
PT90815A (pt) | Processo de preparacao de derivados da fenotiazina | |
ES2085833B1 (es) | Derivados de carboximetilidencicloheptimidazol y metodo para prepararlos. | |
KR870006898A (ko) | 신장염 치료제 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM3A | Annulment or lapse |
Effective date: 20050620 |