PE20020273A1 - Uso de antagonistas de endotelina en la fabricacion de medicamentos utiles para el tratamiento del cancer y el dolor asociado con el mismo - Google Patents

Uso de antagonistas de endotelina en la fabricacion de medicamentos utiles para el tratamiento del cancer y el dolor asociado con el mismo

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Publication number
PE20020273A1
PE20020273A1 PE2001000782A PE2001000782A PE20020273A1 PE 20020273 A1 PE20020273 A1 PE 20020273A1 PE 2001000782 A PE2001000782 A PE 2001000782A PE 2001000782 A PE2001000782 A PE 2001000782A PE 20020273 A1 PE20020273 A1 PE 20020273A1
Authority
PE
Peru
Prior art keywords
alkenylene
alkylene
alkyl
cancer
alkenyl
Prior art date
Application number
PE2001000782A
Other languages
English (en)
Inventor
Todd J Janus
Robert J Padley
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PE20020273A1 publication Critical patent/PE20020273A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P35/00—Antineoplastic agents
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    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
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    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
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    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE AL USO DE UN ANTAGONISTA DEL RECEPTOR DE ENDOTELINA ET-A DE FORMULA I DONDE R ES -(CH2)m-W; Z ES -C(R18)(R19), -C(O)-; R1 Y R2 SON H, ALQUILO, ALQUENILO, ALQUENILO, ALCOXIALQUILO, ALCOXICARBONILALQUILO, ENTRE OTROS; R3 ES R4-C(O)-R5, R4-R5a-, R4-C(O)-R5-N(R6)-, R6-S(O)2-R7-, ENTRE OTROS; R4 Y R6 SON (R11)(R12)N-, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R5 ES UN ENLACE COVALENTE, ALQUILENO, ALQUENILENO, ENTRE OTROS; R6 ES ALQUILO, HALOALQUILO, ALCOXIALQUILO, HALOALCOXIALQUILO, ENTRE OTROS; R7 ES ENLACE COVALENTE, ALQUILENO, ALQUENILENO, ENTRE OTROS; R8 ES ALQUILENO, ALQUENILENO; R9 ES ALQUENILENO; R10 ES ALQUILENO, ALQUENILENO; R11 Y R12 SON H, ALQUILO, HALOALQUILO, ENTRE OTROS; R18 Y R19 SON H, ALQUILO; R5a ES ALQUILENO, ALQUENILENO; W ES -C(O)2-G, -PO3H2, ENTRE OTROS; G ES H, GRUPO PROTECTOR DE CARBOXILO. SE REFIERE TAMBIEN AL USO DE UN ANTAGONISTA DEL RECEPTOR DE ENDOTELINA ETA-SELECTIVO JUNTO A UN ANTICANCEROSO ADICIONAL SELECCIONADO DE LEUPROLIDE, GOSERELIN, BICALUTAMIDA, NILUTAMIDA, FLUTAMIDA, VITAMINA D, ENTRE OTROS PARA INHIBIR LA METASTASIS OSEA, CRECIMIENTO METASTASICO, CANCER
PE2001000782A 2000-08-07 2001-08-06 Uso de antagonistas de endotelina en la fabricacion de medicamentos utiles para el tratamiento del cancer y el dolor asociado con el mismo PE20020273A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63338900A 2000-08-07 2000-08-07

Publications (1)

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PE20020273A1 true PE20020273A1 (es) 2002-04-16

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ID=24539436

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PE2001000782A PE20020273A1 (es) 2000-08-07 2001-08-06 Uso de antagonistas de endotelina en la fabricacion de medicamentos utiles para el tratamiento del cancer y el dolor asociado con el mismo

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Country Link
EP (1) EP1347751B1 (es)
JP (3) JP4217068B2 (es)
KR (1) KR20030027007A (es)
CN (1) CN1635878A (es)
AR (1) AR031122A1 (es)
AT (1) ATE465728T1 (es)
AU (2) AU8113401A (es)
BG (1) BG107577A (es)
BR (1) BR0108865A (es)
CA (1) CA2416879C (es)
DE (1) DE60141979D1 (es)
HU (1) HUP0302977A2 (es)
IL (1) IL153769A0 (es)
MX (1) MXPA03000984A (es)
NO (1) NO20030593L (es)
NZ (1) NZ523562A (es)
PE (1) PE20020273A1 (es)
PL (1) PL366160A1 (es)
SK (1) SK1782003A3 (es)
TW (1) TWI306760B (es)
WO (1) WO2002011713A2 (es)
ZA (1) ZA200300253B (es)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
GB0219660D0 (en) * 2002-08-23 2002-10-02 Astrazeneca Ab Therapeutic use
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
NZ586338A (en) * 2004-06-07 2012-02-24 Qu Biolog Inc Bacterial compositions for the treatment of cancer
US9107864B2 (en) 2004-06-07 2015-08-18 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
EP2190433A2 (en) 2007-08-22 2010-06-02 Gilead Colorado, Inc. Therapy for complications of diabetes
WO2011114103A1 (en) 2010-03-18 2011-09-22 Biolipox Ab Pyrimidinones for use as medicaments
KR102157718B1 (ko) 2010-07-26 2020-09-18 큐 바이올로직스 인코포레이티드 면역원성 소염 조성물
CN102485238A (zh) * 2010-12-06 2012-06-06 陈炯华 芎芷镇痛方
US10251946B2 (en) 2014-05-02 2019-04-09 Qu Biologics Inc. Anti-microbial immunomodulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063911A (en) * 1993-12-01 2000-05-16 Marine Polymer Technologies, Inc. Methods and compositions for treatment of cell proliferative disorders
AU748469B2 (en) 1996-02-13 2002-06-06 Abbott Laboratories Endothelin antagonists
PT885215E (pt) * 1996-02-13 2006-08-31 Abbott Lab Novos derivados de pirrolidina substituidos com benzo-1,3-dioxolilo e benzofuranilo como antagonistas de endotelina
EP1137832A1 (en) * 1998-12-11 2001-10-04 Mactapes Limited Curtain heading tape manufacture
US6545048B1 (en) * 1999-06-29 2003-04-08 California Institute Of Technology Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity

Also Published As

Publication number Publication date
IL153769A0 (en) 2003-07-06
WO2002011713A2 (en) 2002-02-14
TWI306760B (en) 2009-03-01
NZ523562A (en) 2006-10-27
JP2007084564A (ja) 2007-04-05
DE60141979D1 (de) 2010-06-10
MXPA03000984A (es) 2003-09-05
KR20030027007A (ko) 2003-04-03
NO20030593D0 (no) 2003-02-06
SK1782003A3 (en) 2003-08-05
BR0108865A (pt) 2005-04-19
CA2416879A1 (en) 2002-02-14
PL366160A1 (en) 2005-01-24
JP2007063288A (ja) 2007-03-15
JP4217068B2 (ja) 2009-01-28
JP2004520266A (ja) 2004-07-08
BG107577A (bg) 2003-10-31
WO2002011713A3 (en) 2003-07-17
CN1635878A (zh) 2005-07-06
ZA200300253B (en) 2004-11-17
ATE465728T1 (de) 2010-05-15
AU8113401A (en) 2002-02-18
HUP0302977A2 (hu) 2003-12-29
EP1347751B1 (en) 2010-04-28
NO20030593L (no) 2003-02-06
AR031122A1 (es) 2003-09-10
AU2001281134B2 (en) 2005-06-09
CA2416879C (en) 2006-11-07
EP1347751A2 (en) 2003-10-01

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