ATE220673T1 - 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carbonsaure derivate als endothelin-antagonisten - Google Patents
4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carbonsaure derivate als endothelin-antagonistenInfo
- Publication number
- ATE220673T1 ATE220673T1 AT97905897T AT97905897T ATE220673T1 AT E220673 T1 ATE220673 T1 AT E220673T1 AT 97905897 T AT97905897 T AT 97905897T AT 97905897 T AT97905897 T AT 97905897T AT E220673 T1 ATE220673 T1 AT E220673T1
- Authority
- AT
- Austria
- Prior art keywords
- dioxolyl
- pyrrolidine
- benzo
- acid derivatives
- carbonic acid
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60072496A | 1996-02-13 | 1996-02-13 | |
| US79450597A | 1997-02-04 | 1997-02-04 | |
| PCT/US1997/002128 WO1997030046A1 (en) | 1996-02-13 | 1997-02-10 | 4-(benzo-1,3-dioxolyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE220673T1 true ATE220673T1 (de) | 2002-08-15 |
Family
ID=27083691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97905897T ATE220673T1 (de) | 1996-02-13 | 1997-02-10 | 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carbonsaure derivate als endothelin-antagonisten |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0888340B1 (de) |
| JP (1) | JP2000504727A (de) |
| CN (1) | CN1079397C (de) |
| AR (1) | AR005801A1 (de) |
| AT (1) | ATE220673T1 (de) |
| AU (1) | AU714597B2 (de) |
| BR (1) | BR9707394A (de) |
| CA (1) | CA2245684A1 (de) |
| CZ (1) | CZ253698A3 (de) |
| DE (1) | DE69714024T2 (de) |
| DK (1) | DK0888340T3 (de) |
| ES (1) | ES2182029T3 (de) |
| HU (1) | HUP9902316A3 (de) |
| IL (1) | IL125453A0 (de) |
| NZ (2) | NZ503383A (de) |
| PT (1) | PT888340E (de) |
| WO (1) | WO1997030046A1 (de) |
| ZA (1) | ZA971184B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7208517B1 (en) | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
| US6162927A (en) | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
| US6124341A (en) * | 1996-02-13 | 2000-09-26 | Abbott Laboratories | Endothelin antagonists |
| WO1998057933A1 (en) * | 1997-06-17 | 1998-12-23 | Abbott Laboratories | Pyrrolidine carboxylic acid derivatives as endothelin antagonists |
| TR200101233T2 (tr) * | 1997-08-04 | 2002-06-21 | Abbott Laboratories | Endotelin antagonistleri. |
| MXPA03000368A (es) * | 2000-07-19 | 2004-09-13 | Hoffmann La Roche | Derivados de pirrolidina como inhibidores de metalproteasa. |
| WO2002017912A1 (en) * | 2000-08-31 | 2002-03-07 | Abbott Laboratories | Endothelin antagonists |
| RU2259825C9 (ru) * | 2001-06-18 | 2006-04-10 | БиоДием Лимитед | Вещества, проявляющие антимикробную, антигрибковую, антипротозойную активности |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0612244B1 (de) * | 1991-11-05 | 2001-09-19 | Smithkline Beecham Corporation | Endothelin-rezeptor-antagonisten |
| JPH07509465A (ja) * | 1992-07-17 | 1995-10-19 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体アンタゴニスト |
| CA2517691A1 (en) * | 1994-08-19 | 1996-02-29 | Abbott Laboratories | Endothelin antagonists |
-
1997
- 1997-02-10 DE DE69714024T patent/DE69714024T2/de not_active Expired - Lifetime
- 1997-02-10 IL IL12545397A patent/IL125453A0/xx unknown
- 1997-02-10 AU AU22678/97A patent/AU714597B2/en not_active Ceased
- 1997-02-10 HU HU9902316A patent/HUP9902316A3/hu unknown
- 1997-02-10 NZ NZ503383A patent/NZ503383A/en unknown
- 1997-02-10 CA CA002245684A patent/CA2245684A1/en not_active Abandoned
- 1997-02-10 NZ NZ331124A patent/NZ331124A/xx unknown
- 1997-02-10 JP JP9529436A patent/JP2000504727A/ja active Pending
- 1997-02-10 CN CN97193633A patent/CN1079397C/zh not_active Expired - Fee Related
- 1997-02-10 ES ES97905897T patent/ES2182029T3/es not_active Expired - Lifetime
- 1997-02-10 PT PT97905897T patent/PT888340E/pt unknown
- 1997-02-10 EP EP97905897A patent/EP0888340B1/de not_active Expired - Lifetime
- 1997-02-10 CZ CZ982536A patent/CZ253698A3/cs unknown
- 1997-02-10 BR BR9707394A patent/BR9707394A/pt not_active Application Discontinuation
- 1997-02-10 DK DK97905897T patent/DK0888340T3/da active
- 1997-02-10 WO PCT/US1997/002128 patent/WO1997030046A1/en not_active Ceased
- 1997-02-10 AT AT97905897T patent/ATE220673T1/de not_active IP Right Cessation
- 1997-02-12 AR ARP970100554A patent/AR005801A1/es unknown
- 1997-02-12 ZA ZA9701184A patent/ZA971184B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000504727A (ja) | 2000-04-18 |
| HUP9902316A2 (hu) | 1999-11-29 |
| EP0888340A1 (de) | 1999-01-07 |
| DK0888340T3 (da) | 2002-11-04 |
| NZ331124A (en) | 2000-05-26 |
| ZA971184B (en) | 1997-08-27 |
| AU714597B2 (en) | 2000-01-06 |
| AR005801A1 (es) | 1999-07-14 |
| EP0888340B1 (de) | 2002-07-17 |
| PT888340E (pt) | 2002-12-31 |
| AU2267897A (en) | 1997-09-02 |
| CN1215401A (zh) | 1999-04-28 |
| CZ253698A3 (cs) | 1999-03-17 |
| HUP9902316A3 (en) | 2001-12-28 |
| DE69714024D1 (de) | 2002-08-22 |
| ES2182029T3 (es) | 2003-03-01 |
| CA2245684A1 (en) | 1997-08-21 |
| DE69714024T2 (de) | 2003-03-20 |
| WO1997030046A1 (en) | 1997-08-21 |
| CN1079397C (zh) | 2002-02-20 |
| NZ503383A (en) | 2002-02-01 |
| IL125453A0 (en) | 1999-03-12 |
| BR9707394A (pt) | 1999-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |