UY26521A1 - NEW ANTIDIURETIC AGENTS - Google Patents

NEW ANTIDIURETIC AGENTS

Info

Publication number
UY26521A1
UY26521A1 UY26521A UY26521A UY26521A1 UY 26521 A1 UY26521 A1 UY 26521A1 UY 26521 A UY26521 A UY 26521A UY 26521 A UY26521 A UY 26521A UY 26521 A1 UY26521 A1 UY 26521A1
Authority
UY
Uruguay
Prior art keywords
lower alkyl
new
ome
acyl
vasopressin
Prior art date
Application number
UY26521A
Other languages
Spanish (es)
Inventor
Doreen M Ashworth
Gary R W Pitt
Peter Hudson
Richard J Franklin
Christopher M Yea
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of UY26521A1 publication Critical patent/UY26521A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La invención proporciona nuevos compuestos de acuerdo a la fórmula general 1 donde A es un derivado de la azepina bicíclico o tricíclico, V1 y V2 son ambos H, OMe o F, o uno de V1 y V2 es Br, CI, OH, OMe, OBn, OPh, O-acilo, N3, NH2, NHBn o NH-acilo y el otro es H, O V1 y V2 juntos son = O, - O(CH2) pO- o- S /CH2) pS-; W1 es Oo S; X1 y X2 son ambos H, o juntos son =O o =S; Y es OR5 o NR6 R7; R1, R2, R3 y R4 se seleccionan independientemente de entre H, alquilo menor, alquiloxi menor, F, CI y Br; R5 se selecciona de entre H y alquilo menor; R6 y R7 se seleccionan independientemente de entre H y alquilo menor, o juntos son - (CH2) n -; n=3, 4, 5, o 6; y p es 2 o 3. Los compuestos son agonistas en el receptor de vasopresina V2 y son útiles como antidiuréticos y procoagulantes. La invención comprende además las composiciones farmacéuticas que incorporen estos agonistas de la vasopresina, siendo tales composiciones particularmente útiles en el tratamiento de la diabetes insípida central, de la enuresis nocturna y de la nocturia.The invention provides new compounds according to general formula 1 where A is a bicyclic or tricyclic azepine derivative, V1 and V2 are both H, OMe or F, or one of V1 and V2 is Br, CI, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, O V1 and V2 together are = O, - O (CH2) pO- or- S / CH2) pS-; W1 is Oo S; X1 and X2 are both H, or together they are = O or = S; Y is OR5 or NR6 R7; R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, CI and Br; R5 is selected from H and lower alkyl; R6 and R7 are independently selected from H and lower alkyl, or together are - (CH2) n -; n = 3, 4, 5, or 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, such compositions being particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis, and nocturnal.

UY26521A 2000-01-05 2001-01-04 NEW ANTIDIURETIC AGENTS UY26521A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0000079.4A GB0000079D0 (en) 2000-01-05 2000-01-05 Novel antidiuretic agents

Publications (1)

Publication Number Publication Date
UY26521A1 true UY26521A1 (en) 2001-03-16

Family

ID=9883168

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26521A UY26521A1 (en) 2000-01-05 2001-01-04 NEW ANTIDIURETIC AGENTS

Country Status (34)

Country Link
US (3) US7074781B2 (en)
EP (1) EP1248784B1 (en)
JP (2) JP3869723B2 (en)
KR (1) KR100605466B1 (en)
CN (1) CN1183129C (en)
AR (1) AR035327A1 (en)
AT (1) ATE366730T1 (en)
AU (1) AU777538B2 (en)
BR (1) BR0107414B1 (en)
CA (1) CA2396277C (en)
CY (1) CY1108034T1 (en)
CZ (1) CZ303444B6 (en)
DE (1) DE60129298T2 (en)
DK (1) DK1248784T3 (en)
EE (1) EE200200367A (en)
ES (1) ES2288923T3 (en)
GB (1) GB0000079D0 (en)
HK (1) HK1046910B (en)
HR (1) HRP20020481B1 (en)
HU (1) HU229937B1 (en)
IL (1) IL149528A0 (en)
MX (1) MXPA02006546A (en)
MY (1) MY140467A (en)
NO (1) NO322571B1 (en)
NZ (1) NZ518803A (en)
PL (1) PL211341B1 (en)
PT (1) PT1248784E (en)
RU (1) RU2259367C2 (en)
SI (1) SI1248784T1 (en)
SK (1) SK287005B6 (en)
UA (1) UA73152C2 (en)
UY (1) UY26521A1 (en)
WO (1) WO2001049682A1 (en)
ZA (1) ZA200205180B (en)

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GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
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Also Published As

Publication number Publication date
DK1248784T3 (en) 2007-10-29
MXPA02006546A (en) 2002-12-09
MY140467A (en) 2009-12-31
US20060154916A1 (en) 2006-07-13
JP3869723B2 (en) 2007-01-17
RU2002120798A (en) 2004-01-10
NO20023137L (en) 2002-06-27
CN1392875A (en) 2003-01-22
ZA200205180B (en) 2004-02-05
US20080261951A1 (en) 2008-10-23
IL149528A0 (en) 2002-11-10
BR0107414B1 (en) 2014-09-16
SK9112002A3 (en) 2003-01-09
NO322571B1 (en) 2006-10-30
CA2396277A1 (en) 2001-07-12
HRP20020481A2 (en) 2004-08-31
NZ518803A (en) 2003-03-28
CZ303444B6 (en) 2012-09-19
ATE366730T1 (en) 2007-08-15
AU2384601A (en) 2001-07-16
PL211341B1 (en) 2012-05-31
PL355808A1 (en) 2004-05-17
WO2001049682A1 (en) 2001-07-12
HUP0203917A3 (en) 2004-07-28
CA2396277C (en) 2012-03-20
JP3813629B2 (en) 2006-08-23
HUP0203917A2 (en) 2003-03-28
CN1183129C (en) 2005-01-05
HU229937B1 (en) 2015-01-28
US7560454B2 (en) 2009-07-14
JP2003519228A (en) 2003-06-17
CY1108034T1 (en) 2013-09-04
CZ20022305A3 (en) 2002-10-16
PT1248784E (en) 2007-10-02
UA73152C2 (en) 2005-06-15
US7074781B2 (en) 2006-07-11
DE60129298D1 (en) 2007-08-23
HK1046910A1 (en) 2003-01-30
AR035327A1 (en) 2004-05-12
BR0107414A (en) 2002-10-08
KR20020063191A (en) 2002-08-01
JP2006137767A (en) 2006-06-01
HK1046910B (en) 2007-08-31
DE60129298T2 (en) 2008-01-03
KR100605466B1 (en) 2006-07-28
ES2288923T3 (en) 2008-02-01
EP1248784A1 (en) 2002-10-16
SI1248784T1 (en) 2007-12-31
AU777538B2 (en) 2004-10-21
NO20023137D0 (en) 2002-06-27
SK287005B6 (en) 2009-09-07
GB0000079D0 (en) 2000-02-23
US20030087892A1 (en) 2003-05-08
HRP20020481B1 (en) 2009-03-31
EP1248784B1 (en) 2007-07-11
RU2259367C2 (en) 2005-08-27
EE200200367A (en) 2003-12-15

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