JP2007525533A5 - - Google Patents

Info

Publication number

JP2007525533A5

JP2007525533A5 JP2007501287A JP2007501287A JP2007525533A5 JP 2007525533 A5 JP2007525533 A5 JP 2007525533A5 JP 2007501287 A JP2007501287 A JP 2007501287A JP 2007501287 A JP2007501287 A JP 2007501287A JP 2007525533 A5 JP2007525533 A5 JP 2007525533A5

Authority

JP

Japan

Prior art keywords

compound

pharmaceutically acceptable

formula

cholecalciferol

haloalkyl

Prior art date

2005-03-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 48
• 150000003839 salts Chemical class 0.000 claims 8
• 208000005615 Interstitial Cystitis Diseases 0.000 claims 7
• 150000002148 esters Chemical class 0.000 claims 7
• 229910052739 hydrogen Inorganic materials 0.000 claims 6
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
• 239000011647 vitamin D3 Substances 0.000 claims 6
• 229940021056 vitamin d3 Drugs 0.000 claims 6
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 5
• 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 5
• 239000001257 hydrogen Substances 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 5
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• 125000001188 haloalkyl group Chemical group 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
• -1 3-hydroxy-3-methylbutyl Chemical group 0.000 claims 1
• 206010069632 Bladder dysfunction Diseases 0.000 claims 1
• 229940126062 Compound A Drugs 0.000 claims 1
• 206010063057 Cystitis noninfective Diseases 0.000 claims 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
• JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• 239000011737 fluorine Substances 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 239000008177 pharmaceutical agent Substances 0.000 claims 1
• LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1