JP2009114217A5 - - Google Patents
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- Publication number
- JP2009114217A5 JP2009114217A5 JP2009050902A JP2009050902A JP2009114217A5 JP 2009114217 A5 JP2009114217 A5 JP 2009114217A5 JP 2009050902 A JP2009050902 A JP 2009050902A JP 2009050902 A JP2009050902 A JP 2009050902A JP 2009114217 A5 JP2009114217 A5 JP 2009114217A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- fatty acid
- composition
- formula
- acid triglyceride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 14
- -1 bicyclic compound Chemical class 0.000 claims 7
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 6
- 150000004667 medium chain fatty acids Chemical class 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 206010010774 Constipation Diseases 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002430 hydrocarbons Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000008141 laxative Substances 0.000 claims 1
- 230000002475 laxative effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical group CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/655,760 US6414016B1 (en) | 2000-09-05 | 2000-09-05 | Anti-constipation composition |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524492A Division JP2004508327A (ja) | 2000-09-05 | 2001-09-04 | 下剤組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213058A Division JP2009286806A (ja) | 2000-09-05 | 2009-09-15 | 下剤組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009114217A JP2009114217A (ja) | 2009-05-28 |
| JP2009114217A5 true JP2009114217A5 (enExample) | 2009-11-12 |
| JP4684334B2 JP4684334B2 (ja) | 2011-05-18 |
Family
ID=24630250
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524492A Pending JP2004508327A (ja) | 2000-09-05 | 2001-09-04 | 下剤組成物 |
| JP2009050902A Expired - Fee Related JP4684334B2 (ja) | 2000-09-05 | 2009-03-04 | 下剤組成物 |
| JP2009213058A Pending JP2009286806A (ja) | 2000-09-05 | 2009-09-15 | 下剤組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524492A Pending JP2004508327A (ja) | 2000-09-05 | 2001-09-04 | 下剤組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213058A Pending JP2009286806A (ja) | 2000-09-05 | 2009-09-15 | 下剤組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US6414016B1 (enExample) |
| EP (2) | EP1315485B1 (enExample) |
| JP (3) | JP2004508327A (enExample) |
| KR (2) | KR100918223B1 (enExample) |
| CN (1) | CN100335049C (enExample) |
| AR (2) | AR030609A1 (enExample) |
| AT (1) | ATE476975T1 (enExample) |
| AU (2) | AU2001282615B2 (enExample) |
| BR (1) | BRPI0114042B8 (enExample) |
| CA (1) | CA2419741C (enExample) |
| CZ (1) | CZ304740B6 (enExample) |
| DE (2) | DE60131547T2 (enExample) |
| DK (2) | DK1315485T3 (enExample) |
| ES (2) | ES2347697T3 (enExample) |
| HU (1) | HU229319B1 (enExample) |
| IL (2) | IL154534A0 (enExample) |
| MX (1) | MXPA03001959A (enExample) |
| NL (1) | NL300757I1 (enExample) |
| NO (1) | NO332701B1 (enExample) |
| NZ (1) | NZ524401A (enExample) |
| PT (2) | PT1315485E (enExample) |
| RU (1) | RU2694361C3 (enExample) |
| TW (1) | TWI305147B (enExample) |
| WO (1) | WO2002020007A1 (enExample) |
| ZA (1) | ZA200301673B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0014869B8 (pt) * | 1999-10-15 | 2021-05-25 | Sucampo Ag | prostaglandinas bicíclicas, composições estabilizadas das mesmas, bem como processo para sua estabilização |
| US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
| TWI302100B (en) * | 2001-05-02 | 2008-10-21 | Sucampo Ag | Composition for treating drug-induced constipation |
| TWI331920B (en) | 2001-11-14 | 2010-10-21 | Sucampo Ag | Unit dosage form for relieving or treating constipation in human patients |
| US7732487B2 (en) * | 2001-11-19 | 2010-06-08 | Sucampo Ag | Method for treating a disease or condition responsive to opening of C1C-2 channel |
| WO2004037268A1 (en) * | 2002-10-23 | 2004-05-06 | Sucampo Ag | Prostaglandin compounds for the treatment of obesity |
| JP4889219B2 (ja) * | 2002-12-27 | 2012-03-07 | スキャンポ・アーゲー | 腹部不快感の処置のためのプロスタグランジン誘導体 |
| US8337891B2 (en) | 2003-07-03 | 2012-12-25 | Sucampo Ag | Enteric coated composition comprising prostaglandin analogs as chloride channel opener |
| TWI348386B (en) * | 2003-08-12 | 2011-09-11 | R Tech Ueno Ltd | Composition and method for promoting hair growth |
| CN101048163A (zh) * | 2004-09-02 | 2007-10-03 | 苏坎波公司 | 用于治疗胃肠道疾病的前列腺素衍生物 |
| TWI387454B (zh) * | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| CA2595898C (en) * | 2005-01-27 | 2015-04-28 | Sucampo Ag | Method and composition for treating central nervous system disorders |
| DK1853271T3 (da) | 2005-03-04 | 2011-01-24 | Sucampo Ag | Fremgangsmåde og præparat til behandling af perifere vaskulære sygdomme |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| WO2006096626A2 (en) * | 2005-03-07 | 2006-09-14 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US20060281818A1 (en) | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| JP5711442B2 (ja) * | 2005-04-12 | 2015-04-30 | スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ | 胃腸障害の処置のためのプロスタグランジン化合物およびプロトンポンプ阻害剤の併用 |
| KR20140147142A (ko) | 2006-01-24 | 2014-12-29 | 가부시키가이샤 아루떼꾸 우에노 | 바이-사이클릭 화합물을 함유하는 약학적 조성물 및 바이-사이클릭 화합물의 안정화 방법 |
| JP4851467B2 (ja) * | 2006-02-07 | 2012-01-11 | 株式会社アールテック・ウエノ | プロスタグランジン誘導体の製造法 |
| US20090012165A1 (en) * | 2007-07-03 | 2009-01-08 | Sucampo Ag | Pharmaceutical combination of nsaid and prostaglandin compound |
| US20090030072A1 (en) * | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
| US20090082442A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched lubiprostone |
| CN101318948B (zh) * | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
| US8513441B2 (en) * | 2008-08-29 | 2013-08-20 | Alphora Research Inc. | Prostaglandin synthesis and intermediates for use therein |
| US8372425B2 (en) * | 2008-10-31 | 2013-02-12 | Lipid Pharmaceuticals Ehf. | Fatty acids for use as a medicament |
| CA2748607A1 (en) | 2008-12-31 | 2010-07-08 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| CA2750487A1 (en) | 2009-01-22 | 2010-07-29 | Apotex Pharmachem Inc. | Methods of making lubiprostone and intermediates thereof |
| US9084815B2 (en) * | 2009-09-16 | 2015-07-21 | Sucampo Ag | Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor |
| BR112012006069A8 (pt) * | 2009-09-18 | 2017-10-10 | Adolor Corp | Método para tratar ou prevenir constipação induzida e disfunção intestinal induzida por opióide em um humano, e, uso de uma quantidade terapeuticamente efetiva de composto |
| WO2011054087A1 (en) * | 2009-11-03 | 2011-05-12 | Bernard Charles Sherman | Stable pharmaceutical formulations comprising lubiprostone |
| WO2011072383A1 (en) * | 2009-12-18 | 2011-06-23 | Apotex Pharmachem Inc. | Processes for the purification of lubiprostone |
| WO2011091513A1 (en) | 2010-01-28 | 2011-08-04 | Apotex Pharmachem Inc. | Polymorphic forms of lubiprostone |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014029983A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| ES2735992T3 (es) | 2013-04-12 | 2019-12-23 | Ardelyx Inc | Compuestos de unión a NHE3 y procedimientos para inhibir el transporte de fosfatos |
| WO2016161085A1 (en) | 2015-04-01 | 2016-10-06 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
| AR105029A1 (es) * | 2015-06-19 | 2017-08-30 | Sucampo Ag | Composición farmacéutica que comprende derivado de ácido graso |
| JP6957610B2 (ja) | 2016-10-06 | 2021-11-02 | スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ | 医薬品用途のための多層ビーズ |
| JP7292207B2 (ja) | 2017-01-09 | 2023-06-16 | アルデリックス， インコーポレイテッド | 消化管障害を処置するために有用な化合物 |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
| CN110494721B (zh) * | 2017-04-20 | 2022-06-24 | 株式会社岛津制作所 | 分光光度计 |
| US10422729B1 (en) | 2019-03-08 | 2019-09-24 | Biodesix, Inc. | Blood sample separation devices and methods |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5720305B2 (enExample) | 1973-02-28 | 1982-04-27 | ||
| US4034003A (en) | 1974-04-11 | 1977-07-05 | Ono Pharmaceutical Co., Ltd. | 15-Cycloalkyl-prostaglandins |
| JPS5350141A (en) | 1976-10-18 | 1978-05-08 | Ono Pharmaceut Co Ltd | Stabilization of prostaglandin and prostaglandin analogues |
| JPS5391110A (en) | 1977-01-20 | 1978-08-10 | Yamanouchi Pharmaceut Co Ltd | Novel drug composition for rectal infusion |
| JPS6022708B2 (ja) | 1977-07-14 | 1985-06-03 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| US4308595A (en) * | 1979-12-19 | 1981-12-29 | International Business Machines Corporation | Array driver |
| US4670569A (en) | 1981-04-02 | 1987-06-02 | G. D. Searle & Co. | 5-fluoro-PGI2 compounds |
| US4687864A (en) | 1983-12-23 | 1987-08-18 | G. D. Searle & Co. | 5-fluoro-3-oxa-prostacyclin compounds |
| US4579958A (en) | 1983-12-23 | 1986-04-01 | G. D. Searle & Co. | 5-fluoro-3-oxa-6,7-didehydro-PGI1 compounds |
| US5166174A (en) * | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5317032A (en) | 1987-10-02 | 1994-05-31 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Prostaglandin cathartic |
| JPH0681728B2 (ja) * | 1987-10-02 | 1994-10-19 | 株式会社上野製薬応用研究所 | 下 剤 |
| EP0310305B1 (en) | 1987-10-02 | 1992-07-22 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Cathartics |
| JP2579193B2 (ja) | 1988-07-19 | 1997-02-05 | 小野薬品工業株式会社 | １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体 |
| CA2030345C (en) | 1989-11-22 | 1998-12-08 | Ryuji Ueno | Use of 15-keto-prostaglandin compound for improvement of encephalic function |
| CA2030346C (en) * | 1989-11-22 | 2000-04-11 | Ryuji Ueno | Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds |
| JP2515442B2 (ja) * | 1990-05-01 | 1996-07-10 | 株式会社上野製薬応用研究所 | 膵臓疾患処置剤 |
| EP0455448B1 (en) * | 1990-05-01 | 1998-12-09 | R-Tech Ueno Ltd. | Treatment of pancreatic disease with 15-keto-prostaglandin E compounds |
| JP2938579B2 (ja) | 1990-12-15 | 1999-08-23 | 株式会社上野製薬応用研究所 | 消化管壁保護剤 |
| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| US5958876A (en) * | 1996-06-19 | 1999-09-28 | Novartis Ag | Cyclosporin-containing pharmaceutical compositions |
| AUPO665397A0 (en) * | 1997-05-07 | 1997-05-29 | Borody, Thomas Julius | Novel therapy for constipation |
| DK1062952T3 (da) * | 1998-03-11 | 2003-11-24 | Grelan Pharmaceutical Co | Brusende enteropræparater |
| US6471085B1 (en) | 1999-10-04 | 2002-10-29 | Anthony J. Gallo | Temperature cup |
| BRPI0014869B8 (pt) * | 1999-10-15 | 2021-05-25 | Sucampo Ag | prostaglandinas bicíclicas, composições estabilizadas das mesmas, bem como processo para sua estabilização |
| ATE308606T1 (de) * | 2000-07-14 | 2005-11-15 | Henkel Kgaa | Kompartiment-hohlkörper enthaltend wasch-, reinigungs- oder spülmittelportion |
| US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
-
2000
- 2000-09-05 US US09/655,760 patent/US6414016B1/en not_active Expired - Lifetime
-
2001
- 2001-09-04 JP JP2002524492A patent/JP2004508327A/ja active Pending
- 2001-09-04 NZ NZ524401A patent/NZ524401A/en not_active IP Right Cessation
- 2001-09-04 IL IL15453401A patent/IL154534A0/xx unknown
- 2001-09-04 WO PCT/JP2001/007628 patent/WO2002020007A1/en not_active Ceased
- 2001-09-04 CZ CZ2003-787A patent/CZ304740B6/cs not_active IP Right Cessation
- 2001-09-04 DE DE60131547T patent/DE60131547T2/de not_active Expired - Lifetime
- 2001-09-04 EP EP01961333A patent/EP1315485B1/en not_active Expired - Lifetime
- 2001-09-04 DE DE60142810T patent/DE60142810D1/de not_active Expired - Lifetime
- 2001-09-04 CN CNB018183239A patent/CN100335049C/zh not_active Ceased
- 2001-09-04 TW TW090121835A patent/TWI305147B/zh not_active IP Right Cessation
- 2001-09-04 AU AU2001282615A patent/AU2001282615B2/en not_active Expired
- 2001-09-04 AT AT07016834T patent/ATE476975T1/de active
- 2001-09-04 KR KR1020087021218A patent/KR100918223B1/ko not_active Expired - Lifetime
- 2001-09-04 DK DK01961333T patent/DK1315485T3/da active
- 2001-09-04 DK DK07016834.9T patent/DK1857105T3/da active
- 2001-09-04 ES ES07016834T patent/ES2347697T3/es not_active Expired - Lifetime
- 2001-09-04 CA CA2419741A patent/CA2419741C/en not_active Expired - Lifetime
- 2001-09-04 EP EP07016834A patent/EP1857105B1/en not_active Expired - Lifetime
- 2001-09-04 KR KR1020037003261A patent/KR100901102B1/ko not_active Expired - Lifetime
- 2001-09-04 RU RU2003109622A patent/RU2694361C3/ru active Protection Beyond IP Right Term
- 2001-09-04 PT PT01961333T patent/PT1315485E/pt unknown
- 2001-09-04 HU HU0302422A patent/HU229319B1/hu unknown
- 2001-09-04 BR BRPI0114042A patent/BRPI0114042B8/pt not_active IP Right Cessation
- 2001-09-04 AU AU8261501A patent/AU8261501A/xx active Pending
- 2001-09-04 ES ES01961333T patent/ES2296786T3/es not_active Expired - Lifetime
- 2001-09-04 MX MXPA03001959A patent/MXPA03001959A/es active IP Right Grant
- 2001-09-04 PT PT07016834T patent/PT1857105E/pt unknown
- 2001-09-05 AR ARP010104216A patent/AR030609A1/es unknown
-
2002
- 2002-05-06 US US10/138,650 patent/US6610732B2/en not_active Expired - Fee Related
-
2003
- 2003-02-19 IL IL154534A patent/IL154534A/en not_active IP Right Cessation
- 2003-02-28 ZA ZA200301673A patent/ZA200301673B/xx unknown
- 2003-03-04 NO NO20030996A patent/NO332701B1/no not_active IP Right Cessation
- 2003-05-22 US US10/443,046 patent/US20030216465A1/en not_active Abandoned
-
2005
- 2005-06-02 US US11/142,251 patent/US8071613B2/en not_active Expired - Fee Related
-
2009
- 2009-03-04 JP JP2009050902A patent/JP4684334B2/ja not_active Expired - Fee Related
- 2009-09-15 JP JP2009213058A patent/JP2009286806A/ja active Pending
-
2011
- 2011-10-17 US US13/274,612 patent/US8114890B1/en not_active Expired - Lifetime
- 2011-12-27 US US13/337,488 patent/US8748454B2/en not_active Expired - Fee Related
-
2013
- 2013-08-26 AR ARP130103006A patent/AR100291A2/es not_active Application Discontinuation
-
2014
- 2014-04-30 US US14/265,467 patent/US20140235665A1/en not_active Abandoned
-
2015
- 2015-08-28 NL NL300757C patent/NL300757I1/nl unknown
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