JP2010516777A5 - - Google Patents
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- Publication number
- JP2010516777A5 JP2010516777A5 JP2009547366A JP2009547366A JP2010516777A5 JP 2010516777 A5 JP2010516777 A5 JP 2010516777A5 JP 2009547366 A JP2009547366 A JP 2009547366A JP 2009547366 A JP2009547366 A JP 2009547366A JP 2010516777 A5 JP2010516777 A5 JP 2010516777A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- prodrug
- represented
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- -1 3-chloro-5- (hydroxymethyl) phenyl Chemical group 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 0 Cc1nnn[n]1* Chemical compound Cc1nnn[n]1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88601807P | 2007-01-22 | 2007-01-22 | |
| US60/886,018 | 2007-01-22 | ||
| PCT/US2008/051540 WO2008091810A1 (en) | 2007-01-22 | 2008-01-21 | Substituted arylcylopentenes as therapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516777A JP2010516777A (ja) | 2010-05-20 |
| JP2010516777A5 true JP2010516777A5 (enExample) | 2011-03-24 |
| JP5453111B2 JP5453111B2 (ja) | 2014-03-26 |
Family
ID=39493552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547366A Expired - Fee Related JP5453111B2 (ja) | 2007-01-22 | 2008-01-21 | 治療薬としての置換アリールシクロペンタン類 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2114875B1 (enExample) |
| JP (1) | JP5453111B2 (enExample) |
| AU (1) | AU2008208032B2 (enExample) |
| BR (1) | BRPI0806716A2 (enExample) |
| CA (1) | CA2675632A1 (enExample) |
| WO (1) | WO2008091810A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3037820A1 (en) | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| US20230138285A1 (en) | 2021-11-04 | 2023-05-04 | Miltenyi Biotec B.V. & Co. KG | Bright and releasable labels for cell staining based on the conjugates with several sites of fluorophore release |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3446225B2 (ja) * | 1992-08-17 | 2003-09-16 | 日産化学工業株式会社 | シクロペンタン誘導体及びその製造方法 |
| JP2001527063A (ja) * | 1998-12-24 | 2001-12-25 | 小野薬品工業株式会社 | ω−シクロアルキル−プロスタグランジンＥ２誘導体 |
| CN1617868A (zh) * | 2001-11-05 | 2005-05-18 | 阿勒根公司 | 作为EP2－受体激动剂的ω－环烷基17－杂芳基前列腺素E2 类似物 |
| US7091231B2 (en) * | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| NZ555945A (en) * | 2005-01-14 | 2011-01-28 | Allergan Inc | Substituted cyclopentanes or cyclopentanones for the treatment of ocular hypertensive conditions |
-
2008
- 2008-01-21 CA CA002675632A patent/CA2675632A1/en not_active Abandoned
- 2008-01-21 AU AU2008208032A patent/AU2008208032B2/en not_active Ceased
- 2008-01-21 JP JP2009547366A patent/JP5453111B2/ja not_active Expired - Fee Related
- 2008-01-21 WO PCT/US2008/051540 patent/WO2008091810A1/en not_active Ceased
- 2008-01-21 BR BRPI0806716-3A patent/BRPI0806716A2/pt not_active IP Right Cessation
- 2008-01-21 EP EP08713853A patent/EP2114875B1/en not_active Not-in-force
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