JP2010500416A5 - - Google Patents
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- Publication number
- JP2010500416A5 JP2010500416A5 JP2009524741A JP2009524741A JP2010500416A5 JP 2010500416 A5 JP2010500416 A5 JP 2010500416A5 JP 2009524741 A JP2009524741 A JP 2009524741A JP 2009524741 A JP2009524741 A JP 2009524741A JP 2010500416 A5 JP2010500416 A5 JP 2010500416A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- carbon atoms
- substituted
- alkyl
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- -1 5- (3-propyl) thiophen-2-yl Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82210806P | 2006-08-11 | 2006-08-11 | |
| PCT/US2007/075615 WO2008021975A2 (en) | 2006-08-11 | 2007-08-09 | Therapeutic lactams |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010500416A JP2010500416A (ja) | 2010-01-07 |
| JP2010500416A5 true JP2010500416A5 (enExample) | 2010-09-24 |
Family
ID=38683367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524741A Pending JP2010500416A (ja) | 2006-08-11 | 2007-08-09 | 治療用ラクタム類 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7482475B2 (enExample) |
| EP (1) | EP2066660A2 (enExample) |
| JP (1) | JP2010500416A (enExample) |
| KR (1) | KR101422305B1 (enExample) |
| CN (1) | CN101522669B (enExample) |
| AU (1) | AU2007286177B2 (enExample) |
| BR (1) | BRPI0716742A2 (enExample) |
| CA (1) | CA2660608A1 (enExample) |
| MX (1) | MX2009001578A (enExample) |
| NZ (1) | NZ597866A (enExample) |
| WO (1) | WO2008021975A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7592364B2 (en) * | 2006-02-28 | 2009-09-22 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| EP1996546B1 (en) * | 2006-03-20 | 2014-11-26 | Allergan, Inc. | Substituted gamma lactams as prostaglandin ep2 agonists |
| WO2008021975A2 (en) * | 2006-08-11 | 2008-02-21 | Allergan, Inc. | Therapeutic lactams |
| US7589213B2 (en) * | 2007-04-27 | 2009-09-15 | Old David W | Therapeutic substituted lactams |
| US8440819B2 (en) * | 2008-02-22 | 2013-05-14 | Allergan, Inc. | Therapeutic substituted beta-lactams |
| CN102076681A (zh) * | 2008-04-24 | 2011-05-25 | 阿勒根公司 | 作为治疗剂的取代γ-内酰胺 |
| WO2014031581A1 (en) * | 2012-08-21 | 2014-02-27 | Allergan, Inc. | Process for the synthesis of substituted gamma lactams |
| US20150274658A1 (en) * | 2014-03-27 | 2015-10-01 | Allergan, Inc. | Therapeutic lactams |
| HK1249104A1 (zh) | 2015-03-13 | 2018-10-26 | Forma Therapeutics, Inc. | 作为HDAC8抑制剂的α-肉桂酰胺化合物和组合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1991504A (en) * | 1928-09-12 | 1935-02-19 | American District Telegraph Co | Key-trapping valve lock for transmitter-supervised sprinkler systems |
| US5049577A (en) * | 1990-01-29 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith |
| US5902726A (en) * | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
| NZ535024A (en) * | 2002-03-05 | 2006-10-27 | Ono Pharmaceutical Co | 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient |
| AU2003258433A1 (en) | 2002-08-28 | 2004-03-19 | Merck Frosst Canada Ltd | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma |
| JP5128954B2 (ja) * | 2004-12-06 | 2013-01-23 | メルク セローノ ソシエテ アノニム | Ｄｐ１受容体アゴニストとして使用されるピロリジン−２−オン誘導体 |
| BRPI0609021A2 (pt) * | 2005-03-10 | 2010-01-12 | Allergan Inc | gama lactamas substituìdas, composição e uso das mesmas |
| EP1996546B1 (en) * | 2006-03-20 | 2014-11-26 | Allergan, Inc. | Substituted gamma lactams as prostaglandin ep2 agonists |
| WO2008021975A2 (en) * | 2006-08-11 | 2008-02-21 | Allergan, Inc. | Therapeutic lactams |
-
2007
- 2007-08-09 WO PCT/US2007/075615 patent/WO2008021975A2/en not_active Ceased
- 2007-08-09 AU AU2007286177A patent/AU2007286177B2/en not_active Ceased
- 2007-08-09 KR KR1020097004976A patent/KR101422305B1/ko not_active Expired - Fee Related
- 2007-08-09 NZ NZ597866A patent/NZ597866A/xx not_active IP Right Cessation
- 2007-08-09 MX MX2009001578A patent/MX2009001578A/es active IP Right Grant
- 2007-08-09 BR BRPI0716742 patent/BRPI0716742A2/pt not_active IP Right Cessation
- 2007-08-09 JP JP2009524741A patent/JP2010500416A/ja active Pending
- 2007-08-09 CN CN2007800369601A patent/CN101522669B/zh not_active Expired - Fee Related
- 2007-08-09 CA CA002660608A patent/CA2660608A1/en not_active Abandoned
- 2007-08-09 EP EP07840832A patent/EP2066660A2/en not_active Withdrawn
- 2007-08-09 US US11/836,655 patent/US7482475B2/en active Active
-
2008
- 2008-12-15 US US12/334,704 patent/US8686025B2/en not_active Expired - Fee Related
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