JP2010536761A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010536761A5 JP2010536761A5 JP2010521050A JP2010521050A JP2010536761A5 JP 2010536761 A5 JP2010536761 A5 JP 2010536761A5 JP 2010521050 A JP2010521050 A JP 2010521050A JP 2010521050 A JP2010521050 A JP 2010521050A JP 2010536761 A5 JP2010536761 A5 JP 2010536761A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- solvate
- stereoisomer
- acceptable salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 28
- 239000012453 solvate Substances 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 150000003857 carboxamides Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 150000001540 azides Chemical group 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- -1 hydrogen compound Chemical class 0.000 claims 1
- 230000004068 intracellular signaling Effects 0.000 claims 1
- 208000037906 ischaemic injury Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 230000021597 necroptosis Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 0 *c1c(*N*c2c(C3CC3)nn[s]2)c(F)ccc1 Chemical compound *c1c(*N*c2c(C3CC3)nn[s]2)c(F)ccc1 0.000 description 16
- NFGOUMMGMGHCJJ-MRVPVSSYSA-N CC(C)[C@@H](C)c(c(N)ccc1)c1N Chemical compound CC(C)[C@@H](C)c(c(N)ccc1)c1N NFGOUMMGMGHCJJ-MRVPVSSYSA-N 0.000 description 1
- RYPGXQXLHDFTQD-UHFFFAOYSA-N CC(C)c1c(C=C)cccc1N Chemical compound CC(C)c1c(C=C)cccc1N RYPGXQXLHDFTQD-UHFFFAOYSA-N 0.000 description 1
- HDNVDXJTQZMBCR-UHFFFAOYSA-N Cc1c(C(NCc(c(F)ccc2)c2Cl)=O)[s]nn1 Chemical compound Cc1c(C(NCc(c(F)ccc2)c2Cl)=O)[s]nn1 HDNVDXJTQZMBCR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95596607P | 2007-08-15 | 2007-08-15 | |
| US60/955,966 | 2007-08-15 | ||
| US3817508P | 2008-03-20 | 2008-03-20 | |
| US61/038,175 | 2008-03-20 | ||
| PCT/US2008/009793 WO2009023272A1 (en) | 2007-08-15 | 2008-08-15 | Heterocyclic inhibitors of necroptosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536761A JP2010536761A (ja) | 2010-12-02 |
| JP2010536761A5 true JP2010536761A5 (enExample) | 2011-09-29 |
| JP5645663B2 JP5645663B2 (ja) | 2014-12-24 |
Family
ID=40351022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521050A Active JP5645663B2 (ja) | 2007-08-15 | 2008-08-15 | ネクロトーシスのヘテロ環式抑制剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US20090099242A1 (enExample) |
| EP (2) | EP3034494A1 (enExample) |
| JP (1) | JP5645663B2 (enExample) |
| CA (1) | CA2696349A1 (enExample) |
| WO (1) | WO2009023272A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2384753T3 (en) * | 2003-08-29 | 2016-04-11 | Brigham & Womens Hospital | Hydantoin derivatives as inhibitors of cell necrosis |
| US8324262B2 (en) * | 2005-12-20 | 2012-12-04 | The Brigham And Women's Hospital, Inc. | Tricyclic necrostatin compounds |
| WO2010075561A1 (en) | 2008-12-23 | 2010-07-01 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
| EP2560629B1 (en) | 2010-04-23 | 2020-06-03 | Massachusetts Eye & Ear Infirmary | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
| TWI471289B (zh) | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行ｎ－脫烷反應之方法 |
| CA2936749C (en) | 2010-06-11 | 2019-07-09 | Joshua R. Giguere | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| US20140024598A1 (en) | 2010-11-01 | 2014-01-23 | Demetrios Vavvas | Methods and compositions for preserving retinal ganglion cells |
| US9643977B2 (en) | 2011-03-11 | 2017-05-09 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
| CA2888805C (en) | 2011-10-21 | 2020-07-14 | Massachusetts Eye And Ear Infirmary | Methods and compositions for promoting axon regeneration and nerve function |
| TWI637951B (zh) | 2013-02-15 | 2018-10-11 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類 |
| JP2016514693A (ja) | 2013-03-15 | 2016-05-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハイブリッド型ネクロトーシス阻害剤 |
| CN103535358B (zh) * | 2013-10-18 | 2015-04-15 | 孙家隆 | 一组邻位取代苯甲酰化合物的杀菌剂用途 |
| TW201632516A (zh) | 2014-12-11 | 2016-09-16 | 哈佛大學校長及研究員協會 | 細胞壞死抑制劑與相關方法 |
| CA2972366C (en) * | 2014-12-24 | 2020-04-21 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
| AU2015371824B2 (en) | 2014-12-24 | 2019-09-19 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
| IL247368A0 (en) | 2016-08-18 | 2016-11-30 | Yeda Res & Dev | Diagnostic and therapeutic uses of exosomes |
| PE20211383A1 (es) | 2018-05-03 | 2021-07-27 | Rigel Pharmaceuticals Inc | Compuestos inhibidores de rip1 y metodos para preparar y usar los mismos |
| JOP20200277A1 (ar) | 2018-05-03 | 2020-11-03 | Rigel Pharmaceuticals Inc | مركبات تثبيط rip1 وطرق لتحضير واستخدامها |
| WO2020103859A1 (en) | 2018-11-20 | 2020-05-28 | Sironax Ltd | RIP1 Inhibitors |
| CN111978311B (zh) * | 2019-05-21 | 2024-05-31 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| EP4025575B1 (en) | 2019-09-06 | 2025-12-17 | Rigel Pharmaceuticals, Inc. | Rip1 inhibitory compounds and methods for making and using the same |
| CA3149963A1 (en) | 2019-09-06 | 2021-03-11 | Simon Shaw | Heterocyclic rip1 kinase inhibitors |
| WO2021092336A1 (en) | 2019-11-07 | 2021-05-14 | Rigel Pharmaceuticals, Inc. | Heterocyclic rip1 inhibitory compounds |
| AR121717A1 (es) | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
| CA3183676A1 (en) | 2020-05-20 | 2021-11-25 | Sironax Ltd. | Piperazine cyclic ureas |
| TWI840311B (zh) | 2020-07-01 | 2024-04-21 | 美商雷傑製藥公司 | Rip1k抑制劑 |
| AU2021380914B2 (en) * | 2020-11-19 | 2024-08-15 | Acousia Therapeutics Gmbh | Non-aqueous gel composition |
| AR125587A1 (es) | 2021-03-11 | 2023-08-02 | Rigel Pharmaceuticals Inc | Inhibidores heterocíclicos de la quinasa de rip1 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2728523C2 (de) * | 1977-06-23 | 1986-02-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | 4-Methyl-1,2,3-thiadiazol-5-carbonsäure-(cyclohexylmethyl)-amid, Mittel mit herbizider und wachstumsregulatorischer Wirkung enthaltend diese Verbindung sowie Verfahren zu seiner Herstellung |
| US4356787A (en) | 1977-12-30 | 1982-11-02 | Harley Richard C | Float construction |
| JPH10152482A (ja) * | 1996-09-30 | 1998-06-09 | Nippon Nohyaku Co Ltd | １，２，３−チアジアゾール誘導体又はその塩類及び農園芸用病害防除剤ならびにその使用方法 |
| EP0930305B1 (en) | 1996-09-30 | 2003-05-14 | Nihon Nohyaku Co., Ltd. | 1,2,3-thiadiazole derivatives and salts thereof, disease controlling agents for agricultural and horticultural use, and method for the use thereof |
| PT957099E (pt) * | 1998-04-15 | 2003-02-28 | Pfizer Prod Inc | Carboxamidas heterociclicas |
| ATE238661T1 (de) * | 1998-07-30 | 2003-05-15 | Nihon Nohyaku Co Ltd | Fungizide zusammensetzung enthaltend ein 1,2,3- thiadiazolderivat sowie deren verwendung |
| JP2000103710A (ja) * | 1998-07-30 | 2000-04-11 | Nippon Nohyaku Co Ltd | 殺菌剤組成物及びその使用方法 |
| US6756394B1 (en) * | 1999-10-15 | 2004-06-29 | President And Fellow Of Harvard College | Small molecule inhibitors of necrosis |
| US6420400B1 (en) * | 2000-04-07 | 2002-07-16 | Kinetek Pharmaceuticals, Inc. | Antiproliferative 1,2,3-thiadiazole compounds |
| DE60227655D1 (de) * | 2001-04-19 | 2008-08-28 | Dainippon Sumitomo Pharma Co | Pyrrolderivat |
| DE10132686A1 (de) * | 2001-07-05 | 2003-01-16 | Boehringer Ingelheim Pharma | Heteroarylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| EP1438973A4 (en) | 2001-10-05 | 2005-07-13 | Ono Pharmaceutical Co | MEANS FOR THE TREATMENT OF STRESS-RELATED DISEASES WITH MITOCHONDRIENE BENZODIAZEPINE RECEPTOR ANTAGONISTS |
| SI1474395T1 (sl) | 2002-02-12 | 2008-02-29 | Smithkline Beecham Corp | Nikotinamidni derivati, uporabni kot inhibitorji p38 |
| DE10261131A1 (de) * | 2002-12-20 | 2004-07-01 | Grünenthal GmbH | Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide |
| GB0302671D0 (en) * | 2003-02-06 | 2003-03-12 | Astrazeneca Ab | Pharmaceutical formulations |
| EP1638944A1 (en) * | 2003-06-12 | 2006-03-29 | Eli Lilly And Company | Tachykinin receptor antagonists |
| DK2384753T3 (en) | 2003-08-29 | 2016-04-11 | Brigham & Womens Hospital | Hydantoin derivatives as inhibitors of cell necrosis |
| WO2005100342A1 (en) * | 2004-03-26 | 2005-10-27 | Vertex Pharmaceuticals, Incorporated | Pyridine inhibitors of erk2 and uses thereof |
| KR101155288B1 (ko) * | 2004-07-30 | 2012-07-02 | 엑셀리시스, 인코포레이티드 | 의약제로서의 피롤 유도체 |
| PL1848435T3 (pl) * | 2005-01-25 | 2016-08-31 | Synta Pharmaceuticals Corp | Związki przeciwko zapaleniom i zastosowania związane z odpornością |
| EP1852428B1 (en) * | 2005-02-24 | 2012-05-16 | Nihon Nohyaku Co., Ltd. | 4-cyclopropyl-1,2,3-thiadiazole compound, agrohorticultural plant disease controlling agent and method of using the same |
| US8324262B2 (en) | 2005-12-20 | 2012-12-04 | The Brigham And Women's Hospital, Inc. | Tricyclic necrostatin compounds |
| JP2007186435A (ja) * | 2006-01-12 | 2007-07-26 | Astellas Pharma Inc | ニコチンアミド誘導体 |
| JP2009524677A (ja) | 2006-01-25 | 2009-07-02 | シンタ ファーマシューティカルズ コーポレーション | 炎症および免疫関連使用用のチアゾールおよびチアジアゾール化合物 |
| AU2007211276B2 (en) * | 2006-01-31 | 2013-06-06 | Synta Pharmaceuticals Corp. | Pyridylphenyl compounds for inflammation and immune-related uses |
| AU2007227210A1 (en) * | 2006-03-20 | 2007-09-27 | Synta Pharmaceuticals Corp. | Benzoimidazolyl-parazine compounds for inflammation and immune-related uses |
| AU2007230911A1 (en) * | 2006-03-23 | 2007-10-04 | Synta Pharmaceuticals Corp. | Benzimidazolyl-pyridine compounds for inflammation and immune-related uses |
| AU2007307044B2 (en) | 2006-10-10 | 2014-03-20 | President And Fellows Of Harvard College | Compounds, screens, and methods of treatment |
| DE602008000809D1 (de) | 2007-03-23 | 2010-04-29 | Icagen Inc | Ionenkanal-Hemmer |
| WO2010075290A1 (en) | 2008-12-22 | 2010-07-01 | President And Fellows Of Harvard College | Unsaturated heterocyclic inhibitors of necroptosis |
| WO2010075561A1 (en) | 2008-12-23 | 2010-07-01 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
-
2008
- 2008-08-15 EP EP15002668.0A patent/EP3034494A1/en not_active Withdrawn
- 2008-08-15 WO PCT/US2008/009793 patent/WO2009023272A1/en not_active Ceased
- 2008-08-15 US US12/228,750 patent/US20090099242A1/en not_active Abandoned
- 2008-08-15 CA CA2696349A patent/CA2696349A1/en not_active Abandoned
- 2008-08-15 EP EP20080795375 patent/EP2192838A4/en not_active Withdrawn
- 2008-08-15 JP JP2010521050A patent/JP5645663B2/ja active Active
-
2010
- 2010-08-20 US US12/859,997 patent/US8278344B2/en active Active
-
2012
- 2012-08-20 US US13/589,867 patent/US8658689B2/en active Active
-
2014
- 2014-01-10 US US14/152,703 patent/US9108955B2/en active Active
-
2015
- 2015-07-10 US US14/796,378 patent/US20160102053A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010536761A5 (enExample) | ||
| JP4611444B2 (ja) | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール | |
| JP5989660B2 (ja) | 置換１−ベンジルシクロアルキルカルボン酸およびその使用 | |
| WO2016081649A1 (en) | Thieno[2,3-d]pyrimidin-4-one derivatives as nmdar modulators and uses related thereto | |
| WO2017048954A1 (en) | Hepatitis b core protein modulators | |
| JP2010522709A5 (enExample) | ||
| JP2008513496A5 (enExample) | ||
| WO2008054454A2 (en) | Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents | |
| JP2016512531A5 (enExample) | ||
| JP2009542595A5 (enExample) | ||
| JP2006528617A5 (enExample) | ||
| JP2010504351A5 (enExample) | ||
| JP2015508092A5 (enExample) | ||
| JP2010522711A5 (enExample) | ||
| JP2007527913A5 (enExample) | ||
| JP2010522710A5 (enExample) | ||
| JP2025003530A (ja) | アルドースレダクターゼの阻害剤 | |
| JP2010513489A5 (enExample) | ||
| CN1136215C (zh) | 异喹啉衍生物或其盐 | |
| WO2008113747A1 (en) | Medicaments useful as potassium channel modulators | |
| TWI555528B (zh) | 泛醇基二十二碳六烯酸酯及其於治療與預防心血管疾病的用途 | |
| CN1225466C (zh) | Ⅰ型钠－氢交换剂(nhe－1)抑制剂 | |
| JP2007521272A5 (enExample) | ||
| CN1921855A (zh) | 用于选择性增强心房收缩力以及治疗心功能不全的kv1.5－阻滞剂 | |
| JP2006520343A (ja) | ２−（ブチル−１−スルホニルアミノ）−ｎ−［１（ｒ）−（６−メトキシピリジン−３−イル）プロピル］ベンズアミド、医薬としてのその使用及び該化合物を含有する医薬製剤 |