JP2010522711A5 - - Google Patents
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- Publication number
- JP2010522711A5 JP2010522711A5 JP2010500240A JP2010500240A JP2010522711A5 JP 2010522711 A5 JP2010522711 A5 JP 2010522711A5 JP 2010500240 A JP2010500240 A JP 2010500240A JP 2010500240 A JP2010500240 A JP 2010500240A JP 2010522711 A5 JP2010522711 A5 JP 2010522711A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound
- hydrogen
- pharmaceutically acceptable
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 239000011737 fluorine Substances 0.000 claims 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 230000036407 pain Effects 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 150000002222 fluorine compounds Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- QMMZOEZYJBOYMF-UHFFFAOYSA-N n-[(2,4-dichlorophenyl)methyl]-1-ethyl-6-oxopiperidine-2-carboxamide Chemical compound C1CCC(=O)N(CC)C1C(=O)NCC1=CC=C(Cl)C=C1Cl QMMZOEZYJBOYMF-UHFFFAOYSA-N 0.000 claims 1
- YEHSQGUPLMSNOY-UHFFFAOYSA-N n-[(2,4-dichlorophenyl)methyl]-1-methyl-6-oxopiperidine-2-carboxamide Chemical compound C1CCC(=O)N(C)C1C(=O)NCC1=CC=C(Cl)C=C1Cl YEHSQGUPLMSNOY-UHFFFAOYSA-N 0.000 claims 1
- CXJGALUKEJTMJA-UHFFFAOYSA-N n-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-ethyl-6-oxopiperidine-2-carboxamide Chemical compound C1CCC(=O)N(CC)C1C(=O)NCC1=CC=CC(C(F)(F)F)=C1Cl CXJGALUKEJTMJA-UHFFFAOYSA-N 0.000 claims 1
- YGCMKVHDGGAEFD-UHFFFAOYSA-N n-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-6-oxopiperidine-2-carboxamide Chemical compound C1CCC(=O)N(C)C1C(=O)NCC1=CC=CC(C(F)(F)F)=C1Cl YGCMKVHDGGAEFD-UHFFFAOYSA-N 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- -1 or R 9 Chemical compound 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0706030.4A GB0706030D0 (en) | 2007-03-28 | 2007-03-28 | Novel compounds |
| GB0805047A GB0805047D0 (en) | 2008-03-18 | 2008-03-18 | Novel compounds |
| PCT/EP2008/053433 WO2008116845A1 (en) | 2007-03-28 | 2008-03-20 | Piperidinone carboxamide derivatives as p2x7 modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010522711A JP2010522711A (ja) | 2010-07-08 |
| JP2010522711A5 true JP2010522711A5 (enExample) | 2011-05-12 |
Family
ID=39788062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500240A Withdrawn JP2010522711A (ja) | 2007-03-28 | 2008-03-20 | Ｐ２ｘ７調節因子としてのピペリジノンカルボキサミド誘導体 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100168171A1 (enExample) |
| EP (1) | EP2139858A1 (enExample) |
| JP (1) | JP2010522711A (enExample) |
| WO (1) | WO2008116845A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007271182B2 (en) * | 2006-07-06 | 2012-03-15 | Glaxo Group Limited | Substituted N-phenylmethyl -5-oxo-proline-2-amides as P2X7-receptor antagonists and their methods of use |
| JP5478637B2 (ja) * | 2008-12-23 | 2014-04-23 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ７モジュレーターとしてのジヒドロピリドンアミド |
| DK2509609T3 (da) * | 2009-12-08 | 2014-11-10 | Univ Vanderbilt | Forbedrede fremgangsmåder og sammensætninger for venehøst og autotransplantation |
| MX2014000894A (es) | 2011-07-22 | 2014-02-27 | Actelion Pharmaceuticals Ltd | Derivados de amidas heterociclicas como antagonistas de receptores p2x7. |
| TWI576347B (zh) | 2012-01-20 | 2017-04-01 | 艾克泰聯製藥有限公司 | 作為ｐ２ｘ受體拮抗劑之雜環醯胺衍生物 |
| KR102232742B1 (ko) | 2012-12-12 | 2021-03-26 | 이도르시아 파마슈티컬스 리미티드 | Ｐ２ｘ７ 수용체 길항제로서의 인돌 카르복사미드 유도체 |
| WO2014097140A1 (en) | 2012-12-18 | 2014-06-26 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
| JP6282016B2 (ja) * | 2013-01-22 | 2018-02-21 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体 |
| JP6282017B2 (ja) | 2013-01-22 | 2018-02-21 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体 |
| EP3773557A1 (en) | 2018-03-29 | 2021-02-17 | Centre national de la recherche scientifique | P2rx7 modulators in therapy |
| TW202229235A (zh) * | 2021-01-28 | 2022-08-01 | 大陸商深圳晶泰科技有限公司 | 環胺衍生物及其製備方法和應用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054579A (en) * | 1997-06-26 | 2000-04-25 | Leukosite, Inc. | Synthesis of substituted lactams |
| SE9704546D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| AU2007271182B2 (en) * | 2006-07-06 | 2012-03-15 | Glaxo Group Limited | Substituted N-phenylmethyl -5-oxo-proline-2-amides as P2X7-receptor antagonists and their methods of use |
-
2008
- 2008-03-20 EP EP08718137A patent/EP2139858A1/en not_active Withdrawn
- 2008-03-20 WO PCT/EP2008/053433 patent/WO2008116845A1/en not_active Ceased
- 2008-03-20 JP JP2010500240A patent/JP2010522711A/ja not_active Withdrawn
- 2008-03-20 US US12/593,044 patent/US20100168171A1/en not_active Abandoned
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