JP2018537513A5 - - Google Patents
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- Publication number
- JP2018537513A5 JP2018537513A5 JP2018531629A JP2018531629A JP2018537513A5 JP 2018537513 A5 JP2018537513 A5 JP 2018537513A5 JP 2018531629 A JP2018531629 A JP 2018531629A JP 2018531629 A JP2018531629 A JP 2018531629A JP 2018537513 A5 JP2018537513 A5 JP 2018537513A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hepe
- pharmaceutically acceptable
- use according
- configuration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 206010016654 Fibrosis Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- -1 complex Chemical class 0.000 claims description 4
- 230000004761 fibrosis Effects 0.000 claims description 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 4
- 201000000849 skin cancer Diseases 0.000 claims description 4
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 2
- 206010022489 Insulin Resistance Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 210000001789 adipocyte Anatomy 0.000 claims description 2
- 230000004069 differentiation Effects 0.000 claims description 2
- 125000004494 ethyl ester group Chemical group 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 125000004492 methyl ester group Chemical group 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 239000000902 placebo Substances 0.000 claims description 2
- 229940068196 placebo Drugs 0.000 claims description 2
- 125000005457 triglyceride group Chemical group 0.000 claims description 2
- OWFVSJHRFRIEAK-UHFFFAOYSA-N 15-hydroxyicosa-2,4,6,8,10-pentaenoic acid Chemical compound CCCCCC(O)CCCC=CC=CC=CC=CC=CC(O)=O OWFVSJHRFRIEAK-UHFFFAOYSA-N 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 1
- WLKCSMCLEKGITB-XWJJKCKWSA-N 15-HEPE Chemical compound CC\C=C/CC(O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O WLKCSMCLEKGITB-XWJJKCKWSA-N 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 239000002253 acid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562269280P | 2015-12-18 | 2015-12-18 | |
| US62/269,280 | 2015-12-18 | ||
| PCT/IB2016/001878 WO2017103671A1 (en) | 2015-12-18 | 2016-12-19 | Compositions comprising 15-hepe and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019214063A Division JP2020063259A (ja) | 2015-12-18 | 2019-11-27 | １５−ｈｅｐｅを含む組成物及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018537513A JP2018537513A (ja) | 2018-12-20 |
| JP2018537513A5 true JP2018537513A5 (enExample) | 2019-09-19 |
Family
ID=57995240
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531629A Pending JP2018537513A (ja) | 2015-12-18 | 2016-12-19 | １５−ｈｅｐｅを含む組成物及びその使用方法 |
| JP2019214063A Pending JP2020063259A (ja) | 2015-12-18 | 2019-11-27 | １５−ｈｅｐｅを含む組成物及びその使用方法 |
| JP2021118532A Pending JP2021178840A (ja) | 2015-12-18 | 2021-07-19 | １５−ｈｅｐｅを含む組成物及びその使用方法 |
| JP2023118782A Pending JP2023153863A (ja) | 2015-12-18 | 2023-07-21 | １５－ｈｅｐｅを含む組成物及びその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019214063A Pending JP2020063259A (ja) | 2015-12-18 | 2019-11-27 | １５−ｈｅｐｅを含む組成物及びその使用方法 |
| JP2021118532A Pending JP2021178840A (ja) | 2015-12-18 | 2021-07-19 | １５−ｈｅｐｅを含む組成物及びその使用方法 |
| JP2023118782A Pending JP2023153863A (ja) | 2015-12-18 | 2023-07-21 | １５－ｈｅｐｅを含む組成物及びその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US9855238B2 (enExample) |
| EP (2) | EP3389647B1 (enExample) |
| JP (4) | JP2018537513A (enExample) |
| KR (6) | KR20180094516A (enExample) |
| CN (2) | CN108697680A (enExample) |
| AR (2) | AR107143A1 (enExample) |
| AU (4) | AU2016370626B2 (enExample) |
| BR (1) | BR122023026625A2 (enExample) |
| CA (2) | CA3129008A1 (enExample) |
| ES (1) | ES2948444T3 (enExample) |
| IL (3) | IL318963A (enExample) |
| MX (2) | MX394051B (enExample) |
| NZ (1) | NZ744323A (enExample) |
| PH (1) | PH12018501279A1 (enExample) |
| RU (2) | RU2737089C2 (enExample) |
| SG (1) | SG11201805149XA (enExample) |
| WO (1) | WO2017103671A1 (enExample) |
| ZA (2) | ZA201804779B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| CN105899485B (zh) | 2013-11-15 | 2018-10-19 | 尊严科学有限公司 | 多不饱和羟基脂肪酸的药学上可接受的盐 |
| MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| CN113896628A (zh) | 2015-05-13 | 2022-01-07 | Ds生物制药有限公司 | 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法 |
| EP3861995A1 (en) | 2015-07-21 | 2021-08-11 | Affimune Limited | Compositions comprising 15-hepe for use in treating or preventing neurologic disease |
| KR20180094516A (ko) | 2015-12-18 | 2018-08-23 | 애피뮨 리미티드 | 15-hepe를 포함하는 조성물 및 이를 사용하는 방법 |
| CN113116878A (zh) * | 2020-01-10 | 2021-07-16 | 南京大学 | 15s-hepe用于增强t细胞介导的肿瘤免疫治疗的新用途 |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
| US11622495B2 (en) | 2021-06-01 | 2023-04-11 | Gint Co., Ltd. | Method of automatically combining farm vehicle and work machine and farm vehicle |
| CN113855659B (zh) * | 2021-11-24 | 2022-12-23 | 中国人民解放军东部战区总医院 | 12-hepe或其药学上可接受的脂肪酸改善精子发生障碍的应用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05186342A (ja) * | 1992-01-10 | 1993-07-27 | Fujirebio Inc | 免疫調節作用を併せもつ抗炎症剤 |
| GB9301446D0 (en) | 1993-01-26 | 1993-03-17 | Scotia Holdings Plc | Internal radiation damage |
| AU683027B2 (en) | 1993-01-27 | 1997-10-30 | Scotia Holdings Plc | Triglycerides |
| BR9405620A (pt) | 1993-10-01 | 1999-09-08 | Scherer Corp R P | Cápsula de gelatina contendo fragrncia, e, processo para sua preparação |
| GB9715444D0 (en) | 1997-07-22 | 1997-09-24 | Scotia Holdings Plc | Therapeutic and dietary compositions |
| JP2000191525A (ja) | 1998-12-25 | 2000-07-11 | Nof Corp | 皮膚外用剤組成物 |
| ATE504557T1 (de) | 2000-02-16 | 2011-04-15 | Brigham & Womens Hospital | Aspirin-ausgelöste lipidmediatoren |
| US20020188024A1 (en) | 2000-08-23 | 2002-12-12 | Chilton Floyd H. | Fatty acid-containing emulsion with increased bioavailability |
| US20040043013A1 (en) | 2000-12-28 | 2004-03-04 | Mccleary Edward Larry | Metabolic uncoupling therapy |
| US20020198177A1 (en) | 2001-05-30 | 2002-12-26 | Horrobin David Frederick | Coenzyme Q and EPA |
| WO2004048497A1 (ja) | 2002-11-22 | 2004-06-10 | Nippon Suisan Kaisha, Ltd. | 高度不飽和脂肪酸、その塩、またはそのエステルを含有する外用組成物 |
| JP2005179211A (ja) | 2003-12-17 | 2005-07-07 | Idemitsu Kosan Co Ltd | 皮膚外用剤組成物 |
| WO2005063231A2 (en) | 2003-12-31 | 2005-07-14 | Igennus Limited | Formulation containing an eicosapentaenoic acid or an ester thereof and a triterpene or esther thereof |
| US20050239889A1 (en) | 2004-04-26 | 2005-10-27 | Jean Gosselin | In vivo release of endogenous anti-microbial mediators by leukotriene B4 (LTB4) administration |
| CA2572344A1 (en) | 2004-07-01 | 2006-01-19 | Schepens Eye Research | Compositions and methods for treating eye disorders and conditions |
| US7666447B2 (en) | 2004-10-08 | 2010-02-23 | Pharmanutrients | Compositions including Krill extracts and conjugated linoleic acid and methods of using same |
| US7893106B2 (en) | 2004-11-19 | 2011-02-22 | Martek Biosciences, Corporation | Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same |
| JP5504405B2 (ja) * | 2005-06-10 | 2014-05-28 | 国立大学法人山口大学 | 血管病予防に効果を有する食品組成物 |
| WO2008021192A2 (en) | 2006-08-08 | 2008-02-21 | Lipomics Technologies, Inc. | Markers of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) and methods of use thereof |
| GB0802116D0 (en) | 2008-02-05 | 2008-03-12 | Natural Enviromental Res Counc | Treatment |
| US20110105510A1 (en) | 2008-06-17 | 2011-05-05 | Hiroshi Ishikawa | Prophylactic/ameliorating or therapeutic agent for non-alcoholic steatohepatitis |
| JP2010229099A (ja) * | 2009-03-27 | 2010-10-14 | Mochida Pharmaceut Co Ltd | 脂質異常症の改善または治療薬 |
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| EP2433630A4 (en) * | 2009-05-22 | 2014-01-08 | Mochida Pharm Co Ltd | SELF-EMULSIFIABLE COMPOSITION OF FATTY ACID 3 |
| CA2690488C (en) | 2010-01-19 | 2013-06-11 | Accucaps Industries Limited | Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof |
| US10154977B2 (en) | 2011-03-25 | 2018-12-18 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory particles |
| US20120264824A1 (en) | 2011-04-15 | 2012-10-18 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| SG11201401629XA (en) | 2011-10-19 | 2014-05-29 | Dignity Sciences Ltd | Pharmaceutical compositions comprising dgla and/or 15-hetre and methods of use thereof |
| US8293790B2 (en) | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
| JP2015500639A (ja) | 2011-11-29 | 2015-01-08 | ディグニティ サイエンシス リミテッド | ２０−炭素脂肪酸を含む組成物ならびにその製造方法および使用方法 |
| CN104321055A (zh) | 2012-01-06 | 2015-01-28 | 翁特拉制药公司 | 游离酸形式的ω-3多不饱和脂肪酸的富含dpa组合物 |
| US20120264705A1 (en) | 2012-01-26 | 2012-10-18 | Dignity Sciences Limited | Antimicrobial compositions comprising 15-hetre and methods of use thereof |
| US20130267598A1 (en) | 2012-02-23 | 2013-10-10 | Dignity Sciences Limited | Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same |
| IN2014DN08449A (enExample) * | 2012-03-30 | 2015-05-08 | Sancilio & Company Inc | |
| US20150079164A1 (en) | 2012-04-04 | 2015-03-19 | Pronova Biopharma Norge As | Compositions comprising omega-3 fatty acids and vitamin d for acne vulgaris and/or eczema, and methods and uses thereof |
| EP4205546A1 (en) * | 2012-05-10 | 2023-07-05 | Solutex NA LLC | Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors |
| GB201213484D0 (en) * | 2012-07-30 | 2012-09-12 | Dignity Sciences Ltd | Pharmaceutical compositions comprising 15-OHEPA and methods of using the same |
| GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| ES2841344T3 (es) * | 2013-07-18 | 2021-07-08 | Mochida Pharm Co Ltd | Composición autoemulsionante de ácidos grasos omega-3 |
| CN105899485B (zh) * | 2013-11-15 | 2018-10-19 | 尊严科学有限公司 | 多不饱和羟基脂肪酸的药学上可接受的盐 |
| US20150196521A1 (en) * | 2014-01-10 | 2015-07-16 | Dignity Sciences Limited | Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same |
| MA41120A (fr) * | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| CN113893240A (zh) * | 2015-01-16 | 2022-01-07 | 艾菲穆恩有限公司 | 包含15-hepe的组合物和其使用方法 |
| CN113896628A (zh) | 2015-05-13 | 2022-01-07 | Ds生物制药有限公司 | 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法 |
| EP3861995A1 (en) * | 2015-07-21 | 2021-08-11 | Affimune Limited | Compositions comprising 15-hepe for use in treating or preventing neurologic disease |
| KR20180094516A (ko) * | 2015-12-18 | 2018-08-23 | 애피뮨 리미티드 | 15-hepe를 포함하는 조성물 및 이를 사용하는 방법 |
-
2016
- 2016-12-19 KR KR1020187020457A patent/KR20180094516A/ko not_active Ceased
- 2016-12-19 KR KR1020257027779A patent/KR20250130433A/ko active Pending
- 2016-12-19 AR ARP160103915A patent/AR107143A1/es not_active Application Discontinuation
- 2016-12-19 IL IL318963A patent/IL318963A/en unknown
- 2016-12-19 BR BR122023026625-0A patent/BR122023026625A2/pt not_active Application Discontinuation
- 2016-12-19 CA CA3129008A patent/CA3129008A1/en active Pending
- 2016-12-19 RU RU2018126361A patent/RU2737089C2/ru active
- 2016-12-19 US US15/383,889 patent/US9855238B2/en active Active
- 2016-12-19 CN CN201680082030.9A patent/CN108697680A/zh active Pending
- 2016-12-19 WO PCT/IB2016/001878 patent/WO2017103671A1/en not_active Ceased
- 2016-12-19 EP EP16834282.2A patent/EP3389647B1/en active Active
- 2016-12-19 KR KR1020227008483A patent/KR20220038818A/ko not_active Ceased
- 2016-12-19 NZ NZ744323A patent/NZ744323A/en unknown
- 2016-12-19 KR KR1020247011532A patent/KR20240052856A/ko not_active Ceased
- 2016-12-19 RU RU2020137883A patent/RU2020137883A/ru unknown
- 2016-12-19 KR KR1020237010220A patent/KR20230047501A/ko not_active Ceased
- 2016-12-19 CA CA3008774A patent/CA3008774C/en active Active
- 2016-12-19 KR KR1020207013456A patent/KR20200055154A/ko not_active Ceased
- 2016-12-19 MX MX2021000773A patent/MX394051B/es unknown
- 2016-12-19 SG SG11201805149XA patent/SG11201805149XA/en unknown
- 2016-12-19 CN CN202110567290.8A patent/CN113230244A/zh active Pending
- 2016-12-19 MX MX2018007390A patent/MX379262B/es unknown
- 2016-12-19 AU AU2016370626A patent/AU2016370626B2/en active Active
- 2016-12-19 ES ES16834282T patent/ES2948444T3/es active Active
- 2016-12-19 JP JP2018531629A patent/JP2018537513A/ja active Pending
- 2016-12-19 IL IL294736A patent/IL294736A/en unknown
- 2016-12-19 EP EP23158607.4A patent/EP4218736A3/en active Pending
-
2017
- 2017-12-14 US US15/841,363 patent/US10231945B2/en active Active
-
2018
- 2018-06-06 IL IL259846A patent/IL259846A/en unknown
- 2018-06-14 PH PH12018501279A patent/PH12018501279A1/en unknown
- 2018-07-17 ZA ZA2018/04779A patent/ZA201804779B/en unknown
-
2019
- 2019-01-31 US US16/263,486 patent/US20190224154A1/en not_active Abandoned
- 2019-11-27 JP JP2019214063A patent/JP2020063259A/ja active Pending
-
2020
- 2020-11-11 AU AU2020267224A patent/AU2020267224B2/en active Active
-
2021
- 2021-07-15 ZA ZA2021/04969A patent/ZA202104969B/en unknown
- 2021-07-19 JP JP2021118532A patent/JP2021178840A/ja active Pending
-
2022
- 2022-05-20 US US17/750,262 patent/US12274685B2/en active Active
- 2022-12-23 AU AU2022291628A patent/AU2022291628B2/en active Active
-
2023
- 2023-07-21 JP JP2023118782A patent/JP2023153863A/ja active Pending
-
2024
- 2024-11-04 AR ARP240103022A patent/AR134220A2/es unknown
-
2025
- 2025-03-05 AU AU2025201593A patent/AU2025201593A1/en active Pending
- 2025-03-19 US US19/083,602 patent/US20250281442A1/en active Pending
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