RU2737089C2 - Композиции, содержащие 15-hepe, и способы их применения - Google Patents

Композиции, содержащие 15-hepe, и способы их применения Download PDF

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RU2737089C2
RU2737089C2 RU2018126361A RU2018126361A RU2737089C2 RU 2737089 C2 RU2737089 C2 RU 2737089C2 RU 2018126361 A RU2018126361 A RU 2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A RU 2737089 C2 RU2737089 C2 RU 2737089C2
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hepe
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composition
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administration
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RU2018126361A
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RU2018126361A (ru
RU2018126361A3 (enExample
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Дэвид КОГЛЭН
Джон КЛАЙМАКС
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Эфиммьюн Лимитед
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2018126361A 2015-12-18 2016-12-19 Композиции, содержащие 15-hepe, и способы их применения RU2737089C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562269280P 2015-12-18 2015-12-18
US62/269,280 2015-12-18
PCT/IB2016/001878 WO2017103671A1 (en) 2015-12-18 2016-12-19 Compositions comprising 15-hepe and methods of using the same

Related Child Applications (1)

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RU2020137883A Division RU2020137883A (ru) 2015-12-18 2016-12-19 Композиции, содержащие 15-hepe, и способы их применения

Publications (3)

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RU2018126361A RU2018126361A (ru) 2020-01-22
RU2018126361A3 RU2018126361A3 (enExample) 2020-01-22
RU2737089C2 true RU2737089C2 (ru) 2020-11-24

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RU2018126361A RU2737089C2 (ru) 2015-12-18 2016-12-19 Композиции, содержащие 15-hepe, и способы их применения
RU2020137883A RU2020137883A (ru) 2015-12-18 2016-12-19 Композиции, содержащие 15-hepe, и способы их применения

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Country Link
US (5) US9855238B2 (enExample)
EP (2) EP3389647B1 (enExample)
JP (4) JP2018537513A (enExample)
KR (6) KR20220038818A (enExample)
CN (2) CN113230244A (enExample)
AR (1) AR107143A1 (enExample)
AU (4) AU2016370626B2 (enExample)
BR (1) BR122023026625A2 (enExample)
CA (2) CA3008774C (enExample)
ES (1) ES2948444T3 (enExample)
IL (3) IL318963A (enExample)
MX (2) MX394051B (enExample)
NZ (1) NZ744323A (enExample)
PH (1) PH12018501279A1 (enExample)
RU (2) RU2737089C2 (enExample)
SG (1) SG11201805149XA (enExample)
WO (1) WO2017103671A1 (enExample)
ZA (2) ZA201804779B (enExample)

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MA41120A (fr) 2014-12-02 2017-10-10 Afimmune Ltd Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci
MA47141A (fr) 2015-05-13 2019-11-06 Ds Biopharma Ltd Compositions comprenant du15-oxo-epa ou du 15-oxo-dgla et leurs procédés de préparation et d'utilisation
US20170020836A1 (en) 2015-07-21 2017-01-26 Dignity Sciences Limited Compositions Comprising 15-HEPE and Methods of Treating or Preventing Cancer and Neurologic Disease
RU2737089C2 (ru) * 2015-12-18 2020-11-24 Эфиммьюн Лимитед Композиции, содержащие 15-hepe, и способы их применения
CN113116878A (zh) * 2020-01-10 2021-07-16 南京大学 15s-hepe用于增强t细胞介导的肿瘤免疫治疗的新用途
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases
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CN113855659B (zh) * 2021-11-24 2022-12-23 中国人民解放军东部战区总医院 12-hepe或其药学上可接受的脂肪酸改善精子发生障碍的应用

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JPH05186342A (ja) * 1992-01-10 1993-07-27 Fujirebio Inc 免疫調節作用を併せもつ抗炎症剤
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MX394051B (es) 2025-03-24
CN113230244A (zh) 2021-08-10
ZA201804779B (en) 2019-09-25
IL259846A (en) 2018-07-31
JP2018537513A (ja) 2018-12-20
CA3129008A1 (en) 2017-06-22
US20180104207A1 (en) 2018-04-19
KR20220038818A (ko) 2022-03-29
CA3008774A1 (en) 2017-06-22
AU2025201593A1 (en) 2025-03-20
KR20230047501A (ko) 2023-04-07
NZ783466A (en) 2025-05-30
EP3389647A1 (en) 2018-10-24
IL294736A (en) 2022-09-01
US20170172965A1 (en) 2017-06-22
US20190224154A1 (en) 2019-07-25
RU2020137883A (ru) 2020-12-03
CA3008774C (en) 2021-10-12
US12274685B2 (en) 2025-04-15
PH12018501279A1 (en) 2019-01-28
NZ744323A (en) 2020-08-28
ZA202104969B (en) 2023-01-25
MX379262B (es) 2025-03-10
BR112018012313A2 (pt) 2018-12-04
RU2018126361A (ru) 2020-01-22
KR20200055154A (ko) 2020-05-20
US9855238B2 (en) 2018-01-02
MX2021000773A (es) 2022-07-19
KR20240052856A (ko) 2024-04-23
NZ766360A (en) 2025-05-30
JP2020063259A (ja) 2020-04-23
JP2023153863A (ja) 2023-10-18
US20230106655A1 (en) 2023-04-06
US20250281442A1 (en) 2025-09-11
JP2021178840A (ja) 2021-11-18
KR20180094516A (ko) 2018-08-23
ES2948444T3 (es) 2023-09-12
AU2020267224A1 (en) 2020-12-10
AU2022291628A1 (en) 2023-02-02
BR122023026625A2 (pt) 2024-01-16
US10231945B2 (en) 2019-03-19
EP4218736A3 (en) 2023-10-18
RU2018126361A3 (enExample) 2020-01-22
MX2018007390A (es) 2018-11-09
EP3389647B1 (en) 2023-04-05
IL318963A (en) 2025-04-01
AU2020267224B2 (en) 2022-09-29
KR20250130433A (ko) 2025-09-01
WO2017103671A1 (en) 2017-06-22
AU2016370626A1 (en) 2018-08-02
EP4218736A2 (en) 2023-08-02
CN108697680A (zh) 2018-10-23
SG11201805149XA (en) 2018-07-30
AU2022291628B2 (en) 2025-04-03
AU2016370626B2 (en) 2020-08-20
AR107143A1 (es) 2018-03-28

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