AU2016370626B2 - Compositions comprising 15-HEPE and methods of using the same - Google Patents

Compositions comprising 15-HEPE and methods of using the same Download PDF

Info

Publication number
AU2016370626B2
AU2016370626B2 AU2016370626A AU2016370626A AU2016370626B2 AU 2016370626 B2 AU2016370626 B2 AU 2016370626B2 AU 2016370626 A AU2016370626 A AU 2016370626A AU 2016370626 A AU2016370626 A AU 2016370626A AU 2016370626 B2 AU2016370626 B2 AU 2016370626B2
Authority
AU
Australia
Prior art keywords
hepe
subject
pharmaceutically acceptable
composition
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016370626A
Other languages
English (en)
Other versions
AU2016370626A1 (en
Inventor
John Climax
David Coughlan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Afimmune Ltd
Original Assignee
Afimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Afimmune Ltd filed Critical Afimmune Ltd
Publication of AU2016370626A1 publication Critical patent/AU2016370626A1/en
Application granted granted Critical
Publication of AU2016370626B2 publication Critical patent/AU2016370626B2/en
Priority to AU2020267224A priority Critical patent/AU2020267224B2/en
Priority to AU2022291628A priority patent/AU2022291628B2/en
Priority to AU2025201593A priority patent/AU2025201593A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2016370626A 2015-12-18 2016-12-19 Compositions comprising 15-HEPE and methods of using the same Active AU2016370626B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020267224A AU2020267224B2 (en) 2015-12-18 2020-11-11 Compositions comprising 15-HEPE and methods of using the same
AU2022291628A AU2022291628B2 (en) 2015-12-18 2022-12-23 Compositions comprising 15-HEPE and methods of using the same
AU2025201593A AU2025201593A1 (en) 2015-12-18 2025-03-05 Compositions comprising 15-HEPE and methods of using the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562269280P 2015-12-18 2015-12-18
US62/269,280 2015-12-18
PCT/IB2016/001878 WO2017103671A1 (en) 2015-12-18 2016-12-19 Compositions comprising 15-hepe and methods of using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020267224A Division AU2020267224B2 (en) 2015-12-18 2020-11-11 Compositions comprising 15-HEPE and methods of using the same

Publications (2)

Publication Number Publication Date
AU2016370626A1 AU2016370626A1 (en) 2018-08-02
AU2016370626B2 true AU2016370626B2 (en) 2020-08-20

Family

ID=57995240

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2016370626A Active AU2016370626B2 (en) 2015-12-18 2016-12-19 Compositions comprising 15-HEPE and methods of using the same
AU2020267224A Active AU2020267224B2 (en) 2015-12-18 2020-11-11 Compositions comprising 15-HEPE and methods of using the same
AU2022291628A Active AU2022291628B2 (en) 2015-12-18 2022-12-23 Compositions comprising 15-HEPE and methods of using the same
AU2025201593A Pending AU2025201593A1 (en) 2015-12-18 2025-03-05 Compositions comprising 15-HEPE and methods of using the same

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2020267224A Active AU2020267224B2 (en) 2015-12-18 2020-11-11 Compositions comprising 15-HEPE and methods of using the same
AU2022291628A Active AU2022291628B2 (en) 2015-12-18 2022-12-23 Compositions comprising 15-HEPE and methods of using the same
AU2025201593A Pending AU2025201593A1 (en) 2015-12-18 2025-03-05 Compositions comprising 15-HEPE and methods of using the same

Country Status (18)

Country Link
US (5) US9855238B2 (enExample)
EP (2) EP3389647B1 (enExample)
JP (4) JP2018537513A (enExample)
KR (6) KR20180094516A (enExample)
CN (2) CN113230244A (enExample)
AR (2) AR107143A1 (enExample)
AU (4) AU2016370626B2 (enExample)
BR (1) BR122023026625A2 (enExample)
CA (2) CA3129008A1 (enExample)
ES (1) ES2948444T3 (enExample)
IL (3) IL294736A (enExample)
MX (2) MX379262B (enExample)
NZ (1) NZ744323A (enExample)
PH (1) PH12018501279A1 (enExample)
RU (2) RU2737089C2 (enExample)
SG (1) SG11201805149XA (enExample)
WO (1) WO2017103671A1 (enExample)
ZA (2) ZA201804779B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201301626D0 (en) 2013-01-30 2013-03-13 Dignity Sciences Ltd Composition comprising 15-OHEPA and methods of using the same
ES2727387T3 (es) 2013-11-15 2019-10-15 Ds Biopharma Ltd Sal de lisina de ácido 15-hidroxi-8(Z),11(Z),13(E)-eicosatrienoico
MA41120A (fr) 2014-12-02 2017-10-10 Afimmune Ltd Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci
US10047033B2 (en) 2015-05-13 2018-08-14 Ds Biopharma Limited Compositions comprising oxo-derivatives of fatty acids and methods of making and using same
CN112245420A (zh) 2015-07-21 2021-01-22 艾菲穆恩有限公司 用于治疗或预防癌症和神经疾病的包括15-hepe的组合物
AU2016370626B2 (en) * 2015-12-18 2020-08-20 Afimmune Limited Compositions comprising 15-HEPE and methods of using the same
CN113116878A (zh) * 2020-01-10 2021-07-16 南京大学 15s-hepe用于增强t细胞介导的肿瘤免疫治疗的新用途
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases
US11622495B2 (en) 2021-06-01 2023-04-11 Gint Co., Ltd. Method of automatically combining farm vehicle and work machine and farm vehicle
CN113855659B (zh) * 2021-11-24 2022-12-23 中国人民解放军东部战区总医院 12-hepe或其药学上可接受的脂肪酸改善精子发生障碍的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05186342A (ja) * 1992-01-10 1993-07-27 Fujirebio Inc 免疫調節作用を併せもつ抗炎症剤
WO2014019919A1 (en) * 2012-07-30 2014-02-06 Dignity Sciences Limited Pharmaceutical compositions comprising 15-ohepa and methods of using the same
EP2762143A1 (en) * 2013-01-30 2014-08-06 Dignity Sciences Limited Compositions comprising 15-OHEPA and methods of using the same
WO2015071766A1 (en) * 2013-11-15 2015-05-21 Dignity Sciences Limited Pharmaceutically acceptable salts of polyunsaturated hydroxy fatty acids
WO2016090030A1 (en) * 2014-12-02 2016-06-09 Dignity Sciences Limited Compositions comprising 15-hepe and methods of treating or preventing fibrosis using same
WO2016113635A1 (en) * 2015-01-16 2016-07-21 Dignity Sciences Limited Compositions comprising 15-hepe and methods of using the same
WO2017013492A1 (en) * 2015-07-21 2017-01-26 Dignity Sciences Limited Compositions comprising 15-hepe for use in treating or preventing cancer and neurologic disease

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301446D0 (en) 1993-01-26 1993-03-17 Scotia Holdings Plc Internal radiation damage
AU673700B2 (en) 1993-01-27 1996-11-21 Scotia Holdings Plc Triglycerides
DE69407949T2 (de) 1993-10-01 1998-05-14 Scherer Corp R P Zusammensetzungen zum verteilen von duftstoffen
GB9715444D0 (en) 1997-07-22 1997-09-24 Scotia Holdings Plc Therapeutic and dietary compositions
JP2000191525A (ja) 1998-12-25 2000-07-11 Nof Corp 皮膚外用剤組成物
IL151299A0 (en) 2000-02-16 2003-04-10 Brigham & Womens Hospital Aspirin-triggered lipid mediators
US20020188024A1 (en) 2000-08-23 2002-12-12 Chilton Floyd H. Fatty acid-containing emulsion with increased bioavailability
US20040043013A1 (en) 2000-12-28 2004-03-04 Mccleary Edward Larry Metabolic uncoupling therapy
US20020198177A1 (en) 2001-05-30 2002-12-26 Horrobin David Frederick Coenzyme Q and EPA
JPWO2004048497A1 (ja) 2002-11-22 2006-03-30 日本水産株式会社 高度不飽和脂肪酸、その塩、またはそのエステルを含有する外用組成物
JP2005179211A (ja) 2003-12-17 2005-07-07 Idemitsu Kosan Co Ltd 皮膚外用剤組成物
WO2005063231A2 (en) 2003-12-31 2005-07-14 Igennus Limited Formulation containing an eicosapentaenoic acid or an ester thereof and a triterpene or esther thereof
WO2005102309A2 (en) 2004-04-26 2005-11-03 Ltb4 Sweden Ab In vivo release of endogenous anti-microbial mediators by leukotriene b4 (ltb4) administration
AU2005262392A1 (en) 2004-07-01 2006-01-19 Johnson & Johnson Vision Care, Inc. Compositions and methods for treating eye disorders and conditions
US7666447B2 (en) 2004-10-08 2010-02-23 Pharmanutrients Compositions including Krill extracts and conjugated linoleic acid and methods of using same
US7893106B2 (en) 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same
JP5504405B2 (ja) * 2005-06-10 2014-05-28 国立大学法人山口大学 血管病予防に効果を有する食品組成物
JP2010500566A (ja) 2006-08-08 2010-01-07 テシス バイオサイエンス， インコーポレイテッド 非アルコール性脂肪肝疾患（ｎａｆｌｄ）および非アルコール性脂肪性肝炎（ｎａｓｈ）のマーカーおよびその使用方法
GB0802116D0 (en) 2008-02-05 2008-03-12 Natural Enviromental Res Counc Treatment
WO2009154230A1 (ja) 2008-06-17 2009-12-23 持田製薬株式会社 非アルコール性脂肪肝炎の予防／改善・治療薬
JP2010229099A (ja) * 2009-03-27 2010-10-14 Mochida Pharmaceut Co Ltd 脂質異常症の改善または治療薬
GB0907413D0 (en) 2009-04-29 2009-06-10 Equateq Ltd Novel methods
EP3181131A1 (en) * 2009-05-22 2017-06-21 Mochida Pharmaceutical Co., Ltd. Self-emulsifying compositin of 3 fatty acid
CA2690488C (en) 2010-01-19 2013-06-11 Accucaps Industries Limited Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof
US10154977B2 (en) 2011-03-25 2018-12-18 The Brigham And Women's Hospital, Inc. Anti-inflammatory particles
US20120264824A1 (en) 2011-04-15 2012-10-18 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
US8293790B2 (en) 2011-10-19 2012-10-23 Dignity Sciences Limited Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof
RU2014119948A (ru) 2011-10-19 2015-11-27 Дигнити Сайенсиз Лимитед ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ DGLA И/ИЛИ 15-HETrE, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
CA2856715A1 (en) 2011-11-29 2013-06-06 Dignity Sciences Limited Compositions comprising 20-carbon fatty acids and methods of making and using same
CN107050457A (zh) 2012-01-06 2017-08-18 翁特拉制药公司 游离酸形式的ω‑3多不饱和脂肪酸的富含dpa组合物
US20120264705A1 (en) 2012-01-26 2012-10-18 Dignity Sciences Limited Antimicrobial compositions comprising 15-hetre and methods of use thereof
US20130267598A1 (en) 2012-02-23 2013-10-10 Dignity Sciences Limited Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same
IN2014DN08449A (enExample) * 2012-03-30 2015-05-08 Sancilio & Company Inc
EP2833740B1 (en) 2012-04-04 2016-09-14 Pronova BioPharma Norge AS Compositions comprising omega-3 fatty acids and vitamin d for acne vulgaris and/or eczema, and methods and uses thereof
AU2013259503B2 (en) * 2012-05-10 2017-03-16 Solutex Na Llc Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors
CA2918330C (en) * 2013-07-18 2022-08-30 Mochida Pharmaceutical Co., Ltd. Self-emulsifying composition of .omega.3 fatty acid
RU2685706C2 (ru) * 2014-01-10 2019-04-23 Эфиммьюн Лимитед Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением
US10047033B2 (en) * 2015-05-13 2018-08-14 Ds Biopharma Limited Compositions comprising oxo-derivatives of fatty acids and methods of making and using same
AU2016370626B2 (en) * 2015-12-18 2020-08-20 Afimmune Limited Compositions comprising 15-HEPE and methods of using the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05186342A (ja) * 1992-01-10 1993-07-27 Fujirebio Inc 免疫調節作用を併せもつ抗炎症剤
WO2014019919A1 (en) * 2012-07-30 2014-02-06 Dignity Sciences Limited Pharmaceutical compositions comprising 15-ohepa and methods of using the same
EP2762143A1 (en) * 2013-01-30 2014-08-06 Dignity Sciences Limited Compositions comprising 15-OHEPA and methods of using the same
WO2015071766A1 (en) * 2013-11-15 2015-05-21 Dignity Sciences Limited Pharmaceutically acceptable salts of polyunsaturated hydroxy fatty acids
WO2016090030A1 (en) * 2014-12-02 2016-06-09 Dignity Sciences Limited Compositions comprising 15-hepe and methods of treating or preventing fibrosis using same
WO2016113635A1 (en) * 2015-01-16 2016-07-21 Dignity Sciences Limited Compositions comprising 15-hepe and methods of using the same
WO2017013492A1 (en) * 2015-07-21 2017-01-26 Dignity Sciences Limited Compositions comprising 15-hepe for use in treating or preventing cancer and neurologic disease

Also Published As

Publication number Publication date
CA3008774C (en) 2021-10-12
US9855238B2 (en) 2018-01-02
US20180104207A1 (en) 2018-04-19
BR112018012313A2 (pt) 2018-12-04
MX379262B (es) 2025-03-10
SG11201805149XA (en) 2018-07-30
BR122023026625A2 (pt) 2024-01-16
MX2018007390A (es) 2018-11-09
AR107143A1 (es) 2018-03-28
KR20220038818A (ko) 2022-03-29
NZ744323A (en) 2020-08-28
KR20180094516A (ko) 2018-08-23
EP3389647A1 (en) 2018-10-24
RU2020137883A (ru) 2020-12-03
MX2021000773A (es) 2022-07-19
KR20240052856A (ko) 2024-04-23
RU2018126361A3 (enExample) 2020-01-22
IL294736A (en) 2022-09-01
US20250281442A1 (en) 2025-09-11
IL259846A (en) 2018-07-31
AR134220A2 (es) 2025-12-10
RU2737089C2 (ru) 2020-11-24
CA3129008A1 (en) 2017-06-22
CN108697680A (zh) 2018-10-23
US20190224154A1 (en) 2019-07-25
AU2020267224A1 (en) 2020-12-10
JP2020063259A (ja) 2020-04-23
JP2023153863A (ja) 2023-10-18
EP4218736A2 (en) 2023-08-02
AU2016370626A1 (en) 2018-08-02
RU2018126361A (ru) 2020-01-22
NZ766360A (en) 2025-05-30
KR20250130433A (ko) 2025-09-01
AU2022291628B2 (en) 2025-04-03
MX394051B (es) 2025-03-24
JP2021178840A (ja) 2021-11-18
PH12018501279A1 (en) 2019-01-28
NZ783466A (en) 2025-05-30
US10231945B2 (en) 2019-03-19
KR20200055154A (ko) 2020-05-20
ZA202104969B (en) 2023-01-25
WO2017103671A1 (en) 2017-06-22
ES2948444T3 (es) 2023-09-12
KR20230047501A (ko) 2023-04-07
AU2022291628A1 (en) 2023-02-02
US20170172965A1 (en) 2017-06-22
CN113230244A (zh) 2021-08-10
JP2018537513A (ja) 2018-12-20
AU2020267224B2 (en) 2022-09-29
CA3008774A1 (en) 2017-06-22
EP4218736A3 (en) 2023-10-18
EP3389647B1 (en) 2023-04-05
AU2025201593A1 (en) 2025-03-20
ZA201804779B (en) 2019-09-25
US20230106655A1 (en) 2023-04-06
US12274685B2 (en) 2025-04-15
IL318963A (en) 2025-04-01

Similar Documents

Publication Publication Date Title
AU2022291628B2 (en) Compositions comprising 15-HEPE and methods of using the same
US20210228524A1 (en) Compositions comprising 15-ohepa and methods of using the same
US20180008567A1 (en) Compositions comprising 15-hepe and methods of using the same
BR112018012313B1 (pt) Uso de ácido 15-hidroxieicosapentaenoico ou de um derivado farmaceuticamente aceitável do mesmo para inibir ou aliviar uma doença selecionada dentre artrite, doença de huntington, sensibilidade à insulina comprometida, psoríase, câncer de pele, diferenciação de adipócitos, dor e obesidade

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)