RU2018126361A - Композиции, содержащие 15-hepe, и способы их применения - Google Patents
Композиции, содержащие 15-hepe, и способы их применения Download PDFInfo
- Publication number
- RU2018126361A RU2018126361A RU2018126361A RU2018126361A RU2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A
- Authority
- RU
- Russia
- Prior art keywords
- hepe
- composition
- composition according
- pharmaceutically acceptable
- acceptable derivative
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 15
- WLKCSMCLEKGITB-XWJJKCKWSA-N 15-HEPE Chemical compound CC\C=C/CC(O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O WLKCSMCLEKGITB-XWJJKCKWSA-N 0.000 title claims 13
- 238000000034 method Methods 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 150000004702 methyl esters Chemical group 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 125000005457 triglyceride group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Pregnancy & Childbirth (AREA)
Claims (22)
1. Фармацевтическая композиция, содержащая 15-HEPE или ее фармацевтически приемлемое производное.
2. Композиция по п.1, отличающаяся тем, что указанная фармацевтическая композиция содержит от 100 мг до 1000 мг 15-HEPE или ее фармацевтически приемлемого производного.
3. Композиция по п.1, отличающаяся тем, что указанное фармацевтически приемлемое производное содержит сложный эфир, конъюгат, соль или их комбинацию.
4. Композиция по п.1, отличающаяся тем, что 15-HEPE имеет форму свободной кислоты.
5. Композиция по п.1, отличающаяся тем, что 15-HEPE имеет этерифицированную форму.
6. Композиция по п.5, отличающаяся тем, что указанная этерифицированная форма представляет собой форму сложного метилового эфира, сложного этилового эфира или их комбинацию.
7. Композиция по п.5, отличающаяся тем, что указанная этерифицированная форма представляет собой форму триглицерида.
8. Композиция по п.1, отличающаяся тем, что 15-HEPE имеет форму соли.
9. Композиция по п.1, отличающаяся тем, что 15-HEPE содержит 15(S)-HEPE и/или 15(R)-HEPE.
10. Композиция по п.1, отличающаяся тем, что 15-HEPE состоит из 15(S)-HEPE.
11. Композиция по п.1, отличающаяся тем, что 15-HEPE состоит из 15(R)-HEPE.
12. Способ лечения заболевания у субъекта, нуждающегося в этом, включающий введение указанному субъекту эффективного количества композиции, содержащей 15-HEPE или ее фармацевтически приемлемое производное.
13. Способ по п.12, отличающийся тем, что указанное заболевание выбрано из группы, состоящей из нарушения чувствительности к инсулину, псориаза, фиброза, ракового заболевания, нейродегенеративных нарушений, воспалительных заболеваний, дифференцировки адипоцитов, проблем с зачатием или репродуктивной способностью, боли и ожирения.
14. Способ по п.13, отличающийся тем, что указанное раковое заболевание представляет собой рак кожи.
15. Способ по п.14, отличающийся тем, что указанный рак кожи представляет собой меланому.
16. Способ по п.13, отличающийся тем, что указанное нейродегенеративное нарушение представляет собой болезнь Хантингтона.
17. Способ по п.13, отличающийся тем, что указанный фиброз представляет собой идиопатический фиброз легких.
18. Способ по п.12, отличающийся тем, что указанное фармацевтически приемлемое производное включает сложный эфир, конъюгат, соль или их комбинацию.
19. Способ по п.12, отличающийся тем, что указанное заболевание ослабляется по сравнению со вторым субъектом, которому не вводили композицию и необязательно вводили плацебо.
20. Способ по п.12, отличающийся тем, что указанное эффективное количество композиции, содержащей 15-HEPE или ее фармацевтически приемлемое производное, составляет от примерно 100 мг до примерно 2000 мг.
21. Способ увеличения всасывания 15-HEPE, включающий введение композиции, содержащей 15-HEPE или ее производное, субъекту, нуждающемуся в этом, после приема пищи.
22. Способ по п.21, отличающийся тем, что указанное фармацевтически приемлемое производное включает сложный эфир, конъюгат, соль или их комбинацию.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562269280P | 2015-12-18 | 2015-12-18 | |
US62/269,280 | 2015-12-18 | ||
PCT/IB2016/001878 WO2017103671A1 (en) | 2015-12-18 | 2016-12-19 | Compositions comprising 15-hepe and methods of using the same |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2020137883A Division RU2020137883A (ru) | 2015-12-18 | 2016-12-19 | Композиции, содержащие 15-hepe, и способы их применения |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2018126361A3 RU2018126361A3 (ru) | 2020-01-22 |
RU2018126361A true RU2018126361A (ru) | 2020-01-22 |
RU2737089C2 RU2737089C2 (ru) | 2020-11-24 |
Family
ID=57995240
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2018126361A RU2737089C2 (ru) | 2015-12-18 | 2016-12-19 | Композиции, содержащие 15-hepe, и способы их применения |
RU2020137883A RU2020137883A (ru) | 2015-12-18 | 2016-12-19 | Композиции, содержащие 15-hepe, и способы их применения |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2020137883A RU2020137883A (ru) | 2015-12-18 | 2016-12-19 | Композиции, содержащие 15-hepe, и способы их применения |
Country Status (18)
Country | Link |
---|---|
US (4) | US9855238B2 (ru) |
EP (2) | EP4218736A3 (ru) |
JP (4) | JP2018537513A (ru) |
KR (5) | KR20230047501A (ru) |
CN (2) | CN113230244A (ru) |
AR (1) | AR107143A1 (ru) |
AU (3) | AU2016370626B2 (ru) |
BR (2) | BR122023026625A2 (ru) |
CA (2) | CA3008774C (ru) |
ES (1) | ES2948444T3 (ru) |
IL (2) | IL294736A (ru) |
MX (2) | MX2018007390A (ru) |
NZ (1) | NZ744323A (ru) |
PH (1) | PH12018501279A1 (ru) |
RU (2) | RU2737089C2 (ru) |
SG (1) | SG11201805149XA (ru) |
WO (1) | WO2017103671A1 (ru) |
ZA (2) | ZA201804779B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
WO2015071766A1 (en) | 2013-11-15 | 2015-05-21 | Dignity Sciences Limited | Pharmaceutically acceptable salts of polyunsaturated hydroxy fatty acids |
MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
CN117402059A (zh) | 2015-05-13 | 2024-01-16 | Ds生物制药有限公司 | 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法 |
ES2851525T3 (es) | 2015-07-21 | 2021-09-07 | Afimmune Ltd | Composiciones que comprenden 15(S)-HEPE para su uso en la sensibilización de las células cancerosas a la radioterapia |
AU2016370626B2 (en) * | 2015-12-18 | 2020-08-20 | Afimmune Limited | Compositions comprising 15-HEPE and methods of using the same |
CN113116878A (zh) * | 2020-01-10 | 2021-07-16 | 南京大学 | 15s-hepe用于增强t细胞介导的肿瘤免疫治疗的新用途 |
US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
US11622495B2 (en) | 2021-06-01 | 2023-04-11 | Gint Co., Ltd. | Method of automatically combining farm vehicle and work machine and farm vehicle |
CN113855659B (zh) * | 2021-11-24 | 2022-12-23 | 中国人民解放军东部战区总医院 | 12-hepe或其药学上可接受的脂肪酸改善精子发生障碍的应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05186342A (ja) * | 1992-01-10 | 1993-07-27 | Fujirebio Inc | 免疫調節作用を併せもつ抗炎症剤 |
JP2000191525A (ja) | 1998-12-25 | 2000-07-11 | Nof Corp | 皮膚外用剤組成物 |
JP2005179211A (ja) | 2003-12-17 | 2005-07-07 | Idemitsu Kosan Co Ltd | 皮膚外用剤組成物 |
GB2409644B (en) | 2003-12-31 | 2005-12-21 | Igennus Ltd | Formulation comprising eicosapentaenoic acid or an ester thereof and a triterpene or an ester thereof |
US20050239889A1 (en) | 2004-04-26 | 2005-10-27 | Jean Gosselin | In vivo release of endogenous anti-microbial mediators by leukotriene B4 (LTB4) administration |
JP5504405B2 (ja) * | 2005-06-10 | 2014-05-28 | 国立大学法人山口大学 | 血管病予防に効果を有する食品組成物 |
JP2010500566A (ja) | 2006-08-08 | 2010-01-07 | テシス バイオサイエンス, インコーポレイテッド | 非アルコール性脂肪肝疾患(nafld)および非アルコール性脂肪性肝炎(nash)のマーカーおよびその使用方法 |
GB0802116D0 (en) | 2008-02-05 | 2008-03-12 | Natural Enviromental Res Counc | Treatment |
JP2010229099A (ja) * | 2009-03-27 | 2010-10-14 | Mochida Pharmaceut Co Ltd | 脂質異常症の改善または治療薬 |
GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
CA2762939C (en) * | 2009-05-22 | 2017-07-18 | Mochida Phamaceutical Co., Ltd. | Self-emulsifying composition of .omega.3 fatty acid |
WO2012135032A2 (en) | 2011-03-25 | 2012-10-04 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory particles |
CN104010637A (zh) | 2011-10-19 | 2014-08-27 | 尊贵科学有限公司 | 含有双同-γ-次亚麻油酸及/或15-羟基二十碳三烯酸的药物组合物及其使用方法 |
US8293790B2 (en) | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
MX2014006478A (es) | 2011-11-29 | 2015-02-12 | Dignity Sciences Ltd | Composiciones que comprenden acidos grasos de carbono-20 y metodos para elaborar y usar los mismos. |
US20120264705A1 (en) | 2012-01-26 | 2012-10-18 | Dignity Sciences Limited | Antimicrobial compositions comprising 15-hetre and methods of use thereof |
US20130267598A1 (en) | 2012-02-23 | 2013-10-10 | Dignity Sciences Limited | Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same |
WO2013148136A1 (en) * | 2012-03-30 | 2013-10-03 | Sancilio & Company, Inc. | Omega-3 fatty acid ester compositions |
CN116173001A (zh) * | 2012-05-10 | 2023-05-30 | 索卢泰克斯Na有限责任公司 | 含有天然专门促消退介质及其前体的具有抗炎活性的油 |
GB201213484D0 (en) * | 2012-07-30 | 2012-09-12 | Dignity Sciences Ltd | Pharmaceutical compositions comprising 15-OHEPA and methods of using the same |
GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
MY187003A (en) * | 2013-07-18 | 2021-08-26 | Mochida Pharm Co Ltd | Self-emulsifying composition of ?3 fatty acid |
WO2015071766A1 (en) * | 2013-11-15 | 2015-05-21 | Dignity Sciences Limited | Pharmaceutically acceptable salts of polyunsaturated hydroxy fatty acids |
CN106029051A (zh) * | 2014-01-10 | 2016-10-12 | 尊严科学有限公司 | 包含15-hepe的药物组合物以及使用其治疗哮喘和肺病症的方法 |
MA41120A (fr) * | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
WO2016113635A1 (en) * | 2015-01-16 | 2016-07-21 | Dignity Sciences Limited | Compositions comprising 15-hepe and methods of using the same |
CN117402059A (zh) * | 2015-05-13 | 2024-01-16 | Ds生物制药有限公司 | 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法 |
ES2851525T3 (es) * | 2015-07-21 | 2021-09-07 | Afimmune Ltd | Composiciones que comprenden 15(S)-HEPE para su uso en la sensibilización de las células cancerosas a la radioterapia |
AU2016370626B2 (en) * | 2015-12-18 | 2020-08-20 | Afimmune Limited | Compositions comprising 15-HEPE and methods of using the same |
-
2016
- 2016-12-19 AU AU2016370626A patent/AU2016370626B2/en active Active
- 2016-12-19 CN CN202110567290.8A patent/CN113230244A/zh active Pending
- 2016-12-19 KR KR1020237010220A patent/KR20230047501A/ko not_active Application Discontinuation
- 2016-12-19 KR KR1020227008483A patent/KR20220038818A/ko not_active Application Discontinuation
- 2016-12-19 EP EP23158607.4A patent/EP4218736A3/en active Pending
- 2016-12-19 WO PCT/IB2016/001878 patent/WO2017103671A1/en active Application Filing
- 2016-12-19 US US15/383,889 patent/US9855238B2/en active Active
- 2016-12-19 MX MX2018007390A patent/MX2018007390A/es unknown
- 2016-12-19 CN CN201680082030.9A patent/CN108697680A/zh active Pending
- 2016-12-19 RU RU2018126361A patent/RU2737089C2/ru active
- 2016-12-19 SG SG11201805149XA patent/SG11201805149XA/en unknown
- 2016-12-19 NZ NZ744323A patent/NZ744323A/en unknown
- 2016-12-19 KR KR1020207013456A patent/KR20200055154A/ko not_active IP Right Cessation
- 2016-12-19 BR BR122023026625-0A patent/BR122023026625A2/pt active Search and Examination
- 2016-12-19 MX MX2021000773A patent/MX2021000773A/es unknown
- 2016-12-19 KR KR1020187020457A patent/KR20180094516A/ko active Application Filing
- 2016-12-19 ES ES16834282T patent/ES2948444T3/es active Active
- 2016-12-19 IL IL294736A patent/IL294736A/en unknown
- 2016-12-19 BR BR112018012313-7A patent/BR112018012313A2/pt active Search and Examination
- 2016-12-19 RU RU2020137883A patent/RU2020137883A/ru unknown
- 2016-12-19 KR KR1020247011532A patent/KR20240052856A/ko active Search and Examination
- 2016-12-19 AR ARP160103915A patent/AR107143A1/es unknown
- 2016-12-19 CA CA3008774A patent/CA3008774C/en active Active
- 2016-12-19 EP EP16834282.2A patent/EP3389647B1/en active Active
- 2016-12-19 JP JP2018531629A patent/JP2018537513A/ja active Pending
- 2016-12-19 CA CA3129008A patent/CA3129008A1/en active Pending
-
2017
- 2017-12-14 US US15/841,363 patent/US10231945B2/en active Active
-
2018
- 2018-06-06 IL IL259846A patent/IL259846A/en unknown
- 2018-06-14 PH PH12018501279A patent/PH12018501279A1/en unknown
- 2018-07-17 ZA ZA2018/04779A patent/ZA201804779B/en unknown
-
2019
- 2019-01-31 US US16/263,486 patent/US20190224154A1/en not_active Abandoned
- 2019-11-27 JP JP2019214063A patent/JP2020063259A/ja active Pending
-
2020
- 2020-11-11 AU AU2020267224A patent/AU2020267224B2/en active Active
-
2021
- 2021-07-15 ZA ZA2021/04969A patent/ZA202104969B/en unknown
- 2021-07-19 JP JP2021118532A patent/JP2021178840A/ja active Pending
-
2022
- 2022-05-20 US US17/750,262 patent/US20230106655A1/en active Pending
- 2022-12-23 AU AU2022291628A patent/AU2022291628A1/en active Pending
-
2023
- 2023-07-21 JP JP2023118782A patent/JP2023153863A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2018126361A (ru) | Композиции, содержащие 15-hepe, и способы их применения | |
JP2018537513A5 (ru) | ||
JP2019048843A5 (ru) | ||
EA201890852A1 (ru) | Соли валбеназина и их полиморфы | |
RU2018111327A (ru) | Способ ингибирования всасывания и/или повышения выведения липидов с использованием d-псикозы | |
NZ591810A (en) | Pharmaceutical compositions and related methods of delivery the composition comprises a medium chain fatty acid | |
HRP20160203T1 (hr) | Pripravci koji sadrže 15-hepe i postupci njihove upotrebe | |
RU2019116422A (ru) | Фармацевтическое применение композиции пролонгированного действия, содержащей пирфенидон, для лечения и обращения течения стеатогепатита человека (nafld/nash) | |
BR112012019374A2 (pt) | composição farmacêutica, pellet de liberação prolongada, composição farmacêutica oral, método para tratamento de uma doença neurodegenerativa ou um dano ao sistema nervoso em um indivíduo necessitado do mesmo e método para preparação de uma formulação de liberação prolongada de um agente ativo | |
RU2017112149A (ru) | Комбинация омега-3 жирной кислоты и SGLT-2 ингибитора для лечения болезней печени | |
RU2016132762A (ru) | Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением | |
RU2015109566A (ru) | НОВЫЕ ЭКСТРАКТЫ ИЗ CYNARA SCOLYMUS, COFFEA spp. И OLEA EUROPAEA ДЛЯ ЛЕЧЕНИЯ МЕТАБОЛИЧЕСКОГО СИНДРОМА | |
BR112017007428A2 (pt) | composições de éster de ácido graxo e ácidos graxos autocomnizantes e suas utilizações no tratamento de estados da doença | |
JP2018502163A5 (ru) | ||
Wattanapitayakul et al. | Vasorelaxation and antispasmodic effects of Kaempferia parviflora ethanolic extract in isolated rat organ studies | |
JP2016538288A5 (ru) | ||
JP2016514706A5 (ru) | ||
HRP20211661T1 (hr) | Igmezin, namijenjen upotrebi u liječenju alzheimerove bolesti | |
BR112014001503A2 (pt) | composições farmacêuticas compreendendo 4-bromo-n-(imidazolidin-2-ilideno)-1h-benzimidazol-5-amina para o tratamento de doenças de pele | |
BR112022010498A2 (pt) | Cocristal de cetoprofeno e sua preparação, composições farmacêuticas compreendendo o mesmo e seu uso | |
BR112017019824A2 (pt) | compostos; composição farmacêutica; método para o tratamento profilático ou terapêutico da fibrose em um sujeito; usos de um composto; método para a prevenção, redução ou retardamento do acúmulo de gordura no fígado de um sujeito; método para a prevenção, redução ou retardamento da morte das células tubulares renais em um sujeito; e método para a restauração da arquitetura normal dos tecidos em um sujeito | |
BR112021011368A2 (pt) | Cocristal de cetoprofeno, composições compreendendo o mesmo, processo para a sua produção e usos dos mesmos | |
RU2018119120A (ru) | D-пролиновые производные в качестве агента, уменьшающего количество sap | |
EA201592261A1 (ru) | Фармацевтические композиции, включающие агомелатин в форме сокристаллов агомелатина с органической кислотой | |
BR112015028581A2 (pt) | composição farmacêutica de dosagem baixa, utilização do ácido, método para o tratamento da doença inflamatória e composição farmacêutica |